List of works - Birgit Strobl

A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).

scientific article published on 23 July 2011

A completely foreign receptor can mediate an interferon-gamma-like response

scientific article

A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130

scientific article published on 01 September 2001

A time- and dose-dependent STAT1 expression system

scientific article

Bacterial polyphosphates interfere with the innate host defense to infection

scientific article published on 12 August 2020

CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response

scientific article

Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays.

scientific article

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

scientific article published on October 2012

Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection

scientific article (publication date: 2012)

Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance

scientific article published on 3 April 2014

Contribution of cell culture additives to the two-dimensional protein patterns of mouse macrophages

scientific article published in April 2006

Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex

scientific article

Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis ⬇️

scientific article published on 2 May 2011

Editorial: Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis

HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity

scientific article

Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis

scientific article

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

scientific article

IDO1+ Paneth cells promote immune escape of colorectal cancer

scientific article published on 22 May 2020

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation

scientific article

In Vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm

scientific article published on 01 August 1997

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

scientific article

Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo

scientific article

Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.

scientific article

Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis

scientific article

Intestinal Microbiota Signatures Associated with Inflammation History in Mice Experiencing Recurring Colitis

scientific article

Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes

scientific article published on July 2013

Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery

scientific article published on 09 January 2014

Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance

scientific article published on 02 September 2014

Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice.

scientific article

Mutational switch of an IL-6 response to an interferon-gamma-like response

scientific article

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice

scientific article published on 22 January 2015

Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

scientific article published on 27 April 2015

Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus

scientific article published in September 2005

Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses

scientific article

Of JAKs, STATs, blind watchmakers, jeeps and trains

scientific article

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

scientific article

Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription

scientific article

Recombinant viral sialate-O-acetylesterases

scientific article published in January 2004

Reversible inhibition of murine cytomegalovirus replication by gamma interferon (IFN-γ) in primary macrophages involves a primed type I IFN-signaling subnetwork for full establishment of an immediate-early antiviral state

scientific article

STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity

scientific article

STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion

scientific article

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

scientific article published on 02 December 2021

Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase

scientific article (publication date: 15 October 1998)

Studying human pathogens in animal models: fine tuning the humanized mouse

scientific article

TYK2 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 CONTRIBUTE TO INTESTINAL I/R INJURY

TYK2 kinase activity is required for functional type I interferon responses in vivo

scientific article (publication date: 2012)

TYK2 licenses non-canonical inflammasome activation during endotoxemia

scientific article published on 14 September 2020

The STAT3 isoforms alpha and beta have unique and specific functions

scientific article published on 14 March 2004

The antiviral response to gamma interferon

scientific article published on September 2002

The good and the bad faces of STAT1 in solid tumours

scientific article

The impact of tyrosine kinase 2 (Tyk2) on the proteome of murine macrophages and their response to lipopolysaccharide (LPS).

scientific article

The receptor-destroying enzyme of influenza C virus is required for entry into target cells.

scientific article published on February 1993

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

scientific article

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

scientific article published on 19 June 2009

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

scientific article

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

scientific article

Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity

scientific article published on December 2009

Type I interferons have opposing effects during the emergence and recovery phases of colitis.

scientific article

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity

scientific article published on June 2011

Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.

scientific article

Tyrosine kinase 2 controls IL-1ß production at the translational level

scientific article published on 16 August 2010

Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27

scientific article

Use of apathogenic vaccinia virus MVA expressing EHV-1 gC as basis of a combined recombinant MVA/DNA vaccination scheme

scientific article

cDNA cloning and expression of secreted Xenopus laevis dipeptidyl aminopeptidase IV.

scientific article published on July 1997

List of works by Birgit Strobl

A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).

A completely foreign receptor can mediate an interferon-gamma-like response

A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130

A time- and dose-dependent STAT1 expression system

Bacterial polyphosphates interfere with the innate host defense to infection

CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response

Cell-type and donor-specific transcriptional responses to interferon-alpha. Use of customized gene arrays.

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection

Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance

Contribution of cell culture additives to the two-dimensional protein patterns of mouse macrophages

Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex

Cross-talk between interferon-γ and hedgehog signaling regulates adipogenesis ⬇️

Editorial: Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis

HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity

Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

IDO1+ Paneth cells promote immune escape of colorectal cancer

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation

In Vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo

Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.

Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis

Intestinal Microbiota Signatures Associated with Inflammation History in Mice Experiencing Recurring Colitis

Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes

Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery

Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance

Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice.

Mutational switch of an IL-6 response to an interferon-gamma-like response

Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice

Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus

Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses

Of JAKs, STATs, blind watchmakers, jeeps and trains

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription

Recombinant viral sialate-O-acetylesterases

Reversible inhibition of murine cytomegalovirus replication by gamma interferon (IFN-γ) in primary macrophages involves a primed type I IFN-signaling subnetwork for full establishment of an immediate-early antiviral state

STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity

STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection

Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase

Studying human pathogens in animal models: fine tuning the humanized mouse

TYK2 AND SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 CONTRIBUTE TO INTESTINAL I/R INJURY

TYK2 kinase activity is required for functional type I interferon responses in vivo

TYK2 licenses non-canonical inflammasome activation during endotoxemia

The STAT3 isoforms alpha and beta have unique and specific functions

The antiviral response to gamma interferon

The good and the bad faces of STAT1 in solid tumours

The impact of tyrosine kinase 2 (Tyk2) on the proteome of murine macrophages and their response to lipopolysaccharide (LPS).

The receptor-destroying enzyme of influenza C virus is required for entry into target cells.

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity

Type I interferons have opposing effects during the emergence and recovery phases of colitis.

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity

Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.

Tyrosine kinase 2 controls IL-1ß production at the translational level

Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27

Use of apathogenic vaccinia virus MVA expressing EHV-1 gC as basis of a combined recombinant MVA/DNA vaccination scheme

cDNA cloning and expression of secreted Xenopus laevis dipeptidyl aminopeptidase IV.