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List of works by Thomas E. Spencer

"Ménage à Trois": the evolutionary interplay between JSRV, enJSRVs and domestic sheep

scientific article

'Conceptualizing' the Endometrium: Identification of Conceptus-Derived Proteins During Early Pregnancy in Cattle

scientific article

A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses

scientific article (publication date: November 2007)

Actions of progesterone on uterine immunosuppression and endometrial gland development in the uterine gland knockout (UGKO) ewe.

scientific article published in July 2005

Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig.

scientific article

Activin A and follistatin during the oestrous cycle and early pregnancy in ewes

scientific article published on 5 January 2016

Alterations in expression of endometrial genes coding for proteins secreted into the uterine lumen during conceptus elongation in cattle

scientific article

Amino acids and gaseous signaling.

scientific article published on 06 March 2009

Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle

scientific article

Application of next generation sequencing in mammalian embryogenomics: Lessons learned from endogenous betaretroviruses of sheep ⬇️

scientific article (publication date: September 2012)

Arginine metabolism and nutrition in growth, health and disease

scientific article

Author Correction: Evolution of placental invasion and cancer metastasis are causally linked

scientific article published on 01 February 2020

Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health.

scientific article published on May 2010

Biological roles of interferon tau (IFNT) and type I IFN receptors in elongation of the ovine conceptus

scientific article published on 10 December 2014

Biological roles of uterine glands in pregnancy

scientific article

Board-invited review: intrauterine growth retardation: implications for the animal sciences.

scientific article published on September 2006

CRISPR bacon: a sizzling technique to generate genetically engineered pigs.

scientific article published on 6 August 2014

Carbonic anhydrase regulate endometrial gland development in the neonatal uterus

scientific article published on 23 March 2005

Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae

scientific article published on 27 January 2010

Cathepsins in the ovine uterus: regulation by pregnancy, progesterone, and interferon tau.

scientific article published on 11 August 2005

Cell-specific transcriptional profiling reveals candidate mechanisms regulating development and function of uterine epithelia in mice

scientific article

Comparative aspects of implantation.

scientific article published on 05 June 2009

Comparative developmental biology of the uterus: insights into mechanisms and developmental disruption

scientific article published on 08 October 2011

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium1

article

Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol

scientific article

Conceptus signals for establishment and maintenance of pregnancy.

scientific article

Conceptus-derived prostaglandins regulate gene expression in the endometrium prior to pregnancy recognition in ruminants

scientific article published on 21 August 2013

Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?

scientific article published on 23 February 2011

Cortisol and interferon tau regulation of endometrial function and conceptus development in female sheep

scientific article

Development and characterization of immortalized ovine endometrial cell lines.

scientific article published on November 1999

Developmental Changes in Nitric Oxide Synthesis in the Ovine Placenta1 ⬇️

scientific article published on November 12, 2003

Developmental changes in hypothalamic Kiss1 expression during activation of the pulsatile release of luteinising hormone in maturing ewe lambs

scientific article published in September 2011

Developmental changes in polyamine levels and synthesis in the ovine conceptus

scientific article

Developmental changes of amino acids in ovine fetal fluids

scientific article published on 27 December 2002

Dietary supplementation with 0.8% L-arginine between days 0 and 25 of gestation reduces litter size in gilts

scientific article published on 14 April 2010

Differential effects of intrauterine and subcutaneous administration of recombinant ovine interferon tau on the endometrium of cyclic ewes

scientific article published in August 1999

Differential expression of cathepsins and cystatin C in ovine uteroplacental tissues

scientific article published on 07 June 2007

Differential expression of ribosomal L31, Zis, gas-5 and mitochondrial mRNAs following oxidant induction of proliferative vascular smooth muscle cell phenotypes

scientific article published in February 2002

Discovery of candidate genes and pathways in the endometrium regulating ovine blastocyst growth and conceptus elongation

scientific article published on 18 August 2009

Do differences in the endometrial transcriptome between uterine horns ipsilateral and contralateral to the corpus luteum influence conceptus growth to day 14 in cattle?

scientific article published on 01 January 2019

Effect of pregnancy and progesterone concentration on expression of genes encoding for transporters or secreted proteins in the bovine endometrium

scientific article published on 8 December 2009

Effects of exogenous recombinant ovine interferon tau on circulating concentrations of progesterone, cortisol, luteinizing hormone, and antiviral activity; interestrous interval; rectal temperature; and uterine response to oxytocin in cyclic ewes

scientific article published on 01 September 1997

Effects of fertility on gene expression and function of the bovine endometrium

scientific article

Effects of interferon-tau and progesterone on oestrogen-stimulated expression of receptors for oestrogen, progesterone and oxytocin in the endometrium of ovariectomized ewes

scientific article published on 01 January 1996

Effects of the estrous cycle and early pregnancy on uterine expression of Mx protein in sheep (Ovis aries).

scientific article

Effects of the estrous cycle, pregnancy and interferon tau on expression of cyclooxygenase two (COX-2) in ovine endometrium

scientific article

Endogenous retroviruses in trophoblast differentiation and placental development

scientific article published in October 2010

Endogenous retroviruses of sheep: a model system for understanding physiological adaptation to an evolving ruminant genome.

scientific article

Endometrial HSD11B1 and cortisol regeneration in the ovine uterus: effects of pregnancy, interferon tau, and prostaglandins

scientific article published on 27 April 2012

Endometrial glands are essential for blastocyst implantation and decidualization in the mouse uterus

scientific article published on 11 April 2013

Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy

scientific article

Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function ⬇️

scientific article published on December 12, 2011

Estrogen and antiestrogen effects on neonatal ovine uterine development

scientific article published on 16 April 2003

Estrogen disruption of neonatal ovine uterine development: effects on gene expression assessed by suppression subtraction hybridization

scientific article published on 22 June 2005

Estrogen enhances endometrial estrogen receptor gene expression by a posttranscriptional mechanism in the ovariectomized ewe.

scientific article published in March 1996

Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements.

scientific article published on 27 October 2005

Evolution of placental invasion and cancer metastasis are causally linked

scientific article published on 25 November 2019

Exosomal and Non-Exosomal Transport of Extra-Cellular microRNAs in Follicular Fluid: Implications for Bovine Oocyte Developmental Competence.

scientific article

Expression of Endogenous Betaretroviruses in the Ovine Uterus: Effects of Neonatal Age, Estrous Cycle, Pregnancy, and Progesterone ⬇️

scientific article published on December 1, 2001

Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus

scientific article published on 01 September 2002

Expression of interferon regulatory factors one and two in the ovine endometrium: effects of pregnancy and ovine interferon tau

scientific article published on 01 May 1998

Expression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and following endocrine disruption of pregnancy

scientific article published in February 2006

Expression of the interferon tau inducible ubiquitin cross-reactive protein in the ovine uterus

scientific article published on 01 July 1999

Extracellular vesicles in luminal fluid of the ovine uterus

scientific article (publication date: 2014)

Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice.

scientific article published on 16 January 2014

Friendly viruses: the special relationship between endogenous retroviruses and their host

scientific article published in October 2009

Galectin 15 (LGALS15) functions in trophectoderm migration and attachment

scientific article published on 21 September 2007

Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment

scientific article published on 12 September 2007

Galectin-15 in ovine uteroplacental tissues

scientific article published on 01 August 2005

Gene expression profiling of neonatal mouse uterine development.

scientific article published on 25 February 2004

Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches

scientific article published on February 2008

Glutamine synthesis in the developing porcine placenta

scientific article

Growth and development of the ovine conceptus

HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau.

scientific article published on 19 August 2009

High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue

scientific journal article

Hormonal manipulation of endometrial gland development in the horse

scientific article published on 01 September 2009

Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators

scientific article published on 01 April 2020

Identification and characterization of glycosylation-dependent cell adhesion molecule 1-like protein expression in the ovine uterus

scientific article published on 01 February 1999

Identification of endometrial genes regulated by early pregnancy, progesterone, and interferon tau in the ovine uterus

scientific article

Immune mechanisms at the maternal-fetal interface: perspectives and challenges

scientific article published on April 2015

Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production

scientific article published on 23 October 2009

Implantation mechanisms: insights from the sheep.

scientific article

Induction of ovine trophoblast cell fusion by fematrin-1 in vitro.

scientific article published on 24 July 2015

Influences of sire conception rate on pregnancy establishment in dairy cattle

scientific article published on 01 December 2018

Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell Signaling pathways, and stimulates migration of ovine trophectoderm cells

scientific article published on 13 March 2008

Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation.

scientific article published on 4 June 2009

Integrated chromatin immunoprecipitation sequencing and microarray analysis identifies FOXA2 target genes in the glands of the mouse uterus

scientific article published on 11 September 2013

Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals.

scientific article

Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep

scientific article published on 4 November 2004

Interferons and uterine receptivity.

scientific article published on January 2009

Interplay between ovine bone marrow stromal cell antigen 2/tetherin and endogenous retroviruses

scientific article

Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetus

scientific article published on 18 February 2009

Keratinocyte growth factor is up-regulated by estrogen in the porcine uterine endometrium and functions in trophectoderm cell proliferation and differentiation

scientific article

Litter-size-dependent intrauterine growth restriction in sheep

scientific article

Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids

scientific article

Matrix metalloproteinases and their tissue inhibitors in the developing neonatal mouse uterus

scientific article published on 7 July 2004

Mechanistic mammalian target of rapamycin (MTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses.

scientific article published on September 2011

Molecular cloning and characterization of prostaglandin (PG) transporter in ovine endometrium: role for multiple cell signaling pathways in transport of PGF2alpha

scientific article published on 27 September 2007

NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo

scientific article published on 05 December 2019

Neonatal estrogen exposure disrupts uterine development in the postnatal sheep

scientific article published in April 2004

Neonatal exposure to progesterone and estradiol alters uterine morphology and luminal protein content in adult beef heifers

scientific article published in April 1995

Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.

scientific article

OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses

scientific article

Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy

scientific article published on 27 December 2002

Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy

scientific article published on 08 January 2003

Ovarian regulation of endometrial gland morphogenesis and activin-follistatin system in the neonatal ovine uterus

scientific article published on 14 May 2003

Ovary-independent estrogen receptor expression in neonatal porcine endometrium

scientific article published on 01 April 1998

Oviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street?

scientific article published on 29 April 2015

Ovine IFN-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler's virus.

scientific article published in October 2001

Ovine Interferon-τ Regulates Expression of Endometrial Receptors for Estrogen and Oxytocin but not Progesterone1

scientific article published on September 1, 1995

Ovine interferon tau suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium

scientific article published on 01 March 1996

Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period

scientific article published on 01 October 1999

Ovine placental lactogen specifically binds to endometrial glands of the ovine uterus.

scientific article published in March 2003

Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes.

scientific article

Peroxisome proliferator activator receptor gamma (PPARG) regulates conceptus elongation in sheep

scientific article published on 17 December 2014

Physiology and Endocrinology Symposium: biological role of interferon tau in endometrial function and conceptus elongation

scientific article

Pig conceptuses increase uterine interferon-regulatory factor 1 (IRF1), but restrict expression to stroma through estrogen-induced IRF2 in luminal epithelium

scientific article published on 02 May 2007

Polyamine synthesis from proline in the developing porcine placenta.

scientific article published on December 2004

Postnatal uterine development in Inverdale ewe lambs

scientific article

Pregnancy and interferon tau regulate N-myc interactor in the ovine uterus.

scientific article published on 13 October 2010

Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus

scientific article published in January 2007

Pregnancy and interferon tau regulate major histocompatibility complex class I and beta2-microglobulin expression in the ovine uterus.

scientific article published on 11 December 2002

Pregnancy and interferon τ regulate DDX58 and PLSCR1 in the ovine uterus during the peri-implantation period ⬇️

scientific article published on October 6, 2010

Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses.

scientific article published on January 2007

Progesterone and interferon tau regulate hypoxia-inducible factors in the endometrium of the ovine uterus.

scientific article published on 3 January 2008

Progesterone and interferon tau regulate leukemia inhibitory factor receptor and IL6ST in the ovine uterus during early pregnancy

scientific article

Progesterone and interferon tau-regulated genes in the ovine uterine endometrium: identification of periostin as a potential mediator of conceptus elongation.

scientific article published on 27 July 2009

Progesterone and interferon-tau regulate cystatin C in the endometrium

scientific article published on 23 March 2006

Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy

scientific article published on 30 July 2008

Progesterone inhibits uterine gland development in the neonatal mouse uterus

scientific article

Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus.

scientific article

Progesterone regulation of preimplantation conceptus growth and galectin 15 (LGALS15) in the ovine uterus

scientific article

Progesterone regulation of the endometrial WNT system in the ovine uterus

scientific article

Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle.

scientific article published on 24 June 2009

Prolactin regulation of neonatal ovine uterine gland morphogenesis

scientific article

Proline metabolism in the conceptus: implications for fetal growth and development.

scientific article published on 11 March 2008

Prostaglandin-endoperoxide synthase 2 is not required for preimplantation ovine conceptus development in sheep

scientific article published on 20 November 2019

Prostaglandins regulate conceptus elongation and mediate effects of interferon tau on the ovine uterine endometrium

scientific article published on 26 January 2011

Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle

scientific article published on 8 April 2014

RNA sequencing reveals novel gene clusters in bovine conceptuses associated with maternal recognition of pregnancy and implantation

scientific article published on 27 July 2011

Receptor transporter protein 4 (RTP4) in endometrium, ovary, and peripheral blood leukocytes of pregnant and cyclic ewes

scientific article published on 21 May 2008

Receptor usage and fetal expression of ovine endogenous betaretroviruses: implications for coevolution of endogenous and exogenous retroviruses

scientific article

Regulation of expression of fibroblast growth factor 7 in the pig uterus by progesterone and estradiol

scientific article published on 28 March 2007

Regulation of uterine genes during the peri-implantation period, and its relationship to the maternal brain in gestating mice

scientific article published on 22 March 2020

Revealing the history of sheep domestication using retrovirus integrations

scientific article

Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation

scientific article published on 01 December 2006

Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells

scientific article published on 10 April 2010

Secretion of PGF2alpha and oxytocin during hyperthermia in cyclic and pregnant heifers

scientific article published on 01 May 1993

Select nutrients and their associated transporters are increased in the ovine uterus following early progesterone administration

scientific article published on 19 August 2009

Select nutrients in the ovine uterine lumen. I. Amino acids, glucose, and ions in uterine lumenal flushings of cyclic and pregnant ewes.

scientific article published on 27 August 2008

Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses

scientific article published on 26 November 2008

Select nutrients in the ovine uterine lumen. IV. Expression of neutral and acidic amino acid transporters in ovine uteri and peri-implantation conceptuses

scientific article published on 28 January 2009

Select nutrients in the ovine uterine lumen. IX. Differential effects of arginine, leucine, glutamine, and glucose on interferon tau, ornithine decarboxylase, and nitric oxide synthase in the ovine conceptus

scientific article published on 3 February 2011

Select nutrients in the ovine uterine lumen. V. Nitric oxide synthase, GTP cyclohydrolase, and ornithine decarboxylase in ovine uteri and peri-implantation conceptuses

scientific article published on 25 February 2009

Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors of mTORC1 and mTORC2 complexes in ovine uteri and conceptuses

scientific article

Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration

scientific article published on 15 September 2010

Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines

scientific article published on 15 September 2010

Select nutrients in the ovine uterine lumen. ii. glucose transporters in the uterus and peri-implantation conceptuses

scientific article published on 27 August 2008

Self-renewing endometrial epithelial organoids of the human uterus

scientific article published on 30 October 2019

Sexually dimorphic effects of forkhead box a2 (FOXA2) and uterine glands on decidualization and fetoplacental development

scientific article published on 08 September 2020

Sheep endogenous betaretroviruses (enJSRVs) and the hyaluronidase 2 (HYAL2) receptor in the ovine uterus and conceptus

scientific article

Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restriction

scientific article published on 16 December 2009

Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones

scientific article published in February 2006

Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol

scientific article

Staphylococcus-associated abortions in ewes with long-term central venous catheterization

scientific article

Statistical models in assessing fold change of gene expression in real-time RT-PCR experiments

scientific article published in February 2006

Steroid receptor coactivator-1 is a histone acetyltransferase

scientific article

Steroid receptor induction of gene transcription: A two-step model ⬇️

scientific article published on July 22, 1997

Sulfated glycoprotein-1 (SGP-1) expression in ovine endometrium during the oestrous cycle and early pregnancy.

scientific article published on January 1995

Temporal and spatial alterations in uterine estrogen receptor and progesterone receptor gene expression during the estrous cycle and early pregnancy in the ewe

scientific article published on 01 December 1995

The IGF system in the neonatal ovine uterus

scientific article

The activin-follistatin system in the neonatal ovine uterus

scientific article published on 14 May 2003

The endometrium responds differently to cloned versus fertilized embryos

scholarly article

The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions

scientific article

The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.

scientific article

Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone

scientific article published on 03 May 2007

Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin

scientific article published on 28 April 2009

Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production

scientific article published on 17 December 2010

Uterine Glands: Developmental Biology and Functional Roles in Pregnancy

scientific article published on 01 October 2019

Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success.

scientific article

Uterine glands: biological roles in conceptus implantation, uterine receptivity and decidualization

scientific article

Uterine glands: development, function and experimental model systems.

scientific article published on 25 April 2013

Uterine lumen fluid is metabolically semi-autonomous

scientific article published in 2022

Uterine vein infusion of interferon tau (IFNT) extends luteal life span in ewes

scientific article published on 30 December 2009

Validation of an interferon stimulatory response element reporter gene assay for quantifying type I interferons.

scientific article published on 7 January 2014

Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model.

scientific article

WNT pathways in the neonatal ovine uterus: potential specification of endometrial gland morphogenesis by SFRP2.

scientific article published on 11 January 2006

WNTs in the ovine uterus: potential regulation of periimplantation ovine conceptus development

scientific article published on 12 April 2007

Where They're Buried ⬇️

Wnt genes in the mouse uterus: potential regulation of implantation

scientific article

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