List of works - Michelle Linterman

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

scientific article published on 12 March 2021

Accelerated waning of the humoral response to COVID-19 vaccines in obesity

scientific article published in May 2023

Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination

scientific article published in September 2023

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

scientific article published in August 2021

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

scientific article published on 02 January 2021

Alemtuzumab Treatment Leads to Delayed Recovery of T Follicular Regulatory Cells, and May Therefore Predispose Patients to de novo Donor-Specific Antibody Formation

scientific article published on 2 June 2019

Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly

scientific article published in August 2023

Author Correction: The cellular composition of the human immune system is shaped by age and cohabitation

scientific article published on 25 November 2020

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

scientific article published on 01 February 2020

B Cells from Aged Mice Do Not Have Intrinsic Defects in Affinity Maturation in Response to Immunization

scientific article published on 27 September 2023

B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction

scientific article published in September 2022

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

scientific article published on 22 May 2017

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

scientific article

CD4+ T cells that help B cells – a proposal for uniform nomenclature

scientific article published in August 2021

Can follicular helper T cells be targeted to improve vaccine efficacy?

scientific article

Cbls boost B cells

scientific article published on 01 September 2020

Cellular Plasticity of CD4+ T Cells in the Intestine

scientific article

ChAdOx1 nCoV‐19 vaccination generates spike‐specific CD8 + T cells in aged mice

scientific article published on 6 May 2023

Data regarding transplant induced germinal center humoral autoimmunity

scientific article published on 28 December 2018

Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice

scientific article published on 25 January 2017

Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function

scientific article published on 15 May 2017

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

scientific article published on 29 April 2019

Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells

scientific article

Follicular Helper T Cells

scientific article

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

scientific article published on 01 January 2020

Follicular helper T cells are required for systemic autoimmunity

scientific article published on 16 February 2009

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.

scientific article published on 28 January 2016

Follicular regulatory T cells produce neuritin to regulate B cells

scientific article published in April 2021

Foxp3+ follicular regulatory T cells control the germinal center response.

scientific article

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

scientific article published on 21 March 2016

Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice

scientific article published on 14 October 2018

Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury

article

Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy

scientific article published on 07 December 2018

Heterochronic faecal transplantation boosts gut germinal centres in aged mice.

scientific article published on 4 June 2019

How T follicular helper cells and the germinal centre response change with age.

scientific article

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

scientific article published on 12 September 2013

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers

scientific article

Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function.

scientific article published in August 2017

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

scientific article

Identifying Follicular Regulatory T Cells by Confocal Microscopy.

scientific article published on January 2017

Immune system development varies according to age, location, and anemia in African children

scientific article published on 01 February 2020

Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans

scientific article published on 2 November 2021

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

scientific article published on 7 May 2020

Mechanisms underpinning poor antibody responses to vaccines in ageing

scientific article published in January 2022

Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations

scientific article published on 28 September 2018

MicroRNA in the adaptive immune system, in sickness and in health.

scientific article published on 27 February 2010

MicroRNA regulation of T-cell development.

scientific article published on May 2013

No Functional Role for microRNA-342 in a Mouse Model of Pancreatic Acinar Carcinoma.

scientific article

Optimized immunofluorescence staining protocol for imaging germinal centers in secondary lymphoid tissues of vaccinated mice

scientific article published on 17 September 2021

Premature thymic involution is independent of structural plasticity of the thymic stroma.

scientific article

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells

scientific article published on 23 December 2014

Regulation of the Germinal Center Response

scientific article published on 25 October 2018

Regulatory T cells and control of the germinal centre response

scientific article

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

scientific article published on 24 March 2020

Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection

scientific article published on 01 January 2018

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

scientific article published on 18 May 2020

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS

scientific article

Sec22b is a critical and nonredundant regulator of plasma cell maintenance

scientific article published on 10 January 2023

Selenium saves ferroptotic TFH cells to fortify the germinal center

scientific article published on 19 August 2021

Senescence blurs the line between innate and adaptive immune cells

scientific article published on 13 May 2020

Shaping Variation in the Human Immune System.

scientific article

Signals that drive T follicular helper cell formation.

scientific article

Signals that influence T follicular helper cell differentiation and function.

scientific article published on 27 January 2010

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

scientific article published in July 2023

Stromal cell control of conventional and ectopic germinal centre reactions

scientific article published on 20 April 2020

Stromal networking: cellular connections in the germinal centre

scientific article published on 17 March 2017

T cells and follicular dendritic cells in germinal center B-cell formation and selection.

scientific article published on September 2010

T follicular helper cells during immunity and tolerance.

scientific article published on January 2010

T follicular helper cells. Preface.

scientific article

T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells.

scientific article published on May 2012

TFR cells trump autoimmune antibody responses to limit sedition

scientific article

Targeting TFH cells in human diseases and vaccination: rationale and practice

scientific article published on 11 July 2022

Targeting TLR4 during vaccination boosts MAdCAM-1 lymphoid stromal cell activation and promotes the aged germinal center response

scientific article published on 6 May 2022

Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination

scientific article published in December 2022

The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells.

scientific article

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

scientific article published on 07 June 2019

The cellular composition of the human immune system is shaped by age and cohabitation.

scientific article published on 15 February 2016

The dark side of Tregs during aging

scientific article published in 2022

The memory B cell response to influenza vaccination is impaired in older persons

scientific article published on 8 November 2022

The metabolic hormone leptin promotes the function of T cells and supports vaccine responses

scientific article published on 24 May 2021

The temporospatial control of Tfh cells

scientific article published in January 2014

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

scientific article published on 18 December 2011

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

scientific article published on 23 July 2009

Treg cells and CTLA-4: the ball and chain of the germinal center response

article

Type I interferon induces CXCL13 to support ectopic germinal center formation

scholarly article by Alice E. Denton et al published 4 March 2019 in Journal of Experimental Medicine

List of works by Michelle Linterman

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice

Accelerated waning of the humoral response to COVID-19 vaccines in obesity

Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ

Alemtuzumab Treatment Leads to Delayed Recovery of T Follicular Regulatory Cells, and May Therefore Predispose Patients to de novo Donor-Specific Antibody Formation

Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly

Author Correction: The cellular composition of the human immune system is shaped by age and cohabitation

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

B Cells from Aged Mice Do Not Have Intrinsic Defects in Affinity Maturation in Response to Immunization

B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reaction

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency.

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

CD4+ T cells that help B cells – a proposal for uniform nomenclature

Can follicular helper T cells be targeted to improve vaccine efficacy?

Cbls boost B cells

Cellular Plasticity of CD4+ T Cells in the Intestine

ChAdOx1 nCoV‐19 vaccination generates spike‐specific CD8 + T cells in aged mice

Data regarding transplant induced germinal center humoral autoimmunity

Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice

Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells

Follicular Helper T Cells

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

Follicular helper T cells are required for systemic autoimmunity

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.

Follicular regulatory T cells produce neuritin to regulate B cells

Foxp3+ follicular regulatory T cells control the germinal center response.

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice

Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury

Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy

Heterochronic faecal transplantation boosts gut germinal centres in aged mice.

How T follicular helper cells and the germinal centre response change with age.

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers

Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function.

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

Identifying Follicular Regulatory T Cells by Confocal Microscopy.

Immune system development varies according to age, location, and anemia in African children

Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

Mechanisms underpinning poor antibody responses to vaccines in ageing

Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations

MicroRNA in the adaptive immune system, in sickness and in health.

MicroRNA regulation of T-cell development.

No Functional Role for microRNA-342 in a Mouse Model of Pancreatic Acinar Carcinoma.

Optimized immunofluorescence staining protocol for imaging germinal centers in secondary lymphoid tissues of vaccinated mice

Premature thymic involution is independent of structural plasticity of the thymic stroma.

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells

Regulation of the Germinal Center Response

Regulatory T cells and control of the germinal centre response

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS

Sec22b is a critical and nonredundant regulator of plasma cell maintenance

Selenium saves ferroptotic TFH cells to fortify the germinal center

Senescence blurs the line between innate and adaptive immune cells

Shaping Variation in the Human Immune System.

Signals that drive T follicular helper cell formation.

Signals that influence T follicular helper cell differentiation and function.

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging

Stromal cell control of conventional and ectopic germinal centre reactions

Stromal networking: cellular connections in the germinal centre

T cells and follicular dendritic cells in germinal center B-cell formation and selection.

T follicular helper cells during immunity and tolerance.

T follicular helper cells. Preface.

T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells.

TFR cells trump autoimmune antibody responses to limit sedition

Targeting TFH cells in human diseases and vaccination: rationale and practice

Targeting TLR4 during vaccination boosts MAdCAM-1 lymphoid stromal cell activation and promotes the aged germinal center response

Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination

The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells.

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

The cellular composition of the human immune system is shaped by age and cohabitation.

The dark side of Tregs during aging

The memory B cell response to influenza vaccination is impaired in older persons