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List of works by Stephen L. Nutt

A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation

scientific article published on 05 March 2019

A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.

scientific article published on 7 March 2016

A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics

scientific article published on 19 October 2020

A non-canonical function of Ezh2 preserves immune homeostasis.

scientific article published on 21 February 2017

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation

scientific article

A role for Blimp1 in the transcriptional network controlling natural killer cell maturation

scientific article published on 3 December 2010

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

scientific journal article

Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity.

scientific article published on September 2016

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia

scientific article published on 6 February 2015

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

scientific journal article

An Erg-driven transcriptional program controls B cell lymphopoiesis

scientific article published on 15 June 2020

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

scientific article published on December 2009

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

scientific article

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.

scientific article published on 5 March 2018

B cells need their flip-flops

scientific article published on 09 August 2011

B-cell identity--commitment is not forever

scientific article published in January 2008

Bach2: plasma-cell differentiation takes a break

scientific article published on December 2010

Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis.

scientific article published on 11 December 2007

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

scientific article published on 18 January 2016

Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses

scientific article

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.

scientific article published on 14 January 2016

Blimp1 is limiting for transformation in a mouse plasmacytoma model

scientific article published on 27 March 2009

Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice.

scientific article published in December 2007

Blimp1: driving terminal differentiation to a T.

scientific article published on January 2011

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

scientific article published on 07 June 2021

CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells

scientific article published on 11 December 2018

CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3.

scientific article

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

scientific article

Characterization of Blimp-1 function in effector regulatory T cells

scientific article published on 30 April 2018

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function

article published in the Proceedings of the National Academy of Sciences of the United States of America

Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction

scientific article published on 25 February 2013

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

scientific article published on 01 August 2019

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

scientific article published on 27 June 2017

Critical roles for c-Myb in hematopoietic progenitor cells.

scientific article published on 26 June 2008

Critical roles for c-Myb in lymphoid priming and early B-cell development

scientific article

Cytokine profile and induction of T helper type 17 and regulatory T cells by human peripheral mononuclear cells after microbial exposure.

scientific article published on February 2012

Deciphering the epigenetic code of T lymphocytes

scientific article

Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene.

scientific article

Differential RNA editing efficiency of AMPA receptor subunit GluR-2 in human brain

scientific article published on 01 August 1994

Differentiation and function of Foxp3(+) effector regulatory T cells.

scientific article published on 06 December 2012

Directing the conductor: TNF regulation of HSCs

scientific article published on 01 February 2019

Donald Metcalf (1929-2014)

scientific article published on 10 February 2015

Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development.

scientific article published on 23 May 2016

EZH2 function in immune cell development

scientific article published on 28 February 2020

Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.

scientific article

Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis

scientific article published on August 1998

Editorial overview

scientific article published on 13 April 2012

Editorial overview: Lymphocyte development and activation

article

Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice.

scientific article

Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb.

scientific article

Endogenous microglia regulate development of embryonic cortical precursor cells

scientific article published on 6 January 2011

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB.

scientific article published on 10 November 2017

Epigenetic modulators of B cell fate identified through coupled phenotype-transcriptome analysis

scientific article published in 2022

Erratum: Corrigendum: The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

scholarly article published in Nature Immunology

Erratum: Corrigendum: The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

article

Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

article

Essential functions of Pax-5 (BSAP) in pro-B cell development.

scientific article published on December 1997

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus

scientific article published in February 1997

Establishing and maintaining the Langerhans cell network

scientific article published on 07 February 2014

Exposing the core of early thymopoiesis

scientific article published on 01 August 2008

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

scientific article published on 2 February 2014

FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin

scientific article

Fidelity and infidelity in commitment to B-lymphocyte lineage development

scientific article

Functional subsets of mouse natural killer cells

scientific article published on December 2006

Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1

scientific article published on 07 April 2017

Germinal center B and follicular helper T cells: siblings, cousins or just good friends? ⬇️

scientific article published on June 1, 2011

Give and take in the germinal center

scientific article published on 01 June 2010

Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation

scientific article published on 15 August 2016

High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency

scientific article published on 27 August 2012

High affinity germinal center B cells are actively selected into the plasma cell compartment.

scientific article

Hippo Pathway Kinase Mst1 Is Required for Long-Lived Humoral Immunity

scientific article published on 26 November 2018

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.

scientific article

IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines.

scientific article published on 10 July 2009

IL-17-producing γδ T cells switch migratory patterns between resting and activated states

scientific article

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

scientific article

IL-7 and the thymus dictate the NK cell 'labor market'

scientific article published on 01 November 2006

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

scientific article published on 18 September 2018

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

scientific article published on 01 November 2019

Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages

scientific article

Id2 represses E2A-mediated activation of IL-10 expression in T cells.

scientific article published on 10 April 2014

Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation

scientific article

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

scientific article published on April 1998

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

article

Identification of the earliest NK-cell precursor in the mouse BM

scientific article published on 21 March 2011

Independent regulation of the two Pax5 alleles during B-cell development

scientific article published in April 1999

Inhibition of human B-cell development into plasmablasts by histone deacetylase inhibitor valproic acid

article

Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

scientific article published in May 2007

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells.

scientific article published on 14 August 2014

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

scientific article published on 01 August 2019

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

scientific article

Interleukin 21: a key player in lymphocyte maturation

scientific article

Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis

scientific article published on 25 October 2017

Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites

scientific article published on August 2015

LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins

scientific article published on 03 June 2018

Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks

scientific article

Lineage commitment in lymphopoiesis

scientific article

Long-Lived Plasma Cells Have a Sweet Tooth

scientific article published in July 2016

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

scientific article

Losing B cell identity

scientific article

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation

scientific article published in April 1998

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

scientific article published on 20 January 2015

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

scientific article

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge

scientific article (publication date: 7 December 2016)

Mcl-1 is essential for germinal center formation and B cell memory

scientific article

Mcl-1 is essential for the survival of plasma cells

scientific article

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

scientific article published on 24 July 2018

Mitochondrial function provides instructive signals for activation-induced B-cell fates

scientific article

Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit

scientific article

Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?

scientific article

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

scientific article published on 18 January 2016

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.

scientific article

NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism

scientific article published on November 2006

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection

scientific article published on 28 December 2016

Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells

scientific article

New players in the gene regulatory network controlling late B cell differentiation

scientific article published on 24 May 2019

Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.

scientific article

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors.

scientific article published on 11 June 2018

PU.1 controls fibroblast polarization and tissue fibrosis

scientific article published on 30 January 2019

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

scientific article published on 02 March 2016

PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML

scientific article

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain.

scientific article

PU.1 regulates TCR expression by modulating GATA-3 activity.

scientific article published on October 2009

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

scientific article

Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis

scientific article

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

scientific article

Pax5 maintains cellular identity by repressing gene expression throughout B cell differentiation

scientific article

Peripheral natural killer cell maturation depends on the transcription factor Aiolos

scientific article

Plasma cell development: from B-cell subsets to long-term survival niches.

scientific article published on 28 January 2008

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

scientific article published on 05 February 2020

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

scientific article

Polycomb repressive complex 2 is a critical mediator of allergic inflammation

scientific article published on 16 May 2019

Positive feedback between PU.1 and the cell cycle controls myeloid differentiation

scientific article published on 18 July 2013

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators

scientific article

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

scientific article

RNA editing of human kainate receptor subunits ⬇️

scientific article published on December 20, 1994

RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity.

scientific article published on 13 April 2016

Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1.

scientific article

Regulation of murine natural killer cell commitment

scientific article published on 30 January 2013

Role of "cancer stem cells" and cell survival in tumor development and maintenance.

scientific article

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

scientific article published on 26 August 2019

Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer

scientific article

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

scientific article

Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish

scientific article published in March 2006

Standing out from the crowd: How to identify plasma cells

scientific article published in August 2017

Surprising new roles for PU.1 in the adaptive immune response.

scientific article

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

scientific article published on 23 December 2015

Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system.

scientific article

Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall

scientific article published on 22 June 2015

Terminal differentiation of lymphocytes depends on Blimp-1.

scientific article published on 8 February 2007

Th17 cell differentiation proceeds independently of IRF8.

scientific article published on 3 May 2016

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

scientific article published on 9 January 2016

The Interactions of Multiple Cytokines Control NK Cell Maturation

scientific article published on 25 October 2010

The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.

scientific article published on 06 April 2017

The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner

scientific article published on 01 May 2010

The cis-Regulatory Atlas of the Mouse Immune System

scientific article published on 24 January 2019

The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions

scientific article

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

scientific article published in May 2012

The development of functional B lymphocytes in conditional PU.1 knock-out mice

article

The flavors of plasma cells.

scientific article published on 28 June 2015

The generation of antibody-secreting plasma cells.

scientific article

The genetic network controlling plasma cell differentiation ⬇️

scientific article published on September 15, 2011

The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation

scientific article

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

scientific article published on 22 September 2013

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

scientific article published on 04 November 2020

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.

scientific article

The transcription factor PU.1 regulates γδ T cell homeostasis

scientific article

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

scientific article

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

scientific article

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

scientific article

The transcriptional regulation of B cell lineage commitment.

scientific article published on June 2007

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

scientific article published on 19 January 2015

The unique features of follicular T cell subsets ⬇️

scientific article published on July 14, 2013

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

scientific article published on 02 January 2019

Transcription Factor Theft—PU.1 Caught Red-Handed

scientific article published on 01 June 2018

Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism

scientific article published on 3 March 2014

Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses

scientific article published on 18 April 2019

Transcriptional control of pre-B cell development and leukemia prevention

scientific article published on January 2014

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells.

scientific article published on 20 April 2015

Transcriptional programming of the dendritic cell network

scientific article

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

scientific article published on 26 March 2006

Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells.

scientific article published on December 2006

Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy

scientific article published in 2021

Viral Replicative Capacity, Antigen Availability via Hematogenous Spread, and High TFH:TFR Ratios Drive Induction of Potent Neutralizing Antibody Responses

scientific article published on 05 March 2019

Whole transcriptome analysis for T cell receptor-affinity and IRF4-regulated clonal expansion of T cells

scientific article

Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning

scientific article

c-Myb is required for plasma cell migration to bone marrow after immunization or infection

scientific article published on 15 June 2015

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