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List of works by David Henshall

ATPergic signalling during seizures and epilepsy

scientific article

Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death.

scientific article published in October 2002

Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia

scientific article published on 01 April 2000

Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons.

scientific article published on 20 March 2006

Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

scientific article published on 18 June 2019

Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy

scientific article published on 01 July 2000

Antagomirs and microRNA in status epilepticus

scientific article published on September 2013

Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus

scientific article published on 30 May 2014

Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis?

scientific article

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor

scientific article published on 30 July 2010

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus.

scientific article

Bax regulates neuronal Ca2+ homeostasis.

scientific article

Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.

scientific article published on 31 December 2010

Bcl-w expression is increased in brain regions affected by focal cerebral ischemia in the rat

scientific article published on 01 February 2000

Bcl-w protects hippocampus during experimental status epilepticus.

scientific article

Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice.

scientific article published on 17 August 2012

Bilateral intranigral NMDA infusion suppresses neuronal injury without affecting the duration of kainic acid-induced seizures in rats

scientific article published in July 1998

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death.

scientific article

CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures

scientific article published on 29 January 2013

CREB-mediated Bcl-2 protein expression after ischemic preconditioning.

scientific article

Can genes modify stroke outcome and by what mechanisms?

scientific article published on 8 December 2011

Caspase-2 activation is redundant during seizure-induced neuronal death

scientific article

Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy

scientific article published on 01 April 2006

Cell death and survival mechanisms after single and repeated brief seizures

Cell signaling underlying epileptic behavior.

scientific article

Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse

scientific article

Cleavage of bid may amplify caspase-8-induced neuronal death following focally evoked limbic seizures

scientific article published in August 2001

Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice

scientific article published on 17 August 2015

Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy

scientific article published on 02 May 2019

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.

scientific article

Contribution of apoptosis-associated signaling pathways to epileptogenesis: lessons from Bcl-2 family knockouts

scientific article published on 16 July 2013

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

scientific article (publication date: 2016)

Death-associated protein kinase expression in human temporal lobe epilepsy

scientific article

Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus.

scientific article

Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.

scientific article published on 2 May 2008

Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures

scientific article published on 01 June 2008

Detection of MicroRNAs in Brain Slices Using In Situ Hybridization.

scientific article published in January 2017

Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse

scientific article published in April 2004

Differential DNA methylation patterns define status epilepticus and epileptic tolerance.

scientific article published on February 2012

Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy.

scientific article published on 30 December 2014

Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: Ways to close current knowledge gaps

scientific article published on 30 October 2018

Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling

scientific article published on 21 February 2008

Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice.

scientific article published in September 2015

Effects of transient focal cerebral ischemia in mice deficient in puma.

scientific article published on 13 January 2009

Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents

scientific article published on 08 April 2009

Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment

scientific article published on 13 November 2019

Elevated serum Bcl-2 in children with temporal lobe epilepsy

scientific article published on 23 February 2012

Emerging AI Technologies Inspiring the Next Generation of E-Textiles

scientific article published in 2023

Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy

scientific article published in March 2006

Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice

scientific article published on 16 September 2004

Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance

scientific article

Epigenetics and Epilepsy

scientific article published on 5 October 2015

Epilepsy and apoptosis pathways

scientific article

Epilepsy and microRNA.

scientific article published on 26 February 2013

Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice.

scientific article published on 17 September 2010

EpimiRBase: a comprehensive database of microRNA-epilepsy associations

scientific article published on 8 January 2016

Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy

scientific article published on 17 August 2006

Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus

scientific article

Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis

scientific article

Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures

scientific journal article

Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures

scientific article (publication date: September 2003)

Expression of neurogenesis genes in human temporal lobe epilepsy with hippocampal sclerosis.

scientific article

Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death.

scientific article

Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures

scientific article

Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis

scientific article published in May 2002

Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death

scientific journal article

Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death

scientific article published in December 2001

Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat

scientific article published on 01 January 2000

Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice

scientific article published on 21 August 2020

High Throughput qPCR Expression Profiling of Circulating MicroRNAs Reveals Minimal Sex- and Sample Timing-Related Variation in Plasma of Healthy Volunteers.

scientific article published on 23 December 2015

High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy

scientific article published on 18 October 2020

Hippocampal damage after intra-amygdala kainic acid-induced status epilepticus and seizure preconditioning-mediated neuroprotection in SJL mice

scientific article published in February 2010

Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways.

scientific article

Hsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury: a novel cytoprotective mechanism

scientific article

Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection

scientific article

IgG leakage may contribute to neuronal dysfunction in drug-refractory epilepsies with blood-brain barrier disruption

scientific article published in September 2012

In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury

scientific article published on 02 March 2011

Increased Bcl-w expression following focally evoked limbic seizures in the rat.

scientific article published in June 2001

Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition

scientific article published on 04 April 2014

Increased hippocampal neurogenesis in Alzheimer's disease.

scientific article

Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079.

scientific article published on 28 June 2013

Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia

scientific article published on 01 October 2000

Interaction of 14-3-3 with Bid during seizure-induced neuronal death

scientific journal article

Investigating gene promoter methylation in a mouse model of status epilepticus

scientific article published in January 2013

Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures

scientific article published on 01 March 2000

Involvement of microRNAs in epileptogenesis

scientific article published on 21 May 2016

Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy

scientific journal article

Kainic acid-induced seizures modulate Akt (SER473) phosphorylation in the hippocampus of dopamine D2 receptor knockout mice.

scientific article

Manipulating MicroRNAs in Murine Models: Targeting the Multi-Targeting in Epilepsy

scientific article published on January 2017

MicroRNA and epilepsy: profiling, functions and potential clinical applications

scientific article

MicroRNA-34a upregulation during seizure-induced neuronal death ⬇️

scientific article published on March 22, 2012

MicroRNAs as regulators of brain function and targets for treatment of epilepsy

scientific article published on 16 June 2020

MicroRNAs in epilepsy: pathophysiology and clinical utility

scientific article published on December 2016

MicroRNAs in the pathophysiology and treatment of status epilepticus

scientific article

Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain

scientific journal article

Modulators of neuronal cell death in epilepsy.

scientific article published on 10 September 2007

Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology

scientific article

NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner

scientific article

Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation.

scientific article published on 27 July 2016

Neurogenic function in rats with unilateral hippocampal sclerosis that experienced early-life status epilepticus

scientific article

Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism.

scientific article published in September 1997

Overexpression of 14-3-3ζ Increases Brain Levels of C/EBP Homologous Protein CHOP.

scientific article published on 18 February 2015

P2X purinoceptors as a link between hyperexcitability and neuroinflammation in status epilepticus

scientific article published on 02 April 2015

P2X receptors as targets for the treatment of status epilepticus

scientific article

P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control.

scientific article published on 26 December 2012

P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage

scientific article published on 21 April 2014

Parallel dose-response studies of the voltage-dependent Na+ channel antagonist BW619C89, and the voltage-dependent Ca2+ channel antagonist nimodipine, in rat transient focal cerebral ischaemia

scientific article

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

scientific article

Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury

scientific article published on 10 April 2017

Proteomic analysis of 14-3-3 zeta binding proteins in the mouse hippocampus ⬇️

scientific article published on June 23, 2012

Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons

scientific article

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

scientific article published on 4 November 2009

Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis

scientific article

Relationship between seizure-induced transcription of the DNA damage-inducible gene GADD45, DNA fragmentation, and neuronal death in focally evoked limbic epilepsy

scientific article

Seizure preconditioning and epileptic tolerance: models and mechanisms ⬇️

scientific article published on November 2, 2009

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice.

scientific article published on 23 December 2011

Seizure-like activity leads to the release of BAD from 14-3-3 protein and cell death in hippocampal neurons in vitro.

scientific article published in May 2003

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

scientific article

Spatio-temporal profile of DNA fragmentation and its relationship to patterns of epileptiform activity following focally evoked limbic seizures

scientific article published on 01 March 2000

Spatio-temporally restricted blood-brain barrier disruption after intra-amygdala kainic acid-induced status epilepticus in mice

scientific article published on 20 November 2012

Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat

scientific journal article

Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance.

scientific article

The Epigenetics of Epilepsy and Its Progression

scientific article published on May 2017

To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

scientific article

Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning.

scientific article published on 10 March 2015

Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.

scientific article

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.

scientific article published in June 2016

Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance

scientific article

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice.

scientific article published on 4 April 2008

Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia

scientific article

miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132

scientific article

microRNA and Epilepsy

scientific article published on January 2015

microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

scientific article

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