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List of works by Jose A Morales-Garcia

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

scientific article published on 3 February 2012

Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.

scientific article published in December 2009

CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease

scientific article published on 19 October 2017

CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor.

scientific article

Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.

scientific article published on 21 October 2016

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

scientific article published on 17 January 2014

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

scientific article published on 16 March 2012

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

scientific article

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

scientific article

Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8

scientific article

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

scientific article published on 5 October 2012

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

scientific article published on 8 October 2014

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

scientific article published on 28 September 2020

NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders

scientific article

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

scientific article

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

scientific article published on 25 May 2016

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

scientific article published on 01 December 2019

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

scientific article

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

scientific article published on 12 July 2016

Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease ⬇️

scientific article published on 08 February 2019

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

scientific article

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

scientific article

Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo

scientific article published on 01 February 2011

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

scientific article published on 09 May 2017

Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease

scientific article published on 31 August 2019

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

scientific article published on 29 April 2015

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

scientific article (publication date: 24 February 2011)

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

scientific article published on 19 August 2016

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

scientific article published on 13 October 2014

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

scientific article published on 26 May 2017

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

scientific article

Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.

scientific article published in October 2004

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