List of works - J. Evan Sadler

Biochemistry and genetics of von Willebrand factor

scientific article published on January 1, 1998

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

scientific article

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

scientific article

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).

scientific article published on March 2008

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

scientific article

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

scientific article

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

scientific article

Functional architecture of Weibel-Palade bodies

scientific article

Pathogenesis of thrombotic microangiopathies

scientific article

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains

scientific article

Von Willebrand disease type 1: a diagnosis in search of a disease

scientific article

Molecular mapping of the heparin-binding exosite of thrombin

scientific article

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

scientific article

New concepts in von Willebrand disease

scientific article

von Willebrand factor: two sides of a coin

scientific article

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

scientific article published on June 1998

von Willebrand factor assembly and secretion

scientific article published on July 2009

Binding of ADAMTS13 to von Willebrand factor

scientific article

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

scholarly article

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

scholarly article

Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress

scientific article published on 16 October 2008

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

scientific article published on 20 May 2008

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

scientific article published in Journal of Biological Chemistry

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

scientific article published in Journal of Biological Chemistry

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

scientific article published in December 1997

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

scientific article published on January 1999

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

scientific article

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor

scientific article published in Journal of Biological Chemistry

Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow

scientific article published on 17 March 2005

Zinc and calcium ions cooperatively modulate ADAMTS13 activity

scientific article

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide

scientific article

Allosteric activation of ADAMTS13 by von Willebrand factor.

scientific article

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

scientific article

ADAMTS13 and TTP

scientific article (publication date: September 2002)

Multi-step binding of ADAMTS-13 to von Willebrand factor.

scientific article published on 18 September 2009

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

scholarly article

Unfolding the A2 domain of von Willebrand factor with the optical trap

scientific article

Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C

scientific article published on May 15, 1998

A new name in thrombosis, ADAMTS13.

scientific article

Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins

scientific article

Medicine: K is for koagulation

scientific article

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project

scientific article

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin

scientific article

Pathophysiology of thrombotic thrombocytopenic purpura

scientific article published on 2 August 2017

Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency

scientific article

A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization

scientific article published on 22 September 2004

Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor

scientific article published on 01 April 2005

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

scientific article

Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis

scientific article published on 10 October 2013

Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases

scientific article

List of works by J. Evan Sadler

Biochemistry and genetics of von Willebrand factor

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

Functional architecture of Weibel-Palade bodies

Pathogenesis of thrombotic microangiopathies

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains

Von Willebrand disease type 1: a diagnosis in search of a disease

Molecular mapping of the heparin-binding exosite of thrombin

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

New concepts in von Willebrand disease

von Willebrand factor: two sides of a coin

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

von Willebrand factor assembly and secretion

Binding of ADAMTS13 to von Willebrand factor

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor

Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow

Zinc and calcium ions cooperatively modulate ADAMTS13 activity

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide

Allosteric activation of ADAMTS13 by von Willebrand factor.

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

ADAMTS13 and TTP

Multi-step binding of ADAMTS-13 to von Willebrand factor.

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

Unfolding the A2 domain of von Willebrand factor with the optical trap

Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C

A new name in thrombosis, ADAMTS13.

Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins

Medicine: K is for koagulation

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin

Pathophysiology of thrombotic thrombocytopenic purpura

Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency

A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization

Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis

Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases