List of works - Lothar Lilge

A Ratiometric Fluorescence Imaging System for Surgical Guidance

A multi-wavelength, laser-based optical spectroscopy device for breast density and breast cancer risk pre-screening

scientific article

A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors.

scientific article

A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy.

scientific article published on 07 March 2016

A solubilization technique for photosensitizer quantification in ex vivo tissue samples

scientific article published on 01 July 1997

ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia

scientific article published on 31 July 2017

Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters.

scientific article

An observational study of personal ultraviolet dosimetry and acute diffuse reflectance skin changes at extreme altitude

scientific article published on 25 September 2013

Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies

scientific article published on 29 March 2015

Assessing breast tissue density by transillumination breast spectroscopy (TIBS): an intermediate indicator of cancer risk.

scientific article published on 30 May 2007

Association between transillumination breast spectroscopy and quantitative mammographic features of the breast

scientific article published in May 2008

Automatic interstitial photodynamic therapy planning via convex optimization.

scientific article published on 30 January 2018

Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy

scientific article published in September 2004

Changes in optical properties of ex vivo rat prostate due to heating

scientific article published on 01 May 2000

Classification of breast tissue density by optical transillumination spectroscopy: optical and physiological effects governing predictive value

scientific article published in June 2004

Controlled electroporation of the plasma membrane in microfluidic devices for single cell analysis

scientific article published on 28 February 2012

Correlation of intracellular oxygen and cell metabolism by simultaneous PLIM of phosphorescent TLD1433 and FLIM of NAD(P)H

scientific article published on 09 July 2018

Delineation of Tumor Habitats based on Dynamic Contrast Enhanced MRI

scientific article published on 29 August 2017

Design and performance of thin cylindrical diffusers created in Ge-doped multimode optical fibers

scientific article published in May 2005

Development and characterization of multi-sensory fluence rate probes

scientific article published on 21 March 2006

Differential expression of sirtuin family members in the developing, adult, and aged rat brain.

scientific article

Diverse optical characteristic of the prostate and light delivery system: implications for computer modelling of prostatic photodynamic therapy

scientific article published in June 2005

Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

scientific article

Dynamic absorption and scattering of water and hydrogel during high-repetition-rate (>100 MHz) burst-mode ultrafast-pulse laser ablation

scientific article

Effective phthalocyanines mediated photodynamic therapy with doxorubicin or methotrexate combination therapy at sub-micromolar concentrations in vitro

scientific article published on 21 February 2018

Effects of 810 nm laser irradiation on in vitro growth of bacteria: comparison of continuous wave and frequency modulated light

scientific article

Effects of low intensity laser irradiation during healing of infected skin wounds in the rat.

scientific article published on February 2014

Effects of low intensity laser irradiation during healing of skin lesions in the rat.

scientific article

Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model

scientific article published on 28 May 2019

End-faced waveguide mediated optical propulsion of microspheres and single cells in a microfluidic device

scientific article published on 15 February 2013

Energy-partition diagnostic for measuring time-resolved scattering and absorption in burst-mode laser ablation.

scientific article

Estimation of mammographic density on an interval scale by transillumination breast spectroscopy

scientific article published in November 2008

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA BreaksIn vivo

Fluorescence image-guided brain tumour resection with adjuvant metronomic photodynamic therapy: pre-clinical model and technology development

scientific article published on 14 April 2005

FullMonteCUDA: a fast, flexible, and accurate GPU-accelerated Monte Carlo simulator for light propagation in turbid media

scientific article published on 21 August 2019

Hardware acceleration of a Monte Carlo simulation for photodynamic therapy [corrected] treatment planning.

scientific article published on January 2009

High-performance, robustly verified Monte Carlo simulation with FullMonte

scientific article published on 01 August 2018

Implicit and explicit dosimetry in photodynamic therapy: a New paradigm.

scientific article

In vitro influence of hypoxia on bioluminescence imaging in brain tumor cells

In vivo effects of low level laser therapy on inducible nitric oxide synthase

scientific article

In vivo quantification of fluorescent molecular markers in real-time by ratio imaging for diagnostic screening and image-guided surgery.

scientific article

In vivo study of the inflammatory modulating effects of low-level laser therapy on iNOS expression using bioluminescence imaging.

scientific article published in November 2005

In-vitro efficacy of indocyanine green-mediated photodynamic therapy in combination with cisplatin or etoposide

Increased brain tumor resection using fluorescence image guidance in a preclinical model

scientific article published in January 2004

Interpretation of intrinsic optical signals and calcein fluorescence during acute excitotoxic insult in the hippocampal slice

scientific article

Light Dosimetry for Intraperitoneal Photodynamic Therapy in a Murine Xenograft Model of Human Epithelial Ovarian Carcinoma

scientific article published on 01 September 1998

Light propagation within N95 Filtered Face Respirators: A simulation study for UVC decontamination

scientific article published on 05 September 2020

Low-intensity laser therapy efficacy evaluation in FVB mice subjected to acute and chronic arthritis

scientific article published on 30 May 2017

Low-intensity laser therapy efficacy evaluation in mice subjected to acute arthritis condition

scientific article published on 26 July 2017

Medical laser application: translation into the clinics.

scientific article published on June 2015

Metronomic photodynamic therapy as a new paradigm for photodynamic therapy: rationale and preclinical evaluation of technical feasibility for treating malignant brain tumors

scientific article

Microfabricated system for parallel single-cell capillary electrophoresis

scientific article

Miniature isotropic optical fibre probes for quantitative light dosimetry in tissue

scientific article published on 01 February 1993

Modeling localized delivery of Doxorubicin to the brain following focused ultrasound enhanced blood-brain barrier permeability

scientific article published on 17 September 2014

Modulation of PPIX synthesis and accumulation in various normal and glioma cell lines by modification of the cellular signaling and temperature

scientific article

Murine Model Imitating Chronic Wound Infections for Evaluation of Antimicrobial Photodynamic Therapy Efficacy.

scientific article published on 09 August 2016

Next-generation acceleration and code optimization for light transport in turbid media using GPUs

scientific article published on 23 August 2010

Non-invasive optical spectroscopic monitoring of breast development during puberty

scientific article published on 06 February 2017

Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk

scientific article published in July 2004

Novel Osmium-based Coordination Complexes as Photosensitizers for Panchromatic Photodynamic Therapy

scientific article

Optical assessment of mammographic breast density by a 12-wavelength vs a continuous-spectrum optical spectroscopy device

scientific article published on 12 July 2017

Optical characteristics of the canine prostate at 665 nm sensitized with tin etiopurpurin dichloride: need for real-time monitoring of photodynamic therapy

scientific article

Optical spectroscopy of the breast in premenopausal women reveals tissue variation with changes in age and parity

scientific article published on 01 February 2010

Optical transillumination spectroscopy to quantify parenchymal tissue density: an indicator for breast cancer risk.

scientific article published on November 2005

Optimizing interstitial photodynamic therapy with custom cylindrical diffusers

scientific article published on 27 September 2018

Partial least squares based decomposition of five spectrally overlapping factors

scientific article published in November 2005

Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat.

scientific article

Performance evaluation of cylindrical fiber optic light diffusers for biomedical applications

scientific article published in January 2004

Pharmacology of photosensitizer in rats with metastatic breast cancer: time point determination for photodynamic therapy (PDT) treatment of vertebral metastases

scholarly article published 28 September 2005

Photobiomodulation therapy can change actin filaments of 3T3 mouse fibroblast

scientific article published on 13 August 2019

Photodynamic actinometry using microspheres: concept, development and responsivity

scientific article

Photodynamic inactivation of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with Ru(II)-based type I/type II photosensitizers

scientific article published on 5 August 2013

Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinoma.

scientific article

Photonics in the development of personalized medicine

article

Photophysical properties and in vitro photocytotoxicity of disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX (Dimegine)

scientific article published on 06 November 2018

Pioneers in biomedical optics: special section honoring Professor Tayyaba Hasan.

scientific article published in September 2010

Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells.

scientific article published on September 2015

Pulsetrain-burst mode, ultrafast-laser interactions with 3D viable cell cultures as a model for soft biological tissues

scientific article published on 13 December 2013

Silicon nanoparticles produced by femtosecond laser ablation in water as novel contamination-free photosensitizers.

scientific article

Skin color and tissue thickness effects on transmittance, reflectance, and skin temperature when using 635 and 808 nm lasers in low intensity therapeutics.

scientific article published on 27 November 2017

Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue

scientific article

Spatially resolved, diffuse reflectance imaging for subsurface pattern visualization toward development of a lensless imaging platform: phantom experiments.

scientific article published in January 2016

The LEGACY Girls Study: Growth and Development in the Context of Breast Cancer Family History

scientific article published on 29 January 2016

The association between breast tissue optical content and mammographic density in pre- and post-menopausal women

scientific article

The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.

scientific article

The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro

scientific article

The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy.

scientific article

Thin cylindrical diffusers in multimode Ge-doped silica fibers

scientific article published in March 2005

Three-dimensional fluence rate measurement and data acquisition system for minimally invasive light therapies

scientific article

Towards conformal light delivery using tailored cylindrical diffusers: attainable light dose distributions

scientific article published on 30 October 2006

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

article

Transperineal in vivo fluence-rate dosimetry in the canine prostate during SnET2-mediated PDT.

scientific article published in July 2004

Treatment planning using tailored and standard cylindrical light diffusers for photodynamic therapy of the prostate

scientific article published on 5 February 2008

Why do veins appear blue? A new look at an old question.

scientific article

List of works by Lothar Lilge

A Ratiometric Fluorescence Imaging System for Surgical Guidance

A multi-wavelength, laser-based optical spectroscopy device for breast density and breast cancer risk pre-screening

A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors.

A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy.

A solubilization technique for photosensitizer quantification in ex vivo tissue samples

ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia

Absorbed photodynamic dose from pulsed versus continuous wave light examined with tissue-simulating dosimeters.

An observational study of personal ultraviolet dosimetry and acute diffuse reflectance skin changes at extreme altitude

Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies

Assessing breast tissue density by transillumination breast spectroscopy (TIBS): an intermediate indicator of cancer risk.

Association between transillumination breast spectroscopy and quantitative mammographic features of the breast

Automatic interstitial photodynamic therapy planning via convex optimization.

Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy

Changes in optical properties of ex vivo rat prostate due to heating

Classification of breast tissue density by optical transillumination spectroscopy: optical and physiological effects governing predictive value

Controlled electroporation of the plasma membrane in microfluidic devices for single cell analysis

Correlation of intracellular oxygen and cell metabolism by simultaneous PLIM of phosphorescent TLD1433 and FLIM of NAD(P)H

Delineation of Tumor Habitats based on Dynamic Contrast Enhanced MRI

Design and performance of thin cylindrical diffusers created in Ge-doped multimode optical fibers

Development and characterization of multi-sensory fluence rate probes

Differential expression of sirtuin family members in the developing, adult, and aged rat brain.

Diverse optical characteristic of the prostate and light delivery system: implications for computer modelling of prostatic photodynamic therapy

Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

Dynamic absorption and scattering of water and hydrogel during high-repetition-rate (>100 MHz) burst-mode ultrafast-pulse laser ablation

Effective phthalocyanines mediated photodynamic therapy with doxorubicin or methotrexate combination therapy at sub-micromolar concentrations in vitro

Effects of 810 nm laser irradiation on in vitro growth of bacteria: comparison of continuous wave and frequency modulated light

Effects of low intensity laser irradiation during healing of infected skin wounds in the rat.

Effects of low intensity laser irradiation during healing of skin lesions in the rat.

Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model

End-faced waveguide mediated optical propulsion of microspheres and single cells in a microfluidic device

Energy-partition diagnostic for measuring time-resolved scattering and absorption in burst-mode laser ablation.

Estimation of mammographic density on an interval scale by transillumination breast spectroscopy

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA BreaksIn vivo

Fluorescence image-guided brain tumour resection with adjuvant metronomic photodynamic therapy: pre-clinical model and technology development

FullMonteCUDA: a fast, flexible, and accurate GPU-accelerated Monte Carlo simulator for light propagation in turbid media

Hardware acceleration of a Monte Carlo simulation for photodynamic therapy [corrected] treatment planning.

High-performance, robustly verified Monte Carlo simulation with FullMonte

Implicit and explicit dosimetry in photodynamic therapy: a New paradigm.

In vitro influence of hypoxia on bioluminescence imaging in brain tumor cells

In vivo effects of low level laser therapy on inducible nitric oxide synthase

In vivo quantification of fluorescent molecular markers in real-time by ratio imaging for diagnostic screening and image-guided surgery.

In vivo study of the inflammatory modulating effects of low-level laser therapy on iNOS expression using bioluminescence imaging.

In-vitro efficacy of indocyanine green-mediated photodynamic therapy in combination with cisplatin or etoposide

Increased brain tumor resection using fluorescence image guidance in a preclinical model

Interpretation of intrinsic optical signals and calcein fluorescence during acute excitotoxic insult in the hippocampal slice

Light Dosimetry for Intraperitoneal Photodynamic Therapy in a Murine Xenograft Model of Human Epithelial Ovarian Carcinoma

Light propagation within N95 Filtered Face Respirators: A simulation study for UVC decontamination

Low-intensity laser therapy efficacy evaluation in FVB mice subjected to acute and chronic arthritis

Low-intensity laser therapy efficacy evaluation in mice subjected to acute arthritis condition

Medical laser application: translation into the clinics.

Metronomic photodynamic therapy as a new paradigm for photodynamic therapy: rationale and preclinical evaluation of technical feasibility for treating malignant brain tumors

Microfabricated system for parallel single-cell capillary electrophoresis

Miniature isotropic optical fibre probes for quantitative light dosimetry in tissue

Modeling localized delivery of Doxorubicin to the brain following focused ultrasound enhanced blood-brain barrier permeability

Modulation of PPIX synthesis and accumulation in various normal and glioma cell lines by modification of the cellular signaling and temperature

Murine Model Imitating Chronic Wound Infections for Evaluation of Antimicrobial Photodynamic Therapy Efficacy.

Next-generation acceleration and code optimization for light transport in turbid media using GPUs

Non-invasive optical spectroscopic monitoring of breast development during puberty

Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk

Novel Osmium-based Coordination Complexes as Photosensitizers for Panchromatic Photodynamic Therapy

Optical assessment of mammographic breast density by a 12-wavelength vs a continuous-spectrum optical spectroscopy device

Optical characteristics of the canine prostate at 665 nm sensitized with tin etiopurpurin dichloride: need for real-time monitoring of photodynamic therapy

Optical spectroscopy of the breast in premenopausal women reveals tissue variation with changes in age and parity

Optical transillumination spectroscopy to quantify parenchymal tissue density: an indicator for breast cancer risk.

Optimizing interstitial photodynamic therapy with custom cylindrical diffusers

Partial least squares based decomposition of five spectrally overlapping factors

Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat.

Performance evaluation of cylindrical fiber optic light diffusers for biomedical applications

Pharmacology of photosensitizer in rats with metastatic breast cancer: time point determination for photodynamic therapy (PDT) treatment of vertebral metastases

Photobiomodulation therapy can change actin filaments of 3T3 mouse fibroblast

Photodynamic actinometry using microspheres: concept, development and responsivity

Photodynamic inactivation of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with Ru(II)-based type I/type II photosensitizers

Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinoma.

Photonics in the development of personalized medicine

Photophysical properties and in vitro photocytotoxicity of disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX (Dimegine)

Pioneers in biomedical optics: special section honoring Professor Tayyaba Hasan.

Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells.

Pulsetrain-burst mode, ultrafast-laser interactions with 3D viable cell cultures as a model for soft biological tissues

Silicon nanoparticles produced by femtosecond laser ablation in water as novel contamination-free photosensitizers.