List of works - Markus Rehm

ALISSA: an automated live-cell imaging system for signal transduction analyses

scientific article

APOPTO-CELL--a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis.

scientific article published on 19 January 2007

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach

scientific article published on 16 May 2013

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

scientific article published on 31 March 2010

Apoptosis repressor with caspase recruitment domain, a multifunctional modulator of cell death

scientific article published on May 2011

Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance.

scientific article

Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

scientific article published on 27 August 2009

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects

scientific article

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy

scientific article published on 14 November 2011

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism

scientific article published on 21 February 2020

Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution

scientific article published on 6 June 2013

Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death

scientific article

Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization.

scientific article published on 24 February 2011

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

scientific article published on 9 January 2009

Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells.

scientific article published on 24 October 2008

Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons

scientific article

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. ⬇️

scientific article

Linking hyperosmotic stress and apoptotic sensitivity

scientific article published on 31 August 2020

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma

scientific article published on 13 February 2020

Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis

scientific article

Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis

scientific article

Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma

scientific article published on 15 October 2018

Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma

Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.

scientific article published on 9 March 2012

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.

scientific article

Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol

scientific article published on 05 August 2021

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

scientific article published on 29 October 2020

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

scientific article published on 3 June 2008

Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis

scientific article published on 28 December 2005

Role of Smac in cephalostatin-induced cell death

scientific article published on 19 September 2008

Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis

scientific article published on 04 June 2020

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism

scientific article published on 01 November 2018

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.

scientific article published on 2 March 2018

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

scientific article published on 18 April 2002

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

scientific article

Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids

scientific article published on 20 May 2020

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells

scientific article

Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

scientific article

Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions.

scientific article published on 19 April 2013

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma

scientific article published on 08 March 2019

TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.

scientific article published on 7 September 2008

TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies

scientific article published on January 2012

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer

scientific article

The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling

scientific article published on 20 April 2020

The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer

scientific article published on 27 April 2020

The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling

scientific article

The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome

scientific article published on 28 February 2012

The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies.

scientific article published on February 2011

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

scientific article published on 03 August 2021

XIAP impairs Smac release from the mitochondria during apoptosis.

scientific article

List of works by Markus Rehm

ALISSA: an automated live-cell imaging system for signal transduction analyses

APOPTO-CELL--a simulation tool and interactive database for analyzing cellular susceptibility to apoptosis.

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

Apoptosis repressor with caspase recruitment domain, a multifunctional modulator of cell death

Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance.

Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells.

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism

Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution

Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death

Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization.

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells.

Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. ⬇️

Linking hyperosmotic stress and apoptotic sensitivity

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma

Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis

Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis

Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma

Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma

Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8.

Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis

Role of Smac in cephalostatin-induced cell death

Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis

Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells

Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization.

Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions.

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma

TOXI-SIM-A simulation tool for the analysis of mitochondrial and plasma membrane potentials.

TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer

The FLAME-accelerated signalling tool (FaST) for facile parallelisation of flexible agent-based models of cell signalling

The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer

The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling

The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome

The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies.

Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation

XIAP impairs Smac release from the mitochondria during apoptosis.