List of works - Stefan Kunz

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease

scientific article

A dystroglycan mutation associated with limb-girdle muscular dystrophy.

scientific article

A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs

scientific article published on 07 June 2020

Alpha-dystroglycan can mediate arenavirus infection in the absence of beta-dystroglycan.

scientific article published on November 2003

Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.

scientific article

Altering α-dystroglycan receptor affinity of LCMV pseudotyped lentivirus yields unique cell and tissue tropism

scientific article published on 8 April 2011

Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules.

scientific article published on August 2001

Analytical validation of a lymphocytic choriomeningitis virus real-time RT-PCR assay

scientific article published on 6 July 2011

Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease

scientific article

Arenavirus Z-glycoprotein association requires Z myristoylation but not functional RING or late domains.

scientific article

Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease.

scientific article published on 25 May 2011

Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.

scientific article published on 24 April 2012

Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.

scientific article published on 23 May 2012

Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan

scientific article

Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan.

scientific article published on 04 April 2012

Cell entry by human pathogenic arenaviruses

scientific article

Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan

scientific article published on 20 December 2012

Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis

scientific article published on 03 May 2009

Characterization of the cellular receptors for the South American hemorrhagic fever viruses Junin, Guanarito, and Machupo.

scientific article published on 30 March 2006

Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses

scientific article published on 12 September 2019

Conserved Endonuclease Function of Hantavirus L Polymerase

scientific article published on 02 May 2016

Current drug discovery strategies against arenavirus infections.

scientific article

Different mechanisms of cell entry by human-pathogenic Old World and New World arenaviruses

scientific article

Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).

scientific article published on 27 March 2013

Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus

scientific article published on 26 March 2019

Envelope glycoprotein of arenaviruses

scientific article

Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242.

scientific article published on 10 December 2011

Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouse

scientific article

Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner

scientific article

Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells

scientific article

Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers

scientific article

Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

scientific article published on 7 December 2016

Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.

scientific article published on 04 May 2016

Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.

scientific article

Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS.

scientific article published on April 2015

Lymphocytic choriomeningitis virus infection induced by percutaneous exposure.

scientific article published on 28 September 2015

Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P).

scientific article published on 8 December 2015

Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions ⬇️

scientific article published on September 15, 2003

Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan.

scientific article published on 15 October 2001

Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease

scientific article

Molecular evolution of the proopiomelanocortin system in Barn owl species

scientific article published on 05 May 2020

Molecular recognition by LARGE is essential for expression of functional dystroglycan

scientific article

Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule

scientific article

New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor

scientific article

Novel antiviral strategies to combat human Arenavirus infections.

scientific article

Novel approaches in anti-arenaviral drug development

scientific article

Novel drug discovery approaches for treating arenavirus infections

scientific article published on 16 February 2016

O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.

scientific article

Old World Arenaviruses Enter the Host Cell via the Multivesicular Body and Depend on the Endosomal Sorting Complex Required for Transport ⬇️

scientific article published on September 8, 2011

Old World and clade C New World arenaviruses mimic the molecular mechanism of receptor recognition used by alpha-dystroglycan's host-derived ligands

scientific article published on 14 March 2007

Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell

scientific article

Pathogenesis of arenavirus hemorrhagic fevers

scientific article

Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection

scientific article

Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding.

scientific article

Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction.

scientific article published on 25 March 2009

Role of DC-SIGN in Lassa virus entry into human dendritic cells

scientific article published on 21 August 2013

Role of the host cell's unfolded protein response in arenavirus infection.

scientific article

Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway

scientific article

Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito

scientific article

Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination

scientific article

Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses

scientific article

The lectin ERGIC-53 goes viral

scientific article published on November 2013

The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomain

scientific article published on 4 December 2012

The role of the vascular endothelium in arenavirus haemorrhagic fevers

scientific article published in December 2009

Two distinct mechanisms target membrane proteins to the axonal surface

scientific article published on 01 February 2003

Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses

scientific article

Use of alternative receptors different than alpha-dystroglycan by selected isolates of lymphocytic choriomeningitis virus.

scientific article published in August 2004

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway

scientific article published on 12 February 2007

Viral envelope glycoprotein processing by proprotein convertases

scientific article published on 20 April 2013

Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease

scientific article

List of works by Stefan Kunz

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease

A dystroglycan mutation associated with limb-girdle muscular dystrophy.

A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs

Alpha-dystroglycan can mediate arenavirus infection in the absence of beta-dystroglycan.

Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.

Altering α-dystroglycan receptor affinity of LCMV pseudotyped lentivirus yields unique cell and tissue tropism

Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules.

Analytical validation of a lymphocytic choriomeningitis virus real-time RT-PCR assay

Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease

Arenavirus Z-glycoprotein association requires Z myristoylation but not functional RING or late domains.

Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease.

Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.

Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.

Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan

Binding of Lassa virus perturbs extracellular matrix-induced signal transduction via dystroglycan.

Cell entry by human pathogenic arenaviruses

Cell entry of Lassa virus induces tyrosine phosphorylation of dystroglycan

Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis

Characterization of the cellular receptors for the South American hemorrhagic fever viruses Junin, Guanarito, and Machupo.

Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses

Conserved Endonuclease Function of Hantavirus L Polymerase

Current drug discovery strategies against arenavirus infections.

Different mechanisms of cell entry by human-pathogenic Old World and New World arenaviruses

Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).

Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus

Envelope glycoprotein of arenaviruses

Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242.

Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouse

Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner

Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells

Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers

Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.

Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.

Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS.

Lymphocytic choriomeningitis virus infection induced by percutaneous exposure.

Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P).

Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions ⬇️

Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan.

Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease

Molecular evolution of the proopiomelanocortin system in Barn owl species

Molecular recognition by LARGE is essential for expression of functional dystroglycan

Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule

New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor

Novel antiviral strategies to combat human Arenavirus infections.

Novel approaches in anti-arenaviral drug development

Novel drug discovery approaches for treating arenavirus infections

O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.

Old World Arenaviruses Enter the Host Cell via the Multivesicular Body and Depend on the Endosomal Sorting Complex Required for Transport ⬇️

Old World and clade C New World arenaviruses mimic the molecular mechanism of receptor recognition used by alpha-dystroglycan's host-derived ligands

Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell

Pathogenesis of arenavirus hemorrhagic fevers

Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection

Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding.

Receptor binding and cell entry of Old World arenaviruses reveal novel aspects of virus-host interaction.

Role of DC-SIGN in Lassa virus entry into human dendritic cells

Role of the host cell's unfolded protein response in arenavirus infection.

Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway

Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito

Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination

Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses

The lectin ERGIC-53 goes viral

The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomain

The role of the vascular endothelium in arenavirus haemorrhagic fevers

Two distinct mechanisms target membrane proteins to the axonal surface

Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses

Use of alternative receptors different than alpha-dystroglycan by selected isolates of lymphocytic choriomeningitis virus.

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway

Viral envelope glycoprotein processing by proprotein convertases

Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease