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List of works by Raffaele De Francesco

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

scientific article published on March 2006

A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer ⬇️

scientific article published on November 1, 1992

A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease

scientific article published in May 1996

A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates

scientific article published in August 1996

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

scientific article published in February 2002

A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand

scientific article published in August 2005

A high-throughput radiometric assay for hepatitis C virus NS3 protease

scientific article published in January 1999

A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody

scientific article published in November 1999

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR (EMBO reports, February 2003) (Erratum)

article

A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR.

scientific article published on February 2003

A scintillation proximity active site binding assay for the hepatitis C virus serine protease

scientific article published in August 2002

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

scientific article

A zinc binding site in viral serine proteinases

scientific article published on October 1996

Activity of purified hepatitis C virus protease NS3 on peptide substrates

scientific article

Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease ⬇️

scientific article published on May 1, 1997

An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A

scientific article

Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees

scientific article published on 13 June 2022

Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study

scientific article published on 23 December 2021

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

scientific article

Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.

scientific article published in January 2000

Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence

scientific article published in March 2000

Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires ⬇️

scientific article published on October 1, 1997

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

scientific article published on 8 September 2003

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

scientific article published on January 2004

Circular dichroism study on the conformational stability of the dimerization domain of transcription factor LFB1

scientific article published on 01 January 1991

Cirrhosis and Rapid Virological Response to Peginterferon Plus Ribavirin Determine Treatment Outcome in HCV-1 IL28B rs12979860 CC Patients ⬇️

scientific article published on 09 July 2013

Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide

scientific article published in June 1997

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

scientific article

Corrigendum: Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary Cirrhosis

scientific article published on 14 August 2014

Crystallization and preliminary X-ray diffraction studies of the transcriptional regulator TraR bound to its cofactor and to a specific DNA sequence

scientific article

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.

scientific article published on 30 October 2015

Daclatasvir: a team player rather than a prima donna in the treatment of hepatitis C.

scientific article

Design of selective eglin inhibitors of HCV NS3 proteinase

scientific article published on August 1998

Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance

article

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

scientific article

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase

scientific article published in January 2004

Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.

scientific article

Enzymatic properties of hepatitis C virus NS3-associated helicase

scientific article published in May 2000

Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3.

scientific article published on 21 November 2007

Flavodoxin-cytochrome c interactions: circular dichroism and nuclear magnetic resonance studies

scientific article

Genetic variation in the interleukin -28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection

article

Genome-wide analysis of DNA methylation, copy number variation, and gene expression in monozygotic twins discordant for primary biliary cirrhosis

scientific article published on 28 March 2014

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis

scientific article published on October 2004

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

scientific article published on 25 September 2015

Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors

scientific article published on 13 December 2006

Hepatitis C virus-specific directly acting antiviral drugs

scientific article published on January 2013

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

scientific article published on 21 June 2013

IL-10 promotes homeostatic proliferation of human CD8(+) memory T cells and, when produced by CD1c(+) DCs, shapes naive CD8(+) T-cell priming

scientific article published on 30 April 2016

IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B.

scientific article published on 20 December 2012

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

scientific article

Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis

scientific article

In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

scientific article

In vitro antibiofilm activity of bioactive glass S53P4.

scientific article

Influence of 8.alpha.-imidazole substitution of the FMN cofactor on the rate of electron transfer from the neutral semiquinones of two flavodoxins to cytochrome c

scientific article published on 01 August 1987

Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs

scientific article published on 27 January 2003

Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C.

scientific article

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

scientific article published on 13 June 2005

Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients

scientific article published on 12 February 2014

Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4.

scientific article published on 3 January 2012

Kinetic Studies on the Electron-Transfer Reaction between Cytochrome c3 and Flavodoxin from Desulfovibrio vulgaris Strain Hildenborough

scientific article published on 01 August 1994

Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.

scientific article

LFB1/HNF1 acts as a repressor of its own transcription

scientific journal article

Loss of Histone Deacetylase 4 Causes Segregation Defects during Mitosis of p53-Deficient Human Tumor Cells

scientific article published on 21 July 2009

Measurement of homonuclear three-bond J(H(N)Halpha) coupling constants in unlabeled peptides complexed with labeled proteins: application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatitis C virus (HCV).

scientific article published in May 2001

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

scientific article published on December 2003

Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity

scientific article

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

scientific article published on February 1994

Molecular virology of the hepatitis C virus.

scientific article

Multiple determinants influence complex formation of the hepatitis C virus NS3 protease domain with its NS4A cofactor peptide.

scientific article published in April 1999

Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus

scientific article

Mutational analysis of hepatitis C virus NS3-associated helicase

scientific article published in July 2000

Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein

scientific article published on 11 May 2016

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

scientific article

NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes

scientific article published on 15 September 2014

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.

scientific article

Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment

scientific article published on 11 May 2020

New horizons in hepatitis C antiviral therapy with direct-acting antivirals.

scientific article published on 31 May 2013

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

scientific article published on 08 February 2014

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling

scientific article published in January 2003

Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation-dependent viral RNA replication?

scientific article

Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material.

scientific article

Potent Peptide Inhibitors of Human Hepatitis C Virus NS3 Protease Are Obtained by Optimizing the Cleavage Products ⬇️

scientific article published on June 23, 1998

Probing the active site of the hepatitis C virus serine protease by fluorescence resonance energy transfer

scientific article published in May 2000

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

scientific article

Product Inhibition of the Hepatitis C Virus NS3 Protease ⬇️

scientific article published on June 23, 1998

RNA-dependent RNA polymerase of hepatitis C virus.

scientific article

Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

scientific article published on 06 March 2019

Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase

scientific article published on January 1998

Redesigning the substrate specificity of the hepatitis C virus NS3 protease.

scientific article published on January 1996

Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymerase

scientific article

Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis viruses

scientific article

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

scientific article (publication date: April 2002)

Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

scientific article

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

scientific article

Structural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors

scientific article

Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies

scientific article published in June 1999

Structure and function of the hepatitis C virus NS3-NS4A serine proteinase.

scientific article

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

scientific article

Substrate specificity of the hepatitis C virus serine protease NS3.

scientific article published in April 1997

Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease

scientific article published on June 1996

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?

scientific article

The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent

scientific article

The dimerization domain of LFB1/HNF1 related transcription factors: a hidden four helix bundle?

scientific article published on December 1, 1992

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.

scientific article published on 26 January 2015

The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.

scientific article

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase

scientific article published on June 2004

The nonstructural proteins of the hepatitis C virus: structure and functions.

scientific article published on June 1997

The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

scientific article

The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain.

scientific article

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells.

scientific article

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients

scientific article published on 6 May 2015

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

scientific article published on 19 December 2016

Why is it so difficult to develop a hepatitis C virus preventive vaccine?

scientific article published on 19 December 2013

pKa values of the 8α-imidazole substituents in selected flavoenzymes containing 8α-histidylflavins

scientific article published on 01 July 1988

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