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List of works by Mario P. Tschan

Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia

scientific article published on 01 January 1999

Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream

scientific article

Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns

scientific article

Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo.

scientific article published on 21 January 2013

Assessing Autophagy During Retinoid Treatment of Breast Cancer Cells

scientific article published on 01 January 2019

Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot

scientific article published on 21 March 2020

CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway

scientific article published on 26 September 2018

CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation

scientific article

CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation

scientific article

Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression

scientific article published on 09 August 2018

Crizotinib inhibits migration and expression of ID1 in MET-positive lung cancer cells: implications for MET targeting in oncology

scientific article published on February 2014

DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function

scientific article published on 2 June 2008

Deregulated expression of Kruppel-like factors in acute myeloid leukemia.

scientific article

Differential expression of p73 splice variants and protein in benign and malignant ovarian tumours

scientific article published on 01 October 2000

Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid leukemia

scientific article published on 01 October 2000

Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2.

scientific article published on 20 January 2010

Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation

scientific article published on 3 March 2008

Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells

scientific article published on 08 October 2018

Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions

scientific article published on 11 May 2022

Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.

scientific article

Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1

scientific article

Impact of p53 Status on Radiosensitization of Tumor Cells by MET Inhibition-Associated Checkpoint Abrogation

scientific article published on 10 September 2015

Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation

scientific article published on 15 May 2015

Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation

scientific article published on 01 July 2014

Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation

scientific article

Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions

scientific article

Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells.

scientific article

Inhibition of the miR-143/145 cluster attenuated neutrophil differentiation of APL cells

scientific article published on 16 November 2011

Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells

scientific article published on 23 April 2015

Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells

scientific article

Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy.

scientific article published on 18 March 2018

Low DICER1 expression is associated with attenuated neutrophil differentiation and autophagy of NB4 APL cells

scientific article

MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors.

scientific article published on 14 June 2016

MicroRNA-29b is involved in the Src-ID1 signaling pathway and is dysregulated in human lung adenocarcinoma ⬇️

scientific article published on January 16, 2012

MicroRNA-381 represses ID1 and is deregulated in lung adenocarcinoma

scientific article published on 01 July 2012

Modulation of drug resistance by artificial transcription factors.

scientific article

NDRG1/2 expression is inhibited in primary acute myeloid leukemia

scientific article published on 22 September 2009

Overexpression of the p73 gene is a novel finding in high-risk B-cell chronic lymphocytic leukemia.

scientific article published in July 2001

PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity.

scientific article published on 14 January 2008

PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression.

scientific article published on 31 March 2017

Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas

scientific article published on 26 May 2016

Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer.

scientific article published on 26 May 2016

Progress and Challenges in The Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo

scientific article published on 25 May 2020

Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.

scientific article published on 9 January 2013

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy

scientific article published on 19 March 2021

Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry

scientific article published on 5 May 2015

SIRT1 is downregulated during neutrophil differentiation of acute promyelocytic leukaemia cells

scientific article published on 19 May 2009

Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).

scientific article published on 12 June 2009

Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid

scientific article

T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery.

scientific article

Targeting the phosphoinositide 3-kinase p110-α isoform impairs cell proliferation, survival, and tumor growth in small cell lung cancer.

scientific article published on 21 November 2012

The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer

scientific article published on 15 July 2020

The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation.

scientific article published on 19 December 2015

The actin-binding protein CORO1A is a novel PU.1 (SPI1)- and CEBPA-regulated gene with significantly lower expression in APL and CEBPA-mutated AML patients

scientific article published on 17 December 2012

The anti-apoptotic gene BCL2A1 is a novel transcriptional target of PU.1.

scientific article published on 4 March 2010

The autophagy scaffold protein ALFY is critical for the granulocytic differentiation of AML cells

scientific article published on 11 October 2017

The cyclin-dependent kinase inhibitors p18INK4c and p19INK4d are highly expressed in CD34+ progenitor and acute myeloid leukaemic cells but not in normal differentiated myeloid cells

scientific article published on 01 September 1999

The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells

scientific article

The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria

scientific article

The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias

scientific article published on 01 November 2007

The role of autophagy in anticancer therapy: promises and uncertainties

scientific article published on 22 October 2010

The stem cell gene "inhibitor of differentiation 1" (ID1) is frequently expressed in non-small cell lung cancer.

scientific article

The transcription factor encyclopedia

scientific article (publication date: 2012)

The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.

scientific article published on 13 September 2013

The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1.

scientific article

Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation

scientific article

Transcriptional regulation of MIR29B by PU.1 (SPI1) and MYC during neutrophil differentiation of acute promyelocytic leukaemia cells

scientific article published on 07 December 2011

Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma

scientific article published on 03 October 2019

WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells.

scientific article

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

scientific article

miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas

scientific article

miR-29b Mediates NF-κB Signaling in KRAS-Induced Non-Small Cell Lung Cancers.

scientific article published on 19 May 2016

p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells.

scientific article

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene.

scientific article published on 02 August 2013

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