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List of works by Markus Heilig

1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial

scientific article published in February 2003

A key role for corticotropin-releasing factor in alcohol dependence

scientific article published on 16 July 2007

A multiplex calcium assay for identification of GPCR agonists and antagonists

scientific article

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

scientific journal article

A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence

scientific article published in May 2005

A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.

scientific article published on 8 September 2014

A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial

scientific article published in May 2007

A welcome change that stops short of being fully satisfying ⬇️

scientific article published on May 1, 2011

Acamprosate: an alcoholism treatment that may not be what we thought

scientific article published on March 2014

Activation of PPARγ Attenuates the Expression of Physical and Affective Nicotine Withdrawal Symptoms through Mechanisms Involving Amygdala and Hippocampus Neurotransmission

scientific article published on 04 November 2019

Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats

scientific article

Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking

scientific article published on 31 January 2011

Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex

scientific article

Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?

scientific article

Addiction and its brain science

scientific article

Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism

scientific article

Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences

scientific article

Alcohol use disorder causes global changes in splicing in the human brain

scientific article published on 05 January 2021

Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats

scientific article

Alcoholism

Antisense Technology

Antisense inhibition of neuropeptide Y (NPY)-Y1 receptor expression blocks the anxiolytic-like action of NPY in amygdala and paradoxically increases feeding

scientific article published in October 1995

Antisense oligodeoxynucleotides as novel neuropharmacological tools for selective expression blockade in the brain

Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test

scientific article published in January 2002

Anxiolytic-like action of centrally administered galanin

scientific article published in December 1993

Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice

scientific article

Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test

scientific article published on September 3, 1992

Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia

scientific article

Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence

scientific article published on March 2008

Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm

scientific article published in January 2007

Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques

scientific article

Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats

scientific article published on 18 November 2003

Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism

scientific article

Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties

scientific article published in July 2003

Beliefs and reality: detection and prevention of high alcohol consumption in Swedish antenatal clinics

scientific article

Beliefs and reality: detection and prevention of high alcohol consumption in Swedish antenatal clinics

Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective

scientific article published on 13 April 2012

Brain neuropeptide Y (NPY) in stress and alcohol dependence

scientific article

Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking

scientific article published on 23 November 2011

Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series

scientific article published on 19 March 2008

Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system

scientific article

C-fos antisense in the nucleus accumbens blocks the locomotor stimulant action of cocaine

scientific article published in May 1993

CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques

scientific article published on August 2008

Cationic lipid-mediated delivery and expression of prepro-neuropeptide Y cDNA after intraventricular administration in rat: feasibility and limitations

scientific article published on March 1996

Central administration of dopamine D3 receptor antisense to rat: effects on locomotion, dopamine release and [3H]spiperone binding ⬇️

scientific article published on September 1, 1998

Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models

scientific article published on January 1989

Cerebrospinal Fluid Monocyte Chemoattractant Protein-1 in Alcoholics: Support for a Neuroinflammatory Model of Chronic Alcoholism

article

Cerebrospinal fluid monoamine metabolites and atmospheric pressure.

scientific article

Child μ-opioid receptor gene variant influences parent-child relations

scientific article

Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism

scientific article published on 27 December 2012

Cholecystokinin (CCK) in the nervous system (Ellis Horwood health science series)

article

Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse

scientific article

Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat

scientific article

Conditioned preference to a methamphetamine-associated contextual cue in humans

scientific article

Corticotropin-releasing hormone (CRH) mRNA expression in rat central amygdala in cannabinoid tolerance and withdrawal: evidence for an allostatic shift?

scientific article published in January 2004

D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model

scientific article

DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.

scientific article

Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.

scientific article

Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions

scientific article published in June 1997

Decreased measures of experimental anxiety in rats bred for high alcohol preference

scientific article

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

scientific article published on 01 January 1996

Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats

scientific article published in November 2001

Dopamine D3 receptor antisense influences dopamine synthesis in rat brain

scientific article published on February 1995

Dr. Heilig Replies ⬇️

scientific article published on 01 November 2007

Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.

scientific article

Early onset alcohol dependence with high density of family history is not "male limited".

scientific article published in March 2010

Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study

scientific article published on October 2010

Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats

scientific article published on 5 June 2007

Effects of cysteamine and pantethine on open-field behavior, hypothalamic catecholamine concentrations, and somatostatin-induced barrel rotation in rats

scientific article published in March 1989

Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography

scientific article

Effects of intracerebroventricular D-myo-inositol-1,2,6-trisphosphate (PP56), a proposed neuropeptide Y (NPY) antagonist, on locomotor activity, food intake, central effects of NPY and NPY-receptor binding

scientific article published in December 1991

Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol-dependent patients

scientific article

Effects of psychoactive drugs on delta sleep-inducing peptide concentrations in rat brain

scientific article published in January 1989

Effects of the NK1 antagonist, aprepitant, on response to oral and intranasal oxycodone in prescription opioid abusers

scientific article

Electroconvulsive shocks increase the concentration of neocortical and hippocampal neuropeptide Y (NPY)-like immunoreactivity in the rat.

scientific article published in January 1990

Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects

scientific article published on 4 December 2012

Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes

scientific article

Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors

scientific article

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

scientific article

FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice

scientific article

Faculty of 1000 evaluation for Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice

scholarly article published 27 December 2015

Fetus at risk: prevalence of alcohol consumption during pregnancy estimated with a simple screening method in Swedish antenatal clinics

scientific article published in November 2003

Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques

scientific article

Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence

scientific article

Gender differences in neural-behavioral response to self-observation during a novel fMRI social stress task.

scientific article published on 4 December 2013

Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data

scientific article

Gene-environment interactions and response to social intrusion in male and female rhesus macaques

scientific article

Genetic Deletion of Neuronal PPARγ Enhances the Emotional Response to Acute Stress and Exacerbates Anxiety: An Effect Reversed by Rescue of Amygdala PPARγ Function.

scientific article published on 3 November 2016

Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference

scientific article published on 8 February 2006

Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.

scientific article published in April 2000

Hazardous alcohol users during pregnancy: psychiatric health and personality traits

scientific article published on 23 March 2007

High doses of testosterone increase anticonflict behaviour in rat.

scientific article published in December 1998

High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats

scientific article

Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect

scientific article

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats

scientific article

Identification of Functionally Selective Small Molecule Antagonists of the Neuropeptide-S Receptor: Naphthopyranopyrimidines

Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor

Identifying hazardous alcohol consumption during pregnancy: implementing a research-based model in real life

article

Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients

scientific article

Improving translation of animal models of addiction and relapse by reverse translation

scientific article published on 06 October 2020

In vivo antisense inhibition of prodynorphin expression in rat striatum: dose-dependence and sequence specificity

Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden

scientific article published in February 2005

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

scientific article

Intracerebroventricular neuropeptide Y protects against stress-induced gastric erosion in the rat

article

Intracerebroventricular neuropeptide Y suppresses open field and home cage activity in the rat.

scientific article

Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum

scientific article published in October 1997

Kappa-opioid receptor antagonism: a mechanism for treatment of relief drinking?

scientific article published on May 2014

Long-lasting tolerance to alcohol following a history of dependence.

scientific article

Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats

scientific article published on 25 March 2010

Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist

scientific article published on 12 June 2008

Low vitamin D status and suicide: a case-control study of active duty military service members

scientific article

Maintenance buprenorphine for opioid users

scientific article published in The Lancet

Medications development to treat alcohol dependence: a vision for the next decade

scientific article

Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes

scientific article

Models for alcohol dependence: A clinical perspective

Modulation of carbon monoxide production and enhanced spatial learning by tin protoporphyrin

scientific article published in July 1995

Mood and neuroendocrine response to a chemical stressor, metyrapone, in buprenorphine-maintained heroin dependence

scientific article published on 11 September 2007

NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations

scientific article published in January 2003

NPY in alcoholism and psychiatric disorders

scientific article

Neurobiology of Alcohol Use Disorder

Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depression

scientific article published on 24 August 2006

Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice

scientific article published on 30 January 2010

Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat.

scientific article published in August 1987

Neuropeptide Y (NPY)-induced suppression of activity in the rat: evidence for NPY receptor heterogeneity and for interaction with α-adrenoceptors

article

Neuropeptide Y antagonists: a perspective

Neuropeptide Y in Relation to Behavior and Psychiatric Disorders

Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

scientific article published on November 2003

Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence

scientific article published in February 2003

Neuroplasticity in brain reward circuitry following a history of ethanol dependence

scientific article published on April 2008

OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques

scientific article

PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission

scientific article

Persistent behavioral and autonomic supersensitivity to stress following prenatal stress exposure in rats

scientific article published in March 2003

Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system

scientific article published on 25 March 2009

Pharmacogenetic approaches to the treatment of alcohol addiction

scientific article

Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats

scientific article published on 20 October 2011

Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate

scientific article

Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats

scientific article

Possible relationship between neuropeptide Y (NPY) and major depression – evidence from human and animal studies

article by Erik Widerlöv et al published January 1988 in Nordic Journal of Psychiatry

Rapid tolerance and locomotor sensitization in ethanol-naïve adolescent rhesus macaques

scientific article published in July 2008

Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST.

scientific article

Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol

scientific article published in March 2007

Relationship between liver function and brain shrinkage in patients with alcohol dependence

scientific article published on 13 October 2011

Repetitive Transcranial Magnetic Stimulation in Alcohol Dependence: A Randomized, Double-Blind, Sham-Controlled Proof-of-Concept Trial Targeting the Medial Prefrontal and Anterior Cingulate Cortices

scientific article published in 2022

Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats

scientific article

Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes

scientific article published on April 2010

Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers

scientific article

Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats

scientific article published on 12 April 2013

Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor

scientific article

Stress and alcohol interactions: animal studies and clinical significance

scientific article published on 11 March 2014

Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.

scientific article

Stress-related neuropeptides and addictive behaviors: beyond the usual suspects

scientific article

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

scientific article

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor

scientific article (publication date: 27 November 2013)

Suppressed neuroendocrine stress response in depressed women on job-stress-related long-term sick leave: a stable marker potentially suggestive of preexisting vulnerability

scientific article published on 05 December 2008

Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress.

scientific article

Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus

scientific article published on January 2010

Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats

scientific article published on 14 July 2010

Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence

scientific article

Synaptic degeneration in thalamus in schizophrenia

scientific article published in September 1996

Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats

scientific article published on 16 February 2013

The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus

scientific article

The NK1 receptor antagonist L822429 reduces heroin reinforcement

scientific article published on 18 December 2012

The NPY system in stress, anxiety and depression

scientific article

The biometric measurement of alcohol consumption

scientific article

The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study

scientific article

The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety

scientific article published in May 2012

The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study

scientific article published on 18 July 2014

The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice

scientific article published on 22 September 2007

The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety

scientific article

The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking

scientific article published on 31 October 2013

The serotonin transporter gene linked polymorphic region is associated with the behavioral response to repeated stress exposure in infant rhesus macaques

scientific article

The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain

scientific article published in April 1998

Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues

scientific article

Translational Approaches to Medication Development

article

Translational and reverse translational research on the role of stress in drug craving and relapse

scientific article

Translational approaches to medication development

scientific article

Tyrphostin inhibition of ATP-stimulated DNA synthesis, cell proliferation and fos-protein expression in vascular smooth muscle cells.

scientific article published in June 1996

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence

scientific article published on 21 June 2007

[19] Pharmacokinetic properties of oligonucleotides in brain

scientific article published on 01 January 2000

β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol

scientific article published on 19 June 2013

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