List of works - Cecile Denis

A Laboratory Phenotype/Genotype Correlation of 1167 French Patients From 670 Families With von Willebrand Disease: A New Epidemiologic Picture

scientific article published on March 2016

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation-Brief Report.

scientific article published on 22 June 2017

A Thrombin-Activatable Factor X Variant Corrects Hemostasis in a Mouse Model for Hemophilia A

scientific article published on 22 October 2019

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

scientific article published on 31 July 2018

A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation.

scientific article published on 23 May 2016

A hemophilia A mouse model for the in vivo assessment of Emicizumab function

scientific article published on 05 May 2020

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis

scientific journal article

A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor

scientific article published on 20 August 2012

A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation

article

A single-domain antibody that blocks factor VIIa activity in the absence but not presence of tissue factor

scientific article published on 03 September 2019

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

scientific article

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis

scientific article published on 12 April 2018

Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa

scientific article published on 16 May 2008

An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation.

scientific article published on 12 November 2003

Antibody-Based Protection of von Willebrand Factor Degradation

scientific article published on 01 June 2016

Antibody-based prevention of von Willebrand factor degradation mediated by circulatory assist devices.

scientific article published on 17 July 2014

Apoptotic Platelet Events Are Not Observed in Severe von Willebrand Disease-Type 2B Mutation p.V1316M.

scientific article

Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support

Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization

scientific article published on 24 October 2009

Benzodiazepine use among opiate-dependent subjects in buprenorphine maintenance treatment: correlates of use, abuse and dependence

scientific article

Benzodiazepine withdrawal in subjects on opiate substitution treatment

scientific article

Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report

scientific article published on 8 July 2010

Blocking von Willebrand factor for treatment of cutaneous inflammation

scientific article published on 28 June 2013

CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

scientific article published on 01 March 2002

Camelid-derived single-chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

scientific article published on 09 September 2020

Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein

scientific article published on March 2008

Characterization of the interaction between von Willebrand factor and osteoprotegerin

scientific article published on 01 September 2007

Clearance of von Willebrand factor

scientific article published on 01 February 2008

Clearance of von Willebrand factor.

scientific article published on June 2013

Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance

scientific article

Comparison of prescriber evaluations and patient-directed self-reports in office-based practice for buprenorphine treatment of opiate-dependent individuals in France, 2002.

scientific article published on 02 February 2008

Correction of bleeding in experimental severe hemophilia A by systemic delivery of factor VIII-encoding mRNA

scientific article published on 09 July 2019

Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.

scientific article

Correction of the bleeding time in von Willebrand factor (VWF)-deficient mice using murine VWF

scientific article published on 01 March 2007

Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice

scholarly article

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

scientific article published on 02 January 2019

Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member

scientific article

Emerging Therapeutic Strategies in the Treatment of Hemophilia A.

scientific article published on 27 July 2017

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

scientific article published on 17 October 2017

Endothelial-driven increase in plasma thrombin generation characterising a new hypercoagulable phenotype in acute heart failure

scientific article published on 25 July 2018

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.

scientific article

Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5.

scientific article published on 24 June 2012

Factor VIII and von Willebrand factor--too sweet for their own good

scientific article published on July 2010

GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice.

scientific article published on 19 February 2014

Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis

scientific article published on 09 October 2014

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

scientific article

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami

scientific article published on 25 June 2016

Identification of Galectin-1 and Galectin-3 as Novel Partners for Von Willebrand Factor

scientific article published on 19 January 2012

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice.

scientific article

In vivo MRI and ex vivo quantification of iron and Kupffer cells demonstrate residual phagocytic activity in mouse liver after a gadolinium chloride injection

scientific article published on 30 June 2010

In vivo analysis of the role of O-glycosylations of von Willebrand factor.

scientific article

In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.

scientific article published on 11 August 2005

In vivo modulation of a dominant-negative variant in mouse models of von Willebrand disease type 2A

scientific article published on 12 October 2020

Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice.

scientific article published on 23 December 2005

Insights from von Willebrand disease animal models

scientific journal article

Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis

scientific article

Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models

scientific article published in January 2001

LDL receptor-related protein 1 contributes to the clearance of the activated factor VII-antithrombin complex.

scientific article published on 10 September 2016

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.

scientific article

Localized reduction of atherosclerosis in von Willebrand factor-deficient mice

scientific article published in September 2001

Macrophage LRP1 contributes to the clearance of von Willebrand factor.

scientific article

Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X.

scientific article published on 25 November 2015

Macrophage scavenger-receptor SR-AI contributes to the clearance of von Willebrand factor

scientific article published on 11 January 2018

Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo.

scientific article published on 16 June 2008

Measuring beta-galactose exposure on platelets: Standardization and healthy reference values

scientific article published on 02 June 2020

Models for prediction of factor VIII half-life in severe haemophiliacs: distinct approaches for blood group O and non-O patients

scientific article

Molecular and cellular biology of von Willebrand factor

scientific article

Molecular characterization of Iranian patients with type 3 von Willebrand disease

scientific article

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.

scientific article

Mutations in the A3 domain of von Willebrand factor inducing combined qualitative and quantitative defects in the protein.

scientific article published on 18 January 2013

Network-based analysis of omics data: the LEAN method

scientific article

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation

scientific article published on 20 February 2014

Novel Function of Tenascin-C, a Matrix Protein Relevant to Atherosclerosis, in Platelet Recruitment and Activation Under Flow

scientific article published on 22 July 2010

Of von Willebrand factor and platelets

scientific article

P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor

scientific article published on 22 August 2006

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

scientific journal article

Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings

scientific article

Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings

scientific article (publication date: 19 July 2006)

Platelet Functions are Decreased in Obesity and Restored after Weight Loss: Evidence for a Role of the SERCA3-Dependent ADP Secretion Pathway

scientific article published on 16 January 2019

Platelet adhesion receptors and their ligands in mouse models of thrombosis.

scientific article published on February 2007

Platelet von Willebrand factor: sweet resistance.

scientific article published in December 2013

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi

scientific article

Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets

scientific article published on 01 June 2018

Psychotherapeutic interventions for cannabis abuse and/or dependence in outpatient settings

scientific article

Psychotherapeutic interventions for cannabis abuse and/or dependence in outpatient settings

scientific article (publication date: 19 July 2006)

Relationship between anxiety disorders and opiate dependence--a systematic review of the literature: implications for diagnosis and treatment

scientific article published on 08 February 2010

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence

scientific article published on 28 February 2019

Self-perceived motivation for benzodiazepine use and behavior related to benzodiazepine use among opiate-dependent patients

scientific article published on 31 March 2009

Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance.

scientific article

Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity

scientific article

Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.

scientific article published in April 2007

Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia

scientific article published on 01 November 2019

Terminal platelet production is regulated by von Willebrand factor

scientific article (publication date: 2013)

The Clearance Mechanism of Chilled Blood Platelets

scientific article published on 01 January 2003

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.

scientific article

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

scientific article published on 26 October 2018

Towards standardization of in vivo thrombosis studies in mice.

scientific article

Transient von Willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

scientific article

Two residues in the activation peptide domain contribute to the half-life of factor X in vivo

scientific article published on 04 May 2010

Use of a thrombopoietin receptor agonist in von Willebrand disease type 2B (p.V1316M) with severe thrombocytopenia and intracranial hemorrhage

scientific article

VWF clearance: it’s glycomplicated

scientific article published on 01 February 2018

Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels.

scientific article published on 7 November 2006

Vascular endothelial cell expression of JAK2 is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

scientific article published on 31 August 2018

Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis.

scientific article

Von Willebrand factor C1C2 domain is involved in platelet adhesion to polymerized fibrin at high shear rate

scientific article published on 06 November 2003

Von Willebrand factor in vascular pathophysiology

scientific article published on 01 September 2003

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

scientific article published on 18 July 2019

von Willebrand disease biology

scientific article

von Willebrand factor A1 domain: stuck in the middle

scientific article published on 07 April 2007

von Willebrand factor and inflammation

scientific article published on July 2017

von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends

scientific article

von Willebrand factor clearance does not involve proteolysis by ADAMTS-13

scientific article published on 01 October 2010

von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture

scientific article

von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3.

scientific article

von Willebrand factor: at the crossroads of bleeding and thrombosis.

scientific article published on 05 April 2012

von Willebrand factor: the old, the new and the unknown.

scientific article published on December 2012

List of works by Cecile Denis

A Laboratory Phenotype/Genotype Correlation of 1167 French Patients From 670 Families With von Willebrand Disease: A New Epidemiologic Picture

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation-Brief Report.

A Thrombin-Activatable Factor X Variant Corrects Hemostasis in a Mouse Model for Hemophilia A

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation.

A hemophilia A mouse model for the in vivo assessment of Emicizumab function

A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis

A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor

A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation

A single-domain antibody that blocks factor VIIa activity in the absence but not presence of tissue factor

Accelerated uptake of VWF/platelet complexes in macrophages contributes to VWD type 2B-associated thrombocytopenia

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis

Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa

An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation.

Antibody-Based Protection of von Willebrand Factor Degradation

Antibody-based prevention of von Willebrand factor degradation mediated by circulatory assist devices.

Apoptotic Platelet Events Are Not Observed in Severe von Willebrand Disease-Type 2B Mutation p.V1316M.

Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support

Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization

Benzodiazepine use among opiate-dependent subjects in buprenorphine maintenance treatment: correlates of use, abuse and dependence

Benzodiazepine withdrawal in subjects on opiate substitution treatment

Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report

Blocking von Willebrand factor for treatment of cutaneous inflammation

CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

Camelid-derived single-chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Cellular uptake of C4b-binding protein is mediated by heparan sulfate proteoglycans and CD91/LDL receptor-related protein

Characterization of the interaction between von Willebrand factor and osteoprotegerin

Clearance of von Willebrand factor

Clearance of von Willebrand factor.

Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance

Comparison of prescriber evaluations and patient-directed self-reports in office-based practice for buprenorphine treatment of opiate-dependent individuals in France, 2002.

Correction of bleeding in experimental severe hemophilia A by systemic delivery of factor VIII-encoding mRNA

Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.

Correction of the bleeding time in von Willebrand factor (VWF)-deficient mice using murine VWF

Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member

Emerging Therapeutic Strategies in the Treatment of Hemophilia A.

Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII?

Endothelial-driven increase in plasma thrombin generation characterising a new hypercoagulable phenotype in acute heart failure

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.

Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5.

Factor VIII and von Willebrand factor--too sweet for their own good

GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice.

Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami

Identification of Galectin-1 and Galectin-3 as Novel Partners for Von Willebrand Factor

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice.

In vivo MRI and ex vivo quantification of iron and Kupffer cells demonstrate residual phagocytic activity in mouse liver after a gadolinium chloride injection

In vivo analysis of the role of O-glycosylations of von Willebrand factor.

In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphism.

In vivo modulation of a dominant-negative variant in mouse models of von Willebrand disease type 2A

Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice.

Insights from von Willebrand disease animal models

Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis

Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models

LDL receptor-related protein 1 contributes to the clearance of the activated factor VII-antithrombin complex.

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B.

Localized reduction of atherosclerosis in von Willebrand factor-deficient mice

Macrophage LRP1 contributes to the clearance of von Willebrand factor.

Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X.

Macrophage scavenger-receptor SR-AI contributes to the clearance of von Willebrand factor

Macrophages contribute to the cellular uptake of von Willebrand factor and factor VIII in vivo.

Measuring beta-galactose exposure on platelets: Standardization and healthy reference values

Models for prediction of factor VIII half-life in severe haemophiliacs: distinct approaches for blood group O and non-O patients

Molecular and cellular biology of von Willebrand factor

Molecular characterization of Iranian patients with type 3 von Willebrand disease

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.

Mutations in the A3 domain of von Willebrand factor inducing combined qualitative and quantitative defects in the protein.

Network-based analysis of omics data: the LEAN method

Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation

Novel Function of Tenascin-C, a Matrix Protein Relevant to Atherosclerosis, in Platelet Recruitment and Activation Under Flow

Of von Willebrand factor and platelets

P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings

Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings

Platelet Functions are Decreased in Obesity and Restored after Weight Loss: Evidence for a Role of the SERCA3-Dependent ADP Secretion Pathway