List of works - Olivier Lequin

(1)H, (15)N and (13)C resonance assignment of human gammaS-crystallin, a 21 kDa eye-lens protein.

scientific article

(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation

scientific article published in 2015

1H, 13C and 15N resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein

3-Substituted prolines: from synthesis to structural applications, from peptides to foldamers.

scientific article published on 19 February 2013

A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid.

scientific article published on 12 October 2012

Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives

Antibody Recognition in multiple sclerosis and rett syndrome using a collection of linear and cyclicN-glucosylated antigenic probes

scientific article published in 2015

Author Correction: Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids

scientific article published on 15 October 2019

Biophysical investigation of the membrane-disrupting mechanism of the antimicrobial and amyloid-like peptide dermaseptin S9

scientific article

Biophysical studies of the interaction between calmodulin and the R287-T311 region of human estrogen receptor α reveals an atypical binding process

scientific article published in 2012

Calpha methylation in molecular recognition. Application to substance P and the two neurokinin-1 receptor binding sites

scientific article published in May 2001

Characterization of the bioactive conformation of the C-terminal tripeptide Gly-Leu-Met-NH2 of substance P using [3-prolinoleucine10]SP analogues

scientific article

Chiral "basket handle" binaphthyl porphyrins: synthesis, catalytic epoxidation and NMR conformational studies

article by Eric Rose et al published July 2010 in Journal of Porphyrins and Phthalocyanines

Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes

scientific article published on November 2014

Comparison of penetratin and other homeodomain-derived cell-penetrating peptides: interaction in a membrane-mimicking environment and cellular uptake efficiency

scientific article published in February 2006

Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor

scientific article published in May 2005

Correction to Sequence-Dependent Enrichment of a Model Phosphopeptide: A Combined MALDI-TOF and NMR Study

scientific article published in 2011

Corrigendum to “Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids”

scholarly article published in Tetrahedron Letters

Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini

scientific article

Designed Glycopeptidomimetics Disrupt Protein-Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability.

scientific article published on 20 January 2016

Different membrane behaviour and cellular uptake of three basic arginine-rich peptides.

scientific article published on 13 October 2010

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation

scientific article

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation

scientific article published on 23 May 2013

Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.

scientific article published in June 2009

Glaser oxidative coupling on peptides: stabilization of β-turn structure via a 1,3-butadiyne constraint.

scientific article published on 22 October 2014

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins.

scientific article published on 13 April 2018

Helical structure of dermaseptin B2 in a membrane-mimetic environment

scientific article

High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide

scientific article

Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation

Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells

scientific article published on 26 August 2019

Hyperglucosylated adhesin-derived peptides as antigenic probes in multiple sclerosis: Structure optimization and immunological evaluation

scientific article published on 12 August 2020

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

scientific article

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

scientific article published on 4 June 2015

Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent.

scientific article

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides

scientific article published on 24 February 2020

Inverted Lipid Models

Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides

article published in 2015

Investigation of Homeodomain Membrane Translocation Properties: Insights from the Structure Determination of Engrailed-2 Homeodomain in Aqueous and Membrane-Mimetic Environments

scientific article

Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studies

scientific article

Mapping the heparin-binding site on the 13-14F3 fragment of fibronectin.

scientific article

Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain

scientific article

Membrane interactions of two arginine-rich peptides with different cell internalization capacities

scientific article published on 01 July 2012

Methods to determine slow diffusion coefficients of biomolecules. Applications to Engrailed 2, a partially disordered protein

article published in 2011

N- and Calpha-methylation in biologically active peptides: synthesis, structural and functional aspects.

scientific article

Non-canonical Amino Acid Incorporation into 2,5-Diketopiperazines by Cyclodipeptide Synthases

scientific article published on 29 January 2018

Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging

scientific article published on 25 October 2019

Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids

Prolinoamino acids as tools to build bifunctionalized, stable beta-turns in water

scientific article

Rapid synthesis of new DNMT inhibitors derivatives of procainamide

scientific article

Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids

scientific article published on 25 June 2019

Secondary structure and NMR resonance assignments of the C-terminal DNA-binding domain of Uup protein.

scientific article

Solution structure and model membrane interactions of temporins-SH, antimicrobial peptides from amphibian skin. A NMR spectroscopy and differential scanning calorimetry study

scientific article

Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy

scientific article

Structural and biological effects of a β2- or β3-amino acid insertion in a peptide

scientific article published on 01 March 2003

Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates

scientific article

Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor.

scientific article published in July 2003

Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization

scientific article published on 10 September 2014

Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES

scientific article

Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation

scientific article

Synthesis and conformational studies of a stable peptidomimetic β-hairpin based on a bifunctional diketopiperazine turn inducer

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

scientific article published on 9 January 2014

Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide

scientific article

The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif

scientific article

The combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water

scientific article

The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands.

scientific article published on 21 December 2017

Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values

scientific article

Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

scientific article published on 15 August 2016

Tryptophan within basic peptide sequences triggers glycosaminoglycan-dependent endocytosis.

scientific article published on 15 October 2012

β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides

scientific article published on 6 June 2011

List of works by Olivier Lequin

(1)H, (15)N and (13)C resonance assignment of human gammaS-crystallin, a 21 kDa eye-lens protein.

(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation

1H, 13C and 15N resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein

3-Substituted prolines: from synthesis to structural applications, from peptides to foldamers.

A microplate fluorescence assay for DAPA aminotransferase by detection of the vicinal diamine 7,8-diaminopelargonic acid.

Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives

Antibody Recognition in multiple sclerosis and rett syndrome using a collection of linear and cyclicN-glucosylated antigenic probes

Author Correction: Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids

Biophysical investigation of the membrane-disrupting mechanism of the antimicrobial and amyloid-like peptide dermaseptin S9

Biophysical studies of the interaction between calmodulin and the R287-T311 region of human estrogen receptor α reveals an atypical binding process

Calpha methylation in molecular recognition. Application to substance P and the two neurokinin-1 receptor binding sites

Characterization of the bioactive conformation of the C-terminal tripeptide Gly-Leu-Met-NH2 of substance P using [3-prolinoleucine10]SP analogues

Chiral "basket handle" binaphthyl porphyrins: synthesis, catalytic epoxidation and NMR conformational studies

Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes

Comparison of penetratin and other homeodomain-derived cell-penetrating peptides: interaction in a membrane-mimicking environment and cellular uptake efficiency

Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance P bound to the NK-1 receptor

Correction to Sequence-Dependent Enrichment of a Model Phosphopeptide: A Combined MALDI-TOF and NMR Study

Corrigendum to “Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids”

Dermaseptin S9, an alpha-helical antimicrobial peptide with a hydrophobic core and cationic termini

Designed Glycopeptidomimetics Disrupt Protein-Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability.

Different membrane behaviour and cellular uptake of three basic arginine-rich peptides.

Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation

Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation

Evidence that biosynthesis of the neurotoxic alkaloids anatoxin-a and homoanatoxin-a in the cyanobacterium Oscillatoria PCC 6506 occurs on a modular polyketide synthase initiated by L-proline.

Glaser oxidative coupling on peptides: stabilization of β-turn structure via a 1,3-butadiyne constraint.

Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins.

Helical structure of dermaseptin B2 in a membrane-mimetic environment

High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide

Homooligomers of substituted prolines and β-prolines: syntheses and secondary structure investigation

Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells

Hyperglucosylated adhesin-derived peptides as antigenic probes in multiple sclerosis: Structure optimization and immunological evaluation

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease.

Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent.

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides

Inverted Lipid Models

Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides

Investigation of Homeodomain Membrane Translocation Properties: Insights from the Structure Determination of Engrailed-2 Homeodomain in Aqueous and Membrane-Mimetic Environments

Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studies

Mapping the heparin-binding site on the 13-14F3 fragment of fibronectin.

Mechanism of antibacterial action of dermaseptin B2: interplay between helix-hinge-helix structure and membrane curvature strain

Membrane interactions of two arginine-rich peptides with different cell internalization capacities

Methods to determine slow diffusion coefficients of biomolecules. Applications to Engrailed 2, a partially disordered protein

N- and Calpha-methylation in biologically active peptides: synthesis, structural and functional aspects.

Non-canonical Amino Acid Incorporation into 2,5-Diketopiperazines by Cyclodipeptide Synthases

Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging

Prolinoamino acids as a tool to stabilize β-turns with the side chain of natural amino acids

Prolinoamino acids as tools to build bifunctionalized, stable beta-turns in water

Rapid synthesis of new DNMT inhibitors derivatives of procainamide

Reprogramming Escherichia coli for the production of prenylated indole diketopiperazine alkaloids

Secondary structure and NMR resonance assignments of the C-terminal DNA-binding domain of Uup protein.

Solution structure and model membrane interactions of temporins-SH, antimicrobial peptides from amphibian skin. A NMR spectroscopy and differential scanning calorimetry study

Solution structure of bovine angiogenin by 1H nuclear magnetic resonance spectroscopy

Structural and biological effects of a β2- or β3-amino acid insertion in a peptide

Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates

Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor.

Structure-activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization

Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES

Sugar-based peptidomimetics inhibit amyloid β-peptide aggregation

Synthesis and conformational studies of a stable peptidomimetic β-hairpin based on a bifunctional diketopiperazine turn inducer

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1.

Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide

The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif

The combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water

The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands.

Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values

Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

Tryptophan within basic peptide sequences triggers glycosaminoglycan-dependent endocytosis.

β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides