Search filters

List of works by Charles Rudin

A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry

scientific article published in 2021

A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer

scientific article published on 14 December 2020

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

scientific article

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

scientific article

A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers

scientific article published on 09 January 2020

A Self-Assembling and DisAssembling (SADA) bispecific antibody (BsAb) platform for curative 2-step pre-targeted radioimmunotherapy

scientific article published on 21 September 2020

A comparison of FLT to FDG PET/CT in the early assessment of chemotherapy response in stages IB-IIIA resectable NSCLC.

scientific article published on 19 January 2017

A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours.

scientific article published on 13 August 2013

A phase I study of STEALTH cisplatin (SPI-77) and vinorelbine in patients with advanced non small-cell lung cancer

scientific article published on 01 November 2000

A phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies.

scientific article

A phase I trial of the Hedgehog inhibitor, sonidegib (LDE225), in combination with etoposide and cisplatin for the initial treatment of extensive stage small cell lung cancer

scientific article published on 26 April 2016

A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer.

scientific article

A phase II study of bryostatin-1 and paclitaxel in patients with advanced non-small cell lung cancer

scientific article published on 01 February 2003

A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in relapsed small cell lung cancer

scientific article

A phase II study of oxaliplatin and paclitaxel in patients with advanced non-small-cell lung cancer.

scientific article

A phase II tolerability study of cisplatin plus docetaxel as adjuvant chemotherapy for resected non-small cell lung cancer

scientific article published on July 2007

A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer

scientific article

A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists

scientific article

A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro

scientific article

A prospective study of tumor suppressor gene methylation as a prognostic biomarker in surgically resected stage I to IIIA non-small-cell lung cancers.

scientific article

A randomized, multicenter study to determine the safety and efficacy of the immunoconjugate SGN-15 plus docetaxel for the treatment of non-small cell lung carcinoma

scientific article published on 28 August 2006

A randomized, phase 2 trial of Docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic non-small-cell lung cancer.

scientific article

A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer

scientific article published on 13 January 2015

Activation of KRAS mediates resistance to targeted therapy in MET ex on 14 mutant non-small cell lung cancer

article

Age and sex differences in the incidence of esophageal adenocarcinoma: results from the Surveillance, Epidemiology, and End Results (SEER) Registry (1973-2008).

scientific article published on 07 October 2013

Akt stimulates aerobic glycolysis in cancer cells

scientific article (publication date: June 2004)

An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.

scientific article published on 3 November 2003

Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus.

scientific article published on 26 June 2017

Antibody-mediated thyroid dysfunction during T-cell checkpoint blockade in patients with non-small-cell lung cancer

scientific article published on 19 December 2016

Apoptotic signaling in lymphocytes ⬇️

scientific article published on January 1, 1996

Atezolizumab for the treatment of non-small cell lung cancer

scientific article published on 17 July 2017

Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 July 2019

Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection.

scientific article published on August 2003

Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo.

scientific article

Beyond the scalpel: targeting hedgehog in skin cancer prevention.

scientific article published on January 2010

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

scientific article published on 13 June 2016

Cabozantinib in patients with advanced RET-rearranged non-small-cell lung cancer: an open-label, single-centre, phase 2, single-arm trial

scientific article

Cancer stem cells

scientific article published on 01 November 2009

Capturing Genomic Evolution of Lung Cancers through Liquid Biopsy for Circulating Tumor DNA.

scientific article published on 14 March 2017

Carboplatin plus vinorelbine with concomitant radiation therapy in advanced non-small cell lung cancer: a phase I study

scientific article published in October 2002

Characteristics of lung cancers harboring NRAS mutations

scientific article (publication date: May 2013)

Characterization of a full-length infectious cDNA clone and a GFP reporter derivative of the oncolytic picornavirus SVV-001 ⬇️

scientific article published on September 12, 2012

Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.

scientific article published on February 2017

Cigarette smoking and lung cancer--relative risk estimates for the major histological types from a pooled analysis of case-control studies

scientific article published on 14 December 2011

Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations

scientific article published on 12 July 2019

Circulating tumor DNA analysis to assess risk of progression after long-term response to PD-(L)1 blockade in NSCLC

scientific article published on 11 February 2020

Clinical characteristics and course of 63 patients with BRAF mutant lung cancers

scientific article

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer ⬇️

scientific article published on November 9, 2011

Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer

scientific article published on 2 March 2013

Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis.

scientific article published on 3 May 2017

Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

scientific article

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

scientific article published on 2 September 2012

Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation

scientific article published on 16 October 2021

Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy

scientific article published on 26 August 2020

Correction: Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for use in Peptide-Prodrug Therapy.

scientific article published on 19 August 2015

Crizotinib in the treatment of non-small-cell lung cancer.

scientific article

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

scientific article

DNA cleavage and Trp53 differentially affect SINE transcription

scientific article published on March 2007

DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.

scientific article

Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: a phase I study

scientific article

Drug therapy: Preclinical oncology - reporting transparency needed

scientific article published on 15 December 2015

Dual inhibition of the epidermal growth factor receptor pathway with cetuximab and erlotinib: a phase I study in patients with advanced solid malignancies

scientific article published on 31 January 2009

ERK Phosphorylation Is Predictive of Resistance to IGF-1R Inhibition in Small Cell Lung Cancer ⬇️

scientific article published on March 20, 2013

Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis

scientific article published on 24 September 2014

Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study

scientific article published on 10 September 2019

Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

scientific article

Eosinophilic Fasciitis Following Checkpoint Inhibitor Therapy: Four Cases and a Review of Literature

scientific article published on 15 October 2019

Epigenetic targeting of DNA repair in lung cancer

scientific article published on 29 October 2019

Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylases.

scientific article published on 17 July 2013

Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer

scientific article

Factors influencing the utilization of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer

scientific article published on 8 August 2017

Fast, hungry and unstable: finding the Achilles' heel of small-cell lung cancer

scientific article

Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts ⬇️

scientific article published on October 1, 2011

Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma

scientific article published on March 2015

Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts

scientific article published on 19 April 2022

Geographic proximity and racial disparities in cancer clinical trial participation.

scientific article

HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers

scientific article published on 25 March 2020

Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters

scientific article

High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden

scientific article published on 26 April 2019

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

scientific article published on 25 November 2019

Histone Code Aberrancies in Small Cell Lung Cancer.

scientific article published in April 2017

Human Alu element retrotransposition induced by genotoxic stress

scientific article published on 26 October 2003

Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer.

scientific article published on 30 January 2013

Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling ⬇️

scientific article published on October 5, 2011

Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

scientific article

Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer

scientific article

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

scientific article published on 2 October 2017

Large Cell Neuroendocrine Carcinoma of the Lung: Clinico-Pathologic Features, Treatment, and Outcomes.

scientific article

Lineage plasticity in cancer: a shared pathway of therapeutic resistance

scientific article published on 09 March 2020

Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers

scientific article published in December 2017

Lung Adenocarcinoma: Predictive Value of KRAS Mutation Status in Assessing Local Recurrence in Patients Undergoing Image-guided Ablation.

scientific article

MET exon 14-altered lung cancers and MET inhibitor resistance

scientific article published on 10 November 2020

MYC, MAX, and small cell lung cancer.

scientific article

Mammalian target of rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate.

scientific article published on November 2005

Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer.

scientific article published on 03 February 2014

Medians and Milestones in Describing the Path to Cancer Cures: Telling "Tails".

scientific article published on 19 November 2015

Missing the mark in FGFR1-amplified squamous cell cancer of the lung

scientific article published on 17 June 2016

Molecular Engineering of Ultrasmall Silica Nanoparticle-Drug Conjugates as Lung Cancer Therapeutics

scientific article published on 28 July 2020

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

scientific article published on 01 May 2019

Molecularly targeted therapies in non-small-cell lung cancer annual update 2014

scientific article

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

scientific article published on 01 December 2018

Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.

scientific article published on 9 March 2016

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

scientific article (publication date: 22 October 2015)

Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer

scientific article published on 9 May 2017

Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo

scientific article published on 12 October 2011

Novel systemic therapies for small cell lung cancer

scientific article

Novel therapeutic approaches for small cell lung cancer: the future has arrived

scientific article

ONECUT2 is a driver of neuroendocrine prostate cancer

scientific article published in Nature Communications

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment.

scientific article published on June 2016

PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer.

scientific article published on 20 July 2016

Patterns of failure in limited-stage small cell lung cancer: Implications of TNM stage for prophylactic cranial irradiation

scientific article published on August 2017

Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity

scientific article

Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding ⬇️

scientific article published on February 7, 2011

Phase 1 study of twice weekly pulse dose and daily low-dose erlotinib as initial treatment for patients with EGFR-mutant lung cancers

scientific article published on 25 October 2016

Phase 2 Study of Erlotinib in Combination With Linsitinib (OSI-906) or Placebo in Chemotherapy-Naive Patients With Non-Small-Cell Lung Cancer and Activating Epidermal Growth Factor Receptor Mutations

scientific article published on 8 August 2016

Phase 2 Study of Pemetrexed and Itraconazole as Second-Line Therapy for Metastatic Nonsquamous Non–Small-Cell Lung Cancer ⬇️

scientific article published on May 1, 2013

Phase I Clinical Study of Seneca Valley Virus (SVV-001),a Replication-Competent Picornavirus, in Advanced Solid Tumors with Neuroendocrine Features ⬇️

scientific article published on February 8, 2011

Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors

scientific article

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

scientific article

Phase I study of dose-dense alternating doublets in advanced non-small-cell lung cancer

scientific article

Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies

scientific article published on February 2006

Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors

scientific article published on 10 April 2013

Phase I trial of Seneca Valley Virus (NTX-010) in children with relapsed/refractory solid tumors: a report of the Children's Oncology Group

scientific article

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

scientific article published on 07 February 2011

Phase I/II study of pemetrexed with or without ABT-751 in advanced or metastatic non-small-cell lung cancer

scientific article

Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer

scientific article

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

scientific article

Pivotal ERIVANCE basal cell carcinoma (BCC) study: 12-month update of efficacy and safety of vismodegib in advanced BCC.

scientific article published on June 2015

Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.

scientific article published on 19 September 2016

Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.

scientific article published on 23 March 2017

Protein-altering germline mutations implicate novel genes related to lung cancer development

scientific article published on 11 May 2020

Publisher Correction: Lineage plasticity in cancer: a shared pathway of therapeutic resistance

scientific article published on 17 March 2020

Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations

scientific article

Quantitation of Murine Stroma and Selective Purification of the Human Tumor Component of Patient-Derived Xenografts for Genomic Analysis

scientific article

Quantitative <i>In Vivo</i> Analyses Reveal a Complex Pharmacogenomic Landscape in Lung Adenocarcinoma

scientific article published on 02 July 2021

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

scientific article

RET mutations in neuroendocrine tumors: including small-cell lung cancer

scientific article published on September 2014

Randomized phase II study of pulse erlotinib before or after carboplatin and paclitaxel in current or former smokers with advanced non-small-cell lung cancer.

scientific article published on December 2008

Rapamycin rescues ABT-737 efficacy in small cell lung cancer

scientific article published on 10 March 2014

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

scientific article published on 10 February 2020

Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.

scientific article

Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping

scientific article

Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer

scientific article published on 01 December 2021

Rovalpituzumab tesirine, a DLL3-targeted antibody-drug conjugate, in recurrent small-cell lung cancer: a first-in-human, first-in-class, open-label, phase 1 study

scientific article

SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines.

scientific article

SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.

scientific article published on 22 October 2006

Scientific Advances in Thoracic Oncology 2016.

scientific article published on 27 May 2017

Selective tropism of Seneca Valley virus for variant subtype small cell lung cancer.

scientific article published on 05 June 2013

Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy

scientific article published on 12 June 2015

Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers

scientific article

Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis ⬇️

scientific article published on September 21, 2010

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

scientific article published on 29 January 2016

Small cell lung cancer: where do we go from here?

scientific article

Small cell lung cancer: will recent progress lead to improved outcomes?

scientific article published in May 2015

Small-cell lung cancer in 2016: Shining light on novel targets and therapies.

scientific article published on 13 December 2016

Small-cell lung cancer in the era of immunotherapy

scientific article published in December 2017

Solid Predominant Histologic Subtype in Resected Stage I Lung Adenocarcinoma Is an Independent Predictor of Early, Extrathoracic, Multisite Recurrence and of Poor Postrecurrence Survival

scientific article published on 10 August 2015

Stage IV lung carcinoids: spectrum and evolution of proliferation rate, focusing on variants with elevated proliferation indices

scientific article published on 28 March 2019

Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come.

scientific article

Survival after community diagnosis of early-stage non-small cell lung cancer

scientific article

Svf1 inhibits reactive oxygen species generation and promotes survival under conditions of oxidative stress in Saccharomyces cerevisiae.

scientific article

Systemic therapy, clinical outcomes, and overall survival in locally advanced or metastatic pulmonary carcinoid: a brief report.

scientific article

Target engagement imaging of PARP inhibitors in small-cell lung cancer.

scientific article published on 12 January 2018

Targeting Germline and Tumor Associated Nucleotide Excision Repair Defects in Cancer

scientific article published on 16 November 2020

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

scientific article published on 05 February 2019

Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer

scientific article published on 31 August 2018

The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer

scientific article published on 24 July 2020

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

scientific article published on 09 February 2015

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance

scientific article published on 30 July 2019

The addition of anti-angiogenic tyrosine kinase inhibitors to chemotherapy for patients with advanced non-small-cell lung cancers: A meta-analysis of randomized trials

scientific article published on 17 October 2016

The future of epigenetic therapy in solid tumours--lessons from the past.

scientific article published on 02 April 2013

The impact of insurance on access to cancer clinical trials at a comprehensive cancer center

scientific article published on December 2010

The twist box domain is required for Twist1-induced prostate cancer metastasis

scientific article published on 27 August 2013

Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

scientific article

Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline

scientific article published on 8 September 2015

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

scientific article published on 14 January 2019

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

scientific article published on 04 November 2019

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

scientific article published on 17 May 2021

Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model

scientific article published on 12 September 2019

Unravelling the biology of SCLC: implications for therapy

scientific article published on 23 May 2017

Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer.

scientific article

Vismodegib

scientific article published on 07 June 2012

Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508).

scientific article published on 10 May 2016

Paulina is supported by:

About Paulina

Help