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List of works by Luiz A. Basso

2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

scientific article published on 11 January 2016

A structural model for chorismate synthase from Mycobacterium tuberculosis in complex with coenzyme and substrate

scientific article

Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection

scientific article published on 27 June 2012

Analysis of select members of the E26 (ETS) transcription factors family in colorectal cancer

scientific article

Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain

scientific article published on 18 November 2011

Biochemical characterization of recombinant nucleoside hydrolase from Mycobacterium tuberculosis H37Rv

scientific article

Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis

scientific article

Capillary bioreactors based on human purine nucleoside phosphorylase: A new approach for ligands identification and characterization

scientific article published on 28 October 2011

Chorismate synthase: an attractive target for drug development against orphan diseases.

scientific article published on March 2007

Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum

scientific article published on 04 June 2013

Cloning and expression of functional shikimate dehydrogenase (EC 1.1.1.25) from Mycobacterium tuberculosis H37Rv

scientific article published in October 2002

Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase

scientific article

Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv

scientific article published on 04 May 2011

Cooperativity between trimers of the hexameric glutamate dehydrogenase from Clostridium symbiosum

scientific article published on 01 February 1998

Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir.

scientific article published on 20 October 2011

Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products.

scientific article published on 2 February 2011

Crystal structure of human PNP complexed with hypoxanthine and sulfate ion.

scientific article published in January 2005

Crystal structure of human purine nucleoside phosphorylase at 2.3A resolution

scientific article

Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir

scientific article

Crystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis

scientific article published on 20 October 2004

Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis

scientific article published on 21 April 2006

Crystallographic structure of PNP from Mycobacterium tuberculosis at 1.9A resolution

scientific article published in November 2004

Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis

scientific article

DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme

scientific journal article

Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer

scientific article published on 17 January 2019

Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity

scientific article published on 31 October 2013

Determining the structural basis for specificity of ligands using crystallographic screening.

scientific article published on January 2006

Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach.

scientific article

Dynamics of glyphosate-induced conformational changes of Mycobacterium tuberculosis 5-enolpyruvylshikimate-3-phosphate synthase (EC 2.5.1.19) determined by hydrogen-deuterium exchange and electrospray mass spectrometry

scientific article published on 18 June 2008

Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis

scientific article

Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs

scientific article published in February 2005

Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents.

scientific article published on March 2007

Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex.

scientific article

Functional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purification

scientific journal article

Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization.

scientific article published on 27 October 2005

Gene replacement and quantitative mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth.

scientific article published on 8 October 2015

Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: an essential step towards target-based drug design.

scientific article

Human granulocyte colony stimulating factor (hG-CSF): cloning, overexpression, purification and characterization.

scientific article published on 4 April 2008

Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis

scientific article published on 23 July 2014

Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization

scientific journal article

IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages

scientific article published in October 2013

Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis

scientific article published on 28 May 2009

Initial formation of a non-covalent enzyme-reagent complex during the inactivation of clostridial glutamate dehydrogenase by Ellman's reagent: determination of the enzyme's dissociation constant for the binary complex with NAD+ from protection studi

scientific article published on 01 December 1994

Interaction of shikimic acid with shikimate kinase.

scientific article published in December 2004

Ionic states of substrates and transition state analogues at the catalytic sites of N-ribosyltransferases

scientific article published in May 2003

Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

scientific article published on 28 September 2011

Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis

scientific article published on 21 November 2006

Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase

scientific article published on 10 June 2013

Kinetic mechanism determination and analysis of metal requirement of dehydroquinate synthase from Mycobacterium tuberculosis H37Rv: an essential step in the function-based rational design of anti-TB drugs

scientific journal article

Kinetic studies on the binding of 1,N6-etheno-NAD+ to glutamate dehydrogenase from Clostridium symbiosum

scientific article published in June 1997

Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine

scientific article

Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection.

scientific article published on 7 June 2016

Molecular Models of Tryptophan Synthase From Mycobacterium tuberculosis Complexed With Inhibitors

scientific article published on 01 January 2006

Molecular cloning and transgenic expression of a synthetic human erythropoietin gene in tobacco

scientific article published on 18 May 2011

Molecular cloning, expression in Escherichia coli and production of bioactive homogeneous recombinant human granulocyte and macrophage colony stimulating factor

scientific article published on 21 April 2009

Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities

scientific article published on 20 May 2005

Molecular model of shikimate kinase from Mycobacterium tuberculosis

scientific article published in July 2002

Molecular modeling and dynamics simulations of PNP from Streptococcus agalactiae.

scientific article

Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.

scientific article published on 15 March 2008

Molecular modeling and dynamics studies of purine nucleoside phosphorylase from Bacteroides fragilis.

scientific article published on 27 January 2009

Molecular modeling, dynamics and docking studies of purine nucleoside phosphorylase from Streptococcus pyogenes.

scientific article published on 26 February 2009

Molecular models for shikimate pathway enzymes of Xylella fastidiosa

scientific article published in July 2004

Molecular models of protein targets from Mycobacterium tuberculosis.

scientific article

Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase

scientific article

Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23)

scientific article published on 06 June 2011

Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding

scientific article published on 10 December 2007

New Sensitive Fluorophores for Selective DNA Detection

scientific article published on 05 September 2007

New catalytic mechanism for human purine nucleoside phosphorylase

scientific article published in February 2005

Observed crowding effects on Mycobacterium tuberculosis 2-trans-enoyl-ACP (CoA) reductase enzyme activity are not due to excluded volume only

scientific article published on 28 July 2017

On the selective detection of duplex deoxyribonucleic acids by 2,1,3-benzothiadiazole fluorophores

scientific article published on 5 March 2010

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase

scientific article (publication date: 27 May 2003)

Phosphate closes the solution structure of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) from Mycobacterium tuberculosis

scientific article published on 13 June 2006

Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies

scientific article published on 18 November 2014

Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis

scientific article published in PLoS ONE

Production of recombinant human annexin V by fed-batch cultivation

scientific article

Protective Effects of Resveratrol on Hepatotoxicity Induced by Isoniazid and Rifampicin via SIRT1 Modulation

scientific article published on 10 October 2014

Purine Salvage Pathway in Mycobacterium tuberculosis.

scientific article published on January 2011

Purine nucleoside phosphorylase activity and expression are upregulated in sites affected by periodontal disease.

scientific article published on 20 June 2010

Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts

scientific article published in July 2001

Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase ⬇️

scientific article published on April 30, 2012

Real time PCR quantification of viable Mycobacterium tuberculosis from sputum samples treated with propidium monoazide.

scientific article

Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme–ligand binary complex formation

scientific article published on 07 February 2011

Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)

scientific article

Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes

scientific article published in March 2004

Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development.

scientific article

Shikimate kinase: a potential target for development of novel antitubercular agents.

scientific article published on March 2007

Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex.

scientific article published on January 2006

Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase

scientific article

Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis.

scientific article published on December 2003

Structural bioinformatics study of PNP from Listeria monocytogenes

scientific article

Structural bioinformatics study of PNP from Schistosoma mansoni

scientific article

Structural studies of PNP from Toxoplasma gondii.

scientific article

Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function

scientific article

Structural studies of prephenate dehydratase from Mycobacterium tuberculosis H37Rv by SAXS, ultracentrifugation, and computational analysis.

scientific article published in September 2008

Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis

scientific article published in August 2008

Structure of chorismate synthase from Mycobacterium tuberculosis.

scientific article

Structure of human PNP complexed with ligands.

scientific article published on 24 June 2005

Structure of shikimate kinase from Mycobacterium tuberculosis reveals the binding of shikimic acid

scientific journal article

Structures of human purine nucleoside phosphorylase complexed with inosine and ddI

scientific article

Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces

scientific article

Targeting the histidine pathway in Mycobacterium tuberculosis.

scientific article published on January 2013

The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP

scientific journal article

The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials.

scientific article published on March 2007

The kinetic mechanism of Human Thymidine Phosphorylase - a molecular target for cancer drug development

scientific article published on 10 January 2014

The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy

scientific article published on 11 March 2010

The mechanism of substrate and coenzyme binding to clostridial glutamate dehydrogenase during oxidative deamination

scientific article published on 01 May 1993

The mechanism of substrate and coenzyme binding to clostridial glutamate dehydrogenase during reductive amination

scientific article published on 01 December 1995

The mode of action of recombinant Mycobacterium tuberculosis shikimate kinase: kinetics and thermodynamics analyses

scientific article

The transition state analog inhibitor of Purine Nucleoside Phosphorylase (PNP) Immucillin-H arrests bone loss in rat periodontal disease models

UMP kinase from Mycobacterium tuberculosis: Mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation

scientific journal article

Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS?

scientific article

[Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy

scientific article published on 12 August 2014

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