List of works by Rick Pearson

10 Design and use of peptide substrates for protein kinases

scientific article published on January 1, 1991

A functional genetic screen defines the AKT-induced senescence signaling network

scientific article published on 08 July 2019

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

scientific article published on 22 January 2019

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth.

scientific article published on April 2011

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase

scientific article published on 01 January 1986

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition

scientific article published in December 2006

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.

scientific article published on 12 September 2011

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

scientific article

AKT-independent PI3-K signaling in cancer - emerging role for SGK3.

scientific article published on 26 August 2013

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.

scientific article published on March 2003

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF<sup>V600</sup> melanoma

scientific article published on 01 March 2022

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.

scientific article published on 21 June 2013

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors

scientific article published on 8 May 2017

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

scientific article published on 30 June 2016

Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase

scientific article published on 01 August 1988

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

scientific article published on 26 May 2020

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

article

Chemical modification of lysine and arginine residues in the myosin regulatory light chain inhibits phosphorylation

scientific article published on 01 March 1986

Class IA phosphatidylinositol 3-kinase signaling in non-small cell lung cancer

scientific article published on July 2009

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

scientific article

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

scientific article published in September 2016

Comparison of substrate specificity of myosin kinase and cyclic AMP-dependent protein kinase

scientific article published on 01 May 1984

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.

scientific article published on August 2007

Cystathionine β-Synthase in Physiology and Cancer.

scientific article

Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy.

scientific article published on 7 March 2011

Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k

scientific article published on February 1998

Dual posttranscriptional targets of retinoic acid-induced gene expression

scientific article

Dual requirement for a newly identified phosphorylation site in p70s6k

scientific article

Dysregulation of RNA polymerase I transcription during disease.

scientific article

Dysregulation of the basal RNA polymerase transcription apparatus in cancer

scientific article published on May 2013

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

scientific article published on 15 May 2019

Hydroxyamino acid specificity of smooth muscle myosin light chain kinase

scientific article published on 01 January 1988

In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding

scientific article published on 22 January 2011

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

scientific article

Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle

scientific article published on 22 November 1999

Intrasteric regulation of protein kinases and phosphatases

scientific article

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

scientific article published in Nature Communications

Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus

scientific article published on 01 May 2006

Mutation of the PIK3CA gene in ovarian and breast cancer

scientific article published on 01 November 2004

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.

scientific article

Myosin light chain kinase binding to plastic

scientific article published on 01 August 1982

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

scientific article published on 01 March 2015

PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity.

scientific article published on 17 March 2014

Phosphorylation of a synthetic heptadecapeptide by smooth muscle myosin light chain kinase

scientific article published on 01 November 1982

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase.

scientific article published on 2 July 2009

Phosphorylation site sequence of smooth muscle myosin light chain (Mr = 20 000)

scientific article published on 01 March 1984

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase.

scientific article published on March 2003

Proteolytic cleavage sites in smooth muscle myosin-light-chain kinase and their relation to structural and regulatory domains.

scientific article

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

scientific article published on June 1997

Regulatory and structural motifs of chicken gizzard myosin light chain kinase

scientific article

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.

scientific article

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

scientific article published on 18 September 2020

Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.

scientific article

Role of basic residues in the phosphorylation of synthetic peptides by myosin light chain kinase.

scientific article published on December 1983

Role of the pseudosubstrate sequence in smooth muscle myosin light chain kinase thermal stability

scientific article published on 01 June 1993

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila.

scientific article published on 24 July 2015

STIM1: a novel phosphoprotein located at the cell surface.

scientific article published on August 2000

Second AKT: the rise of SGK in cancer signalling

scientific article

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition.

scientific article published on 23 September 2016

Smooth muscle myosin kinase requires residues on the COOH-terminal side of the phosphorylation site. Peptide inhibitors

scientific article published in January 1986

Spatial requirements for location of basic residues in peptide substrates for smooth muscle myosin light chain kinase

scientific article published on 01 March 1985

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

scientific article published on 13 December 2017

Structural basis of the intrasteric regulation of myosin light chain kinases

scientific article

Substrate specificity of a multifunctional calmodulin-dependent protein kinase.

scientific article published in November 1985

Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression

scientific article published on 10 July 2020

Targeting PI3 kinase/AKT/mTOR signaling in cancer.

scientific article published on January 2012

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

scientific article

Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.

scientific article published in November 2011

Targeting the nucleolus for cancer intervention

scientific article

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

scientific article published on 20 January 2017

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

scientific article published on 11 November 2020

The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence

scientific article published on 01 February 1987

The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites

scientific article published on 01 August 1993

The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.

scientific article

The multi-layered regulation of copper translocating P-type ATPases

scientific article published on 07 January 2009

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

scientific article

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

scientific article

The smooth muscle 132 kDa cyclic GMP-dependent protein kinase substrate is not myosin light chain kinase or caldesmon

scientific article published on October 1990

The synthetic peptide RPRAATF allows specific assay of Akt activity in cell lysates

scientific article published on June 2002

Therapeutic Approaches Targeting MYC-Driven Prostate Cancer

scientific article published on 16 February 2017

Too much or too little: harnessing senescence to control oncogene-driven cancer.

scientific article published on 16 August 2012

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

scientific article published on 11 July 2008

Unexpected role of CDK4 in a G2/M checkpoint

scientific article published in January 2015

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells

scientific article

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

scientific article

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