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List of works by Tomáš Šimůnek

Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?

scientific article published on 2 November 2016

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.

scientific article published on 7 May 2016

Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy

scientific article published on 9 July 2003

Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane

scientific article published on 23 December 2015

Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

scientific article published on 12 October 2016

Cardioprotective potential of iron chelators and prochelators

scientific article

Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells

scientific article

Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.

scientific article published on April 2016

Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways.

scientific article

Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits.

scientific article published in December 2002

Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.

scientific article

Comparison of protective effects of two iron chelating compounds – deferiprone and dexrazoxane – against chronic anthracycline cardiotoxicity

Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.

scientific article

Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.

scientific article

Corrigendum to: "Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model" [Exp. Cell Res. 339 2 (2015) 174-186].

scientific article

DNA topoisomerase IIβ: a player in regulation of gene expression and cell differentiation

scientific article published on 24 March 2012

Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo.

scientific article

Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium

scientific article published on 28 December 2012

Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death

scientific article published on 21 July 2009

Direct administration of rutin does not protect against catecholamine cardiotoxicity.

scientific article

Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits.

scientific article published on 4 July 2013

Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships

scientific article

Far-red-absorbing cationic phthalocyanine photosensitizers: synthesis and evaluation of the photodynamic anticancer activity and the mode of cell death induction

scientific article published on 4 February 2015

Flavonoids as protectors against doxorubicin cardiotoxicity: role of iron chelation, antioxidant activity and inhibition of carbonyl reductase

scientific article published on 21 May 2007

Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles

scientific article published on 17 April 2015

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

scientific article

In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

scientific article published on 24 May 2007

In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity ⬇️

scientific article published on November 3, 2010

Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress.

scientific article published on 21 March 2016

Investigation of structure-activity relationships of dexrazoxane analogues reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

scientific article published on 06 April 2020

Iron chelation with salicylaldehyde isonicotinoyl hydrazone protects against catecholamine autoxidation and cardiotoxicity.

scientific article published on 13 December 2010

Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH)

scientific article published on 24 March 2007

Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.

scientific article

LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)

scientific article

Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: novel iron chelators with selective antiproliferative action.

scientific article

Molecular remodeling of left and right ventricular myocardium in chronic anthracycline cardiotoxicity and post-treatment follow up.

scientific article

Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits.

scientific article published in April 2005

Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.

scientific article published on 12 October 2012

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

scientific article

Proteomic insights into chronic anthracycline cardiotoxicity.

scientific article

Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model.

scientific article published on 26 October 2015

Pyridoxal isonicotinoyl hydrazone (PIH) and its analogs as protectants against anthracycline-induced cardiotoxicity

scientific article

Quantitative analysis of the anti-proliferative activity of combinations of selected iron-chelating agents and clinically used anti-neoplastic drugs

scientific article (publication date: 2014)

SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.

scientific article published on August 2005

Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats

scientific article published on 20 November 2013

Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties.

scientific article

Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits.

scientific article published in March 2005

Synthesis and Initial in Vitro Evaluations of Novel Antioxidant Aroylhydrazone Iron Chelators with Increased Stability against Plasma Hydrolysis ⬇️

scientific article published on January 7, 2011

Tetra(3,4-pyrido)porphyrazines Caught in the Cationic Cage: Toward Nanomolar Active Photosensitizers.

scientific article published on 28 September 2016

Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy.

scientific article published on December 2013

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