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Authors whose works are in public domain in at least one jurisdiction

List of works by Colin Jackson

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

scientific article

A 5000-Fold Increase in the Specificity of a Bacterial Phosphotriesterase for Malathion through Combinatorial Active Site Mutagenesis

scientific article

A Polymer Surfactant Corona Dynamically Replaces Water in Solvent-Free Protein Liquids and Ensures Macromolecular Flexibility and Activity

scientific article published on 02 August 2012

A revised biosynthetic pathway for the cofactor F in prokaryotes

scientific article published on 05 April 2019

Active Site Desolvation and Thermostability Trade-Offs in the Evolution of Catalytically Diverse Triazine Hydrolases

scientific article published on 21 October 2016

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

scientific article published on 23 November 2020

An integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorder

scientific article published on 27 April 2018

Ancestral Protein Reconstruction Yields Insights into Adaptive Evolution of Binding Specificity in Solute-Binding Proteins

scientific article

Ancestral Protein Reconstruction and Circular Permutation for Improving the Stability and Dynamic Range of FRET Sensors.

scientific article published in January 2017

Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site

scientific article published on August 2006

Author Correction: Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

scientific article published on 12 June 2020

Biochemistry of microbial degradation of hexachlorocyclohexane and prospects for bioremediation

scientific article

Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera

scientific article

Catalytic improvement and evolution of atrazine chlorohydrolase

scientific article

Characterization of the phenylurea hydrolases A and B: founding members of a novel amidohydrolase subgroup

scientific article

Classification and substrate head-group specificity of membrane fatty acid desaturases.

scientific article published on 12 September 2016

Cloning, expression, purification, crystallization and preliminary X-ray studies of a pyridoxine 5'-phosphate oxidase from Mycobacterium smegmatis

scientific article published on 30 April 2008

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases

scientific article published on 27 September 2017

Competing S(N)2 and E2 reaction pathways for hexachlorocyclohexane degradation in the gas phase, solution and enzymes

scientific article published on 16 November 2010

Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency

scientific article

Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects

scientific article

Consensus Mutagenesis and Ancestral Reconstruction Provide Insight into the Substrate Specificity and Evolution of the Front-End Δ6-Desaturase Family

scientific article published on 02 April 2020

Constrained evolution of a bispecific enzyme: lessons for biocatalyst design

scientific article published on 5 January 2017

Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction

scientific article

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

scientific article published on 05 February 2019

Crystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activation

scientific article

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity

scientific article published on 18 September 2019

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

scientific article

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

scientific article published on 31 January 2019

Dynamic Motion and Communication in the Streptococcal C1 Phage Lysin, PlyC

scientific article (publication date: 2015)

Engineering a solid-state metalloprotein hydrogen evolution catalyst

scientific article published on 28 February 2020

Enhancement of metallomacrocycle-based oxygen reduction catalysis through immobilization in a tunable silk-protein scaffold

scientific article published on 12 December 2019

Enzyme dynamics and engineering: one step at a time

scientific article published in October 2014

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

scientific article

Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein

scientific article published on 23 April 2018

Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron

scientific article

Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series

scientific article

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress

scientific article published on 19 December 2018

Genomic and metagenomic surveys of hydrogenase distribution indicate H2 is a widely utilised energy source for microbial growth and survival

scientific article published on 25 September 2015

Growth of Escherichia coli coexpressing phosphotriesterase and glycerophosphodiester phosphodiesterase, using paraoxon as the sole phosphorus source

scientific article

Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme

scientific article published on 21 October 2019

Hydrophobic Shielding Drives Catalysis of Hydride Transfer in a Family of F420H2-Dependent Enzymes

scientific article published on 30 November 2016

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

scientific article

Improving a natural enzyme activity through incorporation of unnatural amino acids.

scientific article published on 16 December 2010

In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase

scientific article

Increased expression of a bacterial phosphotriesterase in Escherichia coli through directed evolution

scientific article

Intramolecular epistasis and the evolution of a new enzymatic function

scientific article

Iron(III) located in the dinuclear metallo-β-lactamase IMP-1 by pseudocontact shifts

scientific article

Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers

scientific article

Kinetics and efficacy of an organophosphorus hydrolase in a rodent model of methyl-parathion poisoning.

scientific article

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

scientific article published on 13 June 2019

Laboratory evolution of protein conformational dynamics.

scientific article published on 7 November 2017

Malonate-bound structure of the glycerophosphodiesterase fromEnterobacter aerogenes(GpdQ) and characterization of the native Fe2+metal-ion preference

scientific article

Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography

scientific article

Method for Developing Optical Sensors Using a Synthetic Dye-Fluorescent Protein FRET Pair and Computational Modeling and Assessment

scientific article published in January 2017

Mining electron density for functionally relevant protein polysterism in crystal structures ⬇️

scientific article published on December 29, 2010

Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila

scientific article published on 10 April 2017

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

scientific article published on 30 July 2018

Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme

scientific article published on 01 July 2010

Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism.

scientific article

Overcoming insecticide resistance through computational inhibitor design

scientific article published on 01 October 2019

Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions.

scientific article published on 27 April 2016

Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles

scientific article

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

scientific article published on 07 February 2020

Protein engineering with unnatural amino acids

scientific article published on 05 July 2013

Protein engineering: the potential of remote mutations

scientific article published on 22 March 2019

Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis

scientific article published on 15 February 2016

Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling

scientific article

Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

scientific article

Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis

scientific article

Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase

scientific article published on 18 July 2016

Sequence-Structure-Function Classification of a Catalytically Diverse Oxidoreductase Superfamily in Mycobacteria

scientific article

Sequential Electrostatic Assembly of a Polymer Surfactant Corona Increases Activity of the Phosphotriesterase arPTE

scientific article published on 21 October 2019

Strategies for Increasing Protein Stability

scientific article published on 01 January 2020

Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the PII-like Protein, SbtB, from Cyanobium sp. PCC7001

scientific article published on 03 December 2019

Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors

scientific article published on 27 February 2019

Structural and functional characterization of a putative de novo gene in Drosophila

scientific article published on 12 March 2021

Structural reconstruction of protein ancestry

scientific article

Structure and function of an insect  -carboxylesterase ( Esterase7) associated with insecticide resistance

scientific article

Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?

scientific article published on 20 September 2017

Structure-based rational design of a phosphotriesterase

scientific article published on 05 June 2009

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

scientific article published on 04 May 2021

Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases

scientific article published on 19 November 2021

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes

scientific article

Synthesis of a D-Ring Isomer of Galanthamine via a Radical-Based Smiles Rearrangement Reaction

scientific article published on 09 July 2014

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

scientific article published on 31 July 2017

Testing the evolvability of an insect carboxylesterase for the detoxification of synthetic pyrethroid insecticides

scientific article

The Structure and Stability of the Disulfide-Linked γS-Crystallin Dimer Provide Insight into Oxidation Products Associated with Lens Cataract Formation

scientific article published on 13 December 2018

The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase.

scientific article

The effects of substrate orientation on the mechanism of a phosphotriesterase

scientific article published on 16 November 2005

The enzymatic basis for pesticide bioremediation.

scientific article

The evolution of multiple active site configurations in a designed enzyme

scientific article published in Nature Communications

The evolution of new enzyme function: lessons from xenobiotic metabolizing bacteria versus insecticide-resistant insects

scientific article published on March 2011

The methanogenic redox cofactor F420 is widely synthesized by aerobic soil bacteria.

scientific article published on 9 August 2016

The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila

scientific article published on 03 January 2019

The purification, crystallization and preliminary diffraction of a glycerophosphodiesterase from Enterobacter aerogenes

scientific article

The redox cofactor F420 protects mycobacteria from diverse antimicrobial compounds and mediates a reductive detoxification system

scientific article published on 16 September 2016

The role of protein dynamics in the evolution of new enzyme function

scientific article

The structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes

scientific article

The structure of an enzyme-product complex reveals the critical role of a terminal hydroxide nucleophile in the bacterial phosphotriesterase mechanism

scientific article published in August 2005

Total Syntheses of the 3H-Pyrrolo[2,3-c]quinolone-Containing Alkaloids Marinoquinolines A-F, K, and Aplidiopsamine A Using a Palladium-Catalyzed Ullmann Cross-Coupling/Reductive Cyclization Pathway

scientific article published on 18 December 2019

Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning

scientific article published on 18 January 2014

Use of engineered enzymes to identify organophosphate and pyrethroid-related toxicity in toxicity identification evaluations.

scientific article

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