List of works - Frank B. Sachse

3-OST-7 regulates BMP-dependent cardiac contraction

scientific article

A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues

scientific article published on 22 March 2019

A framework for modeling of mechano-electrical feedback mechanisms of cardiac myocytes and tissues

scientific article published in January 2007

A model of electrical conduction in cardiac tissue including fibroblasts

scientific article published on 13 March 2009

A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs

scientific article published on 3 January 2014

A software framework for solving bioelectrical field problems based on finite elements

scientific article published in January 2006

A software framework for solving problems of bioelectricity applying high-order finite elements

scientific article published in January 2004

Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia

scientific article published on 23 November 2012

Adaptation of the Voltage Dependent Muscarinic M2 Receptor on Cardiac Ik,Ach to Different Ligands

scientific article published on 7 September 2013

An Imaging Protocol to Discriminate Specialized Conduction Tissue During Congenital Heart Surgery

scientific article published on 06 February 2019

An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts ⬇️

scientific article published on August 24, 2012

Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy

scientific article

Analyzing Remodeling of Cardiac Tissue: A Comprehensive Approach Based on Confocal Microscopy and 3D Reconstructions.

scientific article

Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure

scientific article

Catheterized Fiber-Optics Confocal Microscopy of the Beating Heart In Situ

scientific article published in October 2017

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.

scientific article

Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation

scientific article

Chloroquine blocks a mutant Kir2.1 channel responsible for short QT syndrome and normalizes repolarization properties in silico.

scientific article

Comparison of macroscopic models of excitation and force propagation in the heart.

scientific article published in January 2002

Comparison of regularization techniques for the reconstruction of transmembrane potentials in the heart

scientific article published on 01 January 2002

Compression of 3- and 4-dimensional medical image data

scientific article

Computational simulations of asymmetric fluxes of large molecules through gap junction channel pores.

scientific article published on 30 August 2016

Conduction velocity in myocardium modulated by strain: measurement instrumentation and initial results

scientific article published on 01 January 2004

Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart.

scientific article published on 4 April 2018

Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels

scientific article published on 16 January 2008

Coxsackievirus B3 modulates cardiac ion channels ⬇️

scientific article published on June 27, 2013

De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero.

scientific article published on 18 August 2005

Development of a human body model for numerical calculation of electrical fields.

scientific article published on May 2000

Diffusion tensor imaging and histology of developing hearts.

scientific article published on 3 August 2016

Electrical stimulation directs engineered cardiac tissue to an age-matched native phenotype.

scientific article

Electrophysiological modeling of fibroblasts and their interaction with myocytes

scientific article published on 13 November 2007

Estimating Intracellular Conductivity Tensors from Confocal Microscopy of Rabbit Ventricular Tissue

scientific article

Evidence for a Heritable Contribution to Atrial Fibrillation Associated With Fibrosis

scientific article published on 27 February 2019

Excitation propagation and force development in the left ventricle of the visible female data set.

scientific article

Experimental and computational studies of strain-conduction velocity relationships in cardiac tissue

scientific article published on 29 February 2008

Extended Bidomain Modeling of Defibrillation: Quantifying Virtual Electrode Strengths in Fibrotic Myocardium

scientific article published on 03 April 2019

Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome

scientific article

Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels.

scientific article published on 8 August 2016

Heterogeneous three-dimensional anatomical and electrophysiological model of human atria

scientific article published in June 2006

Hyperelastic description of elastomechanic properties of the heart: a new material law and its application

scientific article published on 01 January 2002

Identification of nodal tissue in the living heart using rapid scanning fiber-optics confocal microscopy and extracellular fluorophores.

scientific article

Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-β1.

scientific article published on 22 July 2016

Intramural activation and repolarization sequences in canine ventricles. Experimental and simulation studies

scientific article published on 01 October 2005

Intraoperative localization of cardiac conduction tissue regions using real-time fibre-optic confocal microscopy: first in human trial

scientific article published on 21 February 2020

Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex

scientific article published on 16 August 2011

Local delivery of fluorescent dye for fiber-optics confocal microscopy of the living heart.

scientific article

Localization of the sinoatrial and atrioventricular nodal region in neonatal and juvenile ovine hearts

scientific article published on 07 May 2020

Location and function of transient receptor potential canonical channel 1 in ventricular myocytes

scientific article published on 23 January 2020

Measurement of Strain in Cardiac Myocytes at Micrometer Scale Based on Rapid Scanning Confocal Microscopy and Non-Rigid Image Registration.

scientific article published on 21 March 2016

Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes ⬇️

scientific article published on October 1, 2012

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

scientific article

Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function

scientific article published on 10 October 2018

Modeling force development in the sarcomere in consideration of electromechanical coupling.

scientific article published on January 2002

Modeling of IK1 mutations in human left ventricular myocytes and tissue

scientific article published on 25 August 2006

Modelling of short QT syndrome in a heterogeneous model of the human ventricular wall

scientific article published in September 2005

Models of cardiac tissue electrophysiology: progress, challenges and open questions.

scientific article published on 27 May 2010

Modification of hERG1 channel gating by Cd2+.

scientific article

Modulation of Asymmetric Flux in Heterotypic Gap Junctions by Pore Shape, Particle Size and Charge.

scientific article published on 6 April 2017

Modulation of Calcium Transients in Cardiomyocytes by Transient Receptor Potential Canonical 6 Channels

scientific article published on 14 February 2020

Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

scientific article

Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643

scientific article

Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery.

scientific article published on October 2014

No fuzzy space for intracellular Na+ in healthy ventricular myocytes.

scientific article

Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images

scientific article published on 16 May 2008

Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes.

scientific article

Preprocessing of the Visible Female data

scientific article

Quantitative analysis of cardiac tissue including fibroblasts using three-dimensional confocal microscopy and image reconstruction: towards a basis for electrophysiological modeling.

scientific article

Quantitative reconstruction of cardiac electromechanics in human myocardium: assembly of electrophysiologic and tension generation models.

scientific article published on October 2003

Quantitative reconstruction of cardiac electromechanics in human myocardium: regional heterogeneity

scientific article published in October 2003

Relaxation gating of the acetylcholine-activated inward rectifier K+ current is mediated by intrinsic voltage sensitivity of the muscarinic receptor

scientific article published on 31 January 2011

Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy.

scientific article

Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.

scientific article

Reply: does size matter? In search of a physiological definition of myocardial atrophy.

scientific article published in May 2015

Sensitivity analysis of cardiac electrophysiological models using polynomial chaos

scientific article published in January 2005

Sensitivity and Specificity of Cardiac Tissue Discrimination Using Fiber-Optics Confocal Microscopy

scientific article published on 25 January 2016

Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

scientific article

Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading

scientific article

Special issue: Functional imaging and modelling of the heart

scientific article published on 30 August 2008

Stochastic Markovian modeling of electrophysiology of ion channels: reconstruction of standard deviations in macroscopic currents

scientific article published on 20 October 2006

Stoichiometry of altered hERG1 channel gating by small molecule activators

scientific article published on 17 March 2014

Strain Transfer in Ventricular Cardiomyocytes to Their Transverse Tubular System Revealed by Scanning Confocal Microscopy ⬇️

scientific article published on May 18, 2011

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

scholarly article

Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy.

scientific article published on 17 January 2012

TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes

scientific article published on 14 December 2011

The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.

scientific article published on 28 February 2007

The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts

scientific article published on 18 August 2011

The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

scholarly article

Three-dimensional modeling and quantitative analysis of gap junction distributions in cardiac tissue

scientific article

Towards Automated Quantification of Atrial Fibrosis in Images from Catheterized Fiber-Optics Confocal Microscopy Using Convolutional Neural Networks

scientific article published on 30 May 2019

Towards modeling of cardiac micro-structure with catheter-based confocal microscopy: a novel approach for dye delivery and tissue characterization

scientific article

Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule

scientific article

Verification of cardiac tissue electrophysiology simulators using an N-version benchmark.

scientific article published on November 2011

Visualization of electrical current flow with a new streamline technique: application in mono- and bidomain simulations of cardiac tissue

scientific article published in January 2004

Voltage sensitivity of M2 muscarinic receptors underlies the delayed rectifier-like activation of ACh-gated K(+) current by choline in feline atrial myocytes

scientific article published on 7 May 2013