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List of works by Randy Poon

A roller coaster ride with the mitotic cyclins

scientific article

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

scientific article

Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma

scientific article published on 01 June 2002

An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells.

scientific article published on 18 January 2007

Aurora B: Hooking up with cyclin-dependent kinases ⬇️

scientific article published on March 19, 2013

BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death.

scientific article published on 25 May 2016

BS69 is involved in cellular senescence through the p53-p21Cip1 pathway.

scientific article published on 24 August 2007

CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency

scientific article published on 16 September 2016

Cdc37: a protein kinase chaperone?

scientific article published in April 1997

Cell Cycle Control: A System of Interlinking Oscillators.

scientific article published on January 2016

Characterization of the cullin and F-box protein partner Skp1

scientific article

Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT.

scientific article

Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation

scientific article published on 07 January 2019

Critical differences between isoforms of securin reveal mechanisms of separase regulation

scientific article

Cyclin A in cell cycle control and cancer

scientific article (publication date: August 2002)

Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins

scientific article

Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

scientific article

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis.

scientific article published in November 2017

DNA Damage and Polyploidization ⬇️

scientific article published on January 1, 2010

DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin–CDC2 Complexes, and Reverses Cells to Interphase ⬇️

scientific article published on July 25, 2003

DNA damage checkpoints in nasopharyngeal carcinoma.

scientific article published on 04 February 2014

Degradation of Cyclin A Does Not Require Its Phosphorylation by CDC2 and Cyclin-dependent Kinase 2

scientific article published in Journal of Biological Chemistry

Depletion of p31comet protein promotes sensitivity to antimitotic drugs.

scientific article published on 27 April 2012

Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01.

scientific article published on 23 March 2011

Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.

scientific article

Differential responses of proliferating versus quiescent cells to adriamycin

scientific article published on July 1999

Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint

scientific article published on 18 November 2013

G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells

scientific article published on November 1999

Gene down-regulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells.

scientific article published on December 2010

Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe.

scientific article published on 29 September 2008

Generation of phosphorylated cyclin-dependent kinase 2 and functional characterization of threonine-160-specific phosphatase KAP ⬇️

scientific article published on January 1, 1997

Genome reduplication: redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C.

scientific article

How many mutant p53 molecules are needed to inactivate a tetramer?

scientific article published on April 2004

How protein kinases co-ordinate mitosis in animal cells.

scientific article published on April 2011

ING1b decreases cell proliferation through p53-dependent and -independent mechanisms

scientific article published in October 2003

Identification of functional domains in the neuronal Cdk5 activator protein

scientific article

Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics

scientific article published on 05 April 2019

Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe

scientific article published on 20 April 2012

Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit

scientific article

Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes.

scientific article

MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation

scientific article

MDM2 and MDMX bind and stabilize the p53-related protein p73

scientific article

MDM2 and MDMX can interact differently with ARF and members of the p53 family

scientific article published on 01 February 2001

Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints

scientific article

On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells.

scientific article published on August 2000

On the masking of signals on immunoblots by cellular proteins

scientific article published on December 1996

Orderly Inactivation of the Key Checkpoint Protein Mitotic Arrest Deficient 2 (MAD2) during Mitotic Progression ⬇️

scientific article published on February 18, 2011

Reversible Immunoprecipitation Using Histidine- or Glutathione S-Transferase-Tagged Staphylococcal Protein A

scientific article published on 01 April 1994

SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.

scientific article

SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56

scientific article

Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death

scientific article

Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells

scientific article published on 21 March 2017

Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor

scientific article

Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways.

scientific article published on February 2006

Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation.

scientific article published on 28 July 2009

Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia

scientific article

Synchronization of HeLa Cells.

scientific article published in January 2017

Synchronization of HeLa cells

scientific article published in January 2011

Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint

scientific article published on 09 October 2019

TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2.

scientific article published in February 2018

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

scientific article published on 28 January 2016

Tetraploidization increases sensitivity to Aurora B kinase inhibition.

scientific article

The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery.

scientific article

The Spindle Checkpoint in the Dinoflagellate Crypthecodinium cohnii

scientific article published on 01 January 2000

The p53 Isoform Deltap53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity

scientific article published in March 2007

The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint.

scientific article published on 21 November 2004

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair

scientific article

Ubiquitination of p53 at multiple sites in the DNA-binding domain

scientific article published on January 2006

p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells

scientific article

p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases ⬇️

scientific article published on August 19, 2013

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