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List of works by Dennis Discher

23. From stealthy, controlled release polymersomes to cylinder-shaped 'filomicelles' for imaging and delivery: Original research article: Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles, 2004.

scientific article published in September 2014

A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells

scientific article published on 18 April 2006

A hydrodynamic interpretation of crisis in sickle cell anemia

scientific article

Actin protofilament orientation in deformation of the erythrocyte membrane skeleton.

scientific article

Adhesion-contractile balance in myocyte differentiation.

scientific article

Adhesion-induced phase behavior of two-component membranes and vesicles

scientific article published on 22 January 2013

Adhesively-tensed cell membranes: lysis kinetics and atomic force microscopy probing

scientific article

Bio-inspired, bioengineered and biomimetic drug delivery carriers

scientific article published on July 2011

Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug

scientific article published on 20 July 2006

Blood and immune cell engineering: Cytoskeletal contractility and nuclear rheology impact cell lineage and localization: Biophysical regulation of hematopoietic differentiation and trafficking

scientific article

Bubble wrap of cell-like aggregates

scientific article published in Nature

Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: metrics and mathematics

scientific article published on 03 July 2012

Cell culture: Soft gels select tumorigenic cells

scientific article published on 24 July 2012

Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling

scientific article published on 25 October 2008

Cell motion and mechanobiology.

scientific article published on March 2015

Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery.

scientific article published on 14 August 2007

Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II.

scientific article

Cell shape, spreading symmetry and the polarization of stress-fibers in cells.

scientific article published on May 2010

Chemistry on a single protein, vascular cell adhesion molecule-1, during forced unfolding

scientific article

Combining insoluble and soluble factors to steer stem cell fate.

scientific article published on June 2014

Conformational changes and signaling in cell and matrix physics

scientific article published on September 2009

Conformational stabilities of the structural repeats of erythroid spectrin and their functional implications

scientific article published on 13 February 2006

Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.

scientific article

Cooperativity in forced unfolding of tandem spectrin repeats

scientific article

Covalent chemistry on distended proteins

scholarly article

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

scientific article

Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments

scientific article published on March 2009

Curvature-coupled hydration of Semicrystalline Polymer Amphiphiles yields flexible Worm Micelles but favors rigid Vesicles: polycaprolactone-based block copolymers

scientific article

Curvature-driven molecular demixing in the budding and breakup of mixed component Worm-like Micelles.

scientific article

Cys shotgun labeling of macrophages adhering to and engulfing Ig-opsonized cells

scientific article published in February 2008

Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells

scientific article

DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration

scientific article published on 9 December 2016

Defining of the minimal domain of protein 4.1 involved in spectrin-actin binding

scientific article

Deformation-Enhanced Fluctuations of the Erythrocyte's Spectrin-Actin Nodes and Relation to Single Molecule Measures of Spectrin Unfolding

scientific article published on 01 January 2001

Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfolding

scientific article

Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V

scientific article published on 01 February 1996

Developmental biology: holding it together in the eye.

scientific article published in October 2004

Dissipative particle dynamics simulations of polymersomes

scientific article published on 01 September 2005

Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers

scientific article published on November 2011

Domain unfolding in neurofilament sidearms: effects of phosphorylation and ATP.

scientific article published in November 2002

Dynamic domains in polymersomes: mixtures of polyanionic and neutral diblocks respond more rapidly to changes in calcium than to pH.

scientific article

Effect of bilayer thickness on membrane bending rigidity

scientific article published on 01 February 2004

Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers

scientific article published on 27 November 2007

Efficient nuclear delivery and nuclear body localization of antisense oligo-nucleotides using degradable polymersomes.

scientific article published on January 2006

Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration

scientific article

Elasticity of native and cross-linked polyelectrolyte multilayer films.

scientific article published in September 2004

Electric field manipulation of charged copolymer worm micelles

scientific article published in March 2006

Electromechanical limits of polymersomes

scientific article published on 24 October 2001

Elongation and fluctuations of semiflexible polymers in a nematic solvent

scientific article published on 24 March 2004

Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

scientific article

Emerging Applications of Polymersomes in Delivery: from Molecular Dynamics to Shrinkage of Tumors.

scientific article published on August 2007

Endothelial targeting of antibody-decorated polymeric filomicelles

scientific article published on 23 August 2011

Enhancing the efficacy of drug-loaded nanocarriers against brain tumors by targeted radiation therapy.

scientific article

Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1.

scientific article published in December 1995

Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics

scientific article

Extracellular matrix elasticity directs stem cell differentiation.

scientific article published in October 2007

Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase

scientific article

Filomicelles deliver a chemo-differentiation combination of Paclitaxel and Retinoic Acid that durably represses carcinomas in liver to prolong survival

scientific article published on 16 February 2018

Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage

scientific article published on September 2009

Forced Unfolding of Proteins Directs Biochemical Cascades

scientific article published on 25 November 2019

Forced unfolding modulated by disulfide bonds in the Ig domains of a cell adhesion molecule.

scholarly article

Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM.

scientific article published on 15 December 2006

Forced unfolding of proteins within cells

scientific article published on August 2007

Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes

scientific article (publication date: February 2003)

From stealthy polymersomes and filomicelles to "self" Peptide-nanoparticles for cancer therapy

scientific article

Grafting short peptides onto polybutadiene-block-poly(ethylene oxide): a platform for self-assembling hybrid amphiphiles

scientific article published on 01 November 2006

Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating

scientific article published on 21 November 2013

How deeply cells feel: methods for thin gels.

scientific article published on May 2010

Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells

article

Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles

scientific article published in September 2005

Influence of lateral association on forced unfolding of antiparallel spectrin heterodimers

scientific article published on 3 February 2004

Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

scientific article

Interactions of membrane-active peptides with thick, neutral, nonzwitterionic bilayers.

scientific article published on August 2005

Key roles for chain flexibility in block copolymer membranes that contain pores or make tubes

scientific article published on 01 December 2005

Kinematics of red cell aspiration by fluorescence-imaged microdeformation

scientific article

Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells.

scientific article

Lung vascular targeting through inhalation delivery: insight from filamentous viruses and other shapes

scientific article published on 30 June 2011

Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPα structure-function

scientific article published on 18 April 2020

Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα

scientific article published on 06 March 2020

Marker-of-self becomes marker-of-senescence

scientific article published on 01 June 2012

Material control of stem cell differentiation: challenges in nano-characterization

scientific article

Materials science: embedded shells decalcified

scientific article published in August 2007

Matrix elasticity directs stem cell lineage specification

scientific article (publication date: 25 August 2006)

Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin.

scientific article

Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet.

scientific article published on 11 March 2008

Matrix strains induced by cells: Computing how far cells can feel.

scientific article published on March 2009

Mechanical Force in T Cell Receptor Signal Initiation ⬇️

scientific article published on July 20, 2012

Mechanical Signaling Coordinates the Embryonic Heartbeat

article by Kevin K. Chiou et al published February 2016 in Biophysical Journal

Mechanical signaling coordinates the embryonic heartbeat

scientific article

Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates.

scientific article published on 19 June 2013

Mechanochemistry of protein 4.1's spectrin-actin-binding domain: ternary complex interactions, membrane binding, network integration, structural strengthening

scientific article published in August 1995

Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1.

scientific article published in April 1993

Mechanosensing by the nucleus: From pathways to scaling relationships.

scientific article published on 2 January 2017

Membrane fluctuations and acidosis regulate cooperative binding of 'marker of self' protein CD47 with the macrophage checkpoint receptor SIRPα

scientific article published on 16 July 2018

Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling

scientific article published on 11 May 2006

Membrane solubilization by detergent: resistance conferred by thickness

scientific article published in May 2004

Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance

scientific article

Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery.

scientific article

Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy

scientific article published in January 2007

Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation.

scientific article published in January 2007

Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles

scientific article published on February 2013

Molecular maps of red cell deformation: hidden elasticity and in situ connectivity

scientific article published in November 1994

Morphologies of charged diblock copolymers simulated with a neutral coarse-grained model

scientific article published on 4 April 2011

Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water.

scientific article

Multivalent, Soluble Nano-Self Peptides Increase Phagocytosis of Antibody-Opsonized Targets while Suppressing "Self" Signaling

scientific article published on 13 November 2020

Muscle cell peeling from micropatterned collagen: direct probing of focal and molecular properties of matrix adhesion

scientific article published in May 1999

Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes

scientific article

Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia

scientific article

Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments

scientific article

Nanoparticle shape improves delivery: rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles ⬇️

scientific article

Networks with fourfold connectivity in two dimensions

scientific article published on 10 January 2003

Nuclear constriction segregates mobile nuclear proteins away from chromatin

scientific article published on 26 October 2016

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival.

scientific article published on 24 February 2014

Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation

scientific article published on August 2013

Nuclear mechanics and methods.

scientific article

Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins

scientific article published in 2022

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

scientific article published on 31 August 2018

Optimal matrix rigidity for stress fiber polarization in stem cells.

scientific article published on June 2010

Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes

scientific article published on February 2013

Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains

scientific article

Patterning, prestress, and peeling dynamics of myocytes

scientific article

Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site

scientific article published on 10 November 2006

Physical plasticity of the nucleus and its manipulation.

scientific article published on January 2010

Physical plasticity of the nucleus in stem cell differentiation

scholarly article

Polymer Vesicles with a Red Cell-like Surface Charge: Microvascular Imaging and in vivo Tracking with Near-Infrared Fluorescence

scientific article published in December 2009

Polymer vesicles

scientific article

Polymer vesicles in vivo: correlations with PEG molecular weight

scientific article

Polymeric worm micelles as nano-carriers for drug delivery

scientific article published on 18 May 2005

Polymersome carriers: from self-assembly to siRNA and protein therapeutics.

scientific article published on 17 October 2008

Polymersome delivery of siRNA and antisense oligonucleotides.

scientific article

Polymersomes

scientific article published on January 2006

Post-translational regulation of expression and conformation of an immunoglobulin domain in yeast surface display

scientific article published in January 2006

Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures

scientific article

Preparation of collagen-coated gels that maximize in vitro myogenesis of stem cells by matching the lateral elasticity of in vivo muscle.

scientific article published on January 2010

Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells

scientific article published on 9 October 2003

Protein unfolding accounts for the unusual mechanical behavior of fibrin networks.

scientific article

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

scientific article published on 25 June 2019

RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation

scientific article

Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels.

scientific article published on 17 March 2010

Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics

scientific article published on 08 August 2004

Self-assembly: towards precision micelles

scientific article published on 01 July 2004

Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles

scientific article published in April 2004

Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation

scientific article published in May 2006

Simple insoluble cues specify stem cell differentiation

scientific article

Simulations of the Erythrocyte Cytoskeleton at Large Deformation. II. Micropipette Aspiration ⬇️

scientific article published on September 1, 1998

Simulations of the erythrocyte cytoskeleton at large deformation. I. Microscopic models

scientific article

Species- and cell type-specific interactions between CD47 and human SIRPalpha.

scientific article published on 15 November 2005

Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding

scientific article

Stem cells feel the difference.

scientific article published on September 2010

Stem cells, microenvironment mechanics, and growth factor activation.

scientific article published on 15 July 2009

Stress sensitivity and mechanotransduction during heart development

scientific article published on May 2014

Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix

scientific article

Subcellular Organization: Change of Phase in Partitioning the Cellular Milieu ⬇️

scientific article published on March 20, 2012

Substrate compliance versus ligand density in cell on gel responses

scientific article

Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating

scientific article published on 19 January 2015

Systems mechanobiology: tension-inhibited protein turnover is sufficient to physically control gene circuits

scientific article

TCR triggering by pMHC ligands tethered on surfaces via poly(ethylene glycol) depends on polymer length

scientific article

Targeted worm micelles

scientific article published in September 2004

The 'metabolon,' CD47, and the 'phagocytic synapse': molecular co-localization and species divergence

scientific article published in March 2006

The Foldome in cellular force transduction

scientific article published in January 2009

The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation ⬇️

scientific article published on March 22, 2011

The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber

scientific article published on 25 August 2004

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue

scientific article

Tissue cells feel and respond to the stiffness of their substrate

scientific article

Topographical pattern dynamics in passive adhesion of cell membranes

scientific article

Unfolding a linker between helical repeats

scientific article published on 15 April 2005

Visualizing worm micelle dynamics and phase transitions of a charged diblock copolymer in water

scientific article published in March 2005

gamma-Sarcoglycan deficiency increases cell contractility, apoptosis and MAPK pathway activation but does not affect adhesion

scientific article published on 15 March 2005

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