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List of works by Philip Newsome

2020 - A new decade of innovation for EASL

scientific article published on 01 January 2020

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

scientific article published on 28 August 2018

A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells

scientific article published on 28 August 2019

A Modified Protocol for the Isolation of Primary Human Hepatocytes with Improved Viability and Function from Normal and Diseased Human Liver.

scientific article published in January 2017

A biochemical prognostic model of outcome in paracetamol-induced acute liver injury.

scientific article published in December 2005

A concise review of non-alcoholic fatty liver disease

scientific article

A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases

scientific article

A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease ⬇️

scientific article

AAV-mediated liver-directed gene therapy for Acute Intermittent Porphyria: It is safe but is it effective?

scientific article published on 12 July 2016

Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis

scientific article

Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

scientific article published on 25 January 2019

Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis

scientific article

Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.

scientific article

Administration of Human MSC-Derived Extracellular Vesicles for the Treatment of Primary Sclerosing Cholangitis: Preclinical Data in MDR2 Knockout Mice

scientific article published on 23 November 2020

Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome.

scientific article

Aging of bone marrow- and umbilical cord-derived mesenchymal stromal cells during expansion.

scientific article published on 24 April 2017

Alcoholic hepatitis and metabolic disturbance in female mice : a more tractable model than Nrf2-/- animals

scientific article published on 16 October 2020

An improved ex vivo method of primary porcine hepatocyte isolation for use in bioartificial liver systems.

scientific article published in August 2000

Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

scientific article published on 04 February 2020

Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes

scientific article published on 01 November 2011

Biochemical prognostic markers of outcome in non-paracetamol-induced fulminant hepatic failure

scientific article published in January 2004

Birmingham and Lambeth Liver Evaluation Testing Strategies (BALLETS): a prospective cohort study.

scientific article

Bone marrow mesenchymal stem cells and liver regeneration: believe the hypoxia!

scientific article published on 4 September 2013

Bone marrow stem cell therapy for liver disease.

scientific article published on 14 July 2014

Bone marrow stem cells contribute to alcohol liver fibrosis in humans

scientific article published in September 2010

CC Chemokine Receptor 2 Promotes Recruitment of Myeloid Cells Associated with Insulin Resistance in Non-Alcoholic Fatty Liver Disease

scientific article

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism

scientific article published on 15 June 2015

Care standards for non-alcoholic fatty liver disease in the United Kingdom 2016: a cross-sectional survey

scientific article published on 28 April 2017

Caution in Using Non-Invasive Scoring Systems in NAFLD Beyond Highly Selected Study Populations.

scientific article published in April 2017

Cellular therapies for the treatment of immune-mediated GI and liver disease

scientific article published on 09 December 2020

Changes in human hepatic metabolism in steatosis and cirrhosis

scientific article

Clinical effectiveness of cell therapies in patients with chronic liver disease and acute-on-chronic liver failure: a systematic review protocol

scientific article

Combined use of N-acetylcysteine and Liberase improves the viability and metabolic function of human hepatocytes isolated from human liver

scientific article

Commentary: advances in the pharmacotherapy of NASH-anti-diabetic drugs and beyond

scientific article published on 01 January 2020

Comparing clinical presentations, treatments and outcomes of hepatocellular carcinoma due to hepatitis C and non-alcoholic fatty liver disease

scientific article

Critical review of clinical trials of bone marrow stem cells in liver disease.

scientific article published on 15 May 2008

Crosstalk between mesenchymal stem cells and endothelial cells leads to downregulation of cytokine-induced leukocyte recruitment

scientific article published in December 2013

Current therapeutic strategies in non-alcoholic fatty liver disease.

scientific article published on August 2011

Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease.

scientific article published on 8 June 2017

Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure.

scientific article

Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle

scientific article published on 17 March 2014

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

scientific article published in 2021

Disease burden and costs from excess alcohol consumption, obesity, and viral hepatitis: fourth report of the Lancet Standing Commission on Liver Disease in the UK.

scientific article published on 28 November 2017

Dissecting cellulitis of the scalp treated with tumour necrosis factor-α inhibitors: experience with two agents.

scientific article

Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake

scientific article

Early nitisinone treatment reduces the need for liver transplantation in children with tyrosinaemia type 1 and improves post-transplant renal function

scientific article published on 11 February 2014

Editorial: Treatment for NASH - helping the liver or helping the heart?

scientific article published on 01 March 2015

Editorial: early and late mortality following unscheduled admissions for severe liver disease across England and Wales

scientific article published on 01 May 2019

Editorial: liver transplantation in patients with non-alcoholic fatty liver disease and obesity

scientific article published in August 2017

Editorial: optimising non-invasive screening for advanced liver fibrosis in NAFLD.

scientific article published in November 2017

Editorial: re-thinking cardiovascular risk factors in NAFLD with advanced fibrosis?

scientific article published on 01 May 2020

Effect of semaglutide on liver enzymes and markers of inflammation in subjects with type 2 diabetes and/or obesity

scientific article published on 10 June 2019

Effects of Epeleuton, a Novel Synthetic Second-Generation n-3 Fatty Acid, on Non-Alcoholic Fatty Liver Disease, Triglycerides, Glycemic Control, and Cardiometabolic and Inflammatory Markers

scientific article published on 11 August 2020

Effects of acute liver injury on blood coagulation

scientific article published in April 2003

Emerging drugs for complications of end-stage liver disease

scientific article published on 01 March 2008

Emerging therapeutic targets for NASH: key innovations at the preclinical level

scientific article published on 13 February 2020

Entering the GOLDEN Age for Therapies in NASH

scientific article published on 24 March 2016

Epigenetic changes in umbilical cord mesenchymal stromal cells upon stimulation and culture expansion

scientific article published on 20 June 2018

Fat and Fibrosis: Does Empagliflozin Impair the Progression of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus?

scientific article published on 01 February 2020

FibroScan-AST (FAST) score for the non-invasive identification of patients with non-alcoholic steatohepatitis with significant activity and fibrosis: a prospective derivation and global validation study

scientific article published on 03 February 2020

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1.

scientific article published on 04 January 2017

Gathering momentum for the way ahead: fifth report of the Lancet Standing Commission on Liver Disease in the UK

scientific article published in The Lancet

Generation of knockout rabbits using transcription activator-like effector nucleases

scientific article

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.

scientific article

Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial

scientific article published on 7 November 2017

Guidelines for liver transplantation for patients with non-alcoholic steatohepatitis

scientific article published on 10 January 2012

Guidelines on the management of abnormal liver blood tests

scientific article

Haematopoietic stem cells in cirrhosis – Authors' reply

scientific article published on 06 April 2018

Hematopoietic stem cell trafficking in liver injury

scientific article

Hepatic oval cells: helping redefine a paradigm in stem cell biology

scientific article published in January 2004

Hepatocyte cell therapy in liver disease.

scientific article published on 27 July 2015

High incidence of hepatocellular carcinoma and postoperative complications in patients with nonalcoholic steatohepatitis as a primary indication for deceased liver transplantation

scientific article published on 01 February 2019

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

scholarly article

Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion

scientific article published on 01 June 2003

Human mesenchymal stem cells are recruited to injured liver in a β1-integrin and CD44 dependent manner

scientific article published on 12 July 2012

Identifying patients with nonalcoholic steatohepatitis that are nonresponders to therapy

scientific article published on 18 July 2016

Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells.

scientific article published on 17 January 2018

Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.

scientific article published on March 2011

Implementation of the Lancet Standing Commission on Liver Disease in the UK.

scientific article published on 20 November 2015

Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience

scientific article

Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial

scientific article (publication date: 4 November 2013)

Liraglutide for patients with non-alcoholic steatohepatitis - Authors' reply

scientific article published on 01 June 2016

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

scientific article published on 19 November 2015

Liver Transplantation From Donors With Acute Intermittent Porphyria

scientific article published on 01 April 2011

Liver regeneration - mechanisms and models to clinical application

scientific article published on 29 June 2016

Liver transplantation for acute intermittent porphyria is complicated by a high rate of hepatic artery thrombosis.

scientific article

Long-term impact of liver transplantation on respiratory function and nutritional status in children and adults with cystic fibrosis

scientific article published on 6 January 2012

Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice

scientific article

Mesenchymal Stromal Cells, a New Player in Reducing Complications From Liver Transplantation?

scientific article published on 19 June 2020

Mesenchymal stromal cell therapy for liver diseases.

scientific article published on 6 February 2018

Mesenchymal stromal cell therapy in liver disease: opportunities and lessons to be learnt?

scientific article (publication date: 15 November 2015)

Mesenchymal stromal cells - Where art thou?

scientific article published on 25 September 2015

Mesenchymal stromal cells and liver fibrosis: a complicated relationship.

scientific article published on 6 September 2016

Modulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease

scientific article published on 19 July 2019

Murine Models of Acute Alcoholic Hepatitis and Their Relevance to Human Disease.

scientific article published on 30 January 2016

NAFLD in 2017: Novel insights into mechanisms of disease progression

scientific article published on 4 January 2018

NAFLD is underrecognized in the primary care setting: UK experience

scientific article published on 01 September 2014

New horizons for stem cell therapy in liver disease ⬇️

scientific article published on July 26, 2011

New metrics for the Lancet Standing Commission on Liver Disease in the UK.

scientific article published on 15 December 2016

Non-alcoholic fatty liver disease and liver transplantation

scientific article

Non-alcoholic fatty liver disease and the interface between primary and secondary care

scientific article published on 01 July 2018

Non-alcoholic fatty liver disease in 2016.

scientific article

Non-alcoholic fatty liver disease: when to intervene and with what

scientific article published on 01 April 2015

Non-enzymatic dissociation of human mesenchymal stromal cells improves chemokine-dependent migration and maintains immunosuppressive function

scientific article published on 01 April 2014

Obesity in acute alcoholic hepatitis increases morbidity and mortality

scientific article published on 03 July 2019

Origin-Specific Adhesive Interactions of Mesenchymal Stem Cells with Platelets Influence Their Behavior After Infusion

scientific article published on 28 February 2018

Orlistat for overweight subjects with nonalcoholic steatohepatitis.

scientific article published in July 2009

Outcomes of liver transplantation for non-alcoholic steatohepatitis: A European Liver Transplant Registry study

scientific article published on 07 May 2019

Pathogenesis of non-alcoholic fatty liver disease.

scientific article

Persistence of functional hepatocyte-like cells in immune-compromised mice

scientific article published on 10 December 2010

Plasma succinylacetone is persistently raised after liver transplantation in tyrosinaemia type 1.

scientific article published on 29 March 2012

Platelet basal cytosolic calcium: the influence of plasma factors in cirrhosis

scientific article

Potential of hematopoietic stem cell therapy in hepatology: a critical review

scientific article

Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort.

scientific article published on 18 May 2011

Presentation and prognosis of liver disease in alpha-1 antitrypsin deficiency

scientific article published on 28 May 2018

Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.

scientific article published on 29 June 2015

Prothrombin time to assess fulminant hepatic failure

scientific article published on 01 December 2001

REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem

scientific article

Recurrence of nonalcoholic fatty liver disease after liver transplantation: it is common, but does it affect outcome?

scientific article published on 01 April 2010

Referral patterns and social deprivation in paracetamol-induced liver injury in Scotland

scientific article published in November 2001

Renal function in patients undergoing transplantation for nonalcoholic steatohepatitis cirrhosis: Time to reconsider immunosuppression regimens?

scientific article published on 01 November 2011

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

scientific article published on 09 October 2019

Review article: new treatments in non-alcoholic fatty liver disease.

scientific article

SOS liver damage; calling all haematopoietic stem cells

scientific article published on 01 January 2014

Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program.

scientific article

Sarcopenia in nonalcoholic fatty liver disease: new challenges for clinical practice

scientific article published on 23 February 2020

Serum alkaline phosphatase in multidrug resistance 2 (Mdr2-/- ) knockout mice is strain specific

scientific article published on 26 June 2015

Severe asymptomatic non-alcoholic fatty liver disease in routine diabetes care; a multi-disciplinary team approach to diagnosis and management

scientific article published on 15 October 2013

Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.

scientific article

Steatosis and liver stiffness measurements using transient elastography

scientific article published on 04 April 2016

Stem cells for liver regeneration

scientific article

Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

scientific article

Systematic review: the natural history of alpha-1 antitrypsin deficiency, and associated liver disease.

scientific article published on 15 February 2018

The Inhibitory Role of Stromal Cell Mesenchyme on Human Embryonic Stem Cell Hepatocyte Differentiation is Overcome by Wnt3a Treatment

scientific article published on 01 September 2008

The Role of a Dedicated Non-Alcoholic Fatty Liver Disease Clinic in 2016

scientific article published on 03 May 2017

The dawn of a new EASL - A new chapter in the history of the European Association for the Study of the liver

scientific article published on 02 May 2019

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

scientific article published on 04 September 2018

The orthogonal orientation shift and spatial filtering

scientific article published in January 1995

The role of stem cells in liver injury and repair

scientific article published on 20 May 2019

Trials of obeticholic acid for non-alcoholic steatohepatitis

scientific article published in July 2015

UK experience of liver transplantation for erythropoietic protoporphyria.

scientific article

Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK

scientific article published on 29 November 2019

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

scientific article

Use of hepatocyte and stem cells for treatment of post-resectional liver failure: are we there yet?

scientific article published on 19 April 2011

Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease.

scientific article published on 22 December 2017

Volixibat in adults with non-alcoholic steatohepatitis: 24-week interim analysis from a randomized, phase II study

scientific article published on 28 March 2020

Xenotransplantation: still a bridge too far?

scientific article published in September 2010

Yet another role for mesenchmyal stem cells?

scientific article published on June 2008

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