List of works - Adam J Pawson

A novel mammalian receptor for the evolutionarily conserved type II GnRH

scientific article

A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29

scientific article published on 01 May 2020

A role for intracellular calcium downstream of G-protein signaling in undifferentiated human embryonic stem cell culture.

scientific article

A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12

scientific article (publication date: February 2003)

Activation of mitogen-activated protein kinase (MAPK) by GnRH is cell-context dependent

scientific article

BJP is linking its articles to the IUPHAR/BPS Guide to PHARMACOLOGY. ⬇️

scientific article published on 12 May 2015

Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated

scientific article published on 17 August 2006

Challenges of Connecting Chemistry to Pharmacology: Perspectives from Curating the IUPHAR/BPS Guide to PHARMACOLOGY

scientific article published on 01 July 2018

Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations

scientific article

Class A Orphans (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

Class A Orphans (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Class A Orphans in GtoPdb v.2021.3

Contrasting internalization kinetics of human and chicken gonadotropin-releasing hormone receptors mediated by C-terminal tail

scientific article published on 01 March 1998

Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor

scientific article published on 14 October 2003

Diversity of actions of GnRHs mediated by ligand-induced selective signaling

scientific article

Elucidation of mechanisms of the reciprocal cross talk between gonadotropin-releasing hormone and prostaglandin receptors

scientific article published on 14 April 2010

Emerging targets of the GnRH receptor: novel interactions with Wnt signalling mediators

scientific article published on 22 October 2008

Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity

scientific article published on 12 September 2005

GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells

scientific article

Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor

scientific article

Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling

scientific article

Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5.

scientific article published on January 2006

Gonadotropin-releasing hormone receptors

scientific article

Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src

scientific article (publication date: 19 March 2004)

GuideToPharmacology.org--an update

scientific article

IUPHAR-DB: updated database content and new features

scientific article

Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling

scientific article

Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis

scientific article

Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment

scientific article (publication date: June 2005)

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

scientific article

Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: localization of attachment site to Cys residue in N-terminal segment

scientific article published in October 1997

Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology

scientific article published on 18 September 2010

Mammalian type I gonadotropin-releasing hormone receptors undergo slow, constitutive, agonist-independent internalization

scientific article published on 26 November 2007

Multiple determinants for rapid agonist-induced internalization of a nonmammalian gonadotropin-releasing hormone receptor: a putative palmitoylation site and threonine doublet within the carboxyl-terminal tail Are critical

scientific article published in September 2003

Nuclear stabilization of beta-catenin and inactivation of glycogen synthase kinase-3beta by gonadotropin-releasing hormone: targeting Wnt signaling in the pituitary gonadotrope

scientific article published on 23 August 2007

Outside-In and Inside-Out Signaling: The New Concept that Selectivity of Ligand Binding at the Gonadotropin-Releasing Hormone Receptor Is Modulated by the Intracellular Environment

article

Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion

scientific article

Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene

scientific article

Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion

scientific article

Serine residues 338 and 339 in the carboxyl-terminal tail of the type II gonadotropin-releasing hormone receptor are critical for beta-arrestin-independent internalization

scientific article