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List of works by Susan Howlett

"Voltage-activated Ca release" in rabbit, rat and guinea-pig cardiac myocytes, and modulation by internal cAMP.

scientific article published on December 1997

3H-nitrendipine binding to hamster cardiac muscle homogenate

scientific article published on 01 January 1986

A Frailty Index Based on Common Laboratory Tests in Comparison With a Clinical Frailty Index for Older Adults in Long-Term Care Facilities

scientific article published on 5 May 2015

A clinical frailty index in aging mice: comparisons with frailty index data in humans

scientific article

A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes

scientific article published on 13 April 2016

A procedure for creating a frailty index based on deficit accumulation in aging mice.

scientific article published on 21 October 2011

Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart

scientific article published on 28 October 2016

Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging

scientific article published on 04 May 2015

Age and life expectancy clocks based on machine learning analysis of mouse frailty

scientific article published on 15 September 2020

Age and ovariectomy abolish beneficial effects of female sex on rat ventricular myocytes exposed to simulated ischemia and reperfusion

scientific article

Age-associated alterations in retinal arteriole reactivity to endothelin-1 differ between the sexes

scientific article published on 13 August 2012

Age-associated changes in excitation-contraction coupling are more prominent in ventricular myocytes from male rats than in myocytes from female rats.

scientific article published on 4 December 2009

Ageing: Develop models of frailty

scientific article published in Nature

Animal models of frailty: current applications in clinical research

scientific article

Assessment of Frailty in Animal Models

scientific article published on 17 July 2015

Associations between a laboratory frailty index and adverse health outcomes across age and sex

scientific article published on 08 March 2019

Attentuation of cardiac stunning by losartan in a cellular model of ischemia and reperfusion is accompanied by increased sarcoplasmic reticulum Ca2+ stores and prevention of cytosolic Ca2+ elevation

scientific article

Beta-adrenoceptor stimulation exacerbates detrimental effects of ischemia and reperfusion in isolated guinea pig ventricular myocytes

scientific article

Blood pressure in relation to age and frailty.

scientific article published on March 2011

Calcium channels in normal and dystrophic hamster cardiac muscle. [3H]nitrendipine binding studies.

scientific article published in August 1987

Calcium currents in ventricular myocytes of prehypertrophic cardiomyopathic hamsters.

scientific article published in March 1995

Calcium spark properties in ventricular myocytes are altered in aged mice

scientific article published on 3 December 2005

Calcium sparks in mouse ventricular myocytes at physiological temperature

scientific article

Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature

scientific article published on 18 April 2014

Cardiac contraction, calcium transients, and myofilament calcium sensitivity fluctuate with the estrous cycle in young adult female mice.

scientific article published on 24 January 2014

Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice.

scientific article published on 26 May 2006

Changes in excitation-contraction coupling in an isolated ventricular myocyte model of cardiac stunning

scientific article

Characterization of membrane N-glycan binding sites of lysozyme for cardiac depression in sepsis.

scientific article

Commentary: Age-related neurodegenerative disease research needs aging models

scientific article published on 29 January 2016

Contractile properties of myocardium are altered in dystrophin-deficient mdx mice.

scientific article published in October 1996

Contractions in guinea-pig ventricular myocytes triggered by a calcium-release mechanism separate from Na+ and L-currents

scientific article

Contribution of a voltage-sensitive calcium release mechanism to contraction in cardiac ventricular myocytes.

scientific article published in January 1998

Defective excitation-contraction coupling in hearts of rats with congestive heart failure

scientific article published in May 2005

Deficient priming activity of newborn cord blood-derived polymorphonuclear neutrophilic granulocytes with lipopolysaccharide and tumor necrosis factor-alpha triggered with formyl-methionyl-leucyl-phenylalanine

scientific article published in September 1993

Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters

scientific article published on 01 August 1992

Density of Ryanodine Receptors is Increased in Sarcoplasmic Reticulum from Prehypertrophic Cardiomyopathic Hamster Heart

scientific article published on 01 March 1994

Dibenzothiazepinones as potential calcium channel antagonists. I

scientific article published on 01 January 1993

Differential effects of phosphodiesterase-sensitive and -resistant analogs of cAMP on initiation of contraction in cardiac ventricular myocytes

scientific article published on 28 March 2003

Differential effects of the sodium calcium exchange inhibitor, KB-R7943, on ischemia and reperfusion injury in isolated guinea pig ventricular myocytes

scientific article

Diminished Inotropic Response to Amrinone in Ventricular Myocytes from Myopathic Hamsters Is Linked to Depression of High-Gain Ca2+-Induced Ca2+ Release

scientific article (publication date: 9 April 2004)

Direct cloning of differential display products eluted from northern blots

scientific article published on 01 June 1999

Dysnatremia in Relation to Frailty and Age in Community-dwelling Adults in the National Health and Nutrition Examination Survey.

scientific article published on 29 June 2016

Effect of age on cardiac excitation-contraction coupling.

scientific article published on 04 August 2009

Effects of adenosine in simulated ischemia and reperfusion in guinea pig ventricular myocytes

scientific article published in July 1995

Effects of ischemia and reperfusion on isolated ventricular myocytes from young adult and aged Fischer 344 rat hearts

scientific article published on 7 March 2008

Electrophysiologic differences between normal and dystrophic avian muscle

scientific article published on 01 November 1986

Factors that influence reliability of the mouse clinical frailty index.

scientific article

Force-interval relation in normal and cardiomyopathic hamster atria.

scientific article published in November 1991

Frailty: Scaling from Cellular Deficit Accumulation?

scientific article published on 17 July 2015

H-89 decreases the gain of excitation-contraction coupling and attenuates calcium sparks in the absence of beta-adrenergic stimulation.

scientific article

Heterogeneity of Human Aging and Its Assessment

scientific article

How cardiomyocyte excitation, calcium release and contraction become altered with age.

scientific article

Hypothermia increases the gain of excitation-contraction coupling in guinea pig ventricular myocytes

scientific article published on 9 July 2008

Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index

scientific article

In Memoriam: Gregory R. Ferrier, PhD, 1943-2005.

scientific article published in April 2006

In contrast to forskolin and 3-isobutyl-1-methylxanthine, amrinone stimulates the cardiac voltage-sensitive release mechanism without increasing calcium-induced calcium release.

scientific article published in September 2001

Increased expression of the gene for alpha-interferon-inducible protein in cardiomyopathic hamster heart.

scientific article published in January 2000

Increases in diastolic [Ca2+] can contribute to positive inotropy in guinea pig ventricular myocytes in the absence of changes in amplitudes of Ca2+ transients

scientific article

Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice

scientific article published on 23 August 2019

L-Arginine ameliorates effects of ischemia and reperfusion in isolated cardiac myocytes

scientific article published in August 2003

Lipid-lowering agents and the risk of cognitive impairment that does not meet criteria for dementia, in relation to apolipoprotein E status.

scientific article published on 27 November 2007

Long-term testosterone deficiency modifies myofilament and calcium-handling proteins and promotes diastolic dysfunction in the aging mouse heart

scientific article published on 18 January 2019

Losartan exerts antiarrhythmic activity independent of angiotensin II receptor blockade in simulated ventricular ischemia and reperfusion.

scientific article published in September 1996

Losartan improves recovery of contraction and inhibits transient inward current in a cellular model of cardiac ischemia and reperfusion.

scientific article published in November 2000

Microbial shifts in the aging mouse gut.

scientific article

Molecular geometries of dibenzothiazepinone and dibenzoxazepinone calcium antagonists

scientific article published on 01 April 1995

New horizons in frailty: ageing and the deficit-scaling problem

scientific article published on 05 June 2013

Novel cardioprotection strategies for the aged heart: evidence from pre-clinical studies

scientific article published on 14 September 2016

Orthostatic hypotension (OH) and mortality in relation to age, blood pressure and frailty

scientific article published on 10 January 2012

Ovariectomy enhances SR Ca²⁺ release and increases Ca²⁺ spark amplitudes in isolated ventricular myocytes

scientific article published on 12 September 2011

Overexpression of human beta2-adrenergic receptors increases gain of excitation-contraction coupling in mouse ventricular myocytes

scientific article

Pediatric cardioplegia strategy results in enhanced calcium metabolism and lower serum troponin T.

scientific article published in May 2009

Possible mechanisms underlying differences in force production between normal and cardiomyopathic hamster atria

scientific article published in November 1991

Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion

scientific article published on 25 January 2005

Prevalence, Attributes, and Outcomes of Fitness and Frailty in Community-Dwelling Older Adults: Report From the Canadian Study of Health and Aging

scientific article published on 01 December 2004

Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia

scientific article published on 24 July 2010

Protein Kinase A-Mediated Phosphorylation Contributes to Enhanced Contraction Observed in Mice That Overexpress beta-Adrenergic Receptor Kinase-1

scientific article published on 01 September 2006

Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty

scientific article published on 08 October 2020

Radioligand binding to muscle homogenates to quantify receptor and ion channel numbers.

scientific article published on December 1988

Regulation of contraction and relaxation by membrane potential in cardiac ventricular myocytes

scientific article published in May 2000

Reliability of a Frailty Index Based on the Clinical Assessment of Health Deficits in Male C57BL/6J Mice

scientific article

Report of the National Heart, Lung, and Blood Institute Working Group on Sex Differences Research in Cardiovascular Disease: Scientific Questions and Challenges

scientific article published on 14 March 2016

Responsiveness of goal attainment scaling in a randomized controlled trial of comprehensive geriatric assessment

scientific article

Responsiveness of normal and dystrophic avian muscle to acetylcholine, carbamylcholine and d-tubocurarine.

scientific article published on January 1988

Rodent models of frailty and their application in preclinical research

scientific article published on 28 January 2019

Role of cAMP-dependent protein kinase A in activation of a voltage-sensitive release mechanism for cardiac contraction in guinea-pig myocytes

scientific article published in November 1998

Role of voltage-sensitive release mechanism in depression of cardiac contraction in myopathic hamsters

scientific article published on 01 November 1999

Saralasin suppresses arrhythmias in an isolated guinea pig ventricular free wall model of simulated ischemia and reperfusion

scientific article published on 01 September 1995

Sarcoplasmic reticulum calcium release channels in ventricles of older adult hamsters.

scientific article published in January 2006

Screening for Frailty in Canada’s Health Care System: A Time for Action

article

Searching for the ideal inotropic agent to rescue a failing heart

scientific article published on 07 June 2011

Sex Differences in the Biology and Pathology of the Aging Heart

scientific article

Sex differences in SR Ca(2+) release in murine ventricular myocytes are regulated by the cAMP/PKA pathway

scientific article published on 24 July 2014

Sex differences in frailty: A systematic review and meta-analysis

scientific article published on 30 December 2016

Sex differences in mechanisms of cardiac excitation-contraction coupling

scientific article published on 17 February 2013

Sex differences in mechanisms of cardiac excitation-contraction coupling in rat ventricular myocytes

scientific article published on 7 May 2010

Sex differences in the phenotypic expression of avian dystrophy.

scientific article published in July 1983

Simulated ischaemia and reperfusion in isolated guinea pig ventricular myocytes.

scientific article

Simulated ischemia-induced preconditioning of isolated ventricular myocytes from young adult and aged Fischer-344 rat hearts

scientific article published on 20 June 2008

Standard laboratory tests to identify older adults at increased risk of death

scientific article

Subfractionation of cardiac sarcolemma with wheat-germ agglutinin

scientific article published on December 1989

Syntheses, Calcium Channel Agonist-Antagonist Modulation Activities, and Voltage-Clamp Studies of Isopropyl 1,4-Dihydro-2,6-dimethyl-3-nitro- 4-pyridinylpyridine-5-carboxylate Racemates and Enantiomers

scientific article published on 01 July 1995

Syntheses, calcium channel agonist-antagonist modulation activities, nitric oxide release, and voltage-clamp studies of 2-nitrooxyethyl 1,4-dihydro- 2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate enantiomers

scientific article published in February 2002

Synthesis and Calcium Channel Modulating Effects of Isopropyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(thienyl)-5-pyridinecarboxylates

scientific article published on 01 October 1997

Synthesis and Smooth Muscle Calcium Channel Effects of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-aryl-3,5-pyridinedicarboxylates Containing a Nitrone Moiety in the 4-Aryl Substituent

scientific article published on 01 March 1997

Synthesis, characterization, and Ca2+ antagonistic activity of diltiazem metabolites

scientific article published in August 1992

Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms

scientific article

The 1996 Merck Frosst Award. The voltage-sensitive release mechanism: a new trigger for cardiac contraction.

scientific article published on September 1997

The Na+/Ca2+ exchange inhibitor SEA0400 limits intracellular Ca2+ accumulation and improves recovery of ventricular function when added to cardioplegia

scientific article published on 8 January 2014

The Symptoms Targeted for Monitoring in a Web-Based Tracking Tool by Caregivers of People With Dementia and Agitation: Cross-Sectional Study

scientific article published on 28 June 2019

The age-related decrease in catecholamine sensitivity is mediated by beta(1)-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats

scientific article published on 10 October 2008

The biology of frailty in humans and animals: Understanding frailty and promoting translation

scientific article published on 27 March 2019

The effects of isoproterenol on abnormal electrical and contractile activity and diastolic calcium are attenuated in myocytes from aged Fischer 344 rats.

scientific article published on 17 August 2007

The force-interval relation in aged hamster heart.

scientific article published in July 1995

The impact of age and frailty on ventricular structure and function in C57BL/6J mice.

scientific article

The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart.

scientific article

The impact of pacemaker implantation on cognitive functioning in elderly patients

scientific article published in February 1992

The impacts of age and frailty on heart rate and sinoatrial node function

scientific article published on 6 September 2016

Unblock of the slow inward current induces the arrhythmogenic transient inward current in isolated guinea-pig myocytes

scientific article

Use of Patient-Reported Symptoms from an Online Symptom Tracking Tool for Dementia Severity Staging: Development and Validation of a Machine Learning Approach

scientific article published on 11 November 2020

[3H]-nitrendipine binding in normal and cardiomyopathic hamster hearts: Modulation by temperature, verapamil and diltiazem

scientific article published on 01 September 1990

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