List of works - Christopher Williams

1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide

article

A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

scientific article published on 06 February 2020

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

scientific article

A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains

scientific article

Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.

scientific article

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution

scientific article

Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity ⬇️

scientific article published on June 6, 2011

Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria ⬇️

scientific article published on 15 October 2015

Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

scientific article published on 31 January 2019

Control of β-Branching in Kalimantacin Biosynthesis: Application of 13 C NMR to Polyketide Programming

scientific article published on 07 August 2019

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery.

scientific article published on 22 December 2014

Enantioselective carbohydrate recognition by synthetic lectins in water.

scientific article published on 30 March 2017

Engineering protein stability with atomic precision in a monomeric miniprotein.

scientific article

Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor.

scientific article published in February 2007

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

scientific article published on 02 May 2016

Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues.

scientific article

NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL ⬇️

scientific article published on April 25, 2012

Overproduction of the N-terminal anticodon-binding domain of the non-discriminating aspartyl-tRNA synthetase from Helicobacter pylori for crystallization and NMR measurements

scientific article

Practical Considerations in High-Precision Compound-Specific Radiocarbon Analyses: Eliminating the Effects of Solvent and Sample Cross-Contamination on Accuracy and Precision

scientific article published on 07 September 2018

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.

scientific article

Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

scientific article

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.

scientific article

Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein.

scientific article published on 10 December 2015

Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis

scientific article

Solution Structure and Conformational Dynamics of a Doublet Acyl Carrier Protein from Prodigiosin Biosynthesis

scientific article published on 08 January 2021

Stabilizing and Understanding a Miniprotein by Rational Redesign

scientific article published on 08 July 2019

Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11

scientific article

Structural resolution of switchable states of a de novo peptide assembly

scientific article published on 09 March 2021

Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth

scientific article published on 10 February 2009

Structure and malonyl CoA-ACP transacylase binding of streptomyces coelicolor fatty acid synthase acyl carrier protein

scientific article

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

scientific article

The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity

scientific article published in Scientific Reports

The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA

scientific article published in Journal of Biological Chemistry

The role of large-scale motions in catalysis by dihydrofolate reductase.

scientific article published on 22 November 2011

Use of a 700 MHz NMR Microcryoprobe for the Identification and Quantification of Exogenous Carbon in Compounds Purified by Preparative Capillary Gas Chromatography for Radiocarbon Determinations.

scientific article

List of works by Christopher Williams

1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide

A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains

Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.

An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution

Analysis of Streptomyces coelicolor Phosphopantetheinyl Transferase, AcpS, Reveals the Basis for Relaxed Substrate Specificity ⬇️

Antibacterial activity of cyclo(L-Pro-L-Tyr) and cyclo(D-Pro-L-Tyr) from Streptomyces sp. strain 22-4 against phytopathogenic bacteria ⬇️

Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

Control of β-Branching in Kalimantacin Biosynthesis: Application of 13 C NMR to Polyketide Programming

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery.

Enantioselective carbohydrate recognition by synthetic lectins in water.

Engineering protein stability with atomic precision in a monomeric miniprotein.

Functional evaluation of novel soluble insulin-like growth factor (IGF)-II-specific ligand traps based on modified domain 11 of the human IGF2 receptor.

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist

Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues.

NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL ⬇️

Overproduction of the N-terminal anticodon-binding domain of the non-discriminating aspartyl-tRNA synthetase from Helicobacter pylori for crystallization and NMR measurements

Practical Considerations in High-Precision Compound-Specific Radiocarbon Analyses: Eliminating the Effects of Solvent and Sample Cross-Contamination on Accuracy and Precision

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.

Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2)

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.

Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein.

Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis

Solution Structure and Conformational Dynamics of a Doublet Acyl Carrier Protein from Prodigiosin Biosynthesis

Stabilizing and Understanding a Miniprotein by Rational Redesign

Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11

Structural resolution of switchable states of a de novo peptide assembly

Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth

Structure and malonyl CoA-ACP transacylase binding of streptomyces coelicolor fatty acid synthase acyl carrier protein

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation

The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity

The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA

The role of large-scale motions in catalysis by dihydrofolate reductase.

Use of a 700 MHz NMR Microcryoprobe for the Identification and Quantification of Exogenous Carbon in Compounds Purified by Preparative Capillary Gas Chromatography for Radiocarbon Determinations.