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List of works by Charles Rudin

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Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

scientific article (publication date: 22 October 2015)
Akt stimulates aerobic glycolysis in cancer cells

scientific article (publication date: June 2004)
Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

scientific article
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

scientific article published on 2 September 2012
Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer

scientific article published on November 9, 2011
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

scientific article
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

scientific article
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

scientific article published on 07 February 2011
Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

scientific article
Tumor mutational load predicts survival after immunotherapy across multiple cancer types

scientific article published on 14 January 2019
A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro

scientific article
The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

scientific article published on 09 February 2015
The future of epigenetic therapy in solid tumours--lessons from the past.

scientific article published on 02 April 2013
Cigarette smoking and lung cancer--relative risk estimates for the major histological types from a pooled analysis of case-control studies

scientific article published on 14 December 2011
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

scientific article
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.

scientific article published on 19 September 2016
Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping

scientific article
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

scientific article
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

scientific article
Small cell lung cancer: where do we go from here?

scientific article
Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study

scientific article
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma

scientific article published on March 2015
Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

scientific article
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.

scientific article published on 23 March 2017
Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity

scientific article
Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial

scientific article
Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers

scientific article
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

scientific article published on 2 October 2017
Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer

scientific article published on 19 December 2016
Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.

scientific article published on February 2017
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

scientific article published on 13 June 2016
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.

scientific article published on 9 March 2016
Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors

scientific article published on 10 April 2013
DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.

scientific article
Small cell lung cancer: will recent progress lead to improved outcomes?

scientific article published in May 2015
An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.

scientific article published on 3 November 2003
Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

scientific article published on 29 January 2016
Characteristics of lung cancers harboring NRAS mutations

scientific article (publication date: May 2013)
A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer.

scientific article
Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline

scientific article published on 8 September 2015
Human Alu element retrotransposition induced by genotoxic stress

scientific article published on 26 October 2003
Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come.

scientific article
Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection.

scientific article published on August 2003
Unravelling the biology of SCLC: implications for therapy

scientific article published on 23 May 2017
Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding

scientific article published on February 7, 2011
Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer

scientific article
Phase I Clinical Study of Seneca Valley Virus (SVV-001),a Replication-Competent Picornavirus, in Advanced Solid Tumors with Neuroendocrine Features

scientific article published on February 8, 2011
A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung cancer

scientific article
Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer.

scientific article published on 03 February 2014
Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC.

scientific article published on June 2015

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