List of works - Timothy J. Shafer

A multiplexed assay for determination of neurotoxicant effects on spontaneous network activity and viability from microelectrode arrays

scientific article

Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue

scientific article published on 19 November 2004

Accumulation of pyrethroid compounds in primary cultures from rat cortex

scientific article published on 25 August 2010

Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and function

scientific article published on 31 July 2011

Acute toluene exposure and rat visual function in proportion to momentary brain concentration.

scientific article

Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture

scientific article published on 10 June 2011

Aluminum decreases muscarinic, adrenergic, and metabotropic receptor-stimulated phosphoinositide hydrolysis in hippocampal and cortical slices from rat brain

scientific article published on 01 November 1993

Approaches to extrapolating animal toxicity data on organic solvents to public health.

scientific article

Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening

scientific article published on 6 June 2008

Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes

scientific article

Channelopathies: Summary of the hot topic keynotes session ⬇️

scientific article published on July 2, 2011

Comments on: ‘Perinatal toxicity of cyfluthrin in mice: developmental and behavioral effects’ by Soni and colleagues ⬇️

scientific article published on August 1, 2011

Comparison of chemical-induced changes in proliferation and apoptosis in human and mouse neuroprogenitor cells ⬇️

scientific article published on May 25, 2012

Complete inhibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin

scientific article

Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes

scientific article published on 16 May 2007

Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

scientific article published on 10 December 2019

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity

scientific article published on 01 January 2019

Developing an exposure-dose-response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry

scientific article published on May 2005

Development of Micro-Electrode Array Based Tests for Neurotoxicity: Assessment of Interlaboratory Reproducibility with Neuroactive Chemicals ⬇️

scientific article published on April 27, 2011

Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells

scientific article published on 11 June 2008

Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs

scientific article

Developmental neurotoxicity testing: a path forward

scientific article published on September 2012

Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids

scientific article published on 29 April 2008

Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells.

scientific article published on October 1994

Effects of Cd2+, Pb2+ and CH3Hg+ on high voltage-activated calcium currents in pheochromocytoma (PC12) cells: potency, reversibility, interactions with extracellular Ca2+ and mechanisms of block

scientific article published on 01 November 1998

Effects of aluminum on neuronal signal transduction: mechanisms underlying disruption of phosphoinositide hydrolysis.

scientific article published on September 1995

Effects of an environmentally-relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays

scientific article

Effects of gestational methylmercury exposure on immunoreactivity of specific isoforms of PKC and enzyme activity during post-natal development of the rat brain

scientific article

Effects of methylmercury on perineurial Na+ and Ca(2+)-dependent potentials at neuromuscular junctions of the mouse

scientific article published in November 1992

Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltage-sensitive sodium and calcium currents in PC12 cells

scientific article published in June 2002

Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity

scientific article

Effects of the chlorotriazine herbicide, cyanazine, on GABA(A) receptors in cortical tissue from rat brain

scientific article published on 01 December 1999

Evaluating the NMDA-glutamate receptor as a site of action for toluene, in vivo

scientific article published on 9 April 2007

Evaluation of microelectrode array data using Bayesian modeling as an approach to screening and prioritization for neurotoxicity testing.

scientific article

Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set.

scientific article published on 28 May 2012

Extracellular calcium is required for the polychlorinated biphenyl-induced increase of intracellular free calcium levels in cerebellar granule cell culture

scientific article

From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation.

scientific article published on 16 August 2017

Glufosinate binds N-methyl-D-aspartate receptors and increases neuronal network activity in vitro

scientific article published on 28 September 2014

Identification of calcium-dependent and -independent signaling pathways involved in polychlorinated biphenyl-induced cyclic AMP-responsive element-binding protein phosphorylation in developing cortical neurons

scientific article published in January 2002

In vitro assessment of developmental neurotoxicity: use of microelectrode arrays to measure functional changes in neuronal network ontogeny.

scientific article

In vitro exposure to aluminum does not alter long-term potentiation or glutamate release in rat hippocampal slices

scientific article

In vitro screening of silver nanoparticles and ionic silver using neural networks yields differential effects on spontaneous activity and pharmacological responses

scientific article

Inhibition of rat brain phosphatidylinositol-specific phospholipase C by aluminum: regional differences, interactions with aluminum salts, and mechanisms.

scientific article published in January 1996

International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing

scientific article published on 01 January 2019

Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.

scientific article

Mechanisms underlying AlCl3 inhibition of agonist-stimulated inositol phosphate accumulation. Role of calcium, G-proteins, phospholipase C and protein kinase C.

scientific article

Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

scientific article

Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science.

scientific article published on 24 June 2009

Neurotoxicological outcomes of perinatal heptachlor exposure in the rat.

scientific article published in April 2001

Ontogeny of voltage-sensitive calcium channel alpha(1A) and alpha(1E) subunit expression and synaptic function in rat central nervous system

scientific article published in April 2003

Permethrin, but not deltamethrin, increases spontaneous glutamate release from hippocampal neurons in culture.

scientific article

Perturbation by the PCB mixture aroclor 1254 of GABA(A) receptor-mediated calcium and chloride responses during maturation in vitro of rat neocortical cells.

scientific article published on April 2000

Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents

scientific article published on 18 August 2005

Putative adverse outcome pathways relevant to neurotoxicity

scientific article

Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture

scientific article published on 3 December 2007

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

scientific article published on 23 February 2018

Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of changes in tyrosine hydroxylase

scientific article published in December 1998

Role of NMDA, nicotinic, and GABA receptors in the steady-state visual-evoked potential in rats

scientific article published in December 2005

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

scientific article

Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes

scientific article

Toluene inhibits voltage-sensitive calcium channels expressed in pheochromocytoma cells

scientific article

Transcriptional responses in rat brain associated with sub-chronic toluene inhalation are not predicted by effects of acute toluene inhalation

scientific article

Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes

scientific article

Whole-cell patch-clamp electrophysiology of voltage-sensitive channels

scientific article published in November 2003

List of works by Timothy J. Shafer

A multiplexed assay for determination of neurotoxicant effects on spontaneous network activity and viability from microelectrode arrays

Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissue

Accumulation of pyrethroid compounds in primary cultures from rat cortex

Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and function

Acute toluene exposure and rat visual function in proportion to momentary brain concentration.

Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture

Aluminum decreases muscarinic, adrenergic, and metabotropic receptor-stimulated phosphoinositide hydrolysis in hippocampal and cortical slices from rat brain

Approaches to extrapolating animal toxicity data on organic solvents to public health.

Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening

Burst and principal components analyses of MEA data for 16 chemicals describe at least three effects classes

Channelopathies: Summary of the hot topic keynotes session ⬇️

Comments on: ‘Perinatal toxicity of cyfluthrin in mice: developmental and behavioral effects’ by Soni and colleagues ⬇️

Comparison of chemical-induced changes in proliferation and apoptosis in human and mouse neuroprogenitor cells ⬇️

Complete inhibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin

Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes

Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity

Developing an exposure-dose-response model for the acute neurotoxicity of organic solvents: overview and progress on in vitro models and dosimetry

Development of Micro-Electrode Array Based Tests for Neurotoxicity: Assessment of Interlaboratory Reproducibility with Neuroactive Chemicals ⬇️

Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells

Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs

Developmental neurotoxicity testing: a path forward

Developmentally-regulated sodium channel subunits are differentially sensitive to alpha-cyano containing pyrethroids

Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells.

Effects of Cd2+, Pb2+ and CH3Hg+ on high voltage-activated calcium currents in pheochromocytoma (PC12) cells: potency, reversibility, interactions with extracellular Ca2+ and mechanisms of block

Effects of aluminum on neuronal signal transduction: mechanisms underlying disruption of phosphoinositide hydrolysis.

Effects of an environmentally-relevant mixture of pyrethroid insecticides on spontaneous activity in primary cortical networks on microelectrode arrays

Effects of gestational methylmercury exposure on immunoreactivity of specific isoforms of PKC and enzyme activity during post-natal development of the rat brain

Effects of methylmercury on perineurial Na+ and Ca(2+)-dependent potentials at neuromuscular junctions of the mouse

Effects of prolonged exposure to nanomolar concentrations of methylmercury on voltage-sensitive sodium and calcium currents in PC12 cells

Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity

Effects of the chlorotriazine herbicide, cyanazine, on GABA(A) receptors in cortical tissue from rat brain

Evaluating the NMDA-glutamate receptor as a site of action for toluene, in vivo

Evaluation of microelectrode array data using Bayesian modeling as an approach to screening and prioritization for neurotoxicity testing.

Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set.

Extracellular calcium is required for the polychlorinated biphenyl-induced increase of intracellular free calcium levels in cerebellar granule cell culture

From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation.

Glufosinate binds N-methyl-D-aspartate receptors and increases neuronal network activity in vitro

Identification of calcium-dependent and -independent signaling pathways involved in polychlorinated biphenyl-induced cyclic AMP-responsive element-binding protein phosphorylation in developing cortical neurons

In vitro assessment of developmental neurotoxicity: use of microelectrode arrays to measure functional changes in neuronal network ontogeny.

In vitro exposure to aluminum does not alter long-term potentiation or glutamate release in rat hippocampal slices

In vitro screening of silver nanoparticles and ionic silver using neural networks yields differential effects on spontaneous activity and pharmacological responses

Inhibition of rat brain phosphatidylinositol-specific phospholipase C by aluminum: regional differences, interactions with aluminum salts, and mechanisms.

International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing

Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.

Mechanisms underlying AlCl3 inhibition of agonist-stimulated inositol phosphate accumulation. Role of calcium, G-proteins, phospholipase C and protein kinase C.

Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science.

Neurotoxicological outcomes of perinatal heptachlor exposure in the rat.

Ontogeny of voltage-sensitive calcium channel alpha(1A) and alpha(1E) subunit expression and synaptic function in rat central nervous system

Permethrin, but not deltamethrin, increases spontaneous glutamate release from hippocampal neurons in culture.

Perturbation by the PCB mixture aroclor 1254 of GABA(A) receptor-mediated calcium and chloride responses during maturation in vitro of rat neocortical cells.

Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents

Putative adverse outcome pathways relevant to neurotoxicity

Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of changes in tyrosine hydroxylase

Role of NMDA, nicotinic, and GABA receptors in the steady-state visual-evoked potential in rats

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes

Toluene inhibits voltage-sensitive calcium channels expressed in pheochromocytoma cells

Transcriptional responses in rat brain associated with sub-chronic toluene inhalation are not predicted by effects of acute toluene inhalation

Volatile organic compounds inhibit human and rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes

Whole-cell patch-clamp electrophysiology of voltage-sensitive channels