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List of works by Gestur Vidarsson

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

scientific article

A variant RhAG protein encoded by the RHAG*572A allele causes serological weak D expression while maintaining normal RhCE phenotypes

article

Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region

scientific article published on 5 February 2018

Affinity of human IgG subclasses to mouse Fc gamma receptors.

scientific article

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

scientific article published on 23 December 2020

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

scientific article published on 19 May 2020

Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases

scientific article published on 29 May 2015

An IgG3 switch variant of rituximab mediates enhanced complement-dependent cytotoxicity against tumour cells with low CD20 expression levels.

scientific article published on 7 January 2013

An unusual presentation of a patient with severe hypogammaglobulinemia.

scientific article published on 26 October 2018

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura

scientific article published on 20 September 2018

Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy

scientific article published on 30 January 2020

Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets

scientific article published on 27 September 2018

Anti-Hinge Antibodies Recognize IgG Subclass- and Protease-Restricted Neoepitopes.

scientific article

Anti-Platelet Antibodies in Childhood Immune Thrombocytopenia: Prevalence and Prognostic Implications

scientific article published on 13 February 2020

Anti-Tumor Necrosis Factor with a Glyco-engineered Fc Region Has Increased Efficacy in Mice with Colitis

scientific article

Anti-glycoprotein Ibα autoantibodies do not impair circulating thrombopoietin levels in immune thrombocytopenia patients

scientific article published on 11 July 2019

Anti-platelet antibody immunoassays in childhood immune thrombocytopenia: a systematic review

scientific article published on 20 February 2020

Antibodies and their receptors: different potential roles in mucosal defense.

scientific article published on 16 July 2013

Antigen specificity determines anti-red blood cell IgG-Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn

scientific article published on 28 November 2016

Author Correction: Human DC-SIGN and CD23 do not interact with human IgG

scientific article published on 23 July 2020

Biased N-Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation

scientific article published on 08 March 2019

C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia

scientific article

Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice

scientific article published on 01 June 2003

Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G

scientific article published on 10 May 2012

Conserved FcγR- glycan discriminates between fucosylated and afucosylated IgG in humans and mice

scientific article published on 19 December 2017

Coupling porous sheathless interface MS with transient-ITP in neutral capillaries for improved sensitivity in glycopeptide analysis

article

Cross-talk between pathogen recognizing Toll-like receptors and immunoglobulin Fc receptors in immunity

scientific article published in November 2015

Crystal structure of an Anti-meningococcal subtype P1.4 PorA antibody provides basis for peptide-vaccine design

scientific article published in September 2005

DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism

scientific article

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

scientific article

Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19

scientific article published on 30 October 2020

Development of a recombinant anti-Vel immunoglobulin M to identify Vel-negative donors

scientific article published on 31 January 2019

Dimeric IgG complexes from IVIg are incapable of inducing in vitro neutrophil degranulation or complement activation.

scientific article

Dynamics of inter-heavy chain interactions in human immunoglobulin G (IgG) subclasses studied by kinetic Fab arm exchange.

scientific article

Emerging Concepts in Immune Thrombocytopenia.

scientific article

Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile.

scientific article published on 31 May 2017

Erratum to: The Elements Steering Pathogenesis in IgG-Mediated Alloimmune Diseases

scientific article published on 01 May 2016

Expression of human CEACAM1 in transgenic mice limits the Opa-specific immune response against meningococcal outer membrane vesicles.

scientific article published on 6 August 2013

Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation

scientific article

Fc receptor and complement receptor-mediated phagocytosis in host defence.

scientific article published on June 1998

FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis

scientific article published on 18 July 2006

FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming

scientific article published on 28 February 2018

Fcγ receptor expression on splenic macrophages in adult immune thrombocytopenia.

scientific article

FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model

scientific article published on 12 November 2018

FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopenia

scientific article published on 27 February 2020

Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity

scientific article published on 20 November 2019

Functional activity of antibodies against the recombinant OpaJ protein from Neisseria meningitidis.

scientific article

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

scholarly article

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

scientific article published on 28 August 2019

Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts

scientific article

Glycine 236 in the Lower Hinge Region of Human IgG1 Differentiates FcγR from Complement Effector Function

scientific article published on 13 November 2020

Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

scientific article published on 2 May 2018

Glycoform-resolved FcɣRIIIa affinity chromatography-mass spectrometry

scientific article published on 02 August 2019

Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia

scientific article

H435-containing immunoglobulin G3 allotypes are transported efficiently across the human placenta: implications for alloantibody-mediated diseases of the newborn

scientific article

Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3).

scientific article published on 10 March 2015

Human DC-SIGN and CD23 do not interact with human IgG

scientific article published on 10 July 2019

Human IgG3 with extended half-life does not improve Fc-gamma receptor-mediated cancer antibody therapies in mice

scientific article

Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling

Identification of sequence variants influencing immunoglobulin levels.

scientific article published on 19 June 2017

IgA and the IgA Fc receptor.

scientific article

IgG Glyco-Engineering to Improve IVIg Potency

scientific article published on 23 October 2018

IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming

scientific article published on 13 November 2020

IgG subclasses and allotypes: from structure to effector functions

scientific article

IgG-Fc glycosylation before and after rituximab treatment in immune thrombocytopenia

scientific article published on 20 February 2020

IgG-effector functions: "the good, the bad and the ugly".

scientific article published on February 2014

Immune responses of infants vaccinated with serotype 6B pneumococcal polysaccharide conjugated with tetanus toxoid

scientific article published on 01 July 1997

Immunoglobulin A: Fc(alpha)RI interactions induce neutrophil migration through release of leukotriene B4.

scientific article

Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19

scientific article published on 22 March 2022

Inhibition of FcγR-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and FcγRIIb in human macrophages

scientific article

Inside-out regulation of Fc alpha RI (CD89) depends on PP2A.

scientific article published on September 2008

Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial

scientific article published on 26 June 2018

Isotypes and opsonophagocytosis of pneumococcus type 6B antibodies elicited in infants and adults by an experimental pneumococcus type 6B-tetanus toxoid vaccine

scientific article

Label-free cell profiling

scientific article published on 11 April 2013

Label-free detection of immune complexes with myeloid cells.

scientific article published on 08 March 2016

MALDI-TOF-MS reveals differential N-linked plasma- and IgG-glycosylation profiles between mothers and their newborns.

scientific article published on 26 September 2016

Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

scientific article

Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI

scientific article published on 24 July 2018

Molecular analysis of the York antigen of the Knops blood group system

scientific article published on 7 January 2011

Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans.

scientific article

Multiplex blood group typing by cellular surface plasmon resonance imaging

scientific article published on 29 November 2018

Multiplex screening for functionally rearranged immunoglobulin variable regions reveals expression of hybridoma-specific aberrant V-genes

scientific article published on 01 March 2001

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

scientific article published in 2024

Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation

scientific article published on 19 February 2020

Novel Concepts of Altered Immunoglobulin G Galactosylation in Autoimmune Diseases

scientific article published on 19 March 2018

On the perplexingly low rate of transport of IgG2 across the human placenta

scientific article

PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita

scientific article published on 4 July 2016

Pathogenicity of IgG subclass autoantibodies to type VII collagen: induction of dermal-epidermal separation

scientific article published on 30 November 2009

Patients with IgG1-anti-red blood cell autoantibodies show aberrant Fc-glycosylation

scientific article published on 15 August 2017

Pneumococcal pneumonia and bacteremia model in mice for the analysis of protective antibodies

scientific article published on 01 August 2000

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

scientific article published on 15 June 2020

Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D.

scientific article

Protection by meningococcal outer membrane protein PorA-specific antibodies and a serogroup B capsular polysaccharide-specific antibody in complement-sufficient and C6-deficient infant rats

scientific article

Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

scientific article published on 14 May 2019

Regulated glycosylation patterns of IgG during alloimmune responses against human platelet antigens

scientific article

Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease

scientific article published on 03 December 2001

Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

scientific article

Restricted immune activation and internalisation of anti-idiotype complexes between drug and antidrug antibodies

scientific article published on 26 June 2018

RhIg-prophylaxis is not influenced by FCGR2/3 polymorphisms involved in red blood cell clearance

scientific article published on 12 January 2017

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation

scientific article published on 01 April 2018

Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.

scientific article published on 4 August 2017

Role of leukocyte immunoglobuin G receptors in vaccine-induced immunity to Streptococcus pneumoniae

scientific article published on 12 May 2003

Serological blind spots for variants of human IgG3 and IgG4 by a commonly used anti-immunoglobulin reagent

scientific article

Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.

scientific article published on March 2006

Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions.

scientific article

Strategies to develop a prophylaxis for the prevention of HPA-1a immunization and fetal and neonatal alloimmune thrombocytopenia

scientific article published on 31 December 2019

The Elements Steering Pathogenesis in IgG-Mediated Alloimmune Diseases

scientific article

The Ligands for Human IgG and Their Effector Functions

scientific article published on 25 April 2019

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

scientific article published in 2023

The majority of human memory B cells recognizing RhD and tetanus resides in IgM+ B cells

scientific article published on 25 June 2014

The multiple facets of FcRn in immunity.

scientific article

The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases.

scientific article published on 09 March 2010

Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms

scientific article published on 01 July 2019

Trends in SPR Cytometry: Advances in Label-Free Detection of Cell Parameters

scientific article published on 30 October 2018

Vaccination of COPD patients with a pneumococcus type 6B tetanus toxoid conjugate vaccine

scientific article published on 01 October 2002

Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.

scientific article published on 15 February 2018

Working mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 Protease

scientific article published on October 2005

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