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List of works by Craig Lygate

(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism

scientific article

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

scientific article published on 22 June 2018

A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy

scientific journal article

A requirement for Gch1 and tetrahydrobiopterin in embryonic development

scientific journal article

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis

scientific article published on 28 May 2013

ASPP2 deficiency causes features of 1q41q42 microdeletion syndrome.

scientific article published on 22 July 2016

Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice

scientific article

Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

scientific journal article

Accelerated cardiac magnetic resonance imaging in the mouse using an eight‐channel array at 9.4 Tesla ⬇️

scientific article published on January 1, 2011

Accelerating cine-MR imaging in mouse hearts using compressed sensing.

scientific article

Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling

scientific article

Accurate infarct-size measurements from accelerated, compressed sensing reconstructed cine-MRI images in mouse hearts.

scientific article

Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans

scientific article

Adaptation to HIF1α Deletion in Hypoxic Cancer Cells by Upregulation of GLUT14 and Creatine Metabolism

scientific article published on 18 March 2019

Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields

scientific article published in February 2004

Augmentation of Creatine in the Heart.

scientific article

CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system

scientific article published on 01 January 2006

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity

scientific article

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background

scientific article

Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study

scientific article

Changes in creatine transporter function during cardiac maturation in the rat.

scientific article

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

scientific article published on 9 December 2005

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

scientific article

Compressed sensing to accelerate magnetic resonance spectroscopic imaging: evaluation and application to 23Na-imaging of mouse hearts

scientific article published on 15 June 2015

Creatine uptake in mouse hearts with genetically altered creatine levels

scientific article published on 10 June 2008

Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.

scientific article

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.

scientific article

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation

scientific article published on 17 September 2013

Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system

scientific article published in December 2003

Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart

scientific article published on 01 September 2006

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

scientific article published in March 2012

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

scientific article published in July 2006

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.

scientific article

Highly accelerated cardiac functional MRI in rodent hearts using compressed sensing and parallel imaging at 9.4T.

scientific article published in February 2012

How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging

scientific article

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine ⬇️

scientific article

Improved method for quantification of regional cardiac function in mice using phase-contrast MRI.

scientific article

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart

scientific journal article

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

scientific article

Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart.

scientific article published on 10 March 2006

Investigating cardiac energetics in heart failure

scientific article

Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats

scientific article published in February 2002

Letter to the editor: infarct size measurements are critically important when comparing interventions affecting ventricular remodeling

scientific article published in November 2007

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

scientific article

Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR system.

scientific article

MLP accumulation and remodelling in the infarcted rat heart

scientific article published on 2 December 2005

Mechanisms of creatine depletion in chronically failing rat heart

scientific article published on 20 January 2005

Metabolic arithmetic: do two wrongs make a right?

scientific article published on 01 August 2017

Metabolic flux as a predictor of heart failure prognosis

scientific article

Metabolic remodelling in hypertrophied and failing myocardium: a review.

scientific article

Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity

scientific article

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction

scientific article

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart

scientific article

Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus

scientific article published on 8 March 2013

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion ⬇️

scientific article published on 2 March 2018

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure

scientific article published on 10 January 2020

Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia

scientific article published on 14 January 2016

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

scientific article published on 03 May 2016

Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice

scientific article published on 13 September 2004

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice

scientific article published on 9 May 2005

Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo

scientific article published on 8 July 2004

Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart

scientific article

Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale

scientific article

Resolving Fine Cardiac Structures in Rats with High-Resolution Diffusion Tensor Imaging ⬇️

scientific article

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.

scientific article

Serial high resolution 3D–MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic response

scientific article published on 01 September 2005

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice

scientific article published on November 2005

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function

scientific article published in 2022

The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction

scientific article

The Subcellular Localisation of Neuronal Nitric Oxide Synthase Determines the Downstream Effects of NO on Myocardial Function

scientific article

The creatine kinase energy transport system in the failing mouse heart

scientific article published on 27 March 2007

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury

scientific article published on 20 September 2018

Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla

scientific article

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.

scientific article published on 21 June 2013

Validation of diffusion tensor MRI measurements of cardiac microstructure with structure tensor synchrotron radiation imaging ⬇️

scientific article

nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction

scientific article

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