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List of works by Patrick Phillips

A Step toward an Optimized Rifampin Dose Completed.

scientific article

A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens

scientific article published on 24 November 2017

A multi-arm multi-stage clinical trial design for binary outcomes with application to tuberculosis

scientific article

A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)

scientific article

Adaptive clinical trials in tuberculosis: applications, challenges and solutions

scientific article published on June 2015

An analysis with serious flaws

scientific article published on 27 June 2013

An evaluation of culture results during treatment for tuberculosis as surrogate endpoints for treatment failure and relapse.

scientific article

An optimized background regimen design to evaluate the contribution of levofloxacin to multidrug-resistant tuberculosis treatment regimens: study protocol for a randomized controlled trial.

scientific article published on 25 November 2017

Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment

scientific article published on July 2013

Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells ⬇️

scientific article published on August 21, 2010

Biomarkers and surrogate end points in clinical trials of tuberculosis treatment

scientific article published on 01 August 2007

Biomarkers for tuberculosis disease activity, cure, and relapse

scientific article published in February 2010

Challenges in the clinical assessment of novel tuberculosis drugs.

scientific article

Challenges of Phase III study design for trials of new drug regimens for the treatment of TB.

scientific article

Comments on 'A modest proposal for dropping poor arms in clinical trials' by Proschan and Dodd

scientific article

Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.

scientific article published in April 2018

Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial).

scientific article published on 13 October 2016

DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

scientific article published on 24 July 2009

DOOR/RADAR: A Gateway Into the Unknown?

scientific article published on 9 December 2015

Design issues in pivotal drug trials for drug sensitive tuberculosis (TB).

scientific article published on August 2008

Determining the minimum clinically important differences for outcomes in the DOMINO trial.

scientific article published on 16 September 2010

Donepezil and memantine for moderate-to-severe Alzheimer's disease.

scientific article

Drug-resistant tuberculosis clinical trials: proposed core research definitions in adults.

scientific article published on March 2016

Efficacy, safety and tolerability of linezolid for the treatment of XDR-TB: a study in China

scientific article

Erratum to: Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials.

scientific article published on 23 February 2016

Evaluation of a standardized treatment regimen of anti-tuberculosis drugs for patients with multi-drug-resistant tuberculosis (STREAM): study protocol for a randomized controlled trial.

scientific article published on 9 September 2014

Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance

scientific article published on 10 October 2019

Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis

scientific article

Impact of cotrimoxazole on carriage and antibiotic resistance of Streptococcus pneumoniae and Haemophilus influenzae in HIV-infected children in Zambia

scientific article

Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis

scientific article published on 24 September 2018

Innovative Trial Designs Are Practical Solutions for Improving the Treatment of Tuberculosis

scientific article published on 22 March 2012

Is a 4-month regimen adequate to cure patients with non-cavitary tuberculosis and negative cultures at 2 months?

scientific article published in June 2013

Keeping phase III tuberculosis trials relevant: Adapting to a rapidly changing landscape

scientific article published on 22 March 2019

Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials

scientific article published on 4 February 2016

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

scientific article published on 28 March 2018

Methodological considerations in clinical trials for new MDR-TB treatment regimens

scientific article published in December 2016

Non-inferiority trials: are they inferior? A systematic review of reporting in major medical journals

scientific article

Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses.

scientific article published on 26 October 2015

Optimizing the Design of Latent Tuberculosis Treatment Trials: Insights from Mathematical Modeling

scientific article published on 01 March 2020

Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil.

scientific article published on 15 August 2017

Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.

scientific article

Principles for designing future regimens for multidrug-resistant tuberculosis.

scientific article published on 25 October 2013

Proposals on Kaplan-Meier plots in medical research and a survey of stakeholder views: KMunicate

scientific article published on 30 September 2019

Q fever-the superstition of avoiding the word "quiet" as a coping mechanism: randomised controlled non-inferiority trial

scientific article published on 18 December 2019

Radiological cavitation, sputum mycobacterial load and treatment response in pulmonary tuberculosis

scientific article published on 01 December 2010

Randomized clinical trials to identify optimal antibiotic treatment duration

scientific article published on 28 March 2013

Reducing relapse in tuberculosis treatment

scientific article published on 01 October 2015

Reply to Dodd and Proschan

scientific article published on 21 November 2012

Rethinking non-inferiority: a practical trial design for optimising treatment duration

scientific article published on 05 June 2018

Safe and effective treatment for patients with isoniazid drug resistance

scientific article published on 01 April 2015

Setting Tuberculosis Regimen Development on a Firm Foundation

scientific article published on 01 July 2017

Short intensified treatment in children with drug-susceptible tuberculous meningitis

scientific article published on September 2014

Shortening treatment of tuberculosis: lessons from fluoroquinolone trials.

scientific article published on 19 January 2015

Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis.

scientific article

Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.

scientific article published in August 2017

The Impact of a Line Probe Assay Based Diagnostic Algorithm on Time to Treatment Initiation and Treatment Outcomes for Multidrug Resistant TB Patients in Arkhangelsk Region, Russia ⬇️

scientific article published in 2016

The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis.

scientific article published in June 2018

The evolution of and challenges in defining the clinical endpoint in tuberculosis treatment trials with non-inferiority designs.

scientific article

The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations

scientific article

Timing of relapse in short-course chemotherapy trials for tuberculosis.

scientific article published in February 2010

Toxicity associated with tuberculosis chemotherapy in the REMoxTB study

article

Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes.

scientific article published on 2 July 2016

Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial

scientific article

When inferiority meets non-inferiority: implications for interim analyses.

scientific article

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