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List of works by Akio Kihara

2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length

scientific article

A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC).

scientific article published on 02 December 2015

A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells

article

A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry.

scientific article

A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate

scientific article published on 26 August 2008

AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells

scientific article

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

scientific article

Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia

scientific article published on 31 July 2017

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7.

scientific article published on 22 September 2011

Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3

scientific article published on 08 January 2020

Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast

scientific article published on 29 April 2020

Characterization of HACD1 K64Q mutant found in arrhythmogenic right ventricular dysplasia patients.

scientific article published on 19 August 2010

Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis

scientific article

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC-MS/MS

scientific article published on 07 April 2020

Congenital myopathy is caused by mutation of HACD1.

scientific article published on 09 August 2013

Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation.

scientific article

Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry

scientific article

Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p

scientific article

De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy

scientific article published on 28 November 2018

Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4 Knockout Mice.

scientific article published on 22 November 2017

Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats

scientific article published on 15 December 2016

Degradation of long-chain base 1-phosphate (LCBP) in Arabidopsis: functional characterization of LCBP phosphatase involved in the dehydration stress response

scientific article published on 11 September 2011

Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA.

scientific article published on May 1998

Dislocation of membrane proteins in FtsH-mediated proteolysis

scientific article published on June 1999

Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery

scientific article published on 06 April 2016

Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.

scientific article published in September 2003

Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation

scientific article

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

scientific article

Effects on vesicular transport pathways at the late endosome in cells with limited very long-chain fatty acids

scientific article

Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.

scientific article

Erratum: Corrigendum: Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

scientific article published in Nature Communications

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

scientific article

FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane

scientific journal article

FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth.

scientific article

Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains.

scientific article published on 19 September 2015

Host regulation of lysogenic decision in bacteriophage lambda: transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA).

scientific article

Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release

scientific article

Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2

scientific article

Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

scientific article published on 19 November 2013

Identification of residues important for the catalysis, structure maintenance, and substrate specificity of yeast 3-hydroxyacyl-CoA dehydratase Phs1.

scientific article

Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation

scientific article

Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids.

scientific article

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production ⬇️

scientific article published on May 20, 2013

Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress

scientific article published on 10 February 2014

Intracellular Stability of α Fragments of β-Galactosidase: Effects of Amino-Terminally Fused Polypeptides

scientific article published on 01 October 1995

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

scientific article

Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its synthesis to its degradation

scientific article

LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity

scientific article

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

scientific article published on 28 March 2007

Lipid asymmetry of the eukaryotic plasma membrane: functions and related enzymes

scientific article published on August 2006

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

scientific article published on 07 April 2020

Long-chain base kinase Lcb4 Is anchored to the membrane through its palmitoylation by Akr1

scientific article

Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases

scientific article

Loop 5 region is important for the activity of the long-chain base transporter Rsb1.

scientific article published in February 2017

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid

scientific article published on 31 January 2014

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

scientific article

Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast.

scientific article

Membrane protein Rim21 plays a central role in sensing ambient pH in Saccharomyces cerevisiae

scientific article

Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation

scientific article

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate

scientific article published on 14 March 2007

Metabolism of very long-chain Fatty acids: genes and pathophysiology

scientific article

Molecular mechanism of the ichthyosis pathology of Chanarin-Dorfman syndrome: Stimulation of PNPLA1-catalyzed ω-O-acylceramide production by ABHD5

scientific article published on 20 November 2018

Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification

scientific journal article

Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization

scientific article published on 20 December 2005

Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile

scientific article

N-glycosylation of Rim21 at an Unconventional Site Fine-tunes Its Behavior in the Plasma Membrane

scientific article published on 30 November 2019

Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide

scientific article published on 07 August 2018

Novel biallelic FA2H mutations in a Japanese boy with fatty acid hydroxylase-associated neurodegeneration

scientific article published on 16 December 2019

Opt2 mediates the exposure of phospholipids during cellular adaptation to altered lipid asymmetry

scientific article

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide.

scientific article published on March 2017

Phosphorylation by Pho85 Cyclin-dependent Kinase Acts as a Signal for the Down-regulation of the Yeast Sphingoid Long-chain Base Kinase Lcb4 during the Stationary Phase

scientific article published in Journal of Biological Chemistry

Phs1 and the synthesis of very long chain Fatty acids are required for ballistospore formation

scientific article

Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum.

scientific article published on 13 March 2017

Polypeptide binding of Escherichia coli FtsH (HflB).

scientific article published in May 1998

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.

scientific article published on 13 June 2008

Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.

scientific article published on 8 May 2007

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1

scientific article published on 22 November 2019

Regulation of the sphingoid long-chain base kinase Lcb4p by ergosterol and heme: studies in phytosphingosine-resistant mutants

scientific article

Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis.

scientific article published on February 2006

Roles of the Periplasmic Domain of Escherichia coli FtsH (HflB) in Protein Interactions and Activity Modulation

scientific article published in Journal of Biological Chemistry

Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

scientific article published on 26 July 2019

Signaling events of the Rim101 pathway occur at the plasma membrane in a ubiquitination-dependent manner

scientific article

Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid ω-O-acylceramide

scientific article published on 23 January 2020

Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae

scientific article published on 14 June 2011

Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme.

scientific article published on April 2005

Sphingolipids activate the endoplasmic reticulum stress surveillance pathway.

scientific article

Sphingolipids regulate the yeast high-osmolarity glycerol response pathway

scientific article

Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

scientific article published on 27 August 2013

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner

scientific article published on 21 December 2005

Sphingosine 1-phosphate receptor modulator ONO-4641 stimulates CD11b+Gr-1+ cell expansion and inhibits lymphocyte infiltration in the lungs to ameliorate murine pulmonary emphysema

scientific article published on 16 August 2018

Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography.

scientific article

Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.

scientific article

Sphingosine-1-phosphate lyase is involved in the differentiation of F9 embryonal carcinoma cells to primitive endoderm

scientific article published on 12 February 2003

Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor

scientific article published on 01 November 2018

Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1.

scientific article published on 27 May 2013

Subunit a of proton ATPase F0 sector is a substrate of the FtsH protease in Escherichia coli.

scientific article

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides.

scientific article published on 20 April 2016

Systematic analysis of Ca2+ homeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles

scientific article published on 31 May 2017

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.

scientific article

The C-terminal Cytosolic Region of Rim21 Senses Alterations in Plasma Membrane Lipid Composition: INSIGHTS INTO SENSING MECHANISMS FOR PLASMA MEMBRANE LIPID ASYMMETRY.

scientific article

The Rim101 pathway contributes to ER stress adaptation through sensing the state of plasma membrane.

scientific article published on November 2016

The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry

scientific article

The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.

scientific article

The role of PNPLA1 in ω-O-acylceramide synthesis and skin barrier function

scientific article published on 02 October 2018

The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells

scientific article published on 15 May 2019

Translocation, folding, and stability of the HflKC complex with signal anchor topogenic sequences

scientific article

Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p

scientific article

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

scientific article

Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

scientific article (publication date: 2014)

Unperverted synthesis of complex sphingolipids is essential for cell survival under nitrogen starvation

scientific article published on 22 May 2013

Very long-chain fatty acids: elongation, physiology and related disorders ⬇️

scientific article published on September 14, 2012

Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice.

scientific article published on 17 January 2018

Widespread tissue distribution and synthetic pathway of polyunsaturated C24:2 sphingolipids in mammals

scientific article published on 11 September 2018

Yeast Mpo1 Is a Novel Dioxygenase That Catalyzes the α-Oxidation of a 2-Hydroxy Fatty Acid in an Fe2+-Dependent Manner

scientific article published on 15 February 2019

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