List of works - Lyn-Marie Birkholtz

17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines.

scientific article published on 22 January 2014

A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines

scientific article published on 22 April 2015

A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual and Sexual Development

scientific article published on 17 January 2022

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

scientific article published on 26 October 2015

A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail

scientific article

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.

scientific article published on 8 December 2017

Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites

scientific article published on April 2013

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

scientific article published on 17 January 2017

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

scientific article

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

scientific article published on 27 July 2018

Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae)

scholarly article published by Lyn-Marie Birkholtz in 2019

Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum

scientific article published on 22 July 2011

Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.

scientific article published on 10 December 2008

Comparative properties of a three-dimensional model of Plasmodium falciparum ornithine decarboxylase.

scientific article

Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study

scientific article published on 22 May 2007

Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy

scientific article published on 22 September 2014

Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities

scientific article published on 18 May 2016

Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs

scientific article

Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities

scientific article

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

scientific article

Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum.

scientific article published on 09 December 2009

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

scientific article published on 01 April 2021

Heterologous expression of plasmodial proteins for structural studies and functional annotation

scientific article published on October 2008

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

scientific article published on 03 December 2019

Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases

scientific article published on 20 November 2020

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

scientific article published on 17 October 2016

In silico Discovery of Chemotherapeutic Agents

In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species

scientific article published on 16 March 2016

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

scientific article published in Scientific Reports

Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine.

scientific article published on 10 May 2012

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

scientific article

Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

scientific article published on 28 January 2015

Molecular Imaging of a Zirconium-89 Labeled Antibody Targeting Plasmodium falciparum-Infected Human Erythrocytes

scientific article published on 01 February 2020

Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes

scientific article

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action

scientific article published on 07 January 2019

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

scientific article published on 11 January 2021

Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?

scientific article published on 17 September 2020

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites

scientific article published on 05 December 2013

Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling

scientific article

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

scientific article published on 22 May 2015

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions

scientific article published on January 2004

Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

scientific article

Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

scientific article (publication date: September 2011)

Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum

scientific article published on 2 August 2012

Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials

scientific article published on 6 February 2018

Preliminary Evaluation of Artemisinin-Cholesterol Conjugates as Potential Drugs for the Treatment of Intractable Forms of Malaria and Tuberculosis

scientific article published on 28 November 2017

Proteomic profiling of Plasmodium falciparum through improved, semiquantitative two-dimensional gel electrophoresis

scientific article published in May 2010

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites

scientific article

Resisting resistance: is there a solution for malaria?

scientific article published on 29 February 2016

Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities

scientific article published on 9 May 2016

Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase

scientific article published on 13 December 2006

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria

scientific article published on 24 December 2018

Sustainable malaria control: transdisciplinary approaches for translational applications

scientific article published on 26 December 2012

Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters

scientific article

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

scholarly article by Christo de Lange published in October 2018

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives

scientific article published on 26 December 2017

Thermo-responsive non-woven scaffolds for "smart" 3D cell culture.

scientific article

Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion

scientific article published in February 2008

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

scientific article published on 27 August 2018

Ultralow-density Plasmodium falciparum Infections in African Settings

scientific article published on 01 September 2019

Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.

scientific article published on 20 March 2018

Use of a Chimeric Hsp70 to Enhance the Quality of Recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase Protein Produced in Escherichia coli

scientific article

List of works by Lyn-Marie Birkholtz

17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines.

A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines

A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual and Sexual Development

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.

Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae)

Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum

Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.

Comparative properties of a three-dimensional model of Plasmodium falciparum ornithine decarboxylase.

Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study

Differential activity of novel gametocytocidal compounds: drug mode-of-action and ex vivo efficacy

Discovering New Transmission-Blocking Antimalarial Compounds: Challenges and Opportunities

Discovery of compounds blocking the proliferation of Toxoplasma gondii and Plasmodium falciparum in a chemical space based on piperidinyl-benzimidazolone analogs

Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum

Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum.

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum

Heterologous expression of plasmodial proteins for structural studies and functional annotation

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

In silico Discovery of Chemotherapeutic Agents

In vitro inhibition of Plasmodium falciparum early and late stage gametocyte viability by extracts from eight traditionally used South African plant species

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine.

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites

Molecular Imaging of a Zirconium-89 Labeled Antibody Targeting Plasmodium falciparum-Infected Human Erythrocytes

Morphological and Molecular Descriptors of the Developmental Cycle of Babesia divergens Parasites in Human Erythrocytes

Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites

Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination.

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions

Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum

Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials

Preliminary Evaluation of Artemisinin-Cholesterol Conjugates as Potential Drugs for the Treatment of Intractable Forms of Malaria and Tuberculosis

Proteomic profiling of Plasmodium falciparum through improved, semiquantitative two-dimensional gel electrophoresis

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites

Resisting resistance: is there a solution for malaria?

Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities

Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase

Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria

Sustainable malaria control: transdisciplinary approaches for translational applications

Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives

Thermo-responsive non-woven scaffolds for "smart" 3D cell culture.

Transcriptional responses of Plasmodium falciparum to alpha-difluoromethylornithine-induced polyamine depletion

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Ultralow-density Plasmodium falciparum Infections in African Settings

Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa.

Use of a Chimeric Hsp70 to Enhance the Quality of Recombinant Plasmodium falciparum S-Adenosylmethionine Decarboxylase Protein Produced in Escherichia coli