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List of works by Ratko Djukanovic

"T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

scientific article published on 03 January 2019

15-lipoxygenase immunoreactivity in normal and in asthmatic airways

scientific article published on 01 April 1995

A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD

scientific article published on 04 June 2018

A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts

scientific article published on 01 May 2017

A Topological Data Analysis Network Model of Asthma Based on Blood Gene Expression Profiles

article

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED

scientific article published on 15 February 2017

A computational framework for complex disease stratification from multiple large-scale datasets.

scientific article published on 29 May 2018

A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs

scientific article published on May 2015

A panel of antibodies for identifying squamous metaplasia in endobronchial biopsies from smokers

scientific article published on 22 July 2010

A randomised controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist either by instructional DVD or in face-to-face sessions in the management of asthma in adults

scientific article

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

scientific article

Advancing Understanding of Mechanisms of Severe Asthma and Drug Effects Using Transcriptomics

scientific article published on 01 October 2019

Airway inflammation in asthma and its consequences: implications for treatment in children and adults

scientific article

Airway neutrophilia in COPD is not associated with increased neutrophil survival

scientific article published on 13 September 2006

Allergen-induced release of GM-CSF and IL-8 in vitro by nasal polyp tissue from atopic subjects prolongs eosinophil survival

scientific article published on 01 July 1997

Altered airway surfactant phospholipid composition and reduced lung function in asthma

scientific article published on 01 October 2000

Alveolar tissue inflammation in asthma

scientific article published on 01 November 1996

An integrated nano-scale approach to profile miRNAs in limited clinical samples

scientific article published on November 2012

An integrative systems biology approach to understanding pulmonary diseases

scientific article published in June 2010

Analysis of fluid-phase mediators.

scientific article

Analysis of immunoglobulin E VH transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards VH5, and indicates local clonal expansion, somatic mutation and isotype switch events

scientific article published on December 1999

Anaphylactic reaction to Thalamonal and atropine

scientific article

Application of 'omics technologies to biomarker discovery in inflammatory lung diseases

scientific article published on 08 February 2013

Asthma 'of mice and men'--how do animal models help us understand human asthma?

scientific article published on 01 January 1994

Asthma research in Europe: a transformative agenda for innovation and competitiveness.

scientific article published in May 2017

Asthma: A disease of inflammation and repair.

scientific article

Asthma: an inflammatory disease with remodeling of the respiratory tract

scientific article published on 01 November 1997

Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis

scientific article published in August 2002

Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke

scientific article published in July 2002

B7 costimulation is required for IL-5 and IL-13 secretion by bronchial biopsy tissue of atopic asthmatic subjects in response to allergen stimulation

scientific article published on 01 January 1999

Biomarker-based corticosteroid adjustment in severe asthma: a modified Delphi consensus

scientific article published on 01 October 2018

Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma

scientific article published on 10 September 2019

Bronchial angiogenesis in severe glucocorticoid-dependent asthma

scientific article published on 01 June 2000

Bronchial eosinophilic infiltration in Crohn's disease in the absence of pulmonary disease

scientific article published on 01 May 1999

Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls

scientific article published on 01 May 1992

Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.

scientific article published on January 2017

Building the investment case for asthma R&D: the European Asthma Research and Innovation Partnership argument.

scientific article published in September 2016

Care pathways for the selection of a biologic in severe asthma

scientific article

Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum

scientific article published on 01 February 1997

Characteristics and treatment regimens across ERS SHARP severe asthma registries

scientific article published on 09 January 2020

Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients

scientific article published on 17 March 2010

Ciliated cell damage in the bronchial epithelium of asthmatics and non-asthmatics

scientific article published in March 1993

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

scientific article published on 10 September 2015

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET

scientific article published on 11 February 2019

Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum.

scientific article published on 4 March 2004

Control of airway inflammation maintained at a lower steroid dose with 100/50 microg of fluticasone propionate/salmeterol

scientific article

Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells

scientific article

Correction: Synergistic activation of pro-inflammatory type-2 CD8 + T lymphocytes by lipid mediators in severe eosinophilic asthma

scientific article published on 01 March 2019

Cultured nasal polyps from nonatopic and atopic patients release RANTES spontaneously and after stimulation with phytohemagglutinin ⬇️

scientific article

Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages

scientific article published on 01 July 1995

Cyclic nucleotide phosphodiesterases from purified human CD4+ and CD8+ T lymphocytes

scientific article published on 01 July 1995

Cytokine binding to CD4+ inflammatory cells: implications for asthma

scientific article published on 01 November 1994

Defective epithelial barrier function in asthma.

scientific article

Determinants of asthma severity

scientific article published on 01 May 1995

Determinants of lung function improvement with omalizumab in adults with allergic asthma

scientific article published on 22 January 2020

Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K).

scientific article published in September 2005

Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals

scientific article published in December 2002

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma

scientific article

ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions

scientific article published on 28 September 2019

Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma

scientific article published on 01 March 1992

Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma

scientific article published in July 2003

Effect of inhaled platelet-activating factor on bronchial inflammation in atopic non-asthmatic subjects

scientific article published in January 1992

Effect of natural allergen exposure during the grass pollen season on airways inflammatory cells and asthma symptoms.

scientific article

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

scientific article published in December 2000

Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients.

scientific article published on July 1997

Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness

scientific article published on 01 December 2000

Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study

scientific article published on 01 August 1996

Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma

scientific article

Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study

scientific article

Endothelin immunoreactivity of airway epithelium in asthmatic patients

scientific article published on 01 March 1991

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort

scientific article published in PLoS ONE

Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor.

scientific article published on 19 December 2007

Entanglements of loneliness and mental ill health among young adult women

scientific article published on 01 December 2020

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility

scientific article

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

scientific article published on 27 June 2019

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

scientific article published on 20 February 2017

Evaluation of airway inflammation by endobronchial and transbronchial biopsy in nocturnal and nonnocturnal asthma

scientific article published on 01 March 1995

Evidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease

scientific article

Exacerbation Profile and Risk Factors in a Type-2–Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes

scientific article published in 2022

Experimental rhinovirus 16 infection in moderate asthmatics on inhaled corticosteroids

scientific article published on 5 December 2013

Expression of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects

article

Expression of ErbB receptors and mucins in the airways of long term current smokers.

scientific article published on December 2004

Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease.

scientific article published on 07 December 2006

Factors increasing nonspecific reactivity in the bronchial tree in patients with bronchial asthma

scientific article

Free and complexed interleukin-8 in blood and bronchial mucosa in asthma

scientific article published on 01 June 1997

From proteomics to prescription-the search for COPD biomarkers

scientific article

Hypersensitivity reaction with intravenous GnRH after pulsatile subcutaneous GnRH treatment in male hypogonadotrophic hypogonadism.

scientific article published on March 1988

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma

scientific article published on 06 December 2018

Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease

scientific article

Identification of neutrophil chemotactic factors in bronchoalveolar lavage fluid of asthmatic patients

scientific article published on 01 April 1997

IgE-mediated asthma: New revelations and future insights

scientific article

Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease.

scientific article published on 16 November 2006

Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium

scientific article published on January 2003

Increased levels of IL-4 in CD8+ T cells in atopic asthma

scientific article published on 01 September 1997

Induced sputum--a tool with great potential but not without problems

scientific article published on 01 June 2000

Induced sputum: comparison between isotonic and hypertonic saline solution inhalation in patients with asthma

scientific article published on 01 December 2001

Inflammatory cells in the airways in COPD.

scientific article

Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma

scientific article published in June 2001

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms

scientific article

Instability of sputum molecular phenotypes in U-BIOPRED severe asthma

scientific article published on 02 October 2020

Integrated care pathways for airway diseases (AIRWAYS-ICPs).

scientific article published on 12 June 2014

Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects ⬇️

scientific article published on July 1, 1992

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines

scientific article

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

scientific article published on 12 December 2013

Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease

scientific article published in April 2007

Investigative use of bronchoscopy in asthma.

scientific article published on March 1998

Involvement of the epidermal growth factor receptor in IL-13-mediated corticosteroid-resistant airway inflammation

scientific article published on 24 February 2020

Is airways hyperreactivity selective or non-selective?

scientific article

Is the neutrophil a worthy target in severe asthma and chronic obstructive pulmonary disease?

scientific article published on 01 May 2006

Isolation of T-cell subsets by magnetic cell sorting (MACS)

scientific article published on 01 January 2000

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome

scientific article published on 8 May 2018

Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers

scientific article published on 17 September 2018

Longitudinally Stable, Clinically Defined Clusters of Patients with Asthma Independently Identified in the ADEPT and U-BIOPRED Asthma Studies

scientific article published in March 2016

Low-dose methotrexate treatment in severe glucocorticoid-dependent asthma: effect on mucosal inflammation and in vitro sensitivity to glucocorticoids of mitogen-induced T-cell proliferation

scientific article published on 01 March 2000

Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease.

scientific article published on 28 March 2018

Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma

scientific article published on 01 April 1992

Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma

scientific article published on 01 January 1999

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

scientific article published on 02 January 2020

Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma.

scientific article

Metabolomics analysis identifies different metabotypes of asthma severity

scientific article

Microbial products in allergy prevention and therapy.

scientific article

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study

scientific article published on 11 December 2018

Montelukast added to fluticasone propionate does not alter inflammation or outcomes

scientific article published on 14 August 2010

Mucosal Inflammation and Asthma

scientific article published on 01 November 1994

Mucosal inflammation in severe glucocorticoid-dependent asthma

scientific article published on 01 June 1999

Mucosal nerves in endobronchial biopsies in asthma and non-asthma

scientific article published on 01 January 1991

Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.

scientific article

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1

scientific article published on 28 January 2016

Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.

scientific article

Myofibroblasts and subepithelial fibrosis in bronchial asthma

scientific article published on 01 November 1990

Nasal polyps--a model of chronic respiratory mucosal inflammation

scientific article published on 01 July 1995

Nebulised salbutamol administered during sputum induction improves bronchoprotection in patients with asthma.

scientific article published on February 2004

Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects

scientific article published in September 1995

OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma

scientific article published on 02 November 2018

Pathology of rhinitis and bronchial asthma.

scientific article

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

scientific article

Persistence of oxidant and protease burden in the airways after smoking cessation. ⬇️

scientific article

Persistent airway T-lymphocyte activation in chronic corticosteroid-treated symptomatic asthma

scientific article published on 01 December 2000

Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.

scientific article published on 14 September 2012

Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis

scientific article published on 01 February 2000

Physiotherapy breathing retraining for asthma: a randomised controlled trial.

scientific article published on 13 December 2017

Predicting Asthmatic Responses to Inhaled Allergen Using an Unbiased Transcriptomics Approach

scientific article published on 28 November 2017

Predicting Responders to Reslizumab after 16 Weeks of Treatment Using an Algorithm Derived from Clinical Studies of Severe Eosinophilic Asthma Patients

article

Production of IL-8 and IL-4 by positively and negatively selected CD4+ and CD8+ human T cells following a four-step cell separation method including magnetic cell sorting (MACS)

scientific article published on 01 January 1996

Prosurvival activity for airway neutrophils in severe asthma

scientific article

Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic

scientific article published on 24 May 2019

Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry

scientific article published on 01 October 1990

Randomised Controlled Trials in Severe Asthma: Selection by Phenotype or Stereotype

scientific article published on 13 December 2018

Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood

scientific article published on 12 June 2015

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

scientific article (publication date: February 2016)

Safety of biopsies and bronchoalveolar lavage

scientific article published on 01 March 1998

Safety of long-acting beta-agonists: urgent need to clear the air remains

scientific article published on January 2009

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)

scientific article

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study

scientific article published on 6 October 2016

Should PAF inhalation challenge be used as an experimental model of bronchial hyperresponsiveness in man?

scientific article published on 01 June 1992

Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium

scientific article published on 01 November 2001

Skin responses to bradykinin, kallidin, and [desArg9]-bradykinin in nonatopic and atopic volunteers

scientific article published on 01 November 1993

Sputum eosinophilia is more closely associated with airway responsiveness to bradykinin than methacholine in asthma

scientific article published on 01 September 1998

Sputum induction in children.

scientific article

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

scientific article published on 12 April 2018

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.

scientific article published on 17 May 2017

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease

scientific article

Standardised methodology of sputum induction and processing

scientific article published on 01 September 2002

Standardised methodology of sputum induction and processing. Future directions.

scientific article

Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection

scientific article published on 26 April 2016

Stratification of asthma phenotypes by airway proteomic signatures

scientific article published on 28 March 2019

Successful treatment of hemorrhagic syndrome due to an acquired, combined deficiency of factors VII and X in a patient with multiple myeloma and amyloidosis

scientific article published on 01 January 1989

Susceptibility to influenza virus infection of bronchial biopsies in asthma.

scientific article published on March 2017

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma

scientific article published on 15 June 2018

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma

scientific article published on 01 April 1996

T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED.

scientific article

Targeting Eosinophils in Eosinophilic Granulomatosis with Polyangiitis

scientific article published in May 2017

The BREATHE study: Breathing REtraining for Asthma--Trial of Home Exercises. a protocol summary of a randomised controlled trial.

scientific article published in June 2013

The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma

scientific article published on 01 September 2001

The effect of inhaled allergen on circulating basophils in atopic asthma

scientific article published on 01 August 1992

The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics

scientific article

The effect of processing on inflammatory markers in induced sputum

scientific article published on 01 March 1999

The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation

scientific article published on 01 March 1997

The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma

scientific article published in February 2003

The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma

scientific article published on 01 January 1999

The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results

scientific article published on 01 May 1995

The era of research collaborations: new models for working together

scientific article published on 3 January 2017

The influence of refractoriness to adenosine 5'-monophosphate on allergen-provoked bronchoconstriction in asthma

scientific article published on 01 August 1989

The need for a pathological classification of asthma.

scientific article published on April 1991

The relationship between airways inflammation and asthma severity

scientific article published on 01 January 2000

The relationship between eosinophilia and airway remodelling in mild asthma

scientific article

The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma

scientific article published on 01 December 2001

The role of ICAM-1 on T-cells in the pathogenesis of asthma

scientific article published in April 1998

The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma

scientific article published on 01 February 2003

The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma

scientific article published in April 1991

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma.

scientific article

Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid

scientific article published on 01 August 1997

Treatable Traits in the European U-BIOPRED Adult Asthma Cohorts

scientific article published on 12 November 2018

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

scientific article

Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type-2 Inflammation

scientific article published on 15 July 2020

Value of induced sputum in the investigation of asthma

scientific article published in April 2003

Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36.

scientific article

Viral infection of human lung macrophages increases PDL1 expression via IFNβ.

scientific article published on 16 March 2015

Virus infection, asthma, and chronic obstructive pulmonary disease

scientific article published in November 2008

Wheal-and-flare responses to intradermally injected adenosine 5'-monophosphate, hypertonic saline, and histamine: comparison of atopic and nonatopic subjects

scientific article

[Sensitivity of the Alupent test]

scientific article published on 01 January 1982

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