List of works by Dario Neri

(124)I-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of (131)I-L19-SIP radioimmunotherapy

scientific article published on 04 March 2009

1045-189 Plaque targeting in atherosclerotic mice using a small immunoprotein against an angiogenesis-associated fibronectin isoform

14 INVITED Vascular targeting

1H And 13C NMR chemical shifts of the diastereotopic methyl groups of valyl and leucyl residues in peptides and proteins

1H, 15N and 13C NMR assignments of the 434 repressor fragments 1-63 and 44-63 unfolded in 7 M urea.

scientific article published in June 1992

20 years of DNA-encoded chemical libraries.

scientific article

239 Paclitaxel enhances therapeutic efficacy of F8-antibody mediated delivery of interleukin-2 to xenografted melanoma cancer

A 99mTc-Labeled Ligand of Carbonic Anhydrase IX Selectively Targets Renal Cell Carcinoma In Vivo

scientific article published on 18 February 2016

A Chemical Proteomics Approach for the Identification of Accessible Antigens Expressed in Human Kidney Cancer

article by Vincent Castronovo et al published 21 July 2006 in Molecular & Cellular Proteomics

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

scientific article published on 01 June 2018

A Human mAb Specific to Oncofetal Fibronectin Selectively Targets Chronic Skin Inflammation In Vivo

A Monoclonal Antibody to Human DLK1 Reveals Differential Expression in Cancer and Absence in Healthy Tissues

A Novel Fully-Human Potency-Matched Dual Cytokine-Antibody Fusion Protein Targets Carbonic Anhydrase IX in Renal Cell Carcinomas

scientific article published on 13 November 2019

A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

scientific article published on 14 October 2020

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

A Small-Molecule Inhibitor of Lin28.

scientific article

A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library

scientific article

A Traceless Vascular-Targeting Antibody-Drug Conjugate for Cancer Therapy

scholarly article by Gonçalo J. L. Bernardes et al published 15 December 2011 in Angewandte Chemie International Edition

A bivalent small molecule-drug conjugate directed against carbonic anhydrase IX can elicit complete tumour regression in mice

article by N. Krall et al published 20 June 2014 in Chemical Science

A chemically defined trifunctional antibody-cytokine-drug conjugate with potent antitumor activity

scientific article published on 9 September 2014

A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels

scientific article

A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation

scientific article

A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies

article

A comparative immunofluorescence analysis of three clinical-stage antibodies in head and neck cancer ⬇️

scientific article

A comparison of different biotinylation reagents, tryptic digestion procedures, and mass spectrometric techniques for 2-D peptide mapping of membrane proteins

scientific article

A comprehensive surface proteome analysis of myeloid leukemia cell lines for therapeutic antibody development.

scientific article published on 30 January 2014

A critical evaluation of the tumor-targeting properties of bispecific antibodies based on quantitative biodistribution data

scientific article

A dose confirmation and signal-generating study of the immunocytokine L19-IL2 in combination with dacarbazine in patients with metastatic melanoma

A dose-escalation and signal-generating study of the immunocytokine L19-IL2 in combination with dacarbazine for the therapy of patients with metastatic melanoma.

scientific article published on 25 October 2011

A fibrin-specific monoclonal antibody from a designed phage display library inhibits clot formation and localizes to tumors in vivo

scientific article

A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia

scientific article published on 08 March 2019

A general method for the selection of high-level scFv and IgG antibody expression by stably transfected mammalian cells

scientific article

A heteronuclear three-dimensional NMR experiment for measurements of small heteronuclear coupling constants in biological macromolecules

scholarly article by Gerhard Wider et al published November 1989 in Journal of Magnetic Resonance

A high-affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo-vasculature in vivo

scientific article published on June 2008

A highly functional synthetic phage display library containing over 40 billion human antibody clones

scientific article

A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer

scientific article published on January 2014

A monoclonal antibody prevents aggregation of the NBD1 domain of the cystic fibrosis transmembrane conductance regulator

scientific article published on 30 November 2007

A new synthetic route to 2,2′:5′,2″-terthiophene-5-derivatives to conjugate with proteins and monoclonal antibodies

A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo.

scientific article published on 31 August 2017

A novel anti-cancer L19-interleukin-12 fusion protein with an optimized peptide linker efficiently localizes in vivo at the site of tumors

scientific article published on 23 December 2018

A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies

scientific article

A novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivo

scientific article published on 13 October 2020

A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis

scientific article published on 01 January 2020

A novel reactive ester derivative of biotin with reduced membrane permeability for in vivo biotinylation experiments

scientific article published on October 2010

A novel synthetic naïve human antibody library allows the isolation of antibodies against a new epitope of oncofetal fibronectin

scientific article

A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties

scientific article

A phase II study of the L19IL2 immunocytokine in combination with dacarbazine in advanced metastatic melanoma patients

scientific article published on 03 September 2019

A portable albumin binder from a DNA-encoded chemical library

scientific article

A proteomic approach for the identification of vascular markers of liver metastasis

scientific article

A strategy for the isolation of catalytic activities from repertoires of enzymes displayed on phage 1 1Edited by J. Karn

article

A1 AND D DOMAIN OF TENASCIN C – NEW PROGNOSTIC MARKER IN BLADDER CANCER

AB0364 A Novel Approach for Rheumatoid Arthritis: Results of The Ongoing Clinical Trials with The Fully Human Immunocytokine Dekavil (F8-IL10)

scholarly article by Mauro Galeazzi et al published June 2016 in Annals of the Rheumatic Diseases

Abstract 589: Targeting of metastatic osteosarcoma with F8-TNF-alpha in an orthotopic mouse model

Abstract B55: Phase I/II study of the tumor-targeting human L19TNF-monoclonal antibody-cytokine fusion protein in patients with advanced solid tumors

Abstract SY28-04: Targeting the tumor extracellular matrix with armed antibodies

Abstract SY35-04: Arming tumor-targeting antibodies with cytokine payloads: Emerging clinical results

Abundant in vitro expression of the oncofetal ED-B-containing fibronectin translates into selective pharmacodelivery of (131)I-L19SIP in a prostate cancer patient

scientific article published on 17 October 2013

Acetazolamide Serves as Selective Delivery Vehicle for Dipeptide-Linked Drugs to Renal Cell Carcinoma

scientific article published on 08 September 2016

Activation of T cells via tumor antigen specific chimeric receptors: the role of the intracellular signaling domain

scientific article published on January 2003

Advances in antibody engineering for rheumatic diseases

scientific article published on 01 April 2019

Affinity enhancement of protein ligands by reversible covalent modification of neighboring lysine residues

scientific article published on 26 November 2018

Affinity reagents against tumour-associated extracellular molecules and newforming vessels

scientific article published on 01 April 1998

Affinity-capture reagents for protein arrays

scientific article

Alternatively Spliced EDA Domain of Fibronectin Is a Target for Pharmacodelivery Applications in Inflammatory Bowel Disease.

scientific article published in August 2015

An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance.

scientific article published in December 2002

An antibody-tumor necrosis factor fusion protein that synergizes with oxaliplatin for treatment of colorectal cancer

scientific article published on 30 September 2020

An engineered 4-1BBL fusion protein with "activity on demand"

scientific article published on 25 November 2020

An engineered antibody-interleukin-12 fusion protein with enhanced tumor vascular targeting properties

scientific article published on November 2006

Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells

scientific article published on 01 May 2020

Antibodies for angiogenesis inhibition, vascular targeting and endothelial cell transcytosis

scientific article published on 20 May 2006

Antibody Format and Drug Release Rate Determine the Therapeutic Activity of Noninternalizing Antibody-Drug Conjugates

scientific article published on 20 August 2015

Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice

scientific article published on 18 June 2019

Antibody-Based Delivery of IL2 and Cytotoxics Eradicates Tumors in Immunocompetent Mice

Antibody-Based Targeted Delivery of Interleukin-22 Promotes Rapid Clinical Recovery in Mice With DSS-Induced Colitis.

scientific article published in August 2016

Antibody-Based Targeting of Tumor Vasculature and Stroma

Antibody-Cytokine Fusions: Versatile Products for the Modulation of Anticancer Immunity

scientific article published on 01 March 2019

Antibody-Drug Conjugates and Small Molecule-Drug Conjugates: Opportunities and Challenges for the Development of Selective Anticancer Cytotoxic Agents

scientific article published on 16 June 2015

Antibody-Mediated Delivery of VEGFC Ameliorates Experimental Chronic Colitis

scientific article published on 01 August 2019

Antibody-based delivery of IL4 to the neovasculature cures mice with arthritis

scientific article

Antibody-based delivery of TNF to the tumor neo-vasculature potentiates the therapeutic activity of a peptide anti-cancer vaccine

scientific article published on 16 October 2018

Antibody-based delivery of interleukin-2 to neovasculature has potent activity against acute myeloid leukemia

scientific article published on September 2013

Antibody-based targeting of interferon-alpha to the tumor neovasculature: a critical evaluation

scientific article published on 11 January 2011

Antibody-based targeting of the tumor vasculature

scientific article published on 25 August 2007

Antibody-based vascular tumor targeting

scientific article published on January 2010

Antibody-drug conjugates: basic concepts, examples and future perspectives

scientific article published on 28 January 2012

Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis

scientific article published on January 2007

Antibody-mediated delivery of LIGHT to the tumor boosts natural killer cells and delays tumor progression

scientific article published on 01 January 2021

Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation

article published in 2018

Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation

scientific article published on 15 August 2014

Antibody-mediated delivery of interleukin-2 to the stroma of breast cancer strongly enhances the potency of chemotherapy.

scientific article published in October 2008

Antibody-radionuclide conjugates for cancer therapy: historical considerations and new trends

scientific article published on October 2011

Armed antibodies for cancer treatment: a promising tool in a changing era.

scientific article

Automated screening for small organic ligands using DNA-encoded chemical libraries.

scientific article

B and C domain containing tenascin-C: urinary markers for invasiveness of urothelial carcinoma of the urinary bladder?

scientific article published on 27 March 2009

B domain containing Tenascin-C: A new urine marker for surveillance of patients with urothelial carcinoma of the urinary bladder?

Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site

scientific article

Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1.

scientific article

Cancer therapy in mice using a pure population of CD8<sup>+</sup> T cell specific to the AH1 tumor rejection antigen

scientific article published on 01 April 2021

Changes in extra cellular matrix remodelling and re-expression of fibronectin and tenascin-C splicing variants in human myocardial tissue of the right atrial auricle: implications for a targeted therapy of cardiovascular diseases using human SIP form

Characterisation and radioimmunotherapy of L19-SIP, an anti-angiogenic antibody against the extra domain B of fibronectin, in colorectal tumour models

scientific article published on 22 May 2007

Chemical proteomic and bioinformatic strategies for the identification and quantification of vascular antigens in cancer

scientific article published on 09 June 2010

Chemically Defined Antibody- and Small Molecule-Drug Conjugates for in Vivo Tumor Targeting Applications: A Comparative Analysis.

scientific article published on 17 January 2018

Chronic cardiac allograft rejection: critical role of ED-A+fibronectin and implications for targeted therapy strategies

Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7

Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model

scientific article published on 29 June 2015

Combination of temozolomide with immunocytokine F16-IL2 for the treatment of glioblastoma

scientific article

Combination of the immunocytokine F16-IL2 with doxorubicin or paclitaxel in patients with solid tumors: Results from two phase Ib trials

Combinations of the immunocytokine F16-IL2 with doxorubicin or with paclitaxel investigated in phase Ib studies in patients with advanced solid tumors

Comparative analysis of oncofetal fibronectin and tenascin-C expression in right atrial auricular and left ventricular human cardiac tissue from patients with coronary artery disease and aortic valve stenosis.

scientific article

Comparative analysis of the membrane proteome of closely related metastatic and nonmetastatic tumor cells

scientific article

Comparative evaluation of DNA-encoded chemical selections performed using DNA in single-stranded or double-stranded format

scientific article published on 05 May 2020

Comparative immunohistochemical staining of atherosclerotic plaques using F16, F8 and L19: Three clinical-grade fully human antibodies

Comparative immunohistochemistry of L19 and F16 in non-small cell lung cancer and mesothelioma: Two human antibodies investigated in clinical trials in patients with cancer

article published in 2009

Comparative in vivo analysis of the atherosclerotic plaque targeting properties of eight human monoclonal antibodies.

scientific article published on 27 November 2010

Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2

article by C. Schliemann et al published 12 November 2008 in Blood

Complexation with a cognate antibody fragment facilitates affinity measurements of fluorescein-linked small molecule ligands

scientific article published on 03 July 2020

Covalent DNA display as a novel tool for directed evolution of proteins in vitro

scientific article

Critical Evaluation of Photo-cross-linking Parameters for the Implementation of Efficient DNA-Encoded Chemical Library Selections

scientific article published on 06 March 2020

Curative properties of noninternalizing antibody-drug conjugates based on maytansinoids

scientific article published on 11 February 2014

DNA-Compatible Diazo-Transfer Reaction in Aqueous Media Suitable for DNA-Encoded Chemical Library Synthesis

scientific article published on 20 November 2019

DNA-Encoded Chemical Libraries

DNA-encoded chemical libraries

scientific article

DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors

scientific article

DNA-encoded chemical libraries: Achievements and remaining challenges.

scientific article published on 23 April 2018

DNA-encoded chemical libraries: a tool for drug discovery and for chemical biology

scientific article

DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries

scientific article

DNA-encoded chemical libraries: foundations and applications in lead discovery

scientific article

Data Independent Acquisition of HLA Class I Peptidomes on the Q Exactive Mass Spectrometer Platform.

scientific article

De novo expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in human cardiac allografts: potential impact for targeted therapy of rejection

scientific article published on 3 May 2014

DeepQuanTR: MALDI-MS-based label-free quantification of proteins in complex biological samples

scientific article

Design and characterisation of a novel interleukin-15 receptor alpha fusion protein and analysis of interleukin-15 complexation

scientific article published on 26 July 2019

Design and construction of a naïve mouse antibody phage display library

scientific article

Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions

scientific article

Design, construction, and characterization of a large synthetic human antibody phage display library

scientific article

Detection of Soluble ED-A(+) Fibronectin and Evaluation as Novel Serum Biomarker for Cardiac Tissue Remodeling.

scientific article published on 18 August 2016

Determination of the nuclear magnetic resonance solution structure of the DNA-binding domain (residues 1 to 69) of the 434 repressor and comparison with the X-ray crystal structure

scientific article

Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia

scientific article published on 27 June 2019

Diagnostic and therapeutic applications of recombinant antibodies: targeting the extra-domain B of fibronectin, a marker of tumor angiogenesis

scientific article published on January 2004

Different patterns of fibronectin and tenascin-C splice variants expression in primary and metastatic melanoma lesions.

scientific article published on 7 June 2011

Different tissue distribution properties for glycosylation variants of fusion proteins containing the p40 subunit of murine interleukin-12.

scientific article published on 11 August 2016

Differential expression of tenascin-C splicing domains in urothelial carcinomas of the urinary bladder.

scientific article

Differential vascular expression and regulation of oncofetal tenascin-C and fibronectin variants in renal cell carcinoma (RCC): implications for an individualized angiogenesis-related targeted drug delivery

scientific article published on 11 November 2011

Differentiation between high- and low-grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin

scientific article published on November 2002

Discovery and investigation of lead compounds as binders to the Extra-Domain B of the angiogenesis marker, fibronectin

Discovery of TNF inhibitors from a DNA-encoded chemical library based on diels-alder cycloaddition

scientific article

Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library

scientific article

Dosimetry of 131I-L19SIP in Patients with Solid Tumors and Hematologic Malignancies: Final Results of First-in-human Trial

Drug discovery with DNA-encoded chemical libraries

scientific article

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.

scientific article published on 26 January 2015

Dual-pharmacophore DNA-encoded chemical libraries

scientific article published on 13 March 2015

Editorial

Editorial

Editorial overview: Next generation therapeutics: Creating and exploiting the chemistry of large numbers.

scientific article published on 15 April 2015

Efficient one-step direct labelling of recombinant antibodies with technetium-99m

scientific article published on November 1995

Efforts toward the total synthesis of tubulysins: new hopes for a more effective targeted drug delivery to tumors

scientific article published on February 2006

Emerging classes of armed antibody therapeutics against cancer

article

Encoded Self-Assembling Chemical Libraries

Encoded self-assembling chemical libraries

scientific article

Encoding chemistry

scientific article published on 01 July 2009

Engineered vascular-targeting antibody-interferon-γ fusion protein for cancer therapy

Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy

scientific article published on May 2004

Engineering recombinant antibodies for immunotherapy.

scientific article published on August 1995

Enhanced Therapeutic Activity of Non-Internalizing Small Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination With Targeted Interleukin-2.

scientific article published on 24 April 2018

Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature.

scientific article published on March 2002

Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix

scientific article published on 01 March 2002

Erratum: CORRIGENDUM: In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature

scholarly article published in Nature Methods

Erratum: In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinoma

scientific article published on 05 December 2018

Evaluation of F8-TNF-α in Models of Early and Progressive Metastatic Osteosarcoma

scientific article

Evaluation of antibody-chemokine fusion proteins for tumor-targeting applications

scientific article published on 28 May 2014

Evaluation of the radiolabeled human recombinant mini-antibody 131I-L19SIP in patients (pts) with cancer: Results of a phase I/II study

Expression of extra domain A containing fibronectin in chronic cardiac allograft rejection

scientific article

Expression of extradomain-B-containing fibronectin in subretinal choroidal neovascular membranes

scientific article published on January 2003

Expression of the Extra Domain B of Fibronectin, a Marker of Angiogenesis, in Head and Neck Tumors

Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients

scientific article published on 8 January 2009

Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12.

scientific article

Extra cellular matrix remodelling after heterotopic rat heart transplantation: gene expression profiling and involvement of ED-A+ fibronectin, alpha-smooth muscle actin and B+ tenascin-C in chronic cardiac allograft rejection

article

F8-SIP mediated targeted photodynamic therapy leads to microvascular dysfunction and reduced glioma growth

scientific article

FRI0194 A phase IB clinical trial with dekavil (F8-IL10), an anti-inflammatory immunocytokine for the treatment of rheumatoid arthritis, used in combination with methotrexate

scholarly article by Mauro Galeazzi et al published June 2013 in Annals of the Rheumatic Diseases

Fibronectin as target for tumor therapy

scientific article

From target discovery to clinical trials with armed antibody products

scientific article

Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format

Generation and tumor recognition properties of two human monoclonal antibodies specific to cell surface anionic phospholipids

scientific article published on 19 May 2015

Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies

scientific article

High-affinity antigen binding by chelating recombinant antibodies (CRAbs).

scientific article published on February 1995

High-resolution analysis of the murine MHC class II immunopeptidome

scientific article published on 23 October 2015

High-sensitivity HLA class I peptidome analysis enables a precise definition of peptide motifs and the identification of peptides from cell lines and patients' sera.

scientific article published on 15 March 2016

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

scientific article

High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries

scientific article

Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries.

scientific article

Human antibody against C domain of tenascin-C visualizes murine atherosclerotic plaques ex vivo

scientific article published in April 2007

Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours

scientific article published on 21 July 2009

Human monoclonal antibodies to domain C of tenascin-C selectively target solid tumors in vivo

scientific journal article

Identification and relative quantification of membrane proteins by surface biotinylation and two-dimensional peptide mapping

scientific article

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA

scientific article

Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody

scientific article

Identification of new accessible tumor antigens in human colon cancer by ex vivo protein biotinylation and comparative mass spectrometry analysis

scientific article

Identification of specific reachable molecular targets in human breast cancer using a versatileex vivo proteomic method

scholarly article by Vincent Castronovo published in April 2007

Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library

scientific article published on 3 February 2015

Identification of the surface-accessible, lineage-specific vascular proteome by two-dimensional peptide mapping

article by Christoph Roesli et al published June 2008 in FASEB Journal

Imaging T Cells In Vivo.

scientific article

Imaging of tumor angiogenesis using 99mTc-labeled human recombinant anti-ED-B fibronectin antibody fragments

scientific article published on October 2006

Immunocytokines

Immunocytokines and bispecific antibodies: two complementary strategies for the selective activation of immune cells at the tumor site

scientific article

Immunocytokines are a promising immunotherapeutic approach against glioblastoma

scientific article published on 01 October 2020

Immunocytokines for cancer treatment: past, present and future

scientific article published on 06 April 2016

Immunocytokines: a novel class of products for the treatment of chronic inflammation and autoimmune conditions

scientific article published on 22 October 2015

Immunocytokines: a review of molecules in clinical development for cancer therapy

scientific article published on 20 August 2013

Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer

scientific article published in February 2003

Immunoscintigraphy of patients with head and neck carcinomas, with an anti-angiogenetic antibody fragment

scientific article published on April 2007

Immunotherapy of CT26 murine tumors is characterized by an oligoclonal response of tissue-resident memory T cells against the AH1 rejection antigen

scientific article published on 29 May 2020

Impact of a Central Scaffold on the Binding Affinity of Fragment Pairs Isolated from DNA-Encoded Self-Assembling Chemical Libraries.

scientific article

Impact of ligand size and conjugation chemistry on the performance of universal chimeric antigen receptor T-cells for tumor killing

scientific article published on 09 June 2020

Improved protein sequence coverage by on resin deglycosylation and cysteine modification for biomarker discovery

scientific article

In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas

article published in 2018

In vivo biotinylation of the vasculature in B-cell lymphoma identifies BST-2 as a target for antibody-based therapy

scientific article

In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography

scientific article

In vivo protein biotinylation and sample preparation for the proteomic identification of organ- and disease-specific antigens accessible from the vasculature

In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature

scientific article published on 23 March 2005

In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives

scientific article

Interfering with pH regulation in tumours as a therapeutic strategy

scientific article published on 16 September 2011

Internalization via Antennapedia protein transduction domain of an scFv antibody toward c-Myc protein

scientific article published on 29 November 2007

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

scientific article published on 18 March 2015

Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study

scientific article published on 14 May 2015

Intralesional treatment of metastatic melanoma: a review of therapeutic options

scientific article published on 11 January 2017

Intralesional treatment of stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunologic responses.

scientific article published on 4 April 2014

Intratumoral administration of IL2- and TNF-based fusion proteins cures cancer without establishing protective immunity

scientific article published in March 2018

Isolated limb perfusion with the tumor-targeting human monoclonal antibody-cytokine fusion protein L19-TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma

article published in 2012

Isolation and characterization of an inhibitory human monoclonal antibody specific to the urokinase-type plasminogen activator, uPA.

scientific article

Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3.

scientific article published on 12 November 2009

Isolation of a small-molecule inhibitor of the antiapoptotic protein Bcl-xL from a DNA-encoded chemical library

scientific article

Isolation of anti-angiogenesis antibodies from a large combinatorial repertoire by colony filter screening

scientific article

Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library

scientific article

Isolation of potent and specific trypsin inhibitors from a DNA-encoded chemical library

scientific article

Lack of specificity of endoglin expression for tumor blood vessels.

scientific article

Large scale comparative proteomic study of accessible vascular proteins in mouse liver metastases and normal liver

Lead discovery by DNA-encoded chemical libraries

scientific article

Ligand-based vascular targeting of disease

scientific article published on January 2007

Limited efficacy of intratumoral IL-2 applied to large melanoma metastases

scientific article published on 24 July 2014

Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma

scientific article

Lung tissue remodelling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression.

scientific article published on 8 November 2016

Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes

scientific article published on 06 September 2016

Matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, B+ tenascin-C and ED-A+ fibronectin in dilated cardiomyopathy: Potential impact on disease progression and patients' prognosis

Methods for the identification of vascular markers in health and disease: from the bench to the clinic

scientific article published on 10 June 2010

Microvascular biodistribution of L19-SIP in angiogenesis targeting strategies

scientific article published on 9 March 2011

Modulation of gene expression by extracellular pH variations in human fibroblasts: a transcriptomic and proteomic study.

scientific article published in May 2003

Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study

scientific article

Molecular Imaging of Atherosclerotic Plaques Using a Human Antibody Against the Extra-Domain B of Fibronectin

Molecular targeting of angiogenesis

scientific article published on March 2004

Molecular targeting of angiogenesis for imaging and therapy

scientific article published on 5 August 2004

Monoclonal antibodies to murine thrombospondin-1 and thrombospondin-2 reveal differential expression patterns in cancer and low antigen expression in normal tissues

scientific article published on 9 June 2014

Murine analogues of etanercept and of F8-IL10 inhibit the progression of collagen-induced arthritis in the mouse

scientific article published on 27 September 2013

NMR determination of residual structure in a urea-denatured protein, the 434-repressor

scientific article published in Science

NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis

scientific article

New nuclear magnetic resonance experiment for measurements of the vicinal coupling constants 3JHN.alpha. in proteins

scientific article published in 1990

New strategy for the extension of the serum half-life of antibody fragments

scientific article published in December 2009

Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the subendothelial extracellular matrix

scientific article published on 10 December 2016

Noninternalizing targeted cytotoxics for cancer therapy

scientific article published on 18 March 2015

Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo

scientific article published on 01 January 2020

OP0108 The Antibody-Based Delivery of IL4 to the Neo-Vasculature Cures Mice with Arthritis

On the magnitude of the chelate effect for the recognition of proteins by pharmacophores scaffolded by self-assembling oligonucleotides

scientific article published on February 2006

On-DNA hit validation methodologies for ligands identified from DNA-encoded chemical libraries

scientific article published on 30 April 2020

Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries

scientific article

P76 Clinical experiences with therapeutic derivatives of the anti-ED-B fibronectin immunoprotein L19

PHASE I/II STUDY OF THE TUMOUR-TARGETING HUMAN L19- IL2 MONOCLONAL ANTIBODY-CYTOKINE FUSION PROTEIN IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA

Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts

scientific article

Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3.

scientific article

Pharmacotherapy of metastatic melanoma: emerging trends and opportunities for a cure

scientific article published on 24 May 2013

Phase 0 microdosing PET study using the human mini antibody F16SIP in head and neck cancer patients

scientific article published on 18 January 2013

Phase I/II study of the tumour-targeting human monoclonal antibody-cytokine fusion protein L19-TNF in patients with advanced solid tumours

scientific article

Potency-matched Dual Cytokine-Antibody Fusion Proteins for Cancer Therapy

scientific article published on 17 July 2017

Potentiating the activity of rituximab against mantle cell lymphoma in mice by targeting interleukin-2 to the neovasculature

scholarly article by Niklas Börschel et al published July 2015 in Leukemia Research

Potentiation of PD-L1 blockade with a potency-matched dual cytokine-antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains

scientific article published on 04 July 2018

Precise vicinal coupling constants 3JHN alpha in proteins from nonlinear fits of J-modulated [15N,1H]-COSY experiments.

scientific article published in May 1992

Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis

scientific article published on 25 September 2009

Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy

scientific article

Preliminary evaluation of radioimmunotherapy with an 131I labelled small immunoprotein targeted against the extra domain B of fibronectin in combination with whole brain radiation therapy in patients with multiple brain metastases from solid tumors

Preparation of phage antibodies to the ED-A domain of human fibronectin.

scientific article

Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody-Drug Conjugates.

scientific article published on 29 June 2017

Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy

article

Proteomics application exercise of the Swiss Proteomics Society: Report of the SPS'02 session

article

Purification of biotinylated proteins on streptavidin resin: a protocol for quantitative elution

scientific article

Purification of soluble HLA class I complexes from human serum or plasma deliver high quality immuno peptidomes required for biomarker discovery

scientific article published on 12 November 2016

Quantitation of the Tumor-Targeting Properties of Antibody Fragments Conjugated to Cell-Permeating HIV-1 TAT Peptides

article

Quantitative Assessment of Affinity Selection Performance by Using DNA-Encoded Chemical Libraries

scientific article published on 20 February 2019

Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections.

scientific article

Radioactive labeling of recombinant antibody fragments by phosphorylation using human casein kinase II and [gamma-32P]-ATP.

scientific article

Radioimmunotherapy (RIT) with 131l-L19SIP in solid cancers (SC) and lymphoproliferative diseases: Final results of the first human trial

Radioimmunotherapy of head and neck cancer xenografts using 131I-labeled antibody L19-SIP for selective targeting of tumor vasculature

scientific article published on July 2006

Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19).

scientific article published on July 2006

Radioimmunotherapy with Tenarad, a 131I-labelled antibody fragment targeting the extra-domain A1 of tenascin-C, in patients with refractory Hodgkin's lymphoma

scientific article

Radioimmunotherapy with radretumab in patients with relapsed hematologic malignancies

scientific article

Radiotherapy combined with the immunocytokine L19-IL2 provides long-lasting antitumor effects

scientific article

Radretumab radioimmunotherapy in patients with brain metastasis: a 124I-L19SIP dosimetric PET study

scientific article published on 20 May 2013

Recent advances in osteosarcoma

scientific article published on 13 March 2014

Recombinant antibodies for the depletion of abundant proteins from human serum

scientific article

Recombinant antibodies for the selective targeting of tumor neovasculature

scientific article

Recombinant proteins L and LG. Two new tools for purification of murine antibody fragments.

scientific article

Reformatting of scFv antibodies into the scFv-Fc format and their downstream purification

scientific article

SAT0232 A Phase IB Clinical Trial in Rheumatoid Arthritis of Dekavil (F8-IL10), A Novel Anti-Inflammatory Immunocytokine

scholarly article by Mauro Galeazzi et al published June 2014 in Annals of the Rheumatic Diseases

Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+ T-cell Recognition of a Retroviral Antigen

scientific article

Selection and characterization of human antibody fragments specific for psoriasin - a cancer associated protein

scientific article

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

scientific article

Selection of high-affinity human monoclonal antibodies specific to the constant domain of versican as tools for tumor targeting

scientific article published in July 2008

Selection of single domain binding proteins by covalent DNA display

scientific article

Selection of streptavidin binders from a DNA-encoded chemical library

scientific article

Selective fragments for the CREBBP bromodomain identified from an Encoded Self-Assembly Chemical Library

scientific article published on 19 July 2020

Selective imaging of chronic cardiac rejection using a human antibody specific to the alternatively spliced EDA domain of fibronectin.

scientific article

Selective occlusion of tumor blood vessels by targeted delivery of an antibody-photosensitizer conjugate

scientific article published in April 2006

Selective targeted delivery of TNFalpha to tumor blood vessels.

scientific article

Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage-derived human antibody fragment

Selective targeting of tumoral vasculature: Comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin

Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin

scientific article

Sequence determinants of a microtubule tip localization signal (MtLS).

scientific article

Single-chain antibody and its derivatives directed against vascular endothelial growth factor: application for antiangiogenic gene therapy.

scientific article

Site-specific and stoichiometric conjugation of cationic porphyrins to antiangiogenic monoclonal antibodies

scientific article published in February 2010

Site-specific chemical modification of antibody fragments using traceless cleavable linkers

scientific article published on 3 October 2013

Site-specific traceless coupling of potent cytotoxic drugs to recombinant antibodies for pharmacodelivery

scientific article

Small targeted cytotoxics: current state and promises from DNA-encoded chemical libraries

scientific article

Sortase-Mediated Site-Specific Modification of Interleukin-2 for the Generation of a Tumor-Targeting Acetazolamide-Cytokine Conjugate

scientific article published on 30 September 2020

Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature

Special edition on DNA-Encoded chemical libraries

scientific article published on 01 December 2020

Support of1H NMR assignments in proteins by biosynthetically directed fractional13C-labeling

article

Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha

scientific article published on 01 June 2003

Systematic evaluation and optimization of modification reactions of oligonucleotides with amines and carboxylic acids for the synthesis of DNA-encoded chemical libraries

scientific article published on 25 July 2014

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

scientific article published on 10 June 2015

Targeted Delivery of Cytotoxic Drugs: Challenges, Opportunities and New Developments

scientific article published in October 2017

Targeted Delivery of IL2 to the Tumor Stroma Potentiates the Action of Immune Checkpoint Inhibitors by Preferential Activation of NK and CD8+ T Cells

scientific article published on 19 February 2019

Targeted Delivery of TNF Potentiates the Antibody-Dependent Cell-Mediated Cytotoxicity of an Anti-Melanoma Immunoglobulin

scientific article published on 10 December 2018

Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis

Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins

scientific article published on 8 July 2016

Targeted delivery of interleukin-10 to chronic cardiac allograft rejection using a human antibody specific to the extra domain A of fibronectin

scientific article published on 29 May 2015

Targeted delivery of tumor necrosis factor-alpha to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin

scientific article published on April 2006

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade

scientific article published on 19 November 2019

Targeted photolysis of melanoma cells by Alfa-Terthienyl derivative labeled antimelanoma monoclonal antibody

scientific article published on 31 January 1996

Targeting Interleukin-2 to the Bone Marrow Stroma for Therapy of Acute Myeloid Leukemia Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation

Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors

scientific article published on 03 November 2020

Targeting the Vascular Endothelium – Novel Approaches

The Antibody-Mediated Targeted Delivery of Interleukin-15 and GM-CSF to the Tumor Neovasculature Inhibits Tumor Growth and Metastasis

The Discovery and Characterisation of Tumour Endothelial Markers

The Extra-domain A of Fibronectin Is a Vascular Marker of Solid Tumors and Metastases

article published in 2007

The MHC Class II Immunopeptidome of Lymph Nodes in Health and in Chemically Induced Colitis

scientific article published on 23 December 2016

The Targeted Delivery of Interleukin 4 Inhibits Development of Endometriotic Lesions in a Mouse Model

scientific article

The accessible cerebral vascular proteome in a mouse model of cerebral β-amyloidosis

article

The antibody-based delivery of interleukin-12 to solid tumors boosts NK and CD8+ T cell activity and synergizes with immune checkpoint inhibitors

scientific article published on 28 August 2019

The antibody-based delivery of interleukin-12 to the tumor neovasculature eradicates murine models of cancer in combination with paclitaxel

scientific article

The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity

scientific article published on 25 July 2013

The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer

scientific article published on 10 August 2013

The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model

article

The antibody-mediated targeted delivery of interleukin-13 to syngeneic murine tumors mediates a potent anticancer activity

scientific article

The dose-dependent tumor targeting of antibody-IFNγ fusion proteins reveals an unexpected receptor-trapping mechanism in vivo.

scientific article published on 24 March 2014

The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma

scientific article published on 28 October 2010

The immunocytokine L19-IL2 eradicates cancer when used in combination with CTLA-4 blockade or with L19-TNF.

scientific article

The immunocytokine L19-TNF eradicates sarcomas in combination with chemotherapy agents or with immune check-point inhibitors

scientific article published on 16 April 2020

The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate

scientific article

The targeted delivery of interleukin-12 to the carcinoembryonic antigen increases the intratumoral density of NK and CD8+ T cell in an immunocompetent mouse model of colorectal cancer

scientific article published on 01 August 2020

The tumor-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumors and expansion into patients with metastatic breast cancer.

scientific article published on January 2015

The tumour-targeting human L19-IL2 immunocytokine: preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma.

scientific article published on 24 August 2010

Therapeutic approaches to hepatocellular carcinoma

Therapeutic efficacy of the F8-IL2 immunocytokine in a metastatic mouse model of lung adenocarcinoma

scientific article

Three clinical-stage tumor targeting antibodies reveal differential expression of oncofetal fibronectin and tenascin-C isoforms in human lymphoma

Tumor Targeting

article from 2004

Tumor targeting properties of antibody fusion proteins based on different members of the murine tumor necrosis superfamily

scientific article published on 30 December 2013

Tumor vascular targeting

Tumor-targeting antibody-anticalin fusion proteins for in vivo pretargeting applications

scientific article published on 6 February 2013

Tumor-targeting human L19IL2 monoclonal antibody-cytokine fusion protein in combination with DTIC in chemotherapy-naïve stage IV melanoma patients

Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins

Tumor-targeting properties of novel antibodies specific to the large isoform of tenascin-C.

scientific article published in May 2006

Tumor-targeting properties of novel immunocytokines based on murine IL1β and IL6.

scientific article published on 2 May 2014

Tumour vascular targeting

scientific article

Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3

Twenty-five Years of DNA-Encoded Chemical Libraries

scientific article published on 20 March 2017

Two general methods for the isolation of enzyme activities by colony filter screening

scientific article

Two-dimensional mass spectrometric mapping

scientific article

Unexpected observation of concentration-dependent dissociation rates for antibody–antigen complexes and other macromolecular complexes in competition experiments

article

Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis.

scientific article published on April 2007

Vascular targeting antibodies: from the bench to the clinic

Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold.

scientific article

What Is a Biosimilar?

article

“Cap-and-Catch” Purification for Enhancing the Quality of Libraries of DNA Conjugates

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