List of works - Qun Dang

A cascade reaction consisting of Pictet-Spengler-type cyclization and Smiles rearrangement: application to the synthesis of novel pyrrole-fused dihydropteridines

scientific article published on 06 February 2007

A cascade reaction with iminium ion isomerization as the key step leading to tetrahydropyrimido[4,5-d]pyrimidines

scientific article

A new strategy toward fused-pyridine heterocyclic scaffolds: Bischler-Napieralski-type cyclization, followed by sulfoxide extrusion reaction

scientific article

An efficient and regiospecific strategy to N7-substituted purines and its application to a library of trisubstituted purines

scientific article published in May 2006

An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines

scientific article

Aromatic dienophiles. 1. A theoretical study of an inverse-electron demand Diels-Alder reaction between 2-aminopyrrole and 1,3,5-triazine

scientific article

Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration

scientific article published on 02 April 2007

Clarification of the mechanism of the cascade reactions between amino-substituted heterocycles and 1,3,5-triazines

scientific article published on 01 February 2005

Design and synthesis of a tetracyclic pyrimidine-fused benzodiazepine library

scientific article published in May 2006

Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization.

scientific article published on 24 February 2014

Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase

scientific article published on 2 December 2010

Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes.

scientific article published on July 2007

Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors

scientific article published on 21 June 2008

Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes

scientific article published on 28 November 2007

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics

scientific article published in January 2010

Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics

scientific article

Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.

scientific article published on June 2006

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

scientific article

Method development for a pyridobenzodiazepine library with multiple diversification points

scientific article

Novel heterocyclic scaffold consisting of indole-fused pteridines

scientific article published on 01 November 2005

Parallel solution-phase synthesis of a 2,6,8,9-tetrasubstituted purine library via a sulfur intermediate.

scientific article published in July 2005

Rapid access to pyrimido[5,4-c]isoquinolines via a sulfur monoxide extrusion reaction

scientific article published on 01 February 2007

Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity

scientific article published on 28 November 2007

Synthesis of hexahydrobenzo[b]pyrimido[4,5-h][1,6]naphthyridines via an intramolecular hetero-Diels-Alder reaction

scientific article

Synthesis of highly substituted 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 4,6-dichloro-5-formylpyrimidine, amines and aldehydes

scientific article

Synthesis of highly substituted 4H-pyrido[1,2-a]pyrimidines via a one-pot three-component condensation reaction

scientific article published on 22 August 2013

Synthesis of novel 4H-pyrimido[1,6-a]pyrimidines via a one-pot three-component condensation

scientific article

Synthesis of novel 8,9-dihydro-5H-pyrimido[4,5-e][1,4]diazepin-7(6H)-ones

scientific article

Synthesis of novel pyrimidine fused 8-membered heterocycles via iminium ion cyclization reactions

scientific article published on 8 January 2008

Synthesis of novel tricyclic pyrimido[4,5-b][1,4]benzothiazepines via Bischler-Napieralski-type reactions

scientific article published in December 2005

Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

scientific article published on 01 June 1999

Synthesis of pyrido[2,3-e]pyrrolo[1,2-a]pyrazine derivatives via tandem iminium cyclization and smiles rearrangement

scientific article

Synthesis of tricyclic 4-chloro-pyrimido[4,5-b][1,4]benzodiazepines

scientific article

List of works by Qun Dang

A cascade reaction consisting of Pictet-Spengler-type cyclization and Smiles rearrangement: application to the synthesis of novel pyrrole-fused dihydropteridines

A cascade reaction with iminium ion isomerization as the key step leading to tetrahydropyrimido[4,5-d]pyrimidines

A new strategy toward fused-pyridine heterocyclic scaffolds: Bischler-Napieralski-type cyclization, followed by sulfoxide extrusion reaction

An efficient and regiospecific strategy to N7-substituted purines and its application to a library of trisubstituted purines

An efficient synthesis of pyrrolo[2,3-d]pyrimidines via inverse electron demand diels-alder reactions of 2-amino-4-cyanopyrroles with 1,3,5-triazines

Aromatic dienophiles. 1. A theoretical study of an inverse-electron demand Diels-Alder reaction between 2-aminopyrrole and 1,3,5-triazine

Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration

Clarification of the mechanism of the cascade reactions between amino-substituted heterocycles and 1,3,5-triazines

Design and synthesis of a tetracyclic pyrimidine-fused benzodiazepine library

Design of prodrugs to enhance colonic absorption by increasing lipophilicity and blocking ionization.

Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase

Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes.

Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors

Discovery of potent and specific fructose-1,6-bisphosphatase inhibitors and a series of orally-bioavailable phosphoramidase-sensitive prodrugs for the treatment of type 2 diabetes

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics

Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics

Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.

Method development for a pyridobenzodiazepine library with multiple diversification points

Novel heterocyclic scaffold consisting of indole-fused pteridines

Parallel solution-phase synthesis of a 2,6,8,9-tetrasubstituted purine library via a sulfur intermediate.

Rapid access to pyrimido[5,4-c]isoquinolines via a sulfur monoxide extrusion reaction

Structure-guided design of AMP mimics that inhibit fructose-1,6-bisphosphatase with high affinity and specificity

Synthesis of hexahydrobenzo[b]pyrimido[4,5-h][1,6]naphthyridines via an intramolecular hetero-Diels-Alder reaction

Synthesis of highly substituted 2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-ones from 4,6-dichloro-5-formylpyrimidine, amines and aldehydes

Synthesis of highly substituted 4H-pyrido[1,2-a]pyrimidines via a one-pot three-component condensation reaction

Synthesis of novel 4H-pyrimido[1,6-a]pyrimidines via a one-pot three-component condensation

Synthesis of novel 8,9-dihydro-5H-pyrimido[4,5-e][1,4]diazepin-7(6H)-ones

Synthesis of novel pyrimidine fused 8-membered heterocycles via iminium ion cyclization reactions

Synthesis of novel tricyclic pyrimido[4,5-b][1,4]benzothiazepines via Bischler-Napieralski-type reactions

Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

Synthesis of pyrido[2,3-e]pyrrolo[1,2-a]pyrazine derivatives via tandem iminium cyclization and smiles rearrangement

Synthesis of tricyclic 4-chloro-pyrimido[4,5-b][1,4]benzodiazepines