List of works - Andreas Wack

A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population

scientific article

A serpin shapes the extracellular environment to prevent influenza A virus maturation

scientific article

Adjuvant is necessary for a robust immune response to a single dose of H1N1 pandemic flu vaccine in mice.

scientific article

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

scientific article

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

scientific article published on 01 September 1998

An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations

scientific article published on 01 September 1996

Antibody affinity maturation and respiratory syncytial virus disease

scientific article published in July 2009

Bacterial Polysaccharides with Zwitterionic Charge Motifs: Toll-Like Receptor 2 Agonists,T Cell Antigens, or Both?

scholarly article by Andreas Wack & Simona Gallorini published January 2008 in Immunopharmacology and Immunotoxicology

Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co-stimulatory signal for human T cells

scientific article published in January 2001

Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function

scientific article published on July 2008

Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.

scientific article

Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors

Contribution of cytokines to pathology and protection in virus infection

scientific article published on 25 June 2011

Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival

scientific article published on 01 February 2021

Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells

scholarly article by Stefania Crotta et al published April 2006 in European Journal of Immunology

Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects

scientific article published on 7 April 2005

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

scientific article published on 01 October 1996

Disease-promoting effects of type I interferons in viral, bacterial, and coinfections

scientific article

Early onset of CD8 transgene expression inhibits the transition from DN3 to DP thymocytes

scientific article published in August 2000

Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets

scientific article published on 01 March 2007

Guarding the frontiers: the biology of type III interferons

scientific article published on July 2015

Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection

scientific article published on 16 December 2009

Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation

scientific article published on 27 January 2009

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

scientific article published on 11 August 2016

Immunology of TLR-independent vaccine adjuvants

scientific article published on June 2009

In vitro positive selection of alpha beta TCR transgenic thymocytes by a conditionally immortalized cortical epithelial clone.

scientific article published on March 1997

Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway

scientific article published on 09 August 2013

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

scientific article published on 13 January 2020

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

scientific article

Interactions with multiple peptide ligands determine the fate of developing thymocytes.

scientific article

Interfering with transmission.

scientific article

Intranasal administration of CpG induces a rapid and transient cytokine response followed by dendritic and natural killer cell activation and recruitment in the mouse lung

scientific article published on 30 October 2009

Introduction of zwitterionic motifs into bacterial polysaccharides generates TLR2 agonists able to activate APCs

scientific article published on December 2007

MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).

scientific article published on 3 March 2009

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

scientific article published on 01 July 2019

Monocytes work harder under pressure

scientific article published on 01 November 2019

Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.

scientific article published on 8 January 2018

Multiple sites of post-activation CD8+ T cell disposal

scientific article published in March 1997

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

scientific article published on 09 February 2017

Novel vaccines. Vaccinations in the near and distant future

scientific article published in November 2009

Pathogenic potential of interferon αβ in acute influenza infection

scientific article

Plasminogen activator inhibitor type 1 in rat spermatozoa: localisation in the tail, in the acrosome and on the surface of the head

scientific article published on 01 August 1994

Rationally designed strings of promiscuous CD4+ T cell epitopes provide help toHaemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines

article

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

scientific article published on 05 November 2021

Restricted TCR repertoire and long-term persistence of donor-derived antigen-experienced CD4+ T cells in allogeneic bone marrow transplantation recipients

scientific article published in December 1996

Safety of MF59 adjuvant

scientific article published on 21 April 2008

Stop the executioners

scientific article published on January 2015

Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells

Susceptibility and resistance to antigen-induced apoptosis in the thymus of transgenic mice

scientific article published in June 1998

T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck.

scientific article published in February 2003

TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

scientific article

Th cells and Th2 responses can develop in the absence of MHC class II-CD4 interactions.

scientific article published in August 1999

The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature

scientific article

The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells

scientific article

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

scientific article published on 24 August 2016

The repertoire of T-lymphocytes recovered by bronchoalveolar lavage from healthy nonsmokers

scientific article published on 01 February 1996

The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development

scientific article published on 17 February 2014

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

scientific article published on 24 March 2014

Themis2 is not required for B cell development, activation, and antibody responses.

scientific article

Toll-Like Receptor 9-Independent Responsiveness of Human Monocytes to Microbial DNA

Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides

scholarly article

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

scientific article published on 28 June 2019

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

scientific article published on 05 May 2020

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

scientific article

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

scientific article

Type I interferons in infectious disease

scientific article

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

scientific article

Vaccinology at the beginning of the 21st century

scientific article

List of works by Andreas Wack

A comparison of two techniques for the molecular tracking of specific T-cell responses; CD4+ human T-cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population

A serpin shapes the extracellular environment to prevent influenza A virus maturation

Adjuvant is necessary for a robust immune response to a single dose of H1N1 pandemic flu vaccine in mice.

Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88

Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansions in complex T cell populations

Antibody affinity maturation and respiratory syncytial virus disease

Bacterial Polysaccharides with Zwitterionic Charge Motifs: Toll-Like Receptor 2 Agonists,T Cell Antigens, or Both?

Binding of the hepatitis C virus envelope protein E2 to CD81 provides a co-stimulatory signal for human T cells

Coligation of the hepatitis C virus receptor CD81 with CD28 primes naive T lymphocytes to acquire type 2 effector function

Combination adjuvants for the induction of potent, long-lasting antibody and T-cell responses to influenza vaccine in mice.

Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors

Contribution of cytokines to pathology and protection in virus infection

Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival

Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells

Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

Disease-promoting effects of type I interferons in viral, bacterial, and coinfections

Early onset of CD8 transgene expression inhibits the transition from DN3 to DP thymocytes

Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets

Guarding the frontiers: the biology of type III interferons

Hepatitis C virions subvert natural killer cell activation to generate a cytokine environment permissive for infection

Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

Immunology of TLR-independent vaccine adjuvants

In vitro positive selection of alpha beta TCR transgenic thymocytes by a conditionally immortalized cortical epithelial clone.

Influenza A virus impairs control of Mycobacterium tuberculosis coinfection through a type I interferon receptor-dependent pathway

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

Interactions with multiple peptide ligands determine the fate of developing thymocytes.

Interfering with transmission.

Intranasal administration of CpG induces a rapid and transient cytokine response followed by dendritic and natural killer cell activation and recruitment in the mouse lung

Introduction of zwitterionic motifs into bacterial polysaccharides generates TLR2 agonists able to activate APCs

MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).

Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection

Monocytes work harder under pressure

Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.

Multiple sites of post-activation CD8+ T cell disposal

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Novel vaccines. Vaccinations in the near and distant future

Pathogenic potential of interferon αβ in acute influenza infection

Plasminogen activator inhibitor type 1 in rat spermatozoa: localisation in the tail, in the acrosome and on the surface of the head

Rationally designed strings of promiscuous CD4+ T cell epitopes provide help toHaemophilus influenzae type b oligosaccharide: a model for new conjugate vaccines

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Restricted TCR repertoire and long-term persistence of donor-derived antigen-experienced CD4+ T cells in allogeneic bone marrow transplantation recipients

Safety of MF59 adjuvant

Stop the executioners

Surface molecules on stimulated plasmacytoid dendritic cells are sufficient to cross-activate resting myeloid dendritic cells

Susceptibility and resistance to antigen-induced apoptosis in the thymus of transgenic mice

T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck.

TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

Th cells and Th2 responses can develop in the absence of MHC class II-CD4 interactions.

The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature

The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

The repertoire of T-lymphocytes recovered by bronchoalveolar lavage from healthy nonsmokers

The transcription factor E4BP4 is not required for extramedullary pathways of NK cell development

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

Themis2 is not required for B cell development, activation, and antibody responses.

Toll-Like Receptor 9-Independent Responsiveness of Human Monocytes to Microbial DNA

Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

Type I interferons in infectious disease

Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes

Vaccinology at the beginning of the 21st century