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List of works by Garth Cooper

8-37h-CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo

scientific article published in October 1991

A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes.

scientific article published on 18 July 2008

A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled study

scientific article published on 27 January 2009

A potential role for adrenomedullin as a local regulator of bone growth

scientific article published on 01 May 2001

A proteomic approach identifies early pregnancy biomarkers for preeclampsia: novel linkages between a predisposition to preeclampsia and cardiovascular disease.

scientific article

A simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry

scientific article

A unique case of neural amyloidoma diagnosed by mass spectrometry of formalin-fixed tissue using a novel preparative technique

scientific article published in September 2011

Aberrant processing of plasma vitronectin and high-molecular-weight kininogen precedes the onset of preeclampsia

scientific article published on 5 August 2009

Abnormalities of selenium but not of copper homeostasis may drive tissue fibrosis in patients with systemic sclerosis

scientific article published on 18 January 2015

Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic β-cells

scientific article published in August 2006

Acute pancreatitis severity is exacerbated by intestinal ischemia-reperfusion conditioned mesenteric lymph.

scientific article

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities

scientific article

Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit

scientific article

Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

scientific article published on December 2006

Adrenomedullin Attenuates Pressor Response to Angiotensin II in Conscious Sheep

scientific article published in October 2000

Alteration in phosphorylation of P20 is associated with insulin resistance.

scientific article

Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy.

scientific article published on 20 May 2008

Altered metabolic gene expression in the brain of a triprolyl-human amylin transgenic mouse model of type 2 diabetes

scientific article published on 10 October 2019

Amylin hormone

scientific article published in Nature

Amylin stimulates osteoblast proliferation and increases mineralized bone volume in adult mice

scientific article published in February 1995

Amyloid Fibril Formation from Full-Length and Fragments of Amylin

scientific article published in June 2000

Amyloid-like inclusions in Huntington's disease.

scientific article published in January 2000

An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia

scientific article published on 25 August 2008

Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide.

scientific article

BS4-A Applications of proteomics in diabetes: route to new and improved understanding of disease mechanisms and the generation of new therapeutic approaches

scientific article published in February 2008

Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells

scientific article published in May 1988

Calcitonin gene-related peptide-1 (CGRP-1) is a potent regulator of glycogen metabolism in rat skeletal muscle

scientific article published in June 1989

Characterization of proteomic changes in cardiac mitochondria in streptozotocin-diabetic rats using iTRAQ™ isobaric tags

scientific article published in June 2007

Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes.

scientific article published on August 2004

Combined angiotensin-converting enzyme inhibition and adrenomedullin in an ovine model of heart failure

scientific article published in June 2002

Combined endopeptidase inhibition and adrenomedullin in sheep with experimental heart failure

scientific article published in January 2002

Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia

scientific article published in January 2000

Comparison of the Effects of Calcitonin Gene-Related Peptide and Amylin on Osteoblasts

scientific article published in August 1999

Complex formation equilibria of Cu(II) and Zn(II) with triethylenetetramine and its mono- and di-acetyl metabolites

scientific article

Complex formation equilibria of Cu2+ and Zn2+ with Irbesartan and Losartan.

scientific article published on 9 November 2016

Coordination of mammary metabolism and blood flow after refeeding in rats

scientific article published in April 2009

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.

scientific article published on 11 March 2010

Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism

scientific article

Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease.

scientific article published on 20 March 2015

Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in

scientific article published in May 2005

Determination of triethylenetetramine (TETA) and its metabolites in human plasma and urine by liquid chromatography-mass spectrometry (LC-MS).

scientific article published on 14 September 2007

Development and validation of a rapid HPLC method for the simultaneous determination of triethylenetetramine and its two main metabolites in human serum

scientific article published on 10 October 2007

Diabetes-associated peptide

scientific article published on 01 October 1987

Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation.

scientific article published on 18 April 2015

Direct visualisation of peptide hormones in cultured pancreatic islet alpha- and beta-cells by intact-cell mass spectrometry

scientific article

Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men.

scientific article published in January 2006

Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men.

scientific article published in May 2004

Effects of STZ-induced diabetes on contraction and Ca2+ transient in rat left ventricular trabeculae

scientific article published in June 2007

Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development

scientific article published on August 2001

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia.

scientific article published on 09 June 2016

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia.

scientific article

Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

scientific article published on 06 May 2020

Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

scientific article

Evidence that α-Calcitonin Gene-Related Peptide Is a Neurohormone that Controls Systemic Lipid Availability and Utilization

article

Expedient Synthesis of Peptides Containing N ε-Carboxymethyllysine

scientific article published on 6 June 2014

Fates intertwined

scientific article published in March 2006

Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

scientific article published on 7 October 2003

GSK3 involvement in amylin signaling in isolated rat soleus muscle

scientific article published in December 2004

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

scientific article published on 5 March 2016

Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis

scientific article published on 2 November 2016

Hemodynamic, Hormonal, and Renal Effects of Intracerebroventricular Adrenomedullin in Conscious Sheep1

scientific article published in April 1998

Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation

scientific article

Identification and characterization of a bovine myosin light chain-1 fast polymorphism

scientific article published in December 2001

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

scientific article published on 29 October 2015

Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells

scientific article published on May 2002

Illuminating the molecular basis of diabetic arteriopathy: A proteomic comparison of aortic tissue from diabetic and healthy rats

scientific article published on 21 July 2010

Impaired ATP turnover and ADP supply depress cardiac mitochondrial respiration and elevate superoxide in nonfailing spontaneously hypertensive rat hearts.

scientific article published on 24 June 2009

Impaired insulin secretion in perfused pancreases isolated from offspring of female rats fed a low protein whey-based diet.

scientific article published on 10 July 2008

Incorporation of 'click' chemistry glycomimetics dramatically alters triple-helix stability in an adiponectin model peptide

scientific article published in July 2017

Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells

scientific journal article

Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.

scientific article published on July 1999

Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle

scientific article published on 22 November 1999

Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes

scientific article published in December 2005

Intestinal Ischaemia-Reperfusion Increases Plasma Amylin Concentration in Rats

scientific article published in 1999

Is the failing heart out of fuel or a worn engine running rich? A study of mitochondria in old spontaneously hypertensive rats

scientific article published in June 2008

Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

scientific article published on 13 March 2010

Lipid-lowering effects of a modified butter-fat: a controlled intervention trial in healthy men.

scientific article published in January 2002

Low-dose copper infusion into the coronary circulation induces acute heart failure in diabetic rats: New mechanism of heart disease

scientific article

Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy

scientific article published on 15 October 2015

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain

scientific article published on 3 June 2016

Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity

scientific article published on 7 July 2010

Modelling atherosclerosis by proteomics: Molecular changes in the ascending aortas of cholesterol-fed rabbits

scientific article published on 10 July 2015

Molecular Changes Evoked by Triethylenetetramine Treatment in the Extracellular Matrix of the Heart and Aorta in Diabetic Rats

scientific article published on 29 August 2006

No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks

scientific article published on 17 January 2008

Nucleotide sequence of a cDNA for canine amylin

scientific article

P67-S The Insulin Granule: Probing Intracellular Post-Translational Proteolysis.

scientific article published in February 2007

Peripherally administered desacetyl alpha-MSH and alpha-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression.

scientific article published on 25 July 2006

Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults

scientific article published in August 2009

Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial

scientific article published on 9 February 2010

Physicochemical studies on the copper(ii) binding by glycated collagen telopeptides

scientific article published on 01 March 2015

Plasma Clusterin Increased Prior to Small for Gestational Age (SGA) Associated With Preeclampsia and Decreased Prior to SGA in Normotensive Pregnancies

scientific article published on 28 February 2012

Plasma amylin concentration is related to the severity of intestinal ischemic injury in rats

scientific article

Polymorphic Fibrillar Assembly of Human Amylin

scientific article published in June 1997

Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex

scientific article published on 18 April 2006

Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion

scientific article

Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo

scientific article published on 15 August 2006

Proteins Associated with Immunopurified Granules from a Model Pancreatic Islet β-Cell System: Proteomic Snapshot of an Endocrine Secretory Granule

scientific article published on 2 January 2009

Proteome map of the human hippocampus

scientific article published in January 1999

Proteomic analysis of adipocyte differentiation: Evidence that alpha2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes

scientific article published on June 2004

Proteomic analysis of the brain in Alzheimer’s disease: Molecular phenotype of a complex disease process

scientific article published in November 2001

Proteomic analysis of whey and casein proteins in early milk from the marsupial Trichosurus vulpecula, the common brushtail possum

scientific article published in June 2007

Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum

scientific article published in December 2004

Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin

scientific article published in July 2006

Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase

scientific article published on 25 July 2006

Quantitative data describing the impact of the flavonol rutin on in-vivo blood-glucose and fluid-intake profiles, and survival of human-amylin transgenic mice

scientific article published on 29 November 2016

Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.

scientific article published in September 2009

Redox status of acute pancreatitis as measured by cyclic voltammetry: initial rodent studies to assess disease severity

scientific article published in March 2008

Regeneration of the heart in diabetes by selective copper chelation

scientific article

Replacement of the CysA7-CysB7 disulfide bond with a 1,2,3-triazole linker causes unfolding in insulin glargine

scientific article published on April 2015

Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure

scientific article published on 10 December 2019

Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator

scientific article published on 13 March 2007

Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers

scientific article published in October 2010

Rutin suppresses human-amylin/hIAPP misfolding and oligomer formation in-vitro, and ameliorates diabetes and its impacts in human-amylin/hIAPP transgenic mice

scientific article published on 16 November 2016

Selective Divalent Copper Chelation for the Treatment of Diabetes Mellitus ⬇️

scientific article published on January 1, 2012

Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

scientific article published in 2014

Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance

scientific article published on 15 July 2008

Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.

scientific article published on September 2003

Synthesis of Monolysyl Advanced Glycation Endproducts and Their Incorporation into Collagen Model Peptides

scientific article published in November 2012

Synthesis of glycosylated 5-hydroxylysine, an important amino acid present in collagen-like proteins such as adiponectin

scientific article published on 04 January 2012

Synthesis of stable isotope-labelled monolysyl advanced glycation endproducts.

scientific article published on 16 April 2013

Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds

scientific article published on 28 March 2013

Synthesis, crystal structure, and protonation behaviour in solution of the recently-discovered drug metabolite, N1,N10-diacetyltriethylenetetramine

scientific article published in March 2012

Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes

scientific article published on 9 March 2005

Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice

scientific journal article

Thalamic amplification of sensory input in experimental diabetes

scientific article published on 6 May 2016

The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells

scientific article

The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes

scientific article published on November 2010

The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells

scientific article

The proteome of rodent mesenteric lymph

scientific article published on 4 September 2008

The redox status of experimental haemorrhagic shock as measured by cyclic voltammetry

scientific article published in September 2009

Thiol reducing compounds prevent human amylin-evoked cytotoxicity.

scientific article published on October 2005

Three-colour fluorescence immunohistochemistry reveals the diversity of cells staining for macrophage markers in murine spleen and liver

scientific article published in May 2008

Transcriptomic analysis of the cardiac left ventricle in a rodent model of diabetic cardiomyopathy: molecular snapshot of a severe myocardial disease.

scientific article published on 24 October 2006

Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment

scientific article published on 31 January 2013

Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

scientific article published in January 2001

Using mass spectrometry to detect, differentiate, and semiquantitate closely related peptide hormones in complex milieu: measurement of IGF-II and vesiculin.

scientific article published on 29 December 2014

α-Calcitonin gene related peptide (α-CGRP) mediated lipid mobilization in 3T3-L1 adipocytes

scientific article published on 2 June 2014

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