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List of works by Federica Perrone

9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations.

scientific article

A functional gene expression analysis in epithelial sinonasal cancer: Biology and clinical relevance behind three histological subtypes

article

A phase II study of sorafenib in recurrent and/or metastatic salivary gland carcinomas: Translational analyses and clinical impact.

scientific article

AKT1 and BRAF mutations in pediatric aggressive fibromatosis

scientific article published on 08 April 2016

Absence of ALK and MET alterations in head and neck sarcomatoid carcinoma.

scientific article

Activity of abiraterone in rechallenging two AR-expressing salivary gland adenocarcinomas, resistant to androgen-deprivation therapy.

scientific article published on 11 March 2014

Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation.

scientific article

An open-label, single-arm, phase 2 study of the Aurora kinase A inhibitor alisertib in patients with advanced urothelial cancer.

scientific article

Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?

scientific article published on 12 November 2017

Association of Androgen Receptor Expression on Tumor Cells and PD-L1 Expression in Muscle-Invasive and Metastatic Urothelial Carcinoma: Insights for Clinical Research.

scientific article published on 7 October 2017

Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

scientific article published on 25 May 2012

BRAF alterations are associated with complex mutational profiles in malignant melanoma

scientific article published in August 2004

BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis

scientific article published on 7 July 2015

BRAF mutation analysis is a valid tool to implement in Lynch syndrome diagnosis in patients classified according to the Bethesda guidelines

scientific article published in May 2014

Bax expression is predictive of favorable clinical outcome in chemonaive advanced gastric cancer patients treated with capecitabine, oxaliplatin, and irinotecan regimen

scientific article

CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study.

scientific article published on 31 July 2013

Capecitabine, oxaliplatin and irinotecan in combination, with bevacizumab (COI-B regimen) as first-line treatment of patients with advanced colorectal cancer. An Italian Trials of Medical Oncology phase II study

article

Cetuximab in recurrent and/or metastatic salivary gland carcinomas: A phase II study

scientific article published on 18 September 2008

Challenging Lung Carcinoma with Coexistent ΔNp63/p40 and Thyroid Transcription Factor-1 Labeling Within the Same Individual Tumor Cells

scientific article published in October 2015

Circulating free DNA in a screening program for early colorectal cancer detection.

scientific article

Circulating miR-378 in plasma: a reliable, haemolysis-independent biomarker for colorectal cancer

scientific article published on 14 January 2014

Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: case report with molecular analysis.

scientific article published on November 2008

Clinical activity of androgen deprivation therapy in patients with metastatic/relapsed androgen receptor-positive salivary gland cancers

scientific article

Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type.

scientific article

DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells.

scientific article published on 21 January 2013

Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules

scientific article published on 7 April 2016

Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study.

scientific article published on 8 July 2016

Different clinical effects upon separate inhibition of coexisting EGFR and PI3KCA mutations in a lung adenocarcinoma patient.

scientific article published on 19 December 2014

Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge

scientific article published on 26 August 2015

Does immunohistochemistry affect response to therapy and survival of inoperable non-small cell lung carcinoma patients? A survey of 145 stage III-IV consecutive cases.

scientific article

Doing more with less: fluorescence in situ hybridization and gene sequencing assays can be reliably performed on archival stained tumor tissue sections

scientific article published on 27 January 2016

Dose-Dense Temozolomide in Patients with MGMT-Silenced Chemorefractory Colorectal Cancer

scientific article published on 4 November 2015

EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues

scientific article

Epithelioid peritoneal mesothelioma: a hybrid phenotype within a mesenchymal-epithelial/epithelial-mesenchymal transition framework

scientific article published on 26 September 2016

Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients

scientific article

Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation

scientific article

FHIT and p53 status and response to platinum-based treatment in advanced non-small cell lung cancer

scientific article published in August 2008

FOLFOX-4 chemotherapy for patients with unresectable or relapsed peritoneal pseudomyxoma

scientific article

First-line therapy with dacomitinib, an orally available pan-HER tyrosine kinase inhibitor, for locally advanced or metastatic penile squamous cell carcinoma: results of an open-label, single-arm, single-centre, phase 2 study.

scientific article published on 16 September 2017

Frequent Mutation and Nuclear Localization of β-Catenin in Sertoli Cell Tumors of the Testis

article

Functional Genomics Uncover the Biology behind the Responsiveness of Head and Neck Squamous Cell Cancer Patients to Cetuximab.

scientific article

Functional analysis and molecular modeling show a preserved wild-type activity of p53(C238Y).

scientific article published in June 2006

GNAS mutations as prognostic biomarker in patients with relapsed peritoneal pseudomyxoma receiving metronomic capecitabine and bevacizumab: a clinical and translational study

scientific article published on 6 May 2016

Gain of ALK gene copy number may predict lack of benefit from anti-EGFR treatment in patients with advanced colorectal cancer and RAS-RAF-PI3KCA wild-type status

scientific article

Genetic Markers in Sporadic Tumors

Genomics in non-adenoid cystic group of salivary gland cancers: one or more druggable entities?

scientific article published on 04 April 2019

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer.

scientific article published on 25 October 2016

High-Risk Human Papillomavirus Affects Prognosis in Patients With Surgically Treated Oropharyngeal Squamous Cell Carcinoma

scientific article published on 01 December 2006

Identification of potentially druggable molecular alterations in skin adnexal malignancies

scientific article published on 30 April 2019

In situ hybridization detection methods for HPV16 E6/E7 mRNA in identifying transcriptionally active HPV infection of oropharyngeal carcinoma: an updating

scientific article published on 6 October 2017

In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas.

scientific article published on 9 September 2013

Integrative approach for prioritizing cancer genes in sporadic colon cancer.

scientific article published in November 2009

Intestinal type adenocarcinoma of the ethmoid sinus in wood and leather workers: a retrospective study of 153 cases.

scientific article published in April 2011

Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients

scientific article published on 21 December 2016

Isolating p16-positive/HPV-negative oropharyngeal cancer: an effort worth making

scientific article

Lack of Bax expression is associated with irinotecan-based treatment activity in advanced colorectal cancer patients.

scientific article published on 21 November 2012

Lack of KRAS, NRAS, BRAF and TP53 mutations improves outcome of elderly metastatic colorectal cancer patients treated with cetuximab, oxaliplatin and UFT.

scientific article published on 3 July 2013

Lack of SYT-SSX fusion transcripts in malignant peripheral nerve sheath tumors on RT-PCR analysis of 34 archival cases

scientific article published on May 2002

MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer.

scientific article

Molecular and Cytogenetic Subgroups of Oropharyngeal Squamous Cell Carcinoma

scientific article published on 01 November 2006

Molecular and biochemical analyses of platelet-derived growth factor receptor (PDGFR) B, PDGFRA, and KIT receptors in chordomas

scientific article published in December 2006

Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene.

scientific article

Mutated CTSF in adult-onset neuronal ceroid lipofuscinosis and FTD.

scientific article published on 16 September 2016

Negative hyper-selection of metastatic colorectal cancer patients for anti-EGFR monoclonal antibodies: the PRESSING case-control study

scientific article published on 25 September 2017

Neoadjuvant sorafenib, gemcitabine, and cisplatin administration preceding cystectomy in patients with muscle-invasive urothelial bladder carcinoma: An open-label, single-arm, single-center, phase 2 study.

scientific article published on 11 September 2017

Oropharyngeal squamous cell carcinoma treated with radiotherapy or radiochemotherapy: prognostic role of TP53 and HPV status

scientific article published on 04 July 2009

Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b

scientific article published on 14 December 2015

PD-L1 Expression in Unresectable Locally Advanced or Metastatic Skin Squamous Cell Carcinoma Treated with Anti-Epidermal Growth Factor Receptor Agents

scientific article published on 21 May 2019

PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor

scientific article published on December 2009

PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients

article

PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells

scientific article

Panitumumab Treatment for Advanced Penile Squamous Cell Carcinoma When Surgery and Chemotherapy Have Failed.

scientific article published on 11 August 2015

Pathological response after neoadjuvant bevacizumab- or cetuximab-based chemotherapy in resected colorectal cancer liver metastases

article

Pazopanib in advanced germ cell tumors after chemotherapy failure: results of the open-label, single-arm, phase 2 Pazotest trial.

scientific article published on 5 April 2017

Perioperative Triplet Chemotherapy and Cetuximab in Patients With RAS Wild Type High Recurrence Risk or Borderline Resectable Colorectal Cancer Liver Metastases

scientific article published on 06 October 2016

Phase II trial with axitinib in recurrent and/or metastatic salivary gland cancers of the upper aerodigestive tract

scientific article published on 29 July 2019

Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.

scientific article

Polymorphisms of Metabolizing Enzymes and Susceptibility to Ethmoid Intestinal-type Adenocarcinoma in Professionally Exposed Patients

scientific article published on May 2009

Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade

scientific article

Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma

scientific article

Prognostic role of PIK3CA and TP53 in human papillomavirus-negative oropharyngeal cancers

scientific article published in April 2018

Prognostic significance of the CaMBr1 antigen on breast carcinoma: Relevance of the type of recognised glycoconjugate

scientific article published on 01 January 1993

Prolonged response using gefitinib followed by sirolimus for advanced cutaneous squamous cell carcinoma

scientific article published on 01 November 2012

Pulmonary adenocarcinoma with mucin production modulates phenotype according to common genetic traits: a reappraisal of mucinous adenocarcinoma and colloid adenocarcinoma

scientific article

Rationale and protocol of MetNET-2 trial: Lanreotide Autogel plus metformin in advanced gastrointestinal or lung neuroendocrine tumors

scientific article published on 05 June 2017

Re: Odaet al. Frequent alteration ofp16INK4a/p14ARF andp53 pathways in the round cell component of myxoid/round cell liposarcoma:p53 gene alterations and reduced p14ARF expression both correlate with poor prognosis.J Pathol 2005;207:410–421

article

Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.

scientific article published on 6 August 2010

Receptor tyrosine kinase profiles and human papillomavirus status in oropharyngeal squamous cell carcinoma

scientific article published on 14 December 2014

Reproducibility between messenger RNA real-time polymerase chain reaction and messenger RNA in situ hybridization in oropharyngeal squamous cell carcinoma patients

scientific article published on 3 October 2015

Role of BAX for outcome prediction in gastrointestinal malignancies.

scientific article published on 23 May 2013

Role of EGFR family receptors in proliferation of squamous carcinoma cells induced by wound healing fluids of head and neck cancer patients.

scientific article published on 22 February 2011

Single agent panitumumab in KRAS wild-type metastatic colorectal cancer patients following cetuximab-based regimens: Clinical outcome and biomarkers of efficacy

scientific article published on 04 September 2013

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma.

scientific article published on 26 September 2014

Spontaneous regression of primary abdominal wall desmoid tumors: more common than previously thought.

scientific article

Synergistic Activation upon MET and ALK Coamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer

scientific article published on 21 January 2016

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

scientific article published on 23 December 2016

TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma.

scientific article published on 4 January 2010

TP53 mutations in advanced colorectal cancer: the dark side of the moon.

scientific article published on 07 June 2014

TP53 mutations in head and neck cancer

scientific article published in March 2008

TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses

article

Targeted therapies: the rare cancer paradigm

scientific article published on 28 October 2009

Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift

scientific article published on 27 April 2017

Toward the molecular dissection of peritoneal pseudomyxoma.

scientific article published in November 2016

Tp53 status as guide for the management of ethmoid sinus intestinal-type adenocarcinoma.

scientific article published on 29 January 2013

Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs).

scientific article published in July 2009

Treatment-related outcome of oropharyngeal cancer patients differentiated by HPV dictated risk profile: a tertiary cancer centre series analysis.

scientific article

Tumor Biomarkers for the Prediction of Distant Metastasis in Head and Neck Squamous Cell Carcinoma

scientific article published on 09 April 2020

Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study.

scientific article

Uncommon somatic mutations in metastatic NUT midline carcinoma.

scientific article

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma.

scientific article published on 08 February 2016

miRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation.

scientific article

p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx

scientific article published on 01 June 2007

β-Catenin in desmoid-type fibromatosis: deep insights into the role of T41A and S45F mutations on protein structure and gene expression.

scientific article published on 19 June 2017

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