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List of works by James Vickers

'Fit for Purpose': a cohort-centric approach to MOOC design

A cellular mechanism for the neuronal changes underlying Alzheimer's disease.

scientific article published on June 1997

A neurofilament protein antibody selectively labels a large ganglion cell type in the human retina

scientific article published in June 1992

A subpopulation of chicken primary sensory neurons defined by complete co-localization of Peripherin- and ovalbumin-immunoreactivities

scientific article published on 01 November 1993

A vaccine against Alzheimer's disease: developments to date

scientific article

APOE and BDNF Val66Met polymorphisms combine to influence episodic memory function in older adults.

scientific article published on 16 June 2014

Accurate and Unbiased Quantitation of Amyloid-β Fluorescence Images Using ImageSURF

scientific article published on 01 January 2019

Acute reactive and regenerative changes in mature cortical axons following injury.

scientific article published in February 2007

Age Moderates the Effects of Traumatic Brain Injury on Beta-Amyloid Plaque Load in APP/PS1 Mice

scientific article published on 06 March 2019

Age is no barrier: predictors of academic success in older learners

scientific article published on 15 November 2017

Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

scientific article published on 28 November 2005

Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease.

scientific article published in September 1994

Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease.

scientific article published on 27 July 2016

Alterations in neurofilaments associated with reactive brain changes and axonal sprouting following acute physical injury to the rat neocortex.

scientific article published in April 2001

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice.

scientific article published on 30 April 2013

Amyloid β accumulation and inner retinal degenerative changes in Alzheimer's disease transgenic mouse.

scientific article published on 28 April 2016

An Interactive Multimedia Approach to Improving Informed Consent for Induced Pluripotent Stem Cell Research.

scientific article published in March 2016

Annular alpha-synuclein species from purified multiple system atrophy inclusions.

scientific article

Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults

Association between the serotonin transporter gene polymorphism and verbal learning in older adults is moderated by gender.

scientific article published on 6 June 2017

Automated analysis of propositional idea density in older adults

Axonal shearing in mature cortical neurons induces attempted regeneration and the reestablishment of neurite polarity

scientific article published on 26 August 2009

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system.

scientific article published on 13 August 2009

BDNF and COMT polymorphisms have a limited association with episodic memory performance or engagement in complex cognitive activity in healthy older adults.

scientific article published on 24 January 2014

Binding partners L1 cell adhesion molecule and the ezrin-radixin-moesin (ERM) proteins are involved in development and the regenerative response to injury of hippocampal and cortical neurons

scientific journal article

Building dementia knowledge globally through the Understanding Dementia Massive Open Online Course (MOOC)

scientific article published on 10 April 2019

C9ORF72 expression and cellular localization over mouse development.

scientific article

CRISPR/Cas-Mediated Knock-in of Genetically Encoded Fluorescent Biosensors into the AAVS1 Locus of Human-Induced Pluripotent Stem Cells

Change in modifiable dementia risk factors during COVID‐19 lockdown: The experience of over 50s in Tasmania, Australia

Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.

scientific article published on 13 October 2014

Characterization of cortical neuronal and glial alterations during culture of organotypic whole brain slices from neonatal and mature mice

scientific article

Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model

scientific article published on 23 February 2012

Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net

Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer's disease

scientific article published on 20 December 2016

Communication training and its effects on carer and care-receiver outcomes in dementia settings: A systematic review

article

Complementary immunohistochemical distribution of the neurofilament triplet and novel intermediate filament proteins in the autonomic and sensory nervous system of the guinea-pig

scientific article published in July 1991

Connectivity of Pathology: The Olfactory System as a Model for Network-Driven Mechanisms of Alzheimer's Disease Pathogenesis

scientific article

Consumer Access, Appraisal, and Application of Services and Information for Dementia (CAAASI-Dem): a validation study

Cortical murine neurons lacking the neurofilament light chain protein have an attenuated response to injury in vitro.

scientific article published on November 2013

Counting the cost of dementia-related hospital admissions: A regional investigation

scientific article published on 11 March 2016

Currents of memory: recent progress, translational challenges, and ethical considerations in fornix deep brain stimulation trials for Alzheimer's disease.

scientific article published on 11 March 2017

Cyclosporin-A treatment attenuates delayed cytoskeletal alterations and secondary axotomy following mild axonal stretch injury.

scientific article

Cytoplasmic cytochrome c immunolabelling in dystrophic neurites in Alzheimer's disease.

scientific article published on 20 July 2006

Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease

scientific article published on 18 November 2008

Cytoskeletal and Morphological Alterations Underlying Axonal Sprouting after Localized Transection of Cortical Neuron AxonsIn Vitro ⬇️

scientific article published on May 1, 2003

Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice

scientific article published in June 2013

Defining the earliest pathological changes of Alzheimer's disease

scientific article

Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and α-internexin immunoreactivity

scientific article published on 17 May 2012

Delayed plastic responses to anodal tDCS in older adults.

scientific article

Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer' s disease

scientific article

Differential vulnerability of neurochemically identified subpopulations of retinal neurons in a monkey model of glaucoma.

scientific article published on May 1995

Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments.

scientific article

Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease.

scientific article published in May 2003

Disruption of leptin signalling in a mouse model of Alzheimer's disease.

scientific article published on 15 March 2018

Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.

scientific article published in May 2009

Does beta-amyloid plaque formation cause structural injury to neuronal processes?

scientific article

Does the Cambridge Automated Neuropsychological Test Battery (CANTAB) Distinguish Between Cognitive Domains in Healthy Older Adults?

scientific article

Dystrophic neurite formation associated with age-related beta amyloid deposition in the neocortex: clues to the genesis of neurofibrillary pathology

scientific article published in September 1996

Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging.

scientific article published on 22 October 2007

Early Implementation and Evaluation of StepUp for Dementia Research: An Australia-Wide Dementia Research Participation and Public Engagement Platform

Effects of TDP-43 overexpression on neuron proteome and morphology in vitro

Enhanced Anti-Amyloid Effect of Combined Leptin and Pioglitazone in APP/PS1 Transgenic Mice

Enhanced anti-amyloid effect of combined leptin and pioglitazone in APP/PS1 transgenic mice

Enhancing early detection of cognitive impairment in the criminal justice system: feasibility of a proposed method

Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model.

scientific article

Erratum: C9ORF72 expression and cellular localization over mouse development

scientific article published on 4 January 2016

Excitotoxicity and Axon Degeneration

Excitotoxicity in ALS: Overstimulation, or overreaction?

scientific article

Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.

scientific article published on October 2007

Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol.

scientific article published on 09 September 2013

Exploring the effect of the apolipoprotein E (APOE) gene on executive function, working memory, and processing speed during the early recovery period following traumatic brain injury

scientific article published on 22 February 2016

Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity

scientific article published on 28 May 2010

Focal demyelination in Alzheimer's disease and transgenic mouse models.

scientific article published on 3 March 2010

Further education improves cognitive reserve and triggers improvement in selective cognitive functions in older adults: The Tasmanian Healthy Brain Project.

scientific article published on 19 September 2017

Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro

scientific article published in June 2005

Hospital coding of dementia: is it accurate?

scientific article

How is palliative care understood in the context of dementia? Results from a massive open online course.

scientific article published in November 2017

Identification and characterization of a population of motile neurons in long-term cortical culture.

scientific article

Image-Based Quantitation of Kainic Acid-Induced Excitotoxicity as a Model of Neurodegeneration in Human iPSC-Derived Neurons

ImageSURF: An ImageJ Plugin for Batch Pixel-Based Image Segmentation Using Random Forests

scientific article

Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex

scientific article published on 01 February 1995

Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease

scientific article published in November 1998

Information issues for providers of services to people with dementia living in the community in Australia: breaking the cycle of frustration

scientific article published on 17 September 2008

Information pathways into dementia care services

scholarly article by Andrew Robinson et al published February 2009 in Dementia (journal)

Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury

scientific article published on 7 December 2009

Interactive effects of the APOE and BDNF polymorphisms on functional brain connectivity: the Tasmanian Healthy Brain Project

Intraperikaryal neurofilamentous accumulations in a subset of retinal ganglion cells in aged mice that express a human neurofilament gene

scientific article published on 01 December 1995

Intrinsic regenerative ability of mature CNS neurons.

scientific article published in August 2004

Invasive experimental brain surgery for dementia: Ethical shifts in clinical research practices?

Iron is increased in the brains of ageing mice lacking the neurofilament light gene

scientific article published on 23 October 2019

Island Study Linking Aging and Neurodegenerative Disease (ISLAND) Targeting Dementia Risk Reduction: Protocol for a Prospective Web-Based Cohort Study

Island Study Linking Aging and Neurodegenerative Disease (ISLAND) Targeting Dementia Risk Reduction: Protocol for a Prospective Web-Based Cohort Study (Preprint)

KIBRA gene polymorphism has no association with verbal or visual episodic memory performance

scientific article

Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice

scientific article published on 16 April 2019

Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity.

scientific article published in September 2006

Loss of non-phosphorylated neurofilament immunoreactivity, with preservation of tyrosine hydroxylase, in surviving substantia nigra neurons in Parkinson's disease.

scientific article

Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons

Making Neuroscience Important and Relevant: Online Learning in an Innovative Bachelor of Dementia Care Program

Measuring consumer access, appraisal and application of services and information for dementia (CAAASI-Dem): a key component of dementia literacy

scientific article published on 19 November 2020

Measuring dementia carers' unmet need for services--an exploratory mixed method study

scientific article

Metallothionein biology in the ageing and neurodegenerative brain.

scientific article

Metallothionein expression by NG2 glial cells following CNS injury

scientific article published on 01 October 2007

Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury.

scientific article published in April 2003

Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting

scientific journal article

Microtubule-dependent processes precede pathological calcium influx in excitotoxin-induced axon degeneration

scientific article published on 05 December 2019

Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ-associated pathology and positively influences synaptic and cognitive health in healthy ageing.

scientific article published on 17 December 2016

Mild axonal stretch injury in vitro induces a progressive series of neurofilament alterations ultimately leading to delayed axotomy

scientific article published in October 2005

Mixed Methods Data Collection in Dementia Research

scholarly article by Andrew L. Robinson et al published 29 August 2011 in Journal of Mixed Methods Research

Modeling cognitive reserve in healthy middle-aged and older adults: the Tasmanian Healthy Brain Project.

scientific article

Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late stages of Alzheimer's disease

scientific article published on 15 December 2001

Multiple views reveal the complexity of dementia diagnosis.

scientific article published in December 2008

Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models.

scientific article published on 26 September 2013

Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease.

scientific article published in March 1999

Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer's disease.

scientific article published on 10 July 2015

Neurofilament protein triplet immunoreactivity in the dorsal root ganglia of the guinea-pig.

scientific article

Neurofilament protein-triplet immunoreactivity in distinct subpopulations of peptide-containing neurons in the guinea-pig coeliac ganglion

scientific article published in January 1990

Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex.

scientific article published in September 2002

Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease.

scientific article published on 10 May 2016

Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury

scientific article published in January 2004

No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases

scientific article published on 09 January 2006

Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease.

scientific article

Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord.

scientific article

Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord.

scientific article published in January 2004

Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors

scientific article published on 01 May 2004

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

scientific article published on 12 September 2019

Pathological Links between Traumatic Brain Injury and Dementia: Australian Pre-Clinical Research

scientific article published on 01 March 2020

Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques

scientific article published on 01 February 2004

Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy.

scientific article

Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease

scientific article published in October 1992

Properties of microtubules assembled from mammalian tubulin synthesized in Escherichia coli

scientific article published in April 2001

Protective role of metallothioneins in the injured mammalian brain.

scientific article published in January 2004

Quantitative localization of NMDAR1 receptor subunit immunoreactivity in inferotemporal and prefrontal association cortices of monkey and human

scientific article published in February 1997

Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury

scientific article published on 11 March 2008

Reducing false positive diagnoses in mild cognitive impairment: the importance of comprehensive neuropsychological assessment

scientific article published on 19 June 2014

Regional differences in beta amyloid plaque deposition and variable response to midlife environmental enrichment in the cortex of APP/PS1 mice

scientific article published on 26 October 2020

Relationship between education and age-related cognitive decline: a review of recent research.

scientific article

Relationship between participants' level of education and engagement in their completion of the Understanding Dementia Massive Open Online Course.

scientific article

Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice.

scientific article

Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro

scientific article published in January 2007

Selective distribution of the 66-kDa neuronal intermediate filament protein in the sensory and autonomic nervous system of the guinea-pig

scientific article published in July 1992

Selective vulnerability of non-myelinated axons to stretch injury in an in vitro co-culture system

scientific article

Sending your grandparents to university increases cognitive reserve: The Tasmanian Healthy Brain Project

scientific article published on 16 November 2015

Sex-Specific Protective Effects of Cognitive Reserve on Age-Related Cognitive Decline

Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III.

scientific article

Single Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

scientific article published on 05 March 2021

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media

scientific article published on 23 August 2018

Spinal cord tissue affects ensheathing cell proliferation and apoptosis

scientific article published on 01 May 2005

Studying at university in later life slows cognitive decline: A long‐term prospective study

Subpopulations of neurons in the guinea-pig inferior mesenteric ganglia distinguished by the differential distribution of neurofilament triplet epitopes

scientific article published in September 1992

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

scientific article published on 06 January 2021

Targeted MOOC captivates students

scientific article published in Nature

The BDNF Val66Met Polymorphism Modulates Resilience of Neurological Functioning to Brain Ageing and Dementia: A Narrative Review

scientific article published on 25 March 2020

The BDNF Val66Met polymorphism moderates the effect of cognitive reserve on 36-month cognitive change in healthy older adults

scientific article published on 15 May 2017

The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning

scientific article published on 6 March 2018

The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

scientific article published on 30 June 2015

The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model

article

The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer's Disease

scientific article published on 06 March 2019

The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer’s disease and estimate 5-year risks of cognitive decline and dementia

The Tasmanian Healthy Brain Project (THBP): a prospective longitudinal examination of the effect of university-level education in older adults in preventing age-related cognitive decline and reducing the risk of dementia

scientific article

The apolipoprotein epsilon4 gene is associated with elevated risk of normal tension glaucoma.

scientific article published on 14 October 2002

The associations between dual-task walking under three different interference conditions and cognitive function

scientific article published on 18 August 2020

The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease

scientific article published in May 1997

The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions

scientific article published on 27 February 2015

The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.

scientific article

The impact after 50 years of a new medical education programme with a regional workforce mission.

scientific article published on 5 July 2017

The morphologic and neurochemical basis of dementia: aging, hierarchical patterns of lesion distribution and vulnerable neuronal phenotype.

scientific article published in April 1995

The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.

scientific article

The neurofilament triplet is present in distinct subpopulations of neurons in the central nervous system of the guinea-pig

scientific article

The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer’s disease

Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro

scientific article published on April 2012

Vaccination Strategies for Alzheimer???s Disease

scientific article

Validation of a Dynamic Measure of Current Cognitive Reserve in a Longitudinally Assessed Sample of Healthy Older Adults

scientific article published in January 2017

Variations in the APOE allele or BDNF Val66Met polymorphism are not associated with changes in cognitive function following a tertiary education intervention in older adults: the Tasmanian Healthy Brain Project

scientific article published on 2 April 2017

alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury

scientific article

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