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List of works by Ger Stienen

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

scientific journal article

ATP utilization for calcium uptake and force production in different types of human skeletal muscle fibres

scientific article

ATP utilization for calcium uptake and force production in skinned muscle fibres of Xenopus laevis

article

ATPase Activity and Force Production in Skinned Rat Cardiac Muscle under Isometric and Dynamic Conditions

article

ATPase activity of intact single muscle fibres of Xenopus laevis is related to the rate of force redevelopment after rapid shortening

scientific article published in January 1987

Age-dependent changes in myosin composition correlate with enhanced economy of contraction in guinea-pig hearts

article

Alterations in contractile protein composition and function in human atrial dilatation and atrial fibrillation

article

Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction

scientific article published on 4 November 2004

Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2).

scientific article

Calcium handling by the sarcoplasmic reticulum during oscillatory contractions of skinned skeletal muscle fibres

scientific article published on 01 August 1998

Calcium modulates the influence of length changes on the myofibrillar adenosine triphosphatase activity in rat skinned cardiac trabeculae

scientific article published on 01 November 1993

Calcium sensitivity of force in human ventricular cardiomyocytes from donor and failing hearts.

scientific article published in January 2002

Calpain-I induced alterations in the cytoskeletal structure and impaired mechanical properties of single myocytes of rat heart

scientific article published on 01 March 2000

Cardiomyocyte Stiffness in Diastolic Heart Failure

scientific article published on 07 February 2005

Cellular mechanisms of contractile dysfunction in hibernating myocardium

scientific article published on 4 March 2004

Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy.

scientific article

Chemo-mechanical energy transduction in relation to myosin isoform composition in skeletal muscle fibres of the rat

article

Chronicle of skinned muscle fibres

scientific article published on 01 August 2000

Contractile Dysfunction of Left Ventricular Cardiomyocytes in Patients With Pulmonary Arterial Hypertension

scientific article published on 01 July 2014

Cooperative behavior of molecular motors.

scientific article

Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension ⬇️

scientific article published on 24 June 2015

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

scientific article published on 28 May 2013

Depression of force by phosphate in skinned skeletal muscle fibers of the frog

scientific article published in August 1990

Depression of force production and ATPase activity in different types of human skeletal muscle fibers from patients with chronic heart failure.

scientific article published on 28 July 2005

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol

scientific article

Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness.

scientific article

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension

scientific article published on 03 December 2010

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

scientific article published in April 2014

Diaphragm muscle fiber function and structure in humans with hemidiaphragm paralysis.

scientific article published on 27 May 2011

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients

scientific article published on May 2015

Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction

scientific article published on 07 September 2012

Diastolic Stiffness of the Failing Diabetic Heart

scientific article published on 10 December 2007

Differential effects of length on maximum force production and myofibrillar ATPase activity in rat skinned cardiac muscle

article

Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction

scientific article

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

scientific article published on 12 January 2018

ENerGetIcs in hypertrophic cardiomyopathy: traNslation between MRI, PET and cardiac myofilament function (ENGINE study).

scientific article published on December 2013

Early Exercise Training Normalizes Myofilament Function and Attenuates Left Ventricular Pump Dysfunction in Mice With a Large Myocardial Infarction

scientific article published on 08 March 2007

Early adjustments in mitochondrial structure and function in skeletal muscle to high altitude: design and rationale of the first study from the Kilimanjaro Biobank

scientific article published on 22 June 2020

Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts

scientific article published on 9 September 2010

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

scientific article published on 28 April 2015

Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes

scientific article published on 01 June 2000

Effects of 2,3-butanedione monoxime on cross-bridge kinetics in rat cardiac muscle

scientific article published on 01 September 1996

Effects of Ca2+ -sensitizers in permeabilized cardiac myocytes from donor and end-stage failing human hearts

scientific article published in January 2004

Effects of MgATP on ATP utilization and force under normal and simulated ischaemic conditions in rat cardiac trabeculae

scientific article published in October 2001

Effects of contractile protein phosphorylation on force development in permeabilized rat cardiac myocytes.

scientific article published on 05 June 2007

Effects of osmolality and ionic strength on the mechanism of Ca2+ release in skinned skeletal muscle fibres of the toad

scientific article published on 01 May 1993

Effects of pH on myofibrillar ATPase activity in fast and slow skeletal muscle fibers of the rabbit

scientific article published in December 1994

Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits.

scientific article published on 17 October 2016

Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium

scientific article published on 13 December 2010

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes

scientific article published on 12 June 2008

Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes

scholarly article by Theresia Kraft published in April 2013

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

scientific article published on 13 June 2014

Force and force transients in skeletal muscle fibres of the frog skinned by freeze-drying

scientific article published on 01 June 1983

Force and myosin content variation in isolated intact single muscle fibres from Rana temporaria

scientific article published on 01 July 1997

Force production in mechanically isolated cardiac myocytes from human ventricular muscle tissue.

scientific article

Force relaxation, labile heat and parvalbumin content of skeletal muscle fibres of Xenopus laevis

scientific article published on 01 April 1993

Force-dependent and force-independent heat production in single slow- and fast-twitch muscle fibres from Xenopus laevis

article

Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium

scientific article published on 03 May 2007

Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.

scientific article published on 27 December 2005

Gene expression profile in the diaphragm following contractile inactivity during thoracic surgery.

scientific article

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations

article

Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium.

scientific article published on 29 January 2009

Impact of temperature on cross-bridge cycling kinetics in rat myocardium

scientific article published on 23 August 2007

Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle

scientific article

In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype

article

Increase in ATP consumption during shortening in skinned fibres from rabbit psoas muscle: effects of inorganic phosphate

scientific article published on 01 October 1996

Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

scientific article (publication date: 2003)

Increased nitrosative/oxidative stress lowers myocardial protein kinase G activity in heart failure with preserved ejection fraction.

scientific article published on 29 August 2013

Influence of Inorganic Phosphate on ATP in Fast and Slow Skeletal Muscle Fibers of the Rabbit under Isometric Conditions and during Isovelocity Shortenings

Influence of inorganic phosphate and pH on ATP utilization in fast and slow skeletal muscle fibers.

scientific article published on December 1995

Influence of inorganic phosphate and pH on sarcoplasmic reticular ATPase in skinned muscle fibres of Xenopus laevis

scientific article published on 01 August 1999

Influence of phosphate and pH on myofibrillar ATPase activity and force in skinned cardiac trabeculae from rat

scientific article published on 01 May 1994

Inotropic interventions do not change the resting state of myosin motors during cardiac diastole

scientific article published on 03 December 2018

Isometric force production before and after chemical skinning in isolated muscle fibres of the frog Rana temporaria

scientific article published in March 1989

Isometric tension development and its calcium sensitivity in skinned myocyte-sized preparations from different regions of the human heart

article

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

scientific article

Low myocardial protein kinase G activity in heart failure with preserved ejection fraction

scientific article published on 17 July 2012

Mechanical properties of skinned rabbit psoas and soleus muscle fibres during lengthening: effects of phosphate and Ca2+

scientific article published on 01 January 1992

Minoxidil-induced cardiac hypertrophy in guinea pigs

scientific article published on 01 May 1999

Mitochondrial Ca2+-handling in fast skeletal muscle fibers from wild type and calsequestrin-null mice

scientific article

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure.

scientific article published on 11 July 2016

More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.

scientific article

Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs.

scientific article

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

scientific article published on 13 May 2013

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

scientific article published on 17 April 2006

Myocardial adaptations in the failing heart: cause or consequence?

scientific article published on January 2008

Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue

scientific article

Myocardial force development and structural changes associated with monocrotaline induced cardiac hypertrophy and heart failure

scientific article published in January 2002

Myofibrillar ATPase activity and mechanical performance of skinned fibres from rabbit psoas muscle

scientific article published on 01 January 1994

Myofibrillar ATPase activity during isometric contraction and isomyosin composition in rat single skinned muscle fibres

article

Myofibrillar ATPase activity in skinned human skeletal muscle fibres: fibre type and temperature dependence

scientific article published on 01 June 1996

Myofilament degradation and dysfunction of human cardiomyocytes in Fabry disease.

scientific article published on 8 May 2008

Myofilament dysfunction in cardiac disease from mice to men.

scientific article published on January 2008

Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium

scientific article

Myosin light chain composition in non-failing donor and end-stage failing human ventricular myocardium.

scientific article published on January 2003

Negative and positive inotropic effects of propofol via L-type calcium channels and the sodium-calcium exchanger in rat cardiac trabeculae

scientific article published in November 2002

No direct effect of creatine phosphate on the cross-bridge cycle in cardiac myofibrils

scientific article published on 5 January 2006

Optical trap stiffness in the presence and absence of spherical aberrations

scientific article published in March 2006

Origin of concurrent ATPase activities in skinned cardiac trabeculae from rat.

scientific article

Oxidation of myofilament protein sulfhydryl groups reduces the contractile force and its Ca2+ sensitivity in human cardiomyocytes

scientific article published in July 2008

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis

scientific article

Pathomechanisms in heart failure: the contractile connection.

scientific article

Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells

scientific article published on 26 April 2005

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes

scientific article (publication date: 15 July 2014)

Post-tetanic potentiation increases energy cost to a higher extent than work in rat fast skeletal muscle

scientific article published in January 2001

Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats

scientific article

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations

scientific article published on 2 November 2013

Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling

scientific article published on 25 March 2009

Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertension

scientific article

Protein kinase A does not alter economy of force maintenance in skinned rat cardiac trabeculae.

scientific article published on May 1995

Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium

scientific article

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium

scientific article

Quadriceps muscle fibre dysfunction in patients with pulmonary arterial hypertension

article published in 2015

Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies

article

Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity.

scientific article published on 13 March 2015

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes.

scientific article

Rate of tension redevelopment is not modulated by sarcomere length in permeabilized human, murine, and porcine cardiomyocytes

scientific article published on 16 November 2006

Reactive oxygen species-induced stimulation of 5'AMP-activated protein kinase mediates sevoflurane-induced cardioprotection.

scientific article published in September 2009

Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium

scientific article published on 18 January 2007

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension.

scientific article published on 17 May 2016

Relation between force and calcium ion concentration in different fibre types of the iliofibularis muscle of Xenopus laevis

scientific article

Right ventricular diastolic impairment in patients with pulmonary arterial hypertension

scientific article published on 20 September 2013

Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat

scientific article published on 01 September 2006

Sarcomeric Myosin Isoforms: Fine Tuning of a Molecular Motor

scientific article published on 01 February 2000

Sarcomeric dysfunction contributes to muscle weakness in facioscapulohumeral muscular dystrophy

scientific article

Sarcomeric dysfunction in heart failure.

scientific article published on 30 November 2007

Selective Diaphragm Muscle Weakness After Contractile Inactivity During Thoracic Surgery

scientific article published on 01 December 2011

Size and speed of the working stroke of cardiac myosin in situ

scientific article published on 16 March 2016

Stable maintenance heat rate and contractile properties of different single muscle fibres from Xenopus laevis at 20 degrees C.

scientific article published in December 1987

Stunning does not change the relation between calcium and force in skinned rat trabeculae

scientific article published in May 1993

Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness ⬇️

scientific article published on 12 June 2015

Tension development and calcium sensitivity in skinned muscle fibres of the frog

article

Tension responses to rapid length changes in skinned muscle fibres of the frog

scientific article

The cardioprotective effect of sevoflurane depends on protein kinase C activation, opening of mitochondrial K(+)(ATP) channels, and the production of reactive oxygen species

scientific article published in November 2003

The differential effect of propofol on contractility of isolated myocardial trabeculae of rat and guinea-pig

scientific article

The effect of hyperosmolality on the rate of heat production of quiescent trabeculae isolated from the rat heart.

scientific article published on December 1996

The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts

scientific article (publication date: February 2003)

The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration

scientific article published on 27 May 2018

The influence of velocity of length change on tension development in skeletal muscle: model calculations and experimental results

scientific article published in January 1984

The mechanism of the force enhancement by MgADP under simulated ischaemic conditions in rat cardiac myocytes

scientific article published in August 2002

The striated muscles in pulmonary arterial hypertension: adaptations beyond the right ventricle.

scientific article published on 25 June 2015

Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency

scientific article published on 04 April 2009

Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome

scientific article published on 05 January 2012

Training one type of striated muscle to counteract failure of another type

scientific article published on 01 March 2012

Transmission phenomena and early tension recovery in skinned muscle fibres of the frog

article

Troponin I degradation and myocardial stunning

scientific article published on 01 December 2001

Troponin I phosphorylation in human myocardium in health and disease.

scientific article

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

scientific article

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation

scientific article

Uptake and caffeine-induced release of calcium in fast muscle fibers of Xenopus laevis: effects of MgATP and P(i)

scientific article published on 01 September 1993

Variation in normalized isometric tetanic force of isolated fast-twitch muscle fibres of Rana temporaria

scientific article published on 01 February 1997

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