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List of works by Fahd Al-mulla

<i>ACE2</i> and <i>FURIN</i> variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19

scientific article published on 28 January 2021

A comprehensive germline variant and expression analyses of ACE2, TMPRSS2 and SARS-CoV-2 activator FURIN genes from the Middle East: Combating SARS-CoV-2 with precision medicine

scientific article published on 17 May 2020

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

scientific article published on 30 August 2011

A new model for raf kinase inhibitory protein induced chemotherapeutic resistance

scientific article

A novel PKD1 variant demonstrates a disease-modifying role in trans with a truncating PKD1 mutation in patients with autosomal dominant polycystic kidney disease.

scientific article

ANGPTL4: A Predictive Marker for Diabetic Nephropathy ⬇️

scientific article published on 27 October 2019

Adult Diabetes and Prediabetes Prevalence in Kuwait: Data from the Cross-Sectional Kuwait Diabetes Epidemiology Program

scientific article published on 25 October 2020

Age-dependent penetrance of different germline mutations in the BRCA1 gene

scientific article published on April 2009

Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats

scientific article

Analysis of DNA methylation in FFPE tissues using the MethyLight technology

scientific article

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

scientific article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

scientific article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Associations of single nucleotide polymorphisms in the adiponectin gene with adiponectin levels and cardio-metabolic risk factors in patients with cancer ⬇️

scientific article published on January 1, 2011

Atherogenic Index of Plasma (AIP) a Tool to Assess Changes in Cardiovascular Disease Risk Post Laparoscopic Sleeve Gastrectomy

scientific article published on 01 August 2020

Autoimmune signatures for prediction and diagnosis of autoimmune diabetes in Kuwait

scientific article published on 05 April 2019

BRCA1 gene expression in breast cancer in Kuwait: Correlation with prognostic parameters

scientific article published on March 2005

BRCA1 gene expression in breast cancer: A correlative study between real-time RT-PCR and immunohistochemistry

scientific article published on May 2005

Biallelic inactivating variants in the GTPBP2 gene cause a neurodevelopmental disorder with severe intellectual disability.

scientific article published on 15 February 2018

Bridging genomics research between developed and developing countries: the Genomic Medicine Alliance

Capturing all disease-causing mutations for clinical and research use: toward an effortless system for the Human Variome Project

scientific article

Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer

scientific article

Causes of genome instability: the effect of low dose chemical exposures in modern society

scientific article

Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children

scientific article published on 21 December 2018

Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes

scientific journal article

Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions

scientific article

Chemically Defined Conditions Mediate an Efficient Induction of Mesodermal Lineage from Human Umbilical Cord- and Bone Marrow- Mesenchymal Stem Cells and Dental Pulp Pluripotent-Like Stem Cells

scientific article published in February 2018

Circulating cell-free DNA in sickle cell disease: is it a potentially useful biomarker?

scientific article published in May 2014

Clinical implications for loss or diminution of expression of Raf-1 kinase inhibitory protein and its phosphorylated form in ductal breast cancer

scientific article

Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer

scientific article published on April 2007

Comparative Proteomic Analysis Identifies EphA2 as a Specific Cell Surface Marker for Wharton's Jelly-Derived Mesenchymal Stem Cells

scientific article published on 03 September 2020

Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases

article

Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer

research work

Comparison of two probe preparation methods using long oligonucleotide microarrays

scientific article published in November 2004

Correction: RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration

scientific article published on May 2016

Correlation Profile of Suppression of Tumorigenicity 2 and/or Interleukin-33 with Biomarkers in the Adipose Tissue of Individuals with Different Metabolic States

scientific article published on 20 October 2020

Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents

scientific article published on 14 April 2020

Could nuclear matrix protein 22 (NMP22) play a role with urine cytology in screening for bladder cancer? - Experience at Kuwait University

research work

Decreased carbonyl reductase 1 expression promotes malignant behaviours by induction of epithelial mesenchymal transition and its clinical significance

scientific article

Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells

scientific article published on 16 November 2016

Defining umbilical cord blood stem cells

article

Depletion of the Ras Association Domain Family 1, Isoform A-Associated Novel Microtubule-Associated Protein, C19ORF5/MAP1S, Causes Mitotic Abnormalities

scientific article published on 01 January 2007

Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations

scientific article published in December 2001

Directed differentiation of umbilical cord blood stem cells into cortical GABAergic neurons

scientific article published in January 2013

Discovery and clinical introduction of first-in-class imipridone ONC201.

scientific article published on September 2016

Disruptive chemicals, senescence and immortality

scientific article

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

scientific article

Enhanced Adipose Expression of Interferon Regulatory Factor (IRF)-5 Associates with the Signatures of Metabolic Inflammation in Diabetic Obese Patients

scientific article published on 16 March 2020

Environmental immune disruptors, inflammation and cancer risk

scientific article

Epidermal growth factor receptor mutations in nonsmall cell lung carcinoma patients in Kuwait

scientific article published on January 2016

Evaluation of the PrimerDesign™ genesig real-time reverse transcription-polymerase chain reaction assay and the INFINITI® Respiratory Viral Panel Plus assay for the detection of human metapneumovirus in Kuwait

scientific article published in February 2012

Expression of Estrogen Receptor a and Estrogen Receptor β in Fine Needle Aspirates of Breast Carcinoma

FIRST INTERNATIONAL WORKSHOP ON "PROGNOSTIC AND THERAPEUTIC APPLICATIONS OF RKIP IN CANCER"

Functionally-focused algorithmic analysis of high resolution microarray-CGH genomic landscapes demonstrates comparable genomic copy number aberrations in MSI and MSS sporadic colorectal cancer.

scientific article

GALNT2 rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level

scientific article published in 2022

Gender influence in EBV antibody response in multiple sclerosis patients from Kuwait.

scientific article published on 21 May 2015

Gender-associated genomic differences in colorectal cancer: clinical insight from feminization of male cancer cells

scientific article

Generalizability of GWA-Identified Genetic Risk Variants for Metabolic Traits to Populations from the Arabian Peninsula

scientific article published in 2021

Genetic and epigenetic control of RKIP transcription

scientific article

Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse

Genetic tests obtainable through pharmacies: the good, the bad, and the ugly

scientific article published on 8 July 2013

Genotypic and phenotypic differences between nodal and extranodal diffuse large B-Cell lymphomas

scientific article

Global implementation of genomic medicine: We are not alone

scientific article

Glycolaldehyde induces apoptosis in a human breast cancer cell line

scientific article

Hemizygosity of the MAX Gene Locus in HL60 Cells

article

Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality

article

Higher Levels of ANGPTL5 in the Circulation of Subjects With Obesity and Type 2 Diabetes Are Associated With Insulin Resistance

scientific article published on 24 July 2019

Human Variome Project country nodes: documenting genetic information within a country

scientific article published on 18 July 2012

Human metapneumovirus in patients with respiratory tract infection in Kuwait

Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology

scientific article published on 30 October 2018

Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse. ⬇️

scientific article published on 28 April 2016

Identification of Maturity-Onset-Diabetes of the Young (MODY) mutations in a country where diabetes is endemic

scientific article published on 09 August 2021

Identification of a rare germline NBN gene mutation by whole exome sequencing in a lung-cancer survivor from a large family with various types of cancer

scientific article published on 14 November 2016

Immunocytochemical detection of raf kinase inhibitor protein and human papillomavirus profiling of normal and abnormal cervical ThinPrep samples

scientific article published on 25 April 2013

Impact of 226C>T MSH2 gene mutation on cancer phenotypes in two HNPCC-associated highly-consanguineous families from Kuwait: emphasis on premarital genetic testing

article

Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes

scientific article

Increased Adipose Tissue Expression of Interferon Regulatory Factor (IRF)-5 in Obesity: Association with Metabolic Inflammation

scientific article published on 11 November 2019

Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study

scientific article published on 24 August 2020

Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism

scientific article published on 11 April 2010

Ketogenic diet attenuates cerebellar atrophy progression in a subject with a biallelic variant at the ATAD3A locus

scientific article published on 05 June 2019

Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study

scientific article

LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1

scientific article published on 14 October 2020

MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress

scientific article published on 29 July 2020

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.

scientific article

Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

scientific article

Metastatic recurrence of early-stage colorectal cancer is linked to loss of heterozygosity on chromosomes 4 and 14q.

scientific article published on June 2006

Methods for microarray data analysis

scientific article

Microarray-Based CGH and Copy Number Analysis of FFPE Samples ⬇️

scientific article published on January 1, 2011

Mitochondrial DNA D-loop sequencing reveals obesity variants in an Arab population.

scientific article published on 24 May 2019

Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait

article published in 2014

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

scientific article

Mutant K-ras2 in serum

scientific article published in June 2003

Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes

scientific article

Novel Flavonoid Didymin Inhibits Neuroblastomas--Letter

Oxidative Stress Induces Expression of the Toll-Like Receptors (TLRs) 2 and 4 in the Human Peripheral Blood Mononuclear Cells: Implications for Metabolic Inflammation

scientific article published on 01 January 2019

Oxidative stress--mediated alterations in glucose dynamics in a genetic animal model of type II diabetes

scientific article published on September 2005

PKD1 Duplicated regions limit clinical Utility of Whole Exome Sequencing for Genetic Diagnosis of Autosomal Dominant Polycystic Kidney Disease

scientific article published on 11 March 2019

Pathogenic Germline Variants in 10,389 Adult Cancers

scientific article published in April 2018

Planning the human variome project: the Spain report.

scientific article published in April 2009

Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer

scientific article

Prevalence and correlation of human papilloma virus and its types with prognostic markers in patients with invasive ductal carcinoma of the breast in kuwait

scientific article

Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are Associated with the Upregulation of Wingless-Related Integration and Bone Morphogenetic Protein Signaling in Dark Agouti Rats

scientific article published on 10 May 2016

RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility

scientific article published on 23 December 2010

RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.

scientific article published on 26 August 2015

RKIP and cellular motility ⬇️

scientific article published on July 1, 2012

RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration.

scientific article published on 13 August 2015

RKIP-1 and the Cell Cycle: Novel Insight Into Genomic Instability

RKIP: much more than Raf kinase inhibitory protein

scientific article published on August 2013

ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes

scientific article published on 23 February 2012

Rabson-Mendenhall Syndrome in a brother-sister pair in Kuwait: Diagnosis and 5 year follow up

scientific article published on 22 August 2020

Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β.

scientific article published on 8 February 2011

Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients

scientific article published in February 2013

Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients

scientific article published in December 2006

Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability.

scientific article

Raf kinase inhibitory protein role in the molecular subtyping of breast cancer

scientific article published on March 2014

Real-time tracking and forecasting of the COVID-19 outbreak in Kuwait: a mathematical modeling study

scientific article published on 08 May 2020

Recommendations for genetic variation data capture in developing countries to ensure a comprehensive worldwide data collection

scientific article

Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer.

scientific article

Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis

scientific article published on October 2005

Regulation of the MAPK pathway by raf kinase inhibitory protein

scientific article

Retracted: Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer

retracted article

Role of Caveolin-1 in Diabetes and Its Complications

scientific article published on 27 January 2020

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains

scientific article published on 25 May 2021

Senior-Loken syndrome: A novel NPHP5 gene mutation in a family from Kuwait

article

Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity

scientific article published on 17 March 2020

Statistical Class Separation Using sEMG Features Towards Automated Muscle Fatigue Detection and Prediction

article

Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway

scientific article published on 09 October 2020

Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression

scientific article published in March 1999

Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines.

scientific article published on 9 September 2015

Suppression of carbonyl reductase expression enhances malignant behaviour in uterine cervical squamous cell carcinoma: carbonyl reductase predicts prognosis and lymph node metastasis

scientific article

TNF-α Drives the CCL4 Expression in Human Monocytic Cells: Involvement of the SAPK/JNK and NF-κB Signaling Pathways

scientific article published on 01 January 2019

TNF-α Induces a Pro-Inflammatory Phenotypic Shift in Monocytes through ACSL1: Relevance to Metabolic Inflammation

scientific article published on 08 March 2019

Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery

scientific article published on 01 September 2020

Test Pricing and Reimbursement in Genomic Medicine: Towards a General Strategy

scientific article published on 28 September 2016

The Association of Vitamin D Receptor Polymorphisms with Multiple Sclerosis in a Case-Control Study from Kuwait

scientific article published on 5 November 2015

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target ⬇️

scientific article published on 17 May 2020

The effect of environmental chemicals on the tumor microenvironment

scientific article

The effect of prostate tissue inflammation in benign prostatic hyperplasia on enhancer of zeste homolog 2 ribonucleic acid expression

scientific article

The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants

scientific article published on 29 February 2024

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

scientific article

The influence of admixture and consanguinity on population genetic diversity in Middle East

scientific article published on 25 September 2014

The locked genomes: A perspective from Arabia

scientific article

The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia

scientific article published on 11 June 2014

The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling

scientific article

The relationship between genetic profiling, clinicopathological factors and survival in patients undergoing surgery for node-negative colorectal cancer: 10-year follow-up

scientific article published on 26 September 2013

The spectrum of BRCA1 and BRCA2 pathogenic sequence variants in Middle Eastern, North African, and South European countries

scientific article published on 26 July 2019

Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes

scientific article

Uses of microarray platforms in cancer: a correlative study between genomic copy number changes and their expression at mRNA and protein levels

scientific article published on January 2007

Utilization of microarray platforms in clinical practice: an insight on the preparation and amplification of nucleic acids from frozen and fixed tissues.

scientific article

Which obesity index best explains the link between adipokines, coronary heart disease risk and metabolic abnormalities in type 2 diabetes mellitus?

scientific article published on 10 February 2009

Whole genome amplification of DNA extracted from FFPE tissues

scientific article published on January 2011

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