List of works - Santiago Lamas

A "fluorescence switch" technique increases the sensitivity of proteomic detection and identification of S-nitrosylated proteins

scientific article published on December 2009

A novel strategy for global analysis of the dynamic thiol redox proteome

scientific article

A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosis

scientific article

Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells

scientific article published in October 2002

Acute hypoxia produces a superoxide burst in cells

scientific article published on 15 March 2014

Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase.

scientific article

Antioxidant responses and cellular adjustments to oxidative stress

scientific article

Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage

scientific article

Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts

scientific article published on May 2006

Cellular mechanisms of vascular injury mediated by calcineurin inhibitors

scientific article published on 01 August 2005

Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors

scientific article

Cooperation between low density lipoproteins and IGF-I in the promotion of mitogenesis in vascular smooth muscle cells.

scientific article

Correction of hypertension by normalization of endothelial levels of fibroblast growth factor and nitric oxide synthase in spontaneously hypertensive rats.

scientific article published on October 1996

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

scientific article published on 26 October 2017

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress.

scientific article published on 14 January 2012

Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide

scientific article published on 27 January 2010

Data-dependent normalization strategies for untargeted metabolomics-a case study

scientific article published on 14 April 2020

Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis.

scientific article published on 13 April 2018

Deletion of delta-like 1 homologue accelerates renal inflammation by modulating the Th17 immune response

scientific article published on 01 January 2021

Detection and identification of S-nitrosylated proteins in endothelial cells

scientific article

Detection and proteomic identification of S-nitrosylated proteins in endothelial cells

scientific article

Direct interaction between the reductase domain of endothelial nitric oxide synthase and the ryanodine receptor.

scientific article published in June 2005

Editors´ ForumDiscussion of Controversies in the Measurement of Nitric Oxide metabolites in Biological Matrices

scientific article published on 01 August 2015

Endoglin expression regulates basal and TGF-beta1-induced extracellular matrix synthesis in cultured L6E9 myoblasts.

scientific article published on January 2004

Endothelial control of vasomotor tone: the kidney perspective

scientific article published on March 2012

Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells

scientific article published on 7 March 2010

Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis

scientific article published in March 2010

Endothelin 1 does not play a major role in the homeostasis of arterial pressure in cirrhotic rats with ascites.

scientific article published in June 1995

Endothelin-1 expression is strongly repressed by AU-rich elements in the 3'-untranslated region of the gene.

scientific article published on May 2005

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

scientific article published on 18 May 2017

Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation.

scientific article published in February 2009

Expression of endoglin in human mesangial cells: modulation of extracellular matrix synthesis

scientific article published on 01 May 2002

Fenofibrate inhibits endothelin-1 expression by peroxisome proliferator-activated receptor α-dependent and independent mechanisms in human endothelial cells

scientific article published on 17 January 2013

Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression

scientific article published on 22 May 2003

Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells

scientific article

Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis

scientific article published on 14 November 2019

Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding

scientific article published in November 2001

Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability.

scientific article published on 22 September 2008

High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: application to biological studies

scientific article published in November 2007

Hydrogen peroxide signaling in vascular endothelial cells.

scientific article published on March 2014

Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells

scientific article published in January 2013

Imbalance in endothelial vasoactive factors as a possible cause of cyclosporin toxicity: a role for endothelin-converting enzyme

scientific article published on 01 November 2000

Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration

scientific article

Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites

scientific article published in December 1996

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

scientific article published in May 2012

Introduction to Special Issue "Redox regulation of cardiovascular signaling in health and disease"

scientific article published on 24 April 2017

Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells

scientific article published in January 1998

L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions.

scientific article

Lack of association between endothelin-1 gene variants and myocardial infarction

scientific article published on 11 August 2009

Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells.

scientific article published on 17 July 2014

Launch of Redox Biology: A new venue for studies in translational, basic and applied research in the fields of antioxidants, cell signaling and redox therapeutics.

scientific article published on 16 January 2013

Madrid center not quite in limbo

scientific article published on 01 August 2005

Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration.

scientific article

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

scientific article published on 22 November 2019

MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease

scientific article published on 23 March 2016

Mitochondrial dysfunction in human pathologies.

scientific article published on January 2007

Molecular cloning and characterization of human endothelial nitric oxide synthase

scientific article (publication date: 3 August 1992)

Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes.

scientific article published on 26 March 2009

NMDA induces post-transcriptional regulation of alpha2-guanylyl-cyclase-subunit expression in cerebellar granule cells

scientific journal article

NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.

scientific article published on 28 September 2015

Native and oxidized low density lipoproteins oppositely modulate the effects of insulin-like growth factor I on VSMC

scientific article published on 01 February 2004

Nitric Oxide Inhibits c-Jun DNA Binding by Specifically TargetedS-Glutathionylation

scientific article published in Journal of Biological Chemistry

Nitric oxide decreases the expression of endothelin-converting enzyme-1 through mRNA destabilization.

scientific article

Nitric oxide down-regulates caveolin-3 levels through the interaction with myogenin, its transcription factor

scientific article published on 22 May 2007

Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair

scientific article published on 21 May 2008

Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium

Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1α

scientific article published on 04 August 2006

Nitric oxide signaling comes of age: 20 years and thriving

scientific article published on 02 June 2007

Nitric oxide signaling: classical, less classical, and nonclassical mechanisms.

scientific article published on 13 April 2011

Nitric oxide-activated glutathione Sepharose

scientific article published in January 2002

Nitric oxide: from discovery to the clinic

scientific article published on 01 November 1998

Nitrosylation of thiols in vascular homeostasis and disease

scientific article

Nitrosylation. the prototypic redox-based signaling mechanism.

scientific article

Novel application of S-nitrosoglutathione-Sepharose to identify proteins that are potential targets for S-nitrosoglutathione-induced mixed-disulphide formation

scientific article published in July 2000

Off to a good start and a promising future in communicating cutting edge developments in redox biology

scientific article published on 10 September 2013

PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells

scientific article published on 25 February 2005

PPAR agonists amplify iNOS expression while inhibiting NF-kappaB: implications for mesangial cell activation by cytokines.

scientific article published in September 2002

Presence of nitric oxide synthase activity in roots and nodules of Lupinus albus

scientific article published on 01 December 1996

Protective role for miR-9-5p in the fibrogenic transformation of human dermal fibroblasts.

scientific article published on 10 May 2016

Proteomic identification of S-nitrosylated proteins in endothelial cells

scientific article published on 01 January 2007

Redox Biology celebrates its first anniversary with over 100 articles, Listing In PubMed and 120,000 downloads with over 230 citations!

scientific article published on 3 March 2014

Regulation of cyclooxygenase-2 expression in human mesangial cells - transcriptional inhibition by IL-13

scientific article published on 01 February 1999

Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress

scientific article

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

scientific article published in March 2021

Retracted: HLA-B35 and dsRNA Induce Endothelin-1 via Activation of ATF4 in Human Microvascular Endothelial Cells

retracted article

Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells

scientific article published on 25 June 2013

Role of endothelin in the cardiovascular system.

scientific article published on 04 February 2011

Role of glutathione biosynthesis in endothelial dysfunction and fibrosis.

scientific article published on September 2017

Role of non-coding-RNAs in response to environmental stressors and consequences on human health

scientific article published on 18 July 2020

Role of peroxynitrite in endothelial damage mediated by Cyclosporine A

scientific article published on 10 November 2006

Role of reactive oxygen species in the signalling cascade of cyclosporine A‐mediated up‐regulation of eNOS in vascular endothelial cells ⬇️

scientific article published on June 1, 1998

Role of redoximiRs in fibrogenesis

scientific article

S-glutathionylation of NF-kappa B subunit p50.

scientific article

S-glutathionylation: relevance in diabetes and potential role as a biomarker.

scientific article published on October 2013

S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities

scientific article

S-nitrosylation: a potential new paradigm in signal transduction

scientific article published on April 2004

Screening of the endothelin1 gene (EDN1) in a cohort of patients with essential left ventricular hypertrophy

scientific article published on 02 March 2007

Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation

scientific article published on 01 April 2007

Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: convergences and divergences

scientific article published on 24 March 2007

SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex

scientific article published on 15 April 2013

Spanish science

scientific article published in Nature

Specificity in S-nitrosylation: a short-range mechanism for NO signaling?

scientific article published on 04 January 2013

Superoxide limits cyclosporine-A-induced formation of peroxynitrite in endothelial cells(2).

scientific article

Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis

scientific article

Targeting the progression of chronic kidney disease

scientific article published on 14 February 2020

Tetrahydrobiopterin Modulates Cyclooxygenase-2 Expression in Human Mesangial Cells

scientific article published on 01 December 1997

The Role of MicroRNAs in Environmental Risk Factors, Noise-Induced Hearing Loss, and Mental Stress.

scientific article published on 31 May 2017

The non-canonical NOTCH ligand DLK1 exhibits a novel vascular role as a strong inhibitor of angiogenesis.

scientific article published on 8 November 2011

The pHLIP system as a vehicle for microRNAs in the kidney

scientific article published on 18 July 2020

Transcriptional induction of endothelial nitric oxide gene by cyclosporine A. A role for activator protein-1

scientific article published on 01 February 2000

Transforming growth factor-beta induces endothelin-1 expression through activation of the Smad signaling pathway

scientific article published on 01 November 2004

Transforming growth factor-beta receptor requirements for the induction of the endothelin-1 gene

scientific article published on 01 June 2006

Two decades of new concepts in nitric oxide signaling: from the discovery of a gas messenger to the mediation of nonenzymatic posttranslational modifications.

scientific article published on February 2009

Variance analysis by use of a low cost desk top calculator

scientific article published on 01 January 1986

Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis

scholarly article

Virtual issue by COST Action BM1203 (EU-ROS) "Emerging concepts in redox biology and oxidative stress".

scientific article published on 21 December 2015

[Research and projects: some clarification]

scientific article published on 01 January 2009

c-Jun regulation by S-glutathionylation

scientific article published in January 2002

miR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2

scientific article published on 27 August 2015

List of works by Santiago Lamas

A "fluorescence switch" technique increases the sensitivity of proteomic detection and identification of S-nitrosylated proteins

A novel strategy for global analysis of the dynamic thiol redox proteome

A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosis

Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells

Acute hypoxia produces a superoxide burst in cells

Adenoviral gene transfer of endothelin-1 in the lung induces pulmonary fibrosis through the activation of focal adhesion kinase.

Antioxidant responses and cellular adjustments to oxidative stress

Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage

Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts

Cellular mechanisms of vascular injury mediated by calcineurin inhibitors

Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors

Cooperation between low density lipoproteins and IGF-I in the promotion of mitogenesis in vascular smooth muscle cells.

Correction of hypertension by normalization of endothelial levels of fibroblast growth factor and nitric oxide synthase in spontaneously hypertensive rats.

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress.

Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide

Data-dependent normalization strategies for untargeted metabolomics-a case study

Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis.

Deletion of delta-like 1 homologue accelerates renal inflammation by modulating the Th17 immune response

Detection and identification of S-nitrosylated proteins in endothelial cells

Detection and proteomic identification of S-nitrosylated proteins in endothelial cells

Direct interaction between the reductase domain of endothelial nitric oxide synthase and the ryanodine receptor.

Editors´ ForumDiscussion of Controversies in the Measurement of Nitric Oxide metabolites in Biological Matrices

Endoglin expression regulates basal and TGF-beta1-induced extracellular matrix synthesis in cultured L6E9 myoblasts.

Endothelial control of vasomotor tone: the kidney perspective

Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells

Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis

Endothelin 1 does not play a major role in the homeostasis of arterial pressure in cirrhotic rats with ascites.

Endothelin-1 expression is strongly repressed by AU-rich elements in the 3'-untranslated region of the gene.

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation.

Expression of endoglin in human mesangial cells: modulation of extracellular matrix synthesis

Fenofibrate inhibits endothelin-1 expression by peroxisome proliferator-activated receptor α-dependent and independent mechanisms in human endothelial cells

Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression

Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells

Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis

Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding

Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability.

High-sensitivity analysis of specific peptides in complex samples by selected MS/MS ion monitoring and linear ion trap mass spectrometry: application to biological studies

Hydrogen peroxide signaling in vascular endothelial cells.

Hydrogen peroxide signaling mediator in the activation of p38 MAPK in vascular endothelial cells

Imbalance in endothelial vasoactive factors as a possible cause of cyclosporin toxicity: a role for endothelin-converting enzyme

Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration

Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Introduction to Special Issue "Redox regulation of cardiovascular signaling in health and disease"

Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells

L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions.

Lack of association between endothelin-1 gene variants and myocardial infarction

Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells.

Launch of Redox Biology: A new venue for studies in translational, basic and applied research in the fields of antioxidants, cell signaling and redox therapeutics.

Madrid center not quite in limbo

Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration.

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease

Mitochondrial dysfunction in human pathologies.

Molecular cloning and characterization of human endothelial nitric oxide synthase

Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes.

NMDA induces post-transcriptional regulation of alpha2-guanylyl-cyclase-subunit expression in cerebellar granule cells

NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.

Native and oxidized low density lipoproteins oppositely modulate the effects of insulin-like growth factor I on VSMC

Nitric Oxide Inhibits c-Jun DNA Binding by Specifically TargetedS-Glutathionylation

Nitric oxide decreases the expression of endothelin-converting enzyme-1 through mRNA destabilization.

Nitric oxide down-regulates caveolin-3 levels through the interaction with myogenin, its transcription factor

Nitric oxide elicits functional MMP-13 protein-tyrosine nitration during wound repair

Nitric oxide regulates matrix metalloprotease-13 expression and activity in endothelium

Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1α

Nitric oxide signaling comes of age: 20 years and thriving

Nitric oxide signaling: classical, less classical, and nonclassical mechanisms.

Nitric oxide-activated glutathione Sepharose

Nitric oxide: from discovery to the clinic

Nitrosylation of thiols in vascular homeostasis and disease

Nitrosylation. the prototypic redox-based signaling mechanism.

Novel application of S-nitrosoglutathione-Sepharose to identify proteins that are potential targets for S-nitrosoglutathione-induced mixed-disulphide formation

Off to a good start and a promising future in communicating cutting edge developments in redox biology

PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells

PPAR agonists amplify iNOS expression while inhibiting NF-kappaB: implications for mesangial cell activation by cytokines.

Presence of nitric oxide synthase activity in roots and nodules of Lupinus albus

Protective role for miR-9-5p in the fibrogenic transformation of human dermal fibroblasts.