List of works - Sheila M Donnelly

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

scientific article

A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase.

scientific article published on 7 August 2012

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease.

scientific article

An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.

scientific article published on 14 May 2009

Antimicrobial peptides: utility players in innate immunity.

scientific article published on 25 October 2012

Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica.

scientific article

Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation

scientific article (publication date: 2013)

Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells

scientific article published on 30 January 2004

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

scientific article (publication date: 19 January 2007)

Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity

scientific article

De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum.

scientific article published in September 2005

Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines

scientific article

Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses

scientific article published on 24 March 2021

Fasciola hepatica vaccine: we may not be there yet but we're on the right road

scientific article

Fasciola hepatica: the therapeutic potential of a worm secretome.

scientific article published on 05 December 2012

Fasciola hepaticategumental antigens indirectly induce an M2 macrophage-like phenotypein vivo

scientific article published on 01 October 2014

Glycerol-induced seizure: involvement of IL-1beta and glutamate

scientific article

Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.

scientific article published on 15 August 2008

Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.

scientific article

Helminth defence molecules-immunomodulators designed by parasites!

scientific article

Helminth pathogen cathepsin proteases: it's a family affair.

scientific article published on 08 October 2008

Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression

scientific article

Helminths at mucosal barriers--interaction with the immune system

scientific article published on April 2004

Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development

scientific article published on 06 April 2013

Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases

scientific article

Interleukin-1β-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine

scientific article published on 01 November 2000

Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.

scientific article published on May 2004

Long‐term effects of Semliki Forest virus infection in the mouse central nervous system ⬇️

scientific article published on June 1, 1997

Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine

scientific article

Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1).

scientific article published on 25 June 2010

Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors.

scientific article

Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse

scientific article

Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages.

scientific article published on 3 October 2017

Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling.

scientific article

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

scientific article published on 9 August 2007

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

scientific article

Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?

scientific article

The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

scientific article published in June 2009

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

scientific article published on 20 August 2007

The enigmatic asparaginyl endopeptidase of helminth parasites

scientific article

The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease

scientific article

The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular eve

scientific article published on 2 April 2007

Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages

scientific article

Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination

scientific article

Worm secretory molecules are causing alarm

scientific article published on 09 June 2010

List of works by Sheila M Donnelly

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase.

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease.

An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.

Antimicrobial peptides: utility players in innate immunity.

Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica.

Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation

Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development

Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity

De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum.

Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines

Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses

Fasciola hepatica vaccine: we may not be there yet but we're on the right road

Fasciola hepatica: the therapeutic potential of a worm secretome.

Fasciola hepaticategumental antigens indirectly induce an M2 macrophage-like phenotypein vivo

Glycerol-induced seizure: involvement of IL-1beta and glutamate

Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.

Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.

Helminth defence molecules-immunomodulators designed by parasites!

Helminth pathogen cathepsin proteases: it's a family affair.

Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression

Helminths at mucosal barriers--interaction with the immune system

Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development

Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases

Interleukin-1β-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine

Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.

Long‐term effects of Semliki Forest virus infection in the mouse central nervous system ⬇️

Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine

Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1).

Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors.

Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse

Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages.

Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling.

Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?

The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

The enigmatic asparaginyl endopeptidase of helminth parasites

The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease

The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular eve

Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages

Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination

Worm secretory molecules are causing alarm