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List of works by Hieronim Jakubowski

A role for protein--protein interactions in the maintenance of active forms of aminoacyl-tRNA synthetases

scientific article published on July 1979

Adenosylhomocysteinase: adenosine complex

scientific article published in October 1978

Aggregation and structural changes of α(S1)-, β- and κ-caseins induced by homocysteinylation.

scientific article published on 12 June 2011

Amino acid selectivity in the aminoacylation of coenzyme A and RNA minihelices by aminoacyl-tRNA synthetases

scientific article published on 01 November 2000

Aminoacyl Thioester Chemistry of Class II Aminoacyl-tRNA Synthetases ⬇️

scientific article published on September 16, 1997

Aminoacyl-tRNA synthetases and the evolution of coded peptide synthesis: the Thioester World

scientific article published on 2 February 2016

Aminoacylation of coenzyme A and pantetheine by aminoacyl-tRNA synthetases: possible link between noncoded and coded peptide synthesis

scientific article published on 01 April 1998

An on-column derivatization method for the determination of homocysteine-thiolactone and protein N-linked homocysteine

scientific article published on 04 March 2010

Analysis of site-specific N-homocysteinylation of human serum albumin in vitro and in vivo using MALDI-ToF and LC-MS/MS mass spectrometry

scientific article

Anti-N-homocysteinylated protein autoantibodies and cardiovascular disease

scientific article

Antibodies to N-homocysteinylated albumin as a marker for early-onset coronary artery disease in men

scientific article published on 01 February 2005

Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis

scientific article

Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis

scientific article published on 16 March 2014

Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation

scientific article published on 01 February 2000

Cation exchange HPLC analysis of desmosines in elastin hydrolysates

scientific article published on 02 September 2011

Chemical biology of homocysteine thiolactone and related metabolites

scientific article published on January 2011

Chromatography of plant aminoacyl-tRNA synthetases on omega-aminoalkyl sepharose columns

scientific article published on 01 August 1973

Control of RNA and protein synthesis by the concentration of Trp-tRNATrp in Escherichia coli infected with bacteriophage MS2

scientific article published on 01 August 1983

Copper, heart disease and homocysteine thiolactone

scientific article published on 04 May 2020

Cross-talk between Cys34 and lysine residues in human serum albumin revealed by N-homocysteinylation

scientific article

Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs-/- mice and thrombosis-prone CBS-/- humans

scientific article published on 01 July 2020

Demethylation of methionine and keratin damage in human hair.

scientific article published on 26 February 2018

Design and properties of efficient tRNA:EF-Tu FRET system for studies of ribosomal translation

scientific article published on 26 February 2013

Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells.

scientific article

Direct monitoring of albumin lysine-525 N-homocysteinylation in human serum by liquid chromatography/mass spectrometry.

scientific article published on 5 July 2010

Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia

scientific article published on 27 June 2019

Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice

scientific journal article

Effects of Endurance and Endurance-strength Exercise on Renal Function in Abdominally Obese Women with Renal Hyperfiltration: A Prospective Randomized Trial.

scientific article

Effects of betaine on body composition, performance, and homocysteine thiolactone.

scientific article published on 22 August 2013

Effects of endurance and endurance-strength exercise on biochemical parameters of liver function in women with abdominal obesity.

scientific article

Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation

scientific article published on 31 January 2011

Evidence that uncharged tRNA can inhibit a programmed translational frameshift in Escherichia coli.

scientific article

Facile syntheses of [35S]homocysteine-thiolactone, [35S]homocystine, [35S]homocysteine, and [S-nitroso-35S]homocysteine

scientific article published on 07 June 2007

Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice

scientific article published on 31 August 2019

Folic acid administration and antibodies against homocysteinylated proteins in subjects with hyperhomocysteinemia

scientific article published in September 2006

Fractionation of plant aminoacyl-tRNA synthetases on tRNA-Sepharose columns

scientific article published on 01 October 1975

Garlic extract favorably modifies markers of endothelial function in obese patients -randomized double blind placebo-controlled nutritional intervention.

scientific article published on 28 March 2018

Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans

scientific article published on 28 November 2020

Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis.

scientific article

Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice

scientific article published on 9 February 2009

Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees.

scientific article published on November 2002

Homocysteine Editing, Thioester Chemistry, Coenzyme A, and the Origin of Coded Peptide Synthesis †.

scientific article published on 09 February 2017

Homocysteine Modification in Protein Structure/Function and Human Disease

scientific article published on 01 January 2019

Homocysteine editing and growth inhibition in Escherichia coli

scientific article published on 21 April 2009

Homocysteine is a protein amino acid in humans. Implications for homocysteine-linked disease

scientific article published in July 2002

Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells.

scientific article published on 24 March 2015

Homocysteine-thiolactone and S-nitroso-homocysteine mediate incorporation of homocysteine into protein in humans.

scientific article published on November 2003

Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration.

scientific article published in January 2014

Identification and origin of Nε-homocysteinyl-lysine isopeptide in humans and mice.

scientific article published on 30 May 2010

Identification of N-homocysteinylation sites in plasma proteins.

scientific article

Immunohistochemical detection of N-homocysteinylated proteins in humans and mice.

scientific article

Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration

scientific article published in January 2014

Incomplete aminoacylation of tRNALeu catalyzed in vitro by leucyl-tRNA synthetase from Escherichia coli B.

scientific article published on April 1978

L-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats.

scientific article published on 14 November 2015

Labeled EF-Tus for rapid kinetic studies of pretranslocation complex formation

scientific article

Letter by Undas and Jakubowski regarding article, "Relationship between homocysteine and mortality in chronic kidney disease"

scientific article published on 01 October 2006

Mechanism of the condensation of homocysteine thiolactone with aldehydes

scientific article published on 01 October 2006

Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1.

scientific article published on January 2012

Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase.

scientific article published on 8 January 2012

Metabolism of homocysteine-thiolactone in plants.

scientific article

Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease

scientific article published on 24 May 2014

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs

scientific article

Misacylation of tRNALys with noncognate amino acids by lysyl-tRNA synthetase

scientific article published on 01 June 1999

Modification by homocysteine thiolactone affects redox status of cytochrome C.

scientific article

Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat.

scientific article published on 2 November 2009

Molecular basis of homocysteine toxicity in humans.

scientific article published on February 2004

Mutations in Homocysteine Metabolism Genes Increase Keratin -Homocysteinylation and Damage in Mice

article

Mutations in cystathionine beta-synthase or methylenetetrahydrofolate reductase gene increase N-homocysteinylated protein levels in humans

scientific article published on 15 August 2008

Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice

scientific article published on 27 February 2007

N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities.

scientific article published on 16 August 2016

N-homocysteinylation of ovine prion protein induces amyloid-like transformation

scientific article published on 7 July 2012

Negative correlation between the abundance of Escherichia coli aminoacyl-tRNA families and their affinities for elongation factor Tu-GTP.

scientific article

New method for the determination of protein N-linked homocysteine

scientific article

On the health benefits of Allium sp

scientific article published on 01 February 2003

On-column derivatization with o-phthaldialdehyde for fast determination of homocysteine in human urine.

scientific article published on 2 February 2010

Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans

scientific article published on 21 May 2018

Paraoxonase 1 and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis

scientific article published on 28 October 2014

Paraoxonase 1 and homocysteine metabolism.

scientific article

Paraoxonase 1 deficiency and hyperhomocysteinemia alter the expression of mouse kidney proteins involved in renal disease

scientific article published on 17 July 2014

Paraoxonase 1 protects against protein N-homocysteinylation in humans

scientific article published on 30 October 2009

Pathophysiological consequences of homocysteine excess

scientific article

Phosphonate analogues of diadenosine 5',5'''-P1,P4-tetraphosphate as substrates or inhibitors of procaryotic and eucaryotic enzymes degrading dinucleoside tetraphosphates.

scientific article

Plasma Homocysteine Affects Fibrin Clot Permeability and Resistance to Lysis in Human Subjects

scientific article published in June 2006

Plasma homocysteine is a determinant of tissue necrosis factor-alpha in hypertensive patients.

scientific article

Plasma total homocysteine is a determinant of carotid intima-media thickness and circulating endothelial progenitor cells in patients with newly diagnosed hypertension

scientific article published on 14 January 2012

Polyamines and yellow lupin aminoacyl-tRNA synthetases. Spermine and spermidine help to maintain the active structures of aminoacyl-tRNA synthetases

scientific article published on 01 January 1980

Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency.

scientific article published on 3 April 2007

Proofreading in trans by an aminoacyl-tRNA synthetase: a model for single site editing by isoleucyl-tRNA synthetase

scientific article

Properties of Escherichia coli EF-Tu mutants designed for fluorescence resonance energy transfer from tRNA molecules

scientific article

Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase.

scientific article

Protein N-Homocysteinylation and Colorectal Cancer

scientific article published on 13 November 2018

Protein N-homocysteinylation: implications for atherosclerosis.

scientific article

Proteome-Wide Analysis of Protein Lysine N -Homocysteinylation in Saccharomyces cerevisiae

scientific article published on 2 April 2021

Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic

scientific article published on 15 December 2020

Purification of antibodies against N-homocysteinylated proteins by affinity chromatography on Nomega-homocysteinyl-aminohexyl-Agarose

scientific article

Quality control in tRNA charging

scientific article

Quality control in tRNA charging -- editing of homocysteine.

scientific article published on 06 June 2011

Quantification of homocysteine and cysteine by derivatization with pyridoxal 5'-phosphate and hydrophilic interaction liquid chromatography

scientific article published on 21 January 2016

Quantification of homocysteine thiolactone in human saliva and urine by gas chromatography-mass spectrometry

scientific article published on 15 May 2020

Quantification of urinary S- and N-homocysteinylated protein and homocysteine-thiolactone in mice.

scientific article published on 9 June 2016

Reduced homocysteine-thiolactonase activity in Alzheimer's disease

scientific article published in January 2010

Relationship between protein synthesis and concentrations of charged and uncharged tRNATrp in Escherichia coli.

scientific article published on February 1990

Role of carboxy-terminal region in proofreading function of methionyl-tRNA synthetase in Escherichia coli.

scientific article

Role of homocysteine in aortic calcification and osteogenic cell differentiation

scientific article published on 28 May 2008

Role of the metF and metJ genes on the vitamin B12 regulation of methionine gene expression: involvement of N5-methyltetrahydrofolic acid.

scientific article published in January 1992

S-Adenosylhomocysteinase from yellow lupin seeds: stoichiometry and reactions of the enzyme-adenosine complex

scientific article published on 01 November 1981

Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes

scientific article published on 25 June 2019

Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice

scientific article published on 25 February 2019

Simultaneous Determination of Methionine and Homocysteine by on-column derivatization with o-phtaldialdehyde

scientific article published on 15 September 2016

Substrate specificity of S-adenosylhomocysteinase. Cysteine is a substrate of the plant and mammalian enzymes.

scientific article published on January 1983

Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase

scientific article

Synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate (AppppA) from adenosine 5'-phosphosulfate and adenosine 5'-triphosphate catalyzed by yeast AppppA phosphorylase.

scientific article published in April 1988

Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells

scientific article published on February 1993

Telomere Length and mtDNA Copy Number in Human Cystathionine β-synthase Deficiency

scientific article published on 05 August 2020

The Cbs Locus Affects the Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice

scientific article published on 05 April 2020

The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study

scientific article published on 02 April 2020

The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice

scientific article published on 25 October 2016

The determination of aminoacyl adenylate by thin-layer chromatography

scientific article

The determination of homocysteine-thiolactone in biological samples

scientific article published in September 2002

The determination of homocysteine-thiolactone in human plasma.

scientific article published in February 2005

The effects of age and hyperhomocysteinemia on the redox forms of plasma thiols

scientific article published in November 2004

The influence of selected antihypertensive drugs on zinc, copper, and iron status in spontaneously hypertensive rats.

scientific article published on 11 June 2014

The mechanism of inhibition of valyl-tRNA synthetase by S-adenosylhomocysteine.

scientific article published in December 1982

The mechanism of the aminoacylation of transfer ribonucleic acid. The kinetics and stoichiometry of the lysis of aminoacyl-tRNA.

scientific article published on October 1978

The molecular basis of homocysteine thiolactone-mediated vascular disease

scientific article published on January 2007

The nomenclature of 1-aminoalkylphosphonic acids and derivatives: evolution of the code system.

scientific article published on 2 March 2015

The role of paraoxonase 1 in the detoxification of homocysteine thiolactone

scientific article published on January 2010

The synthetic/editing active site of an aminoacyl-tRNA synthetase: evidence for binding of thiols in the editing subsite.

scientific article

Transfer RNA methyltransferases from yellow lupin seeds: purification and properties ⬇️

scientific article published on January 1, 1975

Translational incorporation of S-nitrosohomocysteine into protein

scientific article published on 01 July 2000

Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial

scientific article published on 23 September 2018

Urinary excretion of homocysteine-thiolactone in humans

scientific article published on 2 December 2004

Use of omega-aminohexyl-sepharose in the fractionation of Escherichia coli B aminoacyl-tRNA synthetases

scientific article published on 01 September 1977

Valyl-tRNA synthetase from yellow lupin seeds. Instability of enzyme-bound noncognate adenylates versus cognate adenylate

scientific article published on November 15, 1978

Valyl-tRNA synthetase from yellow lupin seeds: hydrolysis of the enzyme-bound noncognate aminoacyl adenylate as a possible mechanism of increasing specificity of the aminoacyl-tRNA synthetase ⬇️

scientific article published on October 28, 1980

Yeast cytoplasmic and mitochondrial methionyl-tRNA synthetases: two structural frameworks for identical functions

scientific article published in August 2001

Yellow lupin (Lupinus luteus) aminoacyl-tRNA synthetases. Isolation and some properties of enzyme-bound valyl adenylate and seryl adenylate

scientific article published on December 1978

[The role of homocysteine thiolactone in some of human diseases]

scientific article published on 01 January 2006

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