List of works - Heinz Jacobs

AID splice variants lack deaminase activity.

scientific article published in February 2009

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice

scientific article published in May 1997

CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo

scientific article published on 01 April 1994

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma

scientific article published on 17 June 2019

Constitutive expression of the pre-TCR enables development of mature T cells.

scientific article

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

article

DNA damage tolerance in hematopoietic stem and progenitor cells in mice

scientific article published on 31 July 2017

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

scientific article published on May 2002

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

scientific article published on 9 November 2009

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function

scientific article

Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers

scientific article

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

scientific article

Gimap4 accelerates T-cell death.

scientific article

HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase

scientific article

Heterogeneous differentiation patterns of individual CD8+ T cells.

scientific article published on 14 March 2013

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

scientific article published on 07 January 2021

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

scientific journal article

Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.

scientific article

Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.

scientific article published on 16 July 2009

Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells

scientific article published on 01 October 1990

Neutrophil myeloperoxidase activity and the influence of two single-nucleotide promoter polymorphisms

scientific article published on 01 November 2003

Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells

scientific article published on 01 March 1997

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

scientific article

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.

scientific article

PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

scientific article published in September 2011

PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice

scientific article

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

article

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis

scientific article published on 28 February 2016

Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production

scientific article

Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.

scientific article

Reassessing genomic targeting of AID

scientific article published on 01 September 2012

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.

scientific article published on 5 August 2013

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage

scientific article published on 10 December 2014

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis

scientific article

Somatic hypermutation in the heavy chain locus correlates with transcription

scientific article

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

scientific article published in August 1996

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.

scientific article published on March 2009

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

scientific article

TCR-independent T cell development mediated by gain-of-oncogene function or loss-of-tumor-suppressor gene function.

scientific article

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.

scientific article

The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

scientific article

The CD27 and CD70 Costimulatory Pathway Inhibits Effector Function of T Helper 17 Cells and Attenuates Associated Autoimmunity ⬇️

scientific article published on November 15, 2012

The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.

scientific article

The Ig heavy chain protein but not its message controls early B cell development

scientific article published on 23 November 2020

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

scientific article published on 06 August 2020

The primary structure of a feline class I gene: striking similarity to HLA-A.

scientific article

The truncated estrogen receptor alpha variant lacking exon 5 is not involved in progesterone receptor expression in meningiomas

scientific article published on 01 December 1999

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

scientific article

Towards an understanding of C9orf82 protein/CAAP1 function

scientific article published in PLoS ONE

List of works by Heinz Jacobs

AID splice variants lack deaminase activity.

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice

CD3 components at the surface of pro-T cells can mediate pre-T cell developmentin vivo

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma

Constitutive expression of the pre-TCR enables development of mature T cells.

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

DNA damage tolerance in hematopoietic stem and progenitor cells in mice

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function

Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

Gimap4 accelerates T-cell death.

HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase

Heterogeneous differentiation patterns of individual CD8+ T cells.

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.

Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.

Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells

Neutrophil myeloperoxidase activity and the influence of two single-nucleotide promoter polymorphisms

Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.

PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis

Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production

Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA.

Reassessing genomic targeting of AID

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage

Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis

Somatic hypermutation in the heavy chain locus correlates with transcription

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

Somatic hypermutation of immunoglobulin genes: lessons from proliferating cell nuclear antigenK164R mutant mice.

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

TCR-independent T cell development mediated by gain-of-oncogene function or loss-of-tumor-suppressor gene function.

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.

The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

The CD27 and CD70 Costimulatory Pathway Inhibits Effector Function of T Helper 17 Cells and Attenuates Associated Autoimmunity ⬇️

The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.

The Ig heavy chain protein but not its message controls early B cell development

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

The primary structure of a feline class I gene: striking similarity to HLA-A.

The truncated estrogen receptor alpha variant lacking exon 5 is not involved in progesterone receptor expression in meningiomas

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

Towards an understanding of C9orf82 protein/CAAP1 function