List of works - Malin Wickström

Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.

scientific article

Alternative cytotoxic effects of the postulated IGF-IR inhibitor picropodophyllin in vitro

scientific article published on 22 May 2013

Aminopeptidase N (CD13) as a target for cancer chemotherapy

scientific article

Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.

scientific article published on February 2007

Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs

scientific article

Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo

scientific article published on 29 August 2011

Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation.

scientific article

GIT1 protects against breast cancer growth through negative regulation of Notch

scientific article published on 22 March 2022

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

scientific article

Image-based screening for the identification of novel proteasome inhibitors

scientific article

In vitro and in vivo activity of melflufen (J1)in lymphoma

scientific article published on 4 April 2016

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

scientific article published on 9 October 2011

Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo

scientific article published on 27 July 2017

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound

scientific article published on 06 October 2021

Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents

scientific article published on 10 March 2011

Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain

scientific article published on 16 March 2017

Melflufen - a peptidase-potentiated alkylating agent in clinical trials

scientific article published on 8 June 2017

Metronomic scheduling of imatinib abrogates clonogenicity of neuroblastoma cells and enhances their susceptibility to selected chemotherapeutic drugs in vitro and in vivo

scientific article

Molecular mechanisms and therapeutic targets in neuroblastoma

scientific article published on 18 February 2018

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

scientific article

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

scientific article

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

scientific article published in August 2006

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma

scientific article

Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.

scientific article published on March 2014

Rho-associated kinase is a therapeutic target in neuroblastoma

scientific article published on 24 July 2017

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

scientific article

Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

scientific article

Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa

scientific article

Simvastatin reduces the production of prothrombotic prostasomes in human prostate cancer cells.

scientific article

Synthesis and Characterization of a Multi Ring-Fused 2-Pyridone-Based Fluorescent Scaffold

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

scientific article published on 3 October 2012

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

scientific article

The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro.

scientific article

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling

scientific article

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

scientific article

The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

scientific article

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

scientific article

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

scientific article

Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1).

scientific article

Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth

scientific article

Wingless/β-catenin signaling as a modulator of chemoresistance in cancer

scientific article published on 19 January 2016

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

scientific article

List of works by Malin Wickström

Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.

Alternative cytotoxic effects of the postulated IGF-IR inhibitor picropodophyllin in vitro

Aminopeptidase N (CD13) as a target for cancer chemotherapy

Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo.

Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs

Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo

Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation.

GIT1 protects against breast cancer growth through negative regulation of Notch

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Image-based screening for the identification of novel proteasome inhibitors

In vitro and in vivo activity of melflufen (J1)in lymphoma

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound

Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents

Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain

Melflufen - a peptidase-potentiated alkylating agent in clinical trials

Metronomic scheduling of imatinib abrogates clonogenicity of neuroblastoma cells and enhances their susceptibility to selected chemotherapeutic drugs in vitro and in vivo

Molecular mechanisms and therapeutic targets in neuroblastoma

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma

Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment.

Rho-associated kinase is a therapeutic target in neuroblastoma

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

Simvastatin induces apoptosis in human breast cancer cells in a NFkappaB-dependent manner and abolishes the anti-apoptotic signaling of TF/FVIIa and TF/FVIIa/FXa

Simvastatin reduces the production of prothrombotic prostasomes in human prostate cancer cells.

Synthesis and Characterization of a Multi Ring-Fused 2-Pyridone-Based Fluorescent Scaffold

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro.

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1).

Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth

Wingless/β-catenin signaling as a modulator of chemoresistance in cancer

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance