List of works - Zachary Pursell

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

scientific article

DNA polymerase epsilon: a polymerase of unusual size (and complexity).

scientific article published on January 2008

DNA polymerase ε and its roles in genome stability

scientific article

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

scientific article

Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA.

scientific article

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

scientific article

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

scientific article published on 28 February 2018

Human DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides

scientific article

Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction

scientific article published on 17 September 2013

Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon

scientific article

Mismatch repair balances leading and lagging strand DNA replication fidelity.

scientific article

Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.

scientific article

Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development

scientific article published on 03 March 2022

Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.

scientific article published on 22 April 2007

The high fidelity and unique error signature of human DNA polymerase epsilon

scientific article

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.

scientific article published on 14 February 2008

Yeast DNA polymerase epsilon participates in leading-strand DNA replication

scientific article

List of works by Zachary Pursell

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

DNA polymerase epsilon: a polymerase of unusual size (and complexity).

DNA polymerase ε and its roles in genome stability

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA.

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

Human DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides

Human Pol ε-dependent replication errors and the influence of mismatch repair on their correction

Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon

Mismatch repair balances leading and lagging strand DNA replication fidelity.

Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε.

Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development

Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.

The high fidelity and unique error signature of human DNA polymerase epsilon

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.

Yeast DNA polymerase epsilon participates in leading-strand DNA replication