List of works - J. Evan Sadler

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

scientific article

A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization.

scientific article published on 22 September 2004

A new name in thrombosis, ADAMTS13.

scientific article

A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury

scientific article published on 23 March 2004

ADAMTS13 and TTP

scientific article (publication date: September 2002)

Accelerated clearance alone explains ultra-large multimers in von Willebrand disease Vicenza

scientific article published on 17 January 2010

Activation of recombinant proenteropeptidase by duodenase

scientific article (publication date: 28 January 2000)

Adjuvant low-dose rituximab and plasma exchange for acquired TTP

scientific article published on 22 July 2019

Allosteric activation of ADAMTS13 by von Willebrand factor.

scientific article

An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura

scientific article

Aortic Stenosis, von Willebrand Factor, and Bleeding ⬇️

scientific article published on October 30, 2003

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

scientific article published on January 1999

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

scientific article

Atypical HUS may become a diagnosis of inclusion.

scientific article

BIOMEDICINE: Contact-How Platelets Touch von Willebrand Factor

scientific article published in Science

Binding of ADAMTS13 to von Willebrand factor

scientific article

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

scholarly article

Biochemistry and genetics of von Willebrand factor

scientific article published in 1998

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

scientific article published in December 1997

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

scientific article published in February 2002

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

scientific article published in Journal of Biological Chemistry

Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow

scientific article published on 17 March 2005

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

scientific article

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide

scientific article

Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins

scientific article

Effect of ST2, a Fragment of ADAMTS13, on Cleavage of Von Willebrand Factor

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

scientific article

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains

scientific article

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

scholarly article

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

scientific article published on 28 January 2019

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

scientific article published on 20 May 2008

Functional architecture of Weibel-Palade bodies

scientific article

Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor

scientific article

Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

scientific article published in May 2008

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

scientific article published on June 1998

Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress

scientific article published on 16 October 2008

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

scientific article published in Journal of Biological Chemistry

Isolation and Characterization of Glycosyl Transferases

scientific article published on 01 January 1977

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor

scientific article published in Journal of Biological Chemistry

Medicine: K is for koagulation.

scientific article

Molecular mapping of the heparin-binding exosite of thrombin

scientific article

Multi-step binding of ADAMTS-13 to von Willebrand factor.

scientific article published on 18 September 2009

Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency

scientific article

New concepts in von Willebrand disease

scientific article

Pathogenesis of thrombotic microangiopathies

scientific article

Pathophysiology of thrombotic thrombocytopenic purpura

scientific article published on 2 August 2017

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

scientific article published on 30 January 2019

Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor.

scientific article

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.

scientific article

Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor

scientific article published on 01 April 2005

Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases

scientific article

Redeeming ristocetin

scientific article published on July 2010

Refractory Immune Hemolytic Anemia With A High Thermal Amplitude, Low Affinity IgG Anti-PraCold Autoantibody

scientific article published on 01 January 1992

Ring ‘flipping’ in bis(cyclo-octatetraene)titanium(II); an organometallic intramolecular redox reaction which involves only the geometrical deformation of organic ligands

scholarly article by Jeffrey Schwartz & J. Evan Sadler published 1973 in Journal of the Chemical Society. Chemical communications

STRUCTURAL BIOLOGY: A Menage a Trois in Two Configurations

scientific article

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

scientific article

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

scientific article

Should all adult patients with diarrhoea-associated HUS receive plasma exchange?

scientific article published in The Lancet

Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings

scientific article

Slippery criteria for von Willebrand disease type 1

scientific article published on 01 October 2004

Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity

scientific article

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

scientific article

The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner

scientific article

Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis

scientific article published on 10 October 2013

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

scholarly article

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project

scientific article

Unfolding the A2 domain of von Willebrand factor with the optical trap

scientific article

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

scientific article

Von Willebrand disease type 1: a diagnosis in search of a disease

scientific article

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

scientific article

Zinc and calcium ions cooperatively modulate ADAMTS13 activity

scientific article

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).

scientific article published on March 2008

von Willebrand factor assembly and secretion

scientific article published on July 2009

von Willebrand factor in its native environment

scientific article published on 01 April 2013

von Willebrand factor: two sides of a coin

scientific article

List of works by J. Evan Sadler

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

A covalent oxidoreductase intermediate in propeptide-dependent von Willebrand factor multimerization.

A new name in thrombosis, ADAMTS13.

A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury

ADAMTS13 and TTP

Accelerated clearance alone explains ultra-large multimers in von Willebrand disease Vicenza

Activation of recombinant proenteropeptidase by duodenase

Adjuvant low-dose rituximab and plasma exchange for acquired TTP

Allosteric activation of ADAMTS13 by von Willebrand factor.

An optimized fluorogenic ADAMTS13 assay with increased sensitivity for the investigation of patients with thrombotic thrombocytopenic purpura

Aortic Stenosis, von Willebrand Factor, and Bleeding ⬇️

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor

Atypical HUS may become a diagnosis of inclusion.

BIOMEDICINE: Contact-How Platelets Touch von Willebrand Factor

Binding of ADAMTS13 to von Willebrand factor

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

Biochemistry and genetics of von Willebrand factor

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow

Cloning and characterization of two cDNAs coding for human von Willebrand factor.

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide

Crystal structure of von Willebrand factor A1 domain complexed with snake venom, bitiscetin: insight into glycoprotein Ibalpha binding mechanism induced by snake venom proteins

Effect of ST2, a Fragment of ADAMTS13, on Cleavage of Von Willebrand Factor

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains

Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

Functional architecture of Weibel-Palade bodies

Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor

Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

Integrin alpha(v)beta(3) on human endothelial cells binds von Willebrand factor strings under fluid shear stress

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

Isolation and Characterization of Glycosyl Transferases

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor

Medicine: K is for koagulation.

Molecular mapping of the heparin-binding exosite of thrombin

Multi-step binding of ADAMTS-13 to von Willebrand factor.

Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency

New concepts in von Willebrand disease

Pathogenesis of thrombotic microangiopathies

Pathophysiology of thrombotic thrombocytopenic purpura

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor.

Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.

Provisional criteria for the diagnosis of VWD type 1: on behalf of the ISTH SSC Subcommittee on von Willebrand Factor

Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases

Redeeming ristocetin

Refractory Immune Hemolytic Anemia With A High Thermal Amplitude, Low Affinity IgG Anti-PraCold Autoantibody

Ring ‘flipping’ in bis(cyclo-octatetraene)titanium(II); an organometallic intramolecular redox reaction which involves only the geometrical deformation of organic ligands

STRUCTURAL BIOLOGY: A Menage a Trois in Two Configurations

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

Should all adult patients with diarrhoea-associated HUS receive plasma exchange?

Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings

Slippery criteria for von Willebrand disease type 1

Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner

Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project

Unfolding the A2 domain of von Willebrand factor with the optical trap

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

Von Willebrand disease type 1: a diagnosis in search of a disease

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

Zinc and calcium ions cooperatively modulate ADAMTS13 activity

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).

von Willebrand factor assembly and secretion

von Willebrand factor in its native environment

von Willebrand factor: two sides of a coin