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List of works by Annika Thorsell

3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

scientific article published in March 2007

A genetic determinant of the striatal dopamine response to alcohol in men

scientific article

A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats

scientific journal article

A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.

scientific article published on 8 September 2014

Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol

scientific article published on 13 April 2014

Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation

scientific article published on 4 February 2010

Antagonism of neuropeptide YY1 receptors does not inhibit ethanol's effects on cortical EEG and ERPs in Wistar rats.

scientific article published in July 2005

Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test

scientific article published in January 2002

Anxiogenic-like action of galanin after intra-amygdala administration in the rat.

scientific article

Behavioral and endocrine adaptation, and up-regulation of NPY expression in rat amygdala following repeated restraint stress

scientific article published in September 1999

Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.

scientific article published in November 2000

Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective

scientific article published on 13 April 2012

Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats.

scientific article

Brain neuropeptide Y (NPY) in stress and alcohol dependence

scientific article

Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety.

scientific article published on October 2010

Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats

scientific article published in May 2004

D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model

scientific article

Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism.

scientific article

Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions

scientific article published in June 1997

Decreased measures of experimental anxiety in rats bred for high alcohol preference

scientific article

Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats

scientific article published in November 2001

Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats.

scientific article published in January 2001

Diverse functions of neuropeptide Y revealed using genetically modified animals.

scientific article

Effect of social isolation on ethanol consumption and substance P/neurokinin expression in Wistar rats

scientific article published in June 2005

Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats

scientific article published on 5 June 2007

Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposure

scientific article published on 24 February 2005

Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in wistar rats with a history of ethanol exposure

scientific article

Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors

scientific article

Exposure to nicotine during periadolescence or early adulthood alters aversive and physiological effects induced by ethanol

scientific article

Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor

Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: relation to anxiety-like and depressive-like behavior

scientific article published in August 2005

Leptin suppression of hypothalamic NPY expression and feeding, but not amygdala NPY expression and experimental anxiety

scientific article published in March 2002

Lipid mediated gene delivery in the adult rat brain: quantitative analysis of expression

scientific article

Local 5,7-dihydroxytryptamine lesions of rat amygdala: release of punished drinking, unaffected plus-maze behavior and ethanol consumption

scientific article

Long-term neurobehavioral effects of alcohol or nicotine exposure in adolescent animal models

scientific article published in June 2004

Melanin-concentrating hormone receptor 1 (MCH1-R) antagonism: reduced appetite for calories and suppression of addictive-like behaviors

scientific article published on 15 June 2012

Neurokinin 1 receptor antagonism as a possible therapy for alcoholism

scientific article

Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice

scientific article published on 30 January 2010

Neuropeptide Y (NPY) in alcohol intake and dependence.

scientific article published on 18 January 2007

Neuropeptide Y (NPY) mRNA in rat brain tissue: effects of decapitation and high-energy microwave irradiation on post mortem stability

scientific article published in June 2001

Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking

scientific article published on 10 December 2009

Pharmacological blockade of corticotropin-releasing hormone receptor 1 (CRH1R) reduces voluntary consumption of high alcohol concentrations in non-dependent Wistar rats

scientific article published on 20 October 2011

Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons

scientific article

Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism.

scientific article

Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders

scientific article published on 5 February 2018

Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice.

scientific article published on 5 February 2018

Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.

scientific article

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond

scientific article

Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor

scientific article (publication date: 27 November 2013)

Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress.

scientific article

Suppression of alcohol self-administration and reinstatement of alcohol seeking by melanin-concentrating hormone receptor 1 (MCH1-R) antagonism in Wistar rats

scientific article published on 14 July 2010

Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence

scientific article

The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats

scientific article published on January 2006

The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety

scientific article published in May 2012

The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice

scientific article published on 22 September 2007

The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety

scientific article

The μ-opioid receptor and treatment response to naltrexone

scientific article

Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues

scientific article

Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats.

scientific article published on 02 April 2007

β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol

scientific article published on 19 June 2013

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