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List of works by Janko Nikolich-Žugich

A critical role for the cytoplasmic tail of pTα in T lymphocyte development

article

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.

scientific article published on 4 June 2018

Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses

scientific article

Acute systemic DNA damage in youth does not impair immune defense with aging

scientific article

Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging

scientific article published on 11 March 2020

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

scientific article

Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA

scientific article published on May 2013

Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense

scientific article

Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals

scientific article published in September 2006

Age-related changes in CD8 T cell homeostasis and immunity to infection

scientific article

Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication

scientific article

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections

scientific article published on July 2008

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans

scientific article published on 05 February 2014

Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories

scientific article

An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned

scientific article

Antibody Responses to SARS-CoV-2: Let's Stick to Known Knowns

scientific article published on 04 September 2020

Author Correction: Charles D. Surh 1960-2017.

scientific article published on 8 December 2017

Author Correction: The twilight of immunity: emerging concepts in aging of the immune system

scientific article published on 01 October 2018

CMV and Immunosenescence: from basics to clinics

scientific article published on 31 October 2012

Charles D. Surh 1960-2017.

scientific article

Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice

scientific article published on 16 August 2013

Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.

scientific article

Correction: Loss of Naive T Cells and Repertoire Constriction Predict Poor Response to Vaccination in Old Primates

Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses

scientific article published on 14 June 2017

Cutting edge: TLR ligands increase TCR triggering by slowing peptide-MHC class I decay rates

scientific article published on October 2008

Cytomegalovirus (CMV) research in immune senescence comes of age: overview of the 6th International Workshop on CMV and Immunosenescence.

scientific article published on 17 June 2017

Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging

scientific article

Cytomegalovirus-specific T cell immunity is maintained in immunosenescent rhesus macaques

scientific article

Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

scientific article

Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection

scientific article

Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense

scientific article

Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection

scientific article

Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?

scientific article published in April 2019

Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates

scholarly article

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

scientific article

Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques

scientific article

Effective control of chronic gamma-herpesvirus infection by unconventional MHC Class Ia-independent CD8 T cells

scientific article published on 19 May 2006

Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire

scientific article

Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice

scientific article published in November 2004

Functional CD8 T cell memory responding to persistent latent infection is maintained for life

scientific article

Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma

scientific article published on 14 June 2017

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

scientific article published on 27 February 2015

High specificity, not degeneracy, allows T cell alloresponses

scientific article published on 01 April 2007

Histone deacetylation critically determines T cell subset radiosensitivity

scientific article

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

scientific article published on 06 June 2016

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

scientific article

Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections

scientific article published on 2 September 2015

Immune memory and aging: an infinite or finite resource?

scientific article

Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections

scientific article

Immune response to the West Nile virus in aged non-human primates

scientific article

Immune responses in the skin in old age.

scientific article published on 22 June 2011

Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort

scientific article published on 28 September 2018

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

scientific article

Increased efficiency of phorbol ester-induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus during S phase

scientific article

Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors

scientific article

Inflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens

scientific article

Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging

scientific article published on 11 January 2018

Key research opportunities in immune system aging

scientific article published on 27 February 2009

Key role of T cell defects in age-related vulnerability to West Nile virus

scientific article (publication date: 23 November 2009)

Known unknowns: how might the persistent herpesvirome shape immunity and aging?

scientific article published on 3 August 2017

Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection

article published in the Proceedings of the National Academy of Sciences of the United States of America

Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life

scientific article

Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms

scientific article

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates

scientific article

Lost in translation: mice, men and cutaneous immunity in old age.

scientific article published on 16 July 2014

MIFlowCyt: the minimum information about a Flow Cytometry Experiment

scientific article

Mice and flies and monkeys too: caloric restriction rejuvenates the aging immune system of non-human primates

scientific article

Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo

scientific article published in January 2006

Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus

scientific article (publication date: April 2014)

New advances in CMV and immunosenescence

scientific article

Non-human primate models of T-cell reconstitution

scientific article

Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

scientific article

Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates

scientific article published on December 2008

Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets

scientific article published on 17 July 2003

Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection

scientific article published on July 2007

Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis

scientific article

Report from the second cytomegalovirus and immunosenescence workshop

scientific article published on 28 October 2011

Role of cell-intrinsic and environmental age-related changes in altered maintenance of murine T cells in lymphoid organs

scientific article published on 3 June 2017

Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension

scientific article

Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans

scientific article

Structural basis for the restoration of TCR recognition of an MHC allelic variant by peptide secondary anchor substitution

scientific article

Sultam Thiourea Inhibition of West Nile Virus

scientific article

T cell aging: naive but not young

scientific article

T cell recognition of an engineered MHC class I molecule: implications for peptide-independent alloreactivity

scientific article

The Global Thymus Network: past, present and future

scientific article published on 08 April 2009

The aging immune system: Challenges for the 21st century ⬇️

scientific article published on October 1, 2012

The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence

The many important facets of T-cell repertoire diversity

scientific article published on February 2004

The role of mhc polymorphism in anti-microbial resistance

scientific article published on April 2004

The twilight of immunity: emerging concepts in aging of the immune system

scientific article

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency

scientific article published on 20 November 2017

Translational research in immune senescence: assessing the relevance of current models

scientific article

Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging

scientific article

Varicella zoster-specific CD4+Foxp3+ T cells accumulate after cutaneous antigen challenge in humans

scientific article published on 2 January 2013

West Nile Virus Capsid Degradation of Claudin Proteins Disrupts Epithelial Barrier Function

scientific article published in June 2009

West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of v 3 Integrin

scientific article (publication date: June 2008)

West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis

scientific article (publication date: October 2007)

West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection

scientific article

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